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All Journal Biogenesis: Jurnal Ilmiah Biologi BIOEDUSCIENCE Jurnal Saintek Lahan Kering Journal on Education Journal of Primary Education Jurnal Review Pendidikan dan Pengajaran (JRPP) Journal On Teacher Education (Jote) Spizaetus: Jurnal Biologi dan Pendidikan Biologi Tunas Nusantara Jurnal Cakrawala Pendas JIM: Jurnal Ilmiah Mahasiswa Pendidikan Sejarah

Maria Helvina

Unknown Affiliation

Author-ID : 5811930

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Economics, Econometrics & Finance Education Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Public Health Social Sciences Other

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The Analysis of StudentsÃ¢â‚¬â„¢ Concept Comprehension Ability on the Application of CLIS Learning Models Integrated Ethnoscience Helvina, Maria; Linuwih, Suharto; Sumarti, Sri Susilogati
Journal of Primary Education Vol 8 No 8 (2019): October 2019
Publisher : Universitas Negeri Semarang

This study aims to analyze the improvement of students' concept comprehension ability by applying CLIS (Children Learning In Science) learning models integrated ethnoscience. This study employed a quasi experimental method with one group pretest-posttest design. The data used include pretest and posttest score. The data were analyzed using the one-sample test for the average test, proportion test (Z test) to calculate the classical completeness and N-gain calculation. The result revealed that students who fulfill the minimum standard criteria (KKM) were 30 students with the classical completeness 93.75%. The proportion completeness of concept comprehension ability passed over 75%. The improvement of concept comprehension ability was 0.4 and categorized as medium. Each indicators of concept comprehension increased sequentially that is translating 86.3%, exemplifying 91%, classifying 77.5%, summarizing 76.3%, predicting 88.8% and explaining 73.8%. The improvement of indicator concept comprehension generally in the very good category. Based on the result obtained, it can be concluded that the application of CLIS learning models integrated ethnoscience can improve studentsÃ¢â‚¬â„¢ concept comprehension.

The Potential Role of 6-gingerol and 6-shogaol as ACE Inhibitors in Silico Study Yohanes Bare; Maria Helvina; Gabriella Chandrakirana Krisnamurti; Mansur S
Biogenesis: Jurnal Ilmiah Biologi Vol 8 No 2 (2020)
Publisher : Department of Biology, Faculty of Sci and Tech, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/bio.v8i2.15704

Hypertension has become the third highest cause of death in Indonesia. The condition is correlated with angiotensin-converting enzyme (ACE), and possibly managed with the use of drugs. In addition, some natural compounds, including 6-shogaol and 6-gingerol from ginger, are used to decrease blood pressure. However, the mechanism and binding site of these compounds to ACE protein is currently unclear. This study, therefore, aims to investigate the potential role of these compounds as an angiotensin-converting enzyme inhibitor. The ACE protein was downloaded from Protein Data Bank (PDB) database with the ID: 3bkk, while the 6-shogaol (CID: 5281794) and 6-gingerol (CID: 44559528) ligands were obtained from the PubChem database. Meanwhile, molecular docking was established using HEX 8.0.0 software. The analysis examined the amino acid residues and the bonds formed from these interactions. According to the results, 14 amino acid residues were formed by the interaction between 6-shogaol and ACE, while the interaction between 6-gingerol and ACE formed eight amino acids. Also, 13 amino acid residues in the novelty binding site of ACE were discovered to be blocked by the ligands from ginger. Therefore, the compounds have potential roles as inhibitors, and this possibly helps to prevent regulation of the renin-angiotensin system. These interactions also formed hydrogen bonds, as well as electrostatic, unfavorable, and hydrophobic sites, making the binding stronger than others.

Potensi Asam kafeat pada Kopi sebagai Simultan Gen Peroxixme proliferator-activated receptor gamma (PPAR-γ): Studi In silico Yohanes Bare; Maria Helvina; Agustina Elizabeth; Dewi Ratih Tirto Sari
Saintek Lahan Kering Vol 2 No 2 (2019): JSLK Desember 2019
Publisher : Fakultas Pertanian, Universitas Timor

Coffee plants are one of the cultivated plants of the Sikka Regency community. Coffee contains chemical compounds which is needed by humans. One of them is cafeic acid. Cafeic acid was recognized as having the potential as an anti-inflammatory, antioxidant, and healing type 2 diabetes mellitus (T2DM). The Peroxixme proliferator-activated receptor gamma gene (PPAR-γ) has a role in homeostasis regulation, so it can be used as hyperglycemia. But do not study on the interaction of cafeic acid as anti-diabetes molecularly. The purpose of this study was to analyze and predict the physico-chemical properties and potency of cafeic acid as anti-diabetes through the interaction of cafeic acid with PPAR- γ protein in silico. The method used consisted of downloading PPAR-γ protein through protein bank data (GDP) and cafeic acid through the PubChem database, protein preparation (PPAR-γ) and ligands (cafeic acid) with the PyRx program, protein analysis and ligand using the program using the Hex program 8.0 .0 and Discovery Studio V16.1.0.15360. The results showed that occur between cafeic acid and PPAR-γ show the role of anti-diabetes. This is evidenced by the presence of 11 amino acid residues (ASP441, LYS373, ASP396, LYS438, GLU407, PRO398, GLY399, ARG397, LEU400, GLY395, VAL403) which interacted with the chlorogenic acids and their energies of -168.5cal/mol. This function activates GLUT2 and GLUT4 as transportation routes inside and outside the cell. Caffeic acid is predicted to have potential as a natural ingredient in coffee which can be used for DMT2 therapy with genetic care (Nurtigenetics). We suggest further study is required in vivo experiment.

Pengaruh Penggunaan Media Animasi Terhadap Kemampuan Membaca Permulaan Siswa Selama Pandemi Covid-19 Maria Helvina; Agnes Yosefina Noeng; Frederiksen Novenrius Sini Timba
Tunas Nusantara Vol 3, No 2 (2021)
Publisher : Universitas Islam Nahdlatul Ulama Jepara

Beginning reading ability is a person's basic ability to master various fields of knowledge so it is very important to master. The ability to read at the beginning of grade 1 SDI Patisomba is still very low because students do not know letters well. This study aims to determine the effect of using animated media on initial reading skills in grade 1, students at SDI Patisomba during the covid-19 pandemic. This study used quantitative research methods with data collection techniques including tests and observations, analyzed using the t-test. From the results of the t-test calculation, there is a t count of 2.410 and a t-table with dk = 15 and the significant level = 0.05 is 1.753. It can be concluded that t count > t table (2,410>1,753) so that Ho is rejected and Ha is accepted, that is, there is an effect of using animation media on early reading skills in grade 1 students of SDI Patisomba. Based on the test results and observation results and analyzed using the T-test, it can be concluded that the students' initial reading ability and the learning outcomes of class 1 students have changed for the better after using animation media in the experimental class.

Studi In silico Potensi aktivitas 10-shogaol dalam Jahe (Zingiber officinale) terhadap gen ACE Mansur S; Yohanes Bare; Maria Helvina; Aprianus Pani Pili; Gabriella Chandrakirana Krisnamurti
SPIZAETUS: JURNAL BIOLOGI DAN PENDIDIKAN BIOLOGI Vol 1, No 3 (2020): Spizaetus: Jurnal Biologi dan Pendidikan Biologi
Publisher : Universitas Nusa Nipa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55241/spibio.v1i3.23

Peningkatan tekanan darah tinggi (hipertensi) mengakibatkan terpicunya berbagai macam penyakit kronis serta komplikasinya. Salah satu activator dalam kondisi tekanan darah tinggi adalah aktivitas Angiotensin converting enzyme (ACE). ACE berperan dalam mengatur sistem renin-angiotensin. Penurunan hipertensi perlu untuk menekan aktivitas ACE. Tujuan dari penelitian ini adalah untuk menganalisis potensi 10-shogaol terhadap ACE. Metode yang digunakan adalah studi in silico. Protein model ACE (ID: 3bkk) didapatkan dari database Protein data Bank (PDB) sedangkan 10-shogaol (CID: 6442612) didapat dari database PubChem. Docking menggunakan Hex 8.0.0 sedangkan visualisasi dan analisis menggunakan Discovery Studio. Hasil Penelitian menunjukan bahwa bahwa senyawa 10-shogaol memiliki potensi sebagai inhibitor gen ACE dibuktikan 2 residu asam amino yang berikatan dengan ligan. Ikatan tersebut berupa ikatan hidropobik yang meningkatkan kekuatan tersebut dengan besar energi -291.3cal/mol.

Analysis of Molecular Interactions of 8-Gingerol Compounds in Ginger (Zingiber officinale) as ACE Inhibitor Yohanes Bare; Mansur s; Aprianus Pani Pili; Maria Helvina
BIOEDUSCIENCE Vol 4 No 2 (2020): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Background: Hypertension is a disease with increasing characteristics of blood pressure. The ACE gene has a role in the conversion of ATI to ATII in hypertensive conditions. Healing is done by using the 8-gingerol content contained in ginger. The purpose of this study is to analyze the molecular interaction that occurs between 8-gingerol and ACE. Method: ACE model proteins (ID: 3bkk) were obtained from the Bank Data Protein database (PDB) through 8-gingerol ligands (CID: 168114) obtained from the PubChem database. ACE and 8-gingerol were docked by Discovery Study Client 4.1 software. Analysis of amino acid residues, binding energy, Van der Waals forces, and hydrogen bonds formed using Discovery Studio Client 4.1. Results: The interaction between 8-gingerol and ACE showed that there were seven amino acid residues that interacted with 8-gingerol, also found hydrogen bonds, hydrophobic and Van der Waals forces that strengthen and stabilize these bonds. Conclusion: the interaction of 8-ginger with the active side of ACE is determined as an ACE inhibitor, the inhibition is a significant effect on the obstruction of ACE conversion.

SCIENCE PROCESS SKILLS IN THE "NAWU HIPE" CUSTOM OF THE PEOPLE OF PALU'E ISLAND, SIKKA DISTRICT Marianus Yufrinalis; Sukarman Hadi Jaya Putra; Maria Helvina; Maria H.D. Bunga
Jurnal Cakrawala Pendas Vol. 9 No. 1 (2023)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jcp.v9i1.3573

The indigenous people of Palu'e Island, Sikka Regency, NTT Province, have used geothermal energy to meet their needs for drinking water and to cook certain types of food. Geothermal will produce steam, a form of energy conversion where heat energy from within the earth is used for cooking Hi'pe (Canavalia ensivormis). Therefore, this study aims to analyze science process skills in Nawu Hi'pe activities implemented in elementary school science learning. This research uses mixed or mixed method research that combines two research methods: quantitative and qualitative. The research was conducted at Edo Khatolik Elementary School with as many as 22 students and five people from Palu'e Island, Sikka Regency, as a community sample. The results showed that students' science process skills per indicator were forecasting/predicting at 2.7 (good), observing at 3.75 (very good), conducting experiments at 3.7 (good), concluding at 3.6 (good ), and the last indicator is communicating at 3.65 (very good). The indicator with the lowest average is predicting at 2.7 (enough), and the highest is observing at 3.75 (very good). There was a difference in student learning outcomes between the pretest scores of 52.7273 and the posttest scores of 82.7273. The posttest value is much greater than the pretest value. Therefore, the science process skills of students taught through observing Nawu Hi'pe activities obtain higher learning outcomes after being given learning and included in the excellent category. Masyarakat asli Pulau Palu'e, Kabupaten Sikka, Provinsi NTT, telah memanfaatkan energi panas bumi untuk memenuhi kebutuhan air minum dan memasak jenis makanan tertentu. Panas bumi akan menghasilkan uap yang merupakan bentuk konversi energi dimana energi panas dari dalam bumi digunakan untuk memasak Hi'pe (Canavalia ensivormis). Oleh karena itu, penelitian ini bertujuan untuk melakukan analisis terhadap keterampilan proses sains pada kegiatan Nawu Hi’pe yang akan diimplementasikan pada pembelajaran IPA di SD. Penelitian ini menggunakan metode campuran atau mixed method research yang menggabungkan dua metode penelitian yaitu metode kuantitatif dan metode kualitatif. Penelitian dilakukan di Sekolah SD Khatolik Edo sebanyak 22 siswa dan 5 orang Masyarakat Pulau Palu’e, Kabupaten Sikka sebagai sampel masyarakt. Hasil penelitian menunjukkan bahwa keterampilan proses sains peserta didik per indikator yaitu meramal/memprediksi sebesar 2,7 (Baik), mengamati sebesar 3,75 (sangat baik), melakukan percobaan sebesar 3,7 (baik), menyimpulkan sebesar 3,6 (baik), dan indikator yang terahkir yaitu mengkomunikasikan sebesar 3,65 (sangat baik). Indikator yang memperoleh rata-rata rendah yaitu indikator memprediksi sebesar 2,7 (cukup) dan indikator yang paling tinggi yaitu mengamati sebesar 3,75 (sangat baik). Terjadi perbedaan hasil belajar siswa nilai pada pretest sebesar 52,7273 dan nilai postest sebesar 82,7273. Nilai posttest jauh lebih besar dari nilai pretest. Oleh karena itu, Keterampilan proses sains siswa yang dibelajarkan melalui observasi kegiatan Nawu Hi’pe secara langsung memperoleh memiliki hasil belajar lebih tinggi setelah diberikan pembelajaran dan termasuk kategori baik.

Penggunaan Media Pop Up Book Untuk Meningkatkan Minat Baca Dalam Pembelajaran Bahasa Indonesia Materi Dongeng Pada Siswa Kelas III SDK 077 Kewapante Maria Herlina Sunarti; Maria Helvina; Marianus Yufrinalis
Journal on Education Vol 5 No 3 (2023): Journal on Education: Volume 5 Nomor 3 Tahun 2023 In Press
Publisher : Departement of Mathematics Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joe.v5i3.1440

This study aims to increase reading interest in learning Indonesian material for fairy tales in class III SDK 077 Kewapante. This research is a class action research (CAR) using Kurt Lewin's research flow which was carried out for two cycles, where each cycle consisted of 4 meetings consisting of four stages, namely the planning stage, the implementation stage, the observation stage, and the reflection stage. The subjects in this study were class III students at SDK 077 Kewapante, totaling 28 students consisting of 21 boys and 7 girls. Data analysis techniques in this study used quantitative data analysis techniques, namely learning test results and qualitative data analysis techniques in the form of observations and questionnaires. Data collection techniques in this study used observation, questionnaires, tests, and summaries. The results of the study using pop up book media showed that there was an increase in students' reading interest in learning Indonesian material for fairy tales as evidenced by an increase in the average value of students' reading interest in cycle I of 78.66% with a proportion of completeness of 80.35% and in cycle II experienced an increase with an average score of students' reading interest of 87.31% with a completeness proportion of 92.85%. This shows that the use of pop up book media is one of the media that can be further applied in the learning process in class in learning Indonesian to increase students' interest in reading in class III SDK 077 Kewapante..

Meningkatkan Hasil Belajar IPA Materi Perubahan Wujud Benda Menggunakan Video Animasi Pada Siswa Kelas IV SDK 077 Kewapante Orpa Ale Hade; Maria Helvina; Marianus Yufrinalis
Journal on Education Vol 5 No 3 (2023): Journal on Education: Volume 5 Nomor 3 Tahun 2023 In Press
Publisher : Departement of Mathematics Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joe.v5i3.1448

This study aims to improve science learning outcomes material changes in the form of objects. This research is Classroom Action Research (PTK) conducted in 2 cycles where each cycle consists of 3 meetings, which consists of 4 stages, namely planning, implementing, observing and reflecting. The subjects in this study were fourth grade students at SDK 077 Kewapante, totaling 37 students consisting of 23 male students and 14 female students. Data collection techniques used in this study were tests, observation and documentation. The data analysis technique used is the analysis of test results and observation results. The research results show that the use of animated videos can improve student learning outcomes. The increase in student learning outcomes can be seen in the results of the pretest cycle I with a total score of 1,479 with an average of 39.9, and the percentage of completeness of 5.4% increased 45.9% to the results of the posttest cycle I where the total value was 3,028 with an average of 81. 8 and the percentage of completeness is 51.3%. while in cycle II there was an increase with a total value of 3,450 with an average of 93.2 and a completeness percentage of 100%.

Meningkatan Kemampuan Menghitung Perkalian Dan Pembagian Melalui Mediatabel Perkalian dan Pembagian Pada Siswa Kelas II SDK 077 Kewapante Kecamata Kewapante Kabupaten Sikka Novita Dua Laju; Maria Helvina; Marianus Yufrinalis
Journal on Education Vol 5 No 3 (2023): Journal on Education: Volume 5 Nomor 3 Tahun 2023 In Press
Publisher : Departement of Mathematics Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joe.v5i3.1572

This study aimend to improve the learning Outcomes of addition material using smart tree media for 1students at SDK wegoknatar. This research employed clasroom action research ( CAR) which was designed to help teacher ( recearchers) in dinding and solving learning problems that occur in the classroom.This clasroom action research was conducted in cycles, between cycle 1 and 11. The pacticipants were 12 students. The results of the study indicated that after giving action for two cycles the average score of the test result of improving learning Outcomes in addition material using smart tree media in Mathematics subject had increased. The first meeting of the cycle 1 resulted in a score of 45%, and the second meeting 55% meaning that not yet reached the KKM. In the first meeting of cycle ll, there was an increase in value of 65%, and at the second meeting 95%. Thus, the learning Outcomes from cycle ll increased and were includded in the very good category or fulfilled the KKM. This indicated that improving learning Outcomes in Mathematic addition material by using smart tree media could be further applied to improve student learning achievement, especially in the mathematics subject

Co-Authors Agnes Yosefina Noeng Agustina Elizabeth Aprianus Pani Pili Aprianus Pani Pili Avilina Sute Bare, Yohanes Dewi Ratih Tirto Sari Dua Bunga, Maria Herliyani Emilia Flaviana Gabriella Chandrakirana Krisnamurti Gabriella Chandrakirana Krisnamurti Hermus Hero Hero, Hermus Mansur S Mansur s Maria Angelina Fransiska Mbari Maria Aprilia* Maria H.D. Bunga Maria Herlina Sunarti Maria Kriswinda Taek Luti Maria Yuliana Yulastri Tana* Marianus Yufrinalis Non Monika Ketuko Novita Dua Laju Orpa Ale Hade Sri Susilogati Sumarti Suharto Linuwih Timba, Frederiksen Novenrius Sini

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