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All Journal Jurnal Biologi Tropis ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Novem Medika Farmasi
Ayu Wandira
Universitas Islam Makassar
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Tonicum Activity of Red Ginger (Zingiber officinale var. Rubrum) and Elephant Ginger (Zingiber officinale var.Roscoe) Ethanol Extract in Vivo Sitti Fauziah Noer; Ayu Wandira; Asri Mulya Ashari; Rita Kurnia Apindiati; Gusti Eva Tavita; Sri Zha Zha Dilla
Jurnal Biologi Tropis Vol. 23 No. 2 (2023): April-June
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i2.4703

Abstract

The increase in side effects due to the use of chemical drugs encourages people to return to nature, utilize the plants around them in dealing with health problems. Red ginger (Z. officinale Var Rubrum) and elephant ginger (Z. officinale var Roscoe) have been used empirically in medicine especially to boost immunity. This study aims to determine the tonic activity of the ethanol extract of red ginger and elephant ginger in vivo using the natatary exhaustin method with white rats (Rattus norvegicus) as test animals. The natural fatigue method was based on the resistance of the test animals to swimming in water after being treated with ethanol extract of red ginger and elephant ginger rhizome at a dose of 70 mg/kg body weight, using Na-CMC solution as a blank and caffeine solution as a positive comparison. Based on research data testing the tonic activity of red ginger and elephant ginger extracts in vivo showed that the tonic activity of red ginger ethanol extract with the swimming endurance of the test animals was for 27.72 seconds, longer than the swimming endurance of the treated animals. with elephant ginger ethanol extract which is only 16.46 seconds.
Formulation and Effectivity of Henna Leaves (Lawsonia inermis L.) Extract Ointment Against Burn Healing of Rabbit (Orctolagus cuniculus) Ayu Wandira; Dian Astriani; Munifah Wahyudin
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.36124

Abstract

Burns are tissue injury resulting from contact with a source of heat. The henna leaves extract (Lawsonia inermis L.) contains tannin, which acts as an astringent to treat wounds. This research seeks to determine the efficacy and quality of henna leaves ointment (Lawsonia inermis L.). The extraction method for henna leaves (Lawsonia inermis L.) entailed maceration with a 96% ethanol solvent. The phytochemical analysis of the 96% ethanol extract of henna leaves revealed the presence of flavonoids, tannins, saponins, and terpenoids. Variable concentrations of henna leaves extract were used to formulate ointments: 2.5% (F1); 5% (F2); 10% (F3); negative control (C-); and bioplacenton® as the positive control. Organoleptic assays, homogeneity, pH, spreadability, and adhesion were used to evaluate the quality of the formulations. In rabbits with inflicted burns, administer ointments F1, F2, F3, C-, and C+ to determine the efficacy of burn treatment. The healing effect is evaluated based on the time it takes for the wound to close (maturation phase), which is characterised by the incision being covered with new tissue. The ointment made from 96% ethanol extract of henna leaves with various concentrations of F1, F2, and F3 met the test requirements for organoleptic, homogeneity, pH, spreadability, and adhesion, according to the results of the ointment quality test. The ANOVA analysis of the effect test revealed that F1, F2, and F3 had a healing effect on wounds. The lesion healing effect of Formula F3 (10%) was not significantly different from the positive control after 11 days
syiahulhaq Uji Aktivitas Ekstrak Etanol Biji Kakao (Theobroma cacao L.) Asal Kabupaten Bulukumba Terhadap Penurunan Kadar Gula Darah Tikus (Rattus norvegicus): Kata Kunci: Biji Kakao (Theobroma cacao L.); Gula darah; Tikus putih (Rattus norvegicus); Glukometer Syiaulhaq Syiaulhaq
Jurnal Novem Medika Farmasi Vol. 2 No. 2 (2023): volume 2 issue 2 Desember 2023
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v2i2.943

Abstract

Biji kakao (Theobroma cacao L.) memiliki kandungan antioksidan yang mampu menurunkan glukosa darah dalam tubuh. Tujuan penelitian untuk mengetahui aktivitas ekstrak etanol biji kakao (Theobroma cacao L.) asal Kabupaten Bulukumba terhadap penurunan gula darah tikus putih (Rattus norvegicus) yang diinduksi glukosa 20%. Metode penelitian meliputi ekstraksi serbuk simplisia secara maserasi mengunakan pelarut etanol 96%. Penelitiaan ini menggunakan tikus putih (Rattus norvegicus) sebanyak 15 ekor yang dibagi dalam 5 kelompok perlakuan, tiap kelompok terdiri dari 3 ekor tikus, kelompok I diberi Na-CMC 1% sebagai kontrol negatif, kelompok II diberi glibenklamid 0,45 mg/Kg BB, dan kelompok III, IV, V diberi ekstrak biji kakao (Theobroma cacao L.) dengan masing-masing dosis 100 mg/kg BB, 200 mg/kg BB dan 300 mg/kg BB, pengukuran kadar glukosa darah dilakukan pada menit ke-60, 120 dan 180 setelah perlakuan dengan menggunakan alat pengukuran glukosa darah yaitu glukometer, Data hasil penelitian dianalisis statistik menggunakan Rancangan Acak Lengkap (RAL) dan uji Duncan. Hasil penelitian menunjukan bahwa ekstrak etanol 96% biji kakao (Theobroma cacao L.) dosis, 100 mg/kg BB, 200 mg/kg BB dan 300 mg/kg BB memberikan aktivitas dalam menurunkan gula darah yang diinduksi dengan glukosa 20% pada tikus putih (Rattus norvegicus) yang berbeda sangat nyata dengan kontrol negatif Na-CMC 1% dan tidak berbeda nyata dengan kontrol positif glibenklamid 0,45 mg/kg BB.
Co-Authors Andi Dian Astriani Ashari, Asri Mulya Gusti Eva Tavita Munifah Wahyudin Rita Kurnia Apindiati Sitti Fauziah Noer Sri Zha Zha Dilla