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All Journal BIOMA Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan
R Susanti
Semarang State University
Agriculture, Biological Sciences & Forestry Education Health Professions Medicine & Pharmacology Nursing Public Health

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PENGARUH ALAT KONTRASEPSI HORMONAL TERHADAP BERAT BADAN, TEKANAN DARAH DAN SIKLUS MENSTRUASI Desiy Ema Dwi Wahyuni; R Susanti; Talitha Widiatningrum; Danu Sulistyo
DINAMIKA KESEHATAN: JURNAL KEBIDANAN DAN KEPERAWATAN Vol 13, No 2 (2022): Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan
Publisher : Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/dksm.v13i2.825

Abstract

Latar Belakang: Kontrasepsi merupakan usaha untuk mencegah kehamilan. Berdasarkan profil kesehatan Indonesia tahun 2020, sebagian besar pengguna memilih kontrasepsi hormonal dibandingkan non hormonal.Tujuan: Penelitian ini dilakukan untuk menganalisis  pengaruh kontrasepsi hormonal terhadap berat badan, tekanan darah dan siklus menstruasi.Metode: Penelitian ini merupakan kajian pustaka sistematis yang meninjau artikel jurnal dan hasil-hasil penelitian dalam kurun 10 tahun yang terkait dengan kontrasepsi hormonal yaitu kontrasepsi suntik, pil dan implan. Tinjauan difokuskan pada topik tentang pengaruh kontrasepsi hormonal terhadap berat badan, tekanan darah dan siklus menstruasi. Sumber rujukan dieksplorasi melalui database online seperti Scopus, SINTA, Google Cendikia, dan The Education Resources Information Center (ERIC) Elsevier.Hasil: Hasil telaah artikel menunjukkan ada pengaruh penggunaan dan lama penggunaan kontrasepsi hormonal yaitu kontrasepsi suntik, pil, dan implan terhadap peningkatan berat badan, tekanan darah, dan gangguan menstruasi. Kata kunci: kontrasepsi hormonal, kontrasepsi suntik, kontrasepsi pil, kontrasepsi implan, pengaruh kontrasepsi
Association of TCF7L2 Gene Polymorphism With Non Obesetype 2 Diabetes Mellitus in Javanese Population Ari Yuniastuti; R Susanti; Nugrahaningsih Nugrahaningsih; Rahmatika Saputri R
Bioma : Jurnal Ilmiah Biologi Vol 12, No 2: October 2023
Publisher : Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/bioma.v12i2.15365

Abstract

Type 2 diabetes is characterized by insulin deficiency due to inadequate insulin secretion or decreased tissue response to insulin at one or more points. Three important factors that influence the pathogenesis of type 2 DM are individual factors or ethnic genetics, factors of pancreatic β cell damage and insulin resistance factors. The TCF7L2 gene is a gene that codes for TCF7L2 protein, a group of proteins that act as transcription factors in the Wnt signal pathway. TCF7L2 gene polymorphism occurs when cytosine is replaced with thymine in the intron 3 position in wild-type due to alternative splicing.The purpose study was to determine the frequency of TCF7L2 gene polymorphism in Javanese type 2 non-obese DM patients in Semarang. Detection of TCF7L2 gene polymorphism was carried out on 49 people with type 2 non-obese DM patients and 38 people not with type 2 DM using the PCR-RFLP method. The restriction enzyme used is Rsa1. The allele frequency of TCF7L2 gene polymorphism was analyzed by Chi-square and analysis of sample characteristics was carried out with Odds Ratio. The results showed that there were significant differences in the allele frequency of TCF7L2 gene polymorphism and in the characteristics of age, KGD and systole between case subjects and control subjects. From this study it was concluded that TCF7L2 gene polymorphism is associated with the type 2 DM through interactions between genetic factors (T allele) and life style.
Co-Authors Ari Yuniastuti Danu Sulistyo Desiy Ema Dwi Wahyuni Nugrahaningsih Nugrahaningsih Rahmatika Saputri R Talitha Widiatningrum