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All Journal JI-KES (Jurnal Ilmu Kesehatan) Indonesian Journal of Biology Education Jurnal Abdi Insani Avicenna : Journal of Health Research Jurnal Pengabdian kepada Masyarakat International Journal of Advanced Health Science and Technology Jurnal Kesehatan Rajawali Indonesian Journal of Biology Education
Aulia Rahman
Blood Bank Technology Study Programs, STIKes Guna Bangsa Yogyakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Evaluasi Kualitas Sediaan Packed Red Cells Hasil Pemrosesan Metode Top and Top Wiwit Sepvianti; Serafica Btari Christiyani Kusumaningrum; Ikrimah Nafilata; Arum Sari; Aulia Rahman
JI-KES (Jurnal Ilmu Kesehatan) Vol. 6 No. 1 (2022): JI-KES (Jurnal Ilmu Kesehatan)
Publisher : STIKes Hafshawaty Pesantren Zainul Hasan Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33006/ji-kes.v6i1.333

Abstract

ABSTRAKSediaan packed red cells dapat diperoleh melalui beberapa metode pemrosesan di antaranya adalah metode top and top, top and bottom serta leukodepleted. Di antara ketiga metode tersebut metode top and top adalah metode yang paling banyak digunakan di berbagai unit pelayanan darah. Pada penelitian ini dilakukan evaluasi kualitas packed red cells metode top and top dengan parameter uji kadar hemoglobin, residual leukosit, hematokrit dan pH darah. Adapun metode penelitian yang digunakan adalah observasional. Hasil pengujian menunjukkan bahwa rerata kadar hemoglobin diperoleh sebesar 49,02±5,51gram/unit, telah melebihi standar minimal hemoglobin yaitu 45gram/ unit. Selaras dengan kadar hemoglobin, kadar hematokrit juga berada pada kisaran ideal 65-75% dengan rerata kadar hematokrit sebesar 70,45±5,36%. Nilai pH darah kantong terukur berada pada rentangan 7,348±0,064, nilai ini sesuai dengan kriteria packed red cells yang baik yaitu memiliki kadar pH>6,71. Adapun parameter yang belum sesuai dengan standar adalah kadar residual leukosit.  Packed red cells yang baik seharusnya memiliki residual leukosit <1,2x109sel/unit sedangkan pada penelitian ini diperoleh rerata residual leukosit sebesar (3,66±0,41)x109sel/unit yang menunjukkan jumlah leukosit tertinggal masih berada pada jumlah yang cukup banyak. Berdasarkan evaluasi yang dilakukan dapat dinyatakan bahwa packed red cells hasil pemrosesan top and top memiliki kualitas baik dari segi kadar hemoglobin, hematokrit dan pH darah namun kurang baik ditinjau dari level residual leukositnya.Kata kunci: hemoglobin, hematokrit, ph darah, packed red cells, residual leukositABSTRACTPacked red cells(PRC) could be obtained by several processing methods such as top and top, top and bottom and leuko-depleted methods. However, the most widely used method in the blood service unit is the top and top method. Therefore, this research was conducted to evaluate the quality of PRC produced from the top and top method with the haemoglobin level, leukocytes residual, hematocrit, and blood pH parameters. The research method used is observational. In addition, this study was performed to know the QC standard accomplishment. The results showed that the average haemoglobin level was 49,02±5,51gram/unit and reached the minimum (45gram/unit).  The average of hematocrit also reached the minimum standard (65-75%) since it obtained  70,45±5,36%. The pH also had included in the sufficient criteria since it had 7,348±0,064, as pH needs to be >6,71. However, the level of the residual leukocyte had not reached the minimum standard yet (1,2x109cells/unit) since the residual leukocytes of PRC in this research were obtained (3,66±0,41)x109cells/unit. It showed that there were a high proportion of leukocytes left. Overall, based on the evaluation, it was concluded that the PRC produced from the top and top method had better quality in the haemoglobin level, hematocrit, and pH but not in the residual leukocyte level. Keywords: hemoglobin, hematocrit, blood pH, packed red cells, residual leukocytes  
Anti-Bacterial Activity of Novel Synthesized Chalcone Against S. epidermidis and S. aureus Isolated from Packed Red Cell Blood Product Aulia Rahman; Wiwit Sepvianti; Serafica Btari Christiyani Kusumaningrum; Arum Sari; Mohd Nazil Salleh
International Journal of Advanced Health Science and Technology Vol. 2 No. 6 (2022): December
Publisher : Forum Ilmiah Teknologi dan Ilmu Kesehatan (FORITIKES)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/ijahst.v2i6.174

Abstract

Bacterial contamination in blood product was still a problem in Indonesia. Various studies to improve the safety of blood product by inhibiting the bacterial growth in blood product was developed. Chalcone, is one of the natural compounds that has ability to inhibit the bacterial growth, so it can be possible to use that compound for anti-bacterial use in the future. This study aim is to evaluate the anti-bacterial activity of novel synthesis chalcone (E)-1-(4-hydroxyphenyl)-3-phenylprop-2-en-1-one against S. epidermidis and S. aureus isolated from packed red cell blood product. A novel chalcone was synthesized by Claisen-Schmidt Methods while anti-bacterial activity test was done by Agar Diffusion Methods. Chalcone that has been synthesized then characterized by Fourier Transform Infra-Red (FTIR) Methods and Gas Chromatography – Mass Spectrometry (GC-MS). Chalcone was synthesized through a condensation reaction between an aldehyde (benzaldehyde) and ketone (acetophenone) with NaOH as alkaline catalyst. The results from sedimentary analysis using FTIR showed an absorption of the C=C group in the typical medium of chalcone compounds, at the wave number of 1516.96 cm-1. The results of GC-MS characterization resulted a GC chromatogram with one peak with time of retention (tR) 19.68 minutes and relative purity 100%. MS mass spectrum shows that the molecular ion (M+) of this compound was detected at 224 which equivalents to the molecular weight of the chalcone compound. Anti-bacterial test showed that the synthetic chalcone compound with 5% concentration had an inhibitory ability of 56.02% on S. epidermidis and 54.10% on S. aureus, while 2.5% chalcone concentration had an inhibitory ability of 29.17% on S. epidermidis and 50.45% on S. aureus, and 1.25% chalcone concentration had inhibitory ability 0% on S. epidermidis and 37.27% on S. aureus.
PENGEMBANGAN DESA SIAGA DONOR DARAH MELALUI PROGRAM PEMERIKSAAN DAN PENDATAAN GOLONGAN DARAH WARGA DUSUN MANGGONG, KEPUHARJO, CANGKRINGAN, SLEMAN Gravinda Widyaswara; Wiwit Sepvianti; Aulia Rahman; Kumara Rahmawati Zain; Arif Tirtana; Ikrimah Nafilata
J-ABDI: Jurnal Pengabdian kepada Masyarakat Vol. 2 No. 9: February 2023
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53625/jabdi.v2i9.4886

Abstract

The Allert Village is a village that has a Village Health Post or health professionals who are ready to carry out community empowerment, encourage health-oriented development, and be the first referral center for quality health services for the community and health emergencies in the Village. In moving towards the allert village, it is necessary to study various existing community-based activities such as posyandu, polindes, village medicine post, health fund, and inter-guard preparedness, as a starting point for development towards an allert village. One of the Allert Village programs currently being developed is the Blood Donor Allert Viilage. In this program, village communities are prepared to be responsive in dealing with health problems that require blood donors. The development of the Blood Donor Allert Village was initiated with outreach activities, data collection and examination of the blood group of residents in each hamlet. Data on residents' blood groups is then submitted to village midwives, sub-districts and health centers as a data base for the Blood Donor Allert Village. Blood group data collection for the residents of Manggong, one of the hamlets in Kepuharjo Village, obtained the following results: out of a total of 256 r esidents, 62.50% had their blood type recorded while 37.50% was not. As for the 62.50% of Dusun Manggong residents whose blood type was recorded, 26.87% had blood type A; 28.13% blood type B; 41.25% have blood type O and only 3.75% have blood type AB
Antibacterial Activity of 4-hydroxychalcone Against Bacterial Contaminant of Packed Red Cells Serafica Btari Christiyani Kusumaningrum; Wiwit Sepvianti; Relita Pebrina; Aulia Rahman
Indonesian Journal of Biology Education Vol 5, No 2 (2022): INDONESIAN JOURNAL OF BIOLOGY EDUCATION
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/ijobe.v5i2.7158

Abstract

The bacterial contamination of blood products is still become a serious problem in consideration, thus it can cause the risk of blood transfusion, namely bacterial sepsis. Packed red cells is blood product and potentially contain bacterial contaminant. The source of bacterial contamination can come from the skin disinfection process in less aseptic during blood collection, donor bacterimia, and  blood processing. In response, currently there have been many antibacterial compounds developments purposely to reduce the risk of bacterial contamination of blood products. This study aimed to observe the activity of 4-hydroxychalconecompounds in contaminant bacteria isolated from packed red cells blood products. Bacterial isolates isolated from the packed red cells were Staphylococcus aureusbased on cell morphology, biochemistry and colony shape. The antibacterial activity of 4-hydroxychalchone compound against Staphylococcus aureus isolates used the diffusion method. The results showed, there were antibacterial activity of 4-hydroxychalchone at a concentration of 2.5% 1.25% and 0.625% against packed red cells contaminant bacteria based upon the clear zone formed. In conclusion, the bacteria isolate was obtained from the PRC was gram positive bacteria, Staphylococcus aureus. The 4-hydroxychalcone had successfully synthesized and has antibacterial activity against S. aureus isolated from PRC, with the biggest inhibition power was 71,36% at 5,0% of chalcone concentration.
Evaluasi Kualitas Thrombocyte Concentrate (TC) Berdasarkan Kadar pH, Level Kekeruhan, dan Swirling Selama Masa Penyimpanan 5 Hari Aulia Rahman; Wiwit Sepvianti; Arif Tirtana; Gravinda Widyaswara; Kumara Rahmawati Zain
Jurnal Kesehatan Rajawali Vol 13 No 1 (2023): Jurnal Kesehatan Rajawali
Publisher : Sekolah Tinggi Ilmu Kesehatan Rajawali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54350/jkr.v13i1.159

Abstract

Thrombocyte concentrate transfusion was one of the important medical treatments in increasing the number of thrombocytes in patients with medical indications of thrombocytopenia. The monitoring of blood product quality from upstream to downstream must be considered in order to obtain a good quality thrombocyte concentrate. Thrombocyte concentrate was prone to change during storage due to significant changes between in vitro and in vivo conditions. The changes in thrombocyte concentrate quality that commonly occur during storage were the decreased platelet levels, increased of acidity (pH) and turbidity, and loss of thrombocyte swirling in the plasma. Therefore, it was necessary to conduct research to determine the quality of thrombocyte concentrates during the 5-day shelf life to find out whether at the end of the shelf life, these blood products were still suitable for transfusion to the patients. Several tools used in this study were Hematology Analyzer, blood scales, and pH meter. The results of successive studies showed that the thrombocyte concentrate product did not meet the basic quality standards because the number of thrombocytes per unit was below the standard that was set by Regulation of the Ministry of Health of the Republic of Indonesia Number 91 Years 2015.
INISIASI PENGEMBANGAN DESA SIAGA DONOR DARAH MELALUI PROGRAM PEMERIKSAAN DAN PENDATAAN GOLONGAN DARAH WARGA DUSUN KALIADEM, SLEMAN, YOGYAKARTA Kumara Rahmawati Zain; Wiwit Sepvianti; Aulia Rahman; Gravinda Widyaswara; Arif Tirtana
Jurnal Abdi Insani Vol 10 No 3 (2023): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v10i3.997

Abstract

Alert village is a concept of empowerment and community participation at the village level, accompanied by the development of alertness and readiness of the community to maintain their health independently. Residents of Alert Village have the readiness of resources and the ability and willingness to independently prevent and overcome health problems, disasters and health emergencies. The blood donor alert village is expected to be able to accommodate health problems that arise in areas prone to natural disasters, if during a disaster there is the possibility of the route being cut off. The concept of Desa Siaga Donor is to build a system in a village that is responsible for maintaining community health at the village level, it is hoped that it will overcome problems related to maternal mortality so that it can be accommodated, especially those related to meeting the need for blood during childbirth. Collecting residents' blood type data as an initiation of the Village Alert Program for blood donors in Dusun Kaliadem, especially in fulfilling the need for blood during the delivery process. Community service through the Blood Donor Alert Village initiation activity in Kaliadem Hamlet, Kepuharjo Village, Cangkringan District, Sleman Regency involving 14 DIII students of Blood Bank Technology STIKes Guna Bangsa Yogyakarta by running the Donor Alert Village Initiation program. The total number of residents of Kaliadem Hamlet is 215 people, of which 48.83% have their blood type recorded while 51.16% are not recorded. The community empowerment program in Kaliadem Hamlet, Kepuharjo Village, Cangkringan District, Sleman Regency was carried out as part of the Blood Donor Alert Village Initiation Effort by carrying out health education activities as well as data collection and examination of people's blood groups in Kaliadem Hamlet. Based on the results of blood group checking, it was found that 34 residents had blood type A, 30 residents had blood type B, 5 residents had blood type AB and 36 residents had blood type O. Blood checking data for Kaliadem Hamlet residents will be the main data in the Donor Alert Village initiation. The blood group data of Kaliadem Hamlet residents then becomes part of the Kepuharjo Village database.
JUMLAH ERITROSIT PADA KOMPONEN WHOLE BLOOD SELAMA 28 HARI PENYIMPANAN Gravinda Widyaswara; Aulia Rahman; Kumara Rahmawati Zain
Avicenna : Journal of Health Research Vol 6, No 2 (2023): OKTOBER
Publisher : STIKES Mamba'ul 'Ulum Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36419/avicenna.v6i2.937

Abstract

Screening Parameters of Transfusion-Transmitted Infection using Rapid Diagnostic Method Gravinda Widyaswara; Aulia Rahman; Prilly Layyinatunnisa; Maria Regina Sepe; Rosadelima Dagaina Koten; Zakia Tanzila; Syofianis; Delia Irjayanti Tamu Apu
Indonesian Journal of Biology Education Vol. 7 No. 1 (2024): INDONESIAN JOURNAL OF BIOLOGY EDUCATION
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Blood transfusions are an important part of medicine for patient recovery. Therefore, the transfused blood must be free from viruses, bacteria, and even parasites that can be transmitted through blood transfusions. Human Immunodeficiency Virus (HIV/AIDS), Hepatitis C, Hepatitis B, and Syphilis are among the illnesses that can be transferred through blood transfusions. This research aims to determine screening parameters for transfusion-transmitted infection using the rapid diagnostic test method. This type of research is experimental with a cross-sectional design. The samples used were ten blood samples, taken intravenously and then centrifuged at a speed of 1300 rpm for 4 minutes. After that, screening is carried out with a rapid diagnostic test. The screening results of the ten blood samples examined were valid and negative or non-reactive for HIV/AIDS, Hepatitis C, Hepatitis B, and Syphilis. These results indicate that the blood samples tested can be categorized as blood samples that passed the screening test or the blood examination test for four parameters of transfusion-transmitted infection.
Co-Authors Arif Tirtana Arif Tirtana Arif Tirtana Arum Sari Arum Sari Delia Irjayanti Tamu Apu Gravinda Widyaswara Gravinda Widyaswara Gravinda Widyaswara Ikrimah Nafilata Ikrimah Nafilata Kumara Rahmawati Zain Kumara Rahmawati Zain Kumara Rahmawati Zain Kumara Rahmawati Zain Kusumaningrum, Serafica Btari Christiyani Maria Regina Sepe Mohd Nazil Salleh Prilly Layyinatunnisa Relita Pebrina Rosadelima Dagaina Koten Sepvianti, Wiwit Syofianis Zakia Tanzila