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All Journal Jurnal Fitofarmaka Indonesia Jurnal Sains Teknologi dan Lingkungan (JSTL) Jurnal Farmasi Indonesia Jurnal Mandala Pharmacon Indonesia Jurnal Kesehatan Madani Medika Abdimas Madani
Dwi Larasati
Program Studi DIII Farmasi, STIKes Madani, Yogyakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Jurnal Farmasi Indonesia

 1 
Elimination of the Ultraviolet Spectrophotometric-Based Limitation on the Quantification of Metformin HCl in Acid-Stage Medium for a Comparative Dissolution Testing Syaiful Choiri; Dwi Larasati; Ilham Kuncahyo
Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i1.2150

Abstract

Herein, this work aimed to develop an ultraviolet spectrophotometric assay for metformin HCl in comparative dissolution testing along with the acid stage medium due to low molar absorptivity. Metformin HCl was incorporated into the immediate tablet formulation to mimic the analytical matrix system. The dissolution validation procedure was carried out by linearity, accuracy, precision, the limit of quantification, filter compatibility, and aliquot stability that fulfil the USP method for validation of dissolution procedure, particularly assay of the analyte.The results revealed that metformin HCl had difficulty quantifying in acid pH due to the absence UV-band peak. The addition of pH-shifting agents promoted better performance for metformin quantification. Therefore, the method was successfully developed along with R2, predicted R2, accuracy, and precision of 0.9999, 0,9998, 100.57%, and 1.27%, respectively. In addition, it had the minimum placebo interference (0.47%) and was stable for long-term storage under determined conditions.
Co-Authors Arviani Arviani Athira Sevija, Fathi Dwi Larasati, Dwi Ellaine Nur Danastry Ferli Eko Kurniantoro Ferli Eko Kurniantoro Filu Marwati Santoso Putri Helda Nurfitriana Hernowo, bingar Ilham Kuncahyo Istiqomah, Farichatun Kiki Siti Fatimah Maulana Tegar AdityaNugraha Melinda Fitriani Muhammad Fariez Kurniawan Renny Sulistian Syaiful Choiri Windarsih, Anjar