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All Journal Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional JPSriwijaya Science and Technology Indonesia Jurnal Penelitian Sains Jurnal Ilmiah Farmako Bahari ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Abdi Insani
Dina Permata Wijaya
Department Of Pharmacy, Faculty Of Mathematics And Natural Sciences, Sriwijaya University Jl. Raya Palembang-Prabumulih Km. 32, Indralaya, Sumatera Selatan, 30662, Indonesia
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Journal : Science and Technology Indonesia

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Physical Interaction Of Chitosan-Alginate Entrapping Extract Of Papaya Leaf And Formation Of Submicron Particles Dosage Form Untari, Budi; Wijaya, Dina Permata; Mardiyanto, Mardiyanto; Herlina, Herlina; Angraeni, Via; Firana, Ario
Science and Technology Indonesia Vol 4 No 3 (2019): July
Publisher : ARTS Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1814 KB) | DOI: 10.26554/sti.2019.4.3.64-69

Abstract

Research on physical interaction of chitosan-alginate entrapping extract of papaya leaf (Carica papaya L) into submicron particles formation has been performed. Preparation of papaya leaf extract into submicron particle dosage form of chitosan and sodium alginate polymer using ionic gelation method aimed to increase the solubility of extract. Submicron particles consisting of papaya leaf extract, chitosan, sodium alginate and CaCl2 were combined using variation of stirrer speed of 500, 750, and 1000 RPM. The optimum formula obtained has a speed of 1000 RPM with the percent EE value of 71.90%. The results of submicron particles characterization such as diameter and particle size distribution (PDI) using particle size analyzer (PSA) tools were 189.2 nm and 0.330. The results of XRD revealed the changes of type of crystalinity form to amorphous on submicron particles. The results of FTIR revealed the physical interaction without shifting of wave number of carbonyl, amine, and hydroxyl group which indicated that there were no chemical interactions occurred. These data indicated that papaya extract can be formulated into submicron particles of chitosan-alginate polymer.
Preparation and Characterization of Petai Pods Extract (Parkia speciosa Hassk.) Loaded Ethosomes Fitrya Fitrya; Najma Annuria Fithri; Annisa Amriani; Annisa Haryati; Dina Permata Wijaya
Science and Technology Indonesia Vol. 6 No. 1 (2021): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1542.739 KB) | DOI: 10.26554/sti.2021.6.1.19-24

Abstract

Preparation of petai pods extract (Parkia speciosa) into ethosome aim to increased penetration through the skin. The method of cold is used in preparing petai pods extract encapsulation by ethosome with variation in concentration of soya lecithin, propylene glycol, and ethanol. The proportion of optimum formula ethosome consisted were 0,2 g soya lecithin, 1 ml propylene glycol, and 4 ml ethanol that response values obtained pH of 4,74, viscosity of 0,950 cP, %EE of 74,326%, and stability of 7,288%. The resulted of optimum formula obtained were PDI of 0,23, zeta potential of -7,5 mV, and particle size of 818,7 nm. Ethosome showed spheric particle using Transmissin Electron Microscopy. The diffusion analysis showed highest on ethosome of petai pods extract (9,525%) than petai pods extract (5,466%). The interaction study used FTIR show no chemical interaction extract pods and ethosome components
Co-Authors Adik Ahmadi Angraeni, Via Annisa Amriani Annisa Amriani Annisa Amriani S Annisa Haryati Ayu Adelia Lestari Budi Untari Budi Untari Detri Novelia Dian Wahyuni Elsa Fitria Apriani Fauziyah Fauziyah Filla Nur Oktriliansih Firana, Ario Firnando Firnando Fitrya . Fitrya Fitrya Herlina Herlina Herlina Herlina Herlina Herlina Herlina Herlina Herlina Herlina Herlina Herlina Khazanah Nurain Mardiyanto Mardiyanto Mardiyanto Mardiyanto Mustikasanti Mustikasanti Najma Annuria Fithri Najma Annuria Fithri Najma Annuria Fitri Puspa Ayu Pitayati Putri Siti Rahayu Regina Astryani Rennie Puspa Novita Vitri Agustiarini