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Standardization Methods for the Determination of Curcumin in Turmeric and Its Anticancer Activities : A Review Imel Ramelia Hudaya; Vina Luthfiana Hasna; Febi Febriani Hasanah; Khamairah Azzahrawaani Hermawan; Vriezka Mierza
Jurnal EduHealth Vol. 14 No. 01 (2023): Jurnal eduHealth, Periode Januari-Maret, 2023
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (243.465 KB)

Abstract

Cancer is one of the deadliest diseases in the world. Indonesia is a country with cancer rates that ranks 8th in Southeast Asia. Cancer that has the highest number of sufferers in Indonesian men is lung cancer, as much as 19.4 per 100,000 population, with an average death rate of 10.9 per 100,000. Meanwhile, for women, breast cancer is the highest cancer incidence rate, which is 42.1 per 100,000 population, with an average death rate of 17 per 100,000 population. Although chemotherapy remains a highly efficient way to treat cancer, it is the drawbacks related to its side effects that are often feared. Natural products such as plants are more beneficial for improving treatment results because they are safe and can minimize side effects on healthy cells. Herbal plants that are often associated with anticancer drugs are turmeric. Currently, several standardized methods have been developed to analyze curcumin in turmeric, and from these methods, there are advantages and disadvantages of each method. Therefore, selecting the analytical method is very important to get better results.
Metode Isolasi Metabolit Sekunder pada Bahan Bahari Makro Alga Vina Luthfiana Hasna; Nisa Alifia Zahra; Imel Ramelia Hudaya; Herdiana Verliani; Febi Febriani Hasanah
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol 2 No 1 (2021): PharmaCine : Journal of Pharmacy, Medical and Health Science
Publisher : Program Studi Farmasi Fakultas Ilmu Kesehatan Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v2i1.5580

Abstract

Indonesia merupakan negara yang kaya akan biota laut, salah satunya adalah makro alga. Pembuatan review artikel ini dilakukan untuk menambah pengetahuan tentang ilmu bahari khususnya dalam isolasi metabolit sekunder pada makro alga. Kelompok makro alga atau lebih dikenal dengan sebutan rumput laut merupakan tumbuhan tingkat rendah yang memproduksi senyawa metabolit sekunder. Isolasi pada makro alga menunjukkan adanya senyawa metabolit sekunder yang terkandung (flavonoid, steroid, terpenoid, alkaloid, fenol, saponin). Metode yang digunakan pada review ini merupakan suatu tinjauan literatur (literatur review) terhadap lima jurnal dan berdasarkan teori-teori yang relevan. Adapun untuk mendapatkan ekstrak sampel dilakukan teknik yang sama yaitu maserasi menggunakan pelarut yang sesuai karakteristik zat yang akan diisolasi selama 1-3 hari. Sedangkan untuk mengisolasi senyawa metabolit sekunder digunakan teknik kromatografi kolom, kromatografi gas-spektometri massa (GC-MS) dan kromatografi lapis tipis (KLT).