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All Journal AcTion: Aceh Nutrition Journal JURNAL INFO KESEHATAN Buletin Poltanesa
I Putu Bayu Agus Saputra
Department Of Herbal Medicine And Nutrigenomic, Faculty Of Medicine, Universitas Islam Al-Azhar Mataram, West Nusa Tenggara, Indonesia
Agriculture, Biological Sciences & Forestry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Immunological Profile of Patients with Controlled and Uncontrolled Type 2 Diabetes Melitus in Mataram City, West Nusa Tenggara I Putu Dedy Arjita; I Gede Angga Adnyana; Ayu Anulus; I Putu Bayu Agus Saputra; Maruni Wiwin Diarti
JURNAL INFO KESEHATAN Vol 21 No 2 (2023): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol21.Iss2.933

Abstract

The prevalence of DM disease in West Nusa Tenggara Province is not much different from that in Indonesia. DM cases in NTB are included in the ten most non-communicable illnesses suffered by the community and the incidence continues to increase from year to year. An increase in the levels of pro-inflammatory cytokines in the body is one of the causes of insulin resistance in cells which can further develop into type 2 diabetes. This study involved diabetic patients at the Mataram Community Health Center, who were assigned into 2 groups, namely the controlled diabetes group and the uncontrolled diabetes group and involved a standard group which was a group consisted of healthy people. Each group was examined for Fasting Blood Glucose (FBG) and HbA1c levels. The results of the examination in the standard group, controlled diabetes group and uncontrolled diabetes group obtained the FBG levels of 89.22 mg/dl, 110.0 mg/dl, and 245.80 mg/dl, respectively. Furthermore, the results of the HbA1c test in the standard group, controlled diabetes group and uncontrolled diabetes group were 5.44%, 6.03%, and 10.49%, respectively. The results of the examination of IL-6 levels in the standard group, controlled diabetes group and uncontrolled diabetes were 329.36 pg/ml, 331.52 pg/ml, and 320.33 pg/ml, respectively. The results of the IL-10 test in the standard group, controlled diabetes group and uncontrolled diabetes were 71.80 pg/ml, 116.60 pg/ml, and 128.10 pg/ml, respectively. Based on the results of the study, there was no significant difference in the levels of interleukin 6 and interleukin 10 between respondents with diabetes mellitus and healthy respondents (p>0.05). It can be concluded that there were no differences in interleukin 6 and 10 levels between healthy people with patients with controlled and uncontrolled diabetes.
Soy-Ipoghurt as an antidiabetic on hiperglicemic animal modelling Rattus norvegicus I Putu Dedy Arjita; Dhika Juliana Sukmana; Hardani Hardani; Diani Sri Hidayati; I Putu Bayu Agus Saputra
AcTion: Aceh Nutrition Journal Vol 8, No 2 (2023): June
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v8i2.909

Abstract

Treatment of Diabetes Mellitus (DM) is generally through optimizing a balanced diet. Soybeans and sweet potatoes have good antioxidants and can be developed as healthy foods for people with diabetes. Soybeans and sweet potatoes are processed into Soy-yoghurt. This study aims to determine the potential of soy yogurt as an antidiabetic in experimental animals, Rattus norvegicus induced by hyperglycemia, using Streptozotocin. This study used a experiment design with a total of 40 experimental animals. The research was conducted at the Medica Farma Husada Polytechnic Laboratory, Mataram, in 2022. The experimental animals that Streptozotocin (STZ) induced were then given Soy-yogurt orally at 3 ml and 3.5 ml doses. Experimental animals' Fasting Blood Glucose (FBG) levels were measured weekly using a Glucometer, while body weight (BW) was measured every three days. The results obtained were then analyzed statistically using the ANOVA test. The test results showed that there was a significant difference in blood sugar levels (p<0,05) in fasting given soy but no difference in BW (p>0,05). This study concludes that the provision of soybeans can affect the level of FBG  of the experimental animals but does not affect the BW of the experimental animals.
PTEN: The Potential Therapeutic Target of Diabetes Mellitus Ni Made Wiasty Sukanty; I Putu Bayu Agus Saputra; Lina Yunita
Poltanesa Vol 24 No 1 (2023): June 2023
Publisher : P2M Politeknik Pertanian Negeri Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51967/tanesa.v24i1.2004

Abstract

Diabetes mellitus is a metabolic disease characterized by high blood glucose levels. The cause of glucose control failure is decreased insulin production by pancreatic β-cells and insulin resistance. Both lead to the obstacle of glucose uptake into cells. The mechanism of glucose uptake into cells is crucial in carbohydrate metabolism. This mechanism aims to produce energy in the form of ATP. The main signaling pathway after the process of glucose uptake is the PI3K/Akt pathway. This pathway involves many proteins activated by phosphorylation mechanisms. One of the proteins involved in this pathway is PTEN, a PI3K regulator. PTEN activity can dephosphorylate PI3K so that the insulin signaling pathway becomes blocked and glucose cannot be uptaken into cells. It causes blood glucose levels to increase. The role of PTEN in inhibiting the PI3K/Akt pathway seems to be a crucial matter to observe. By inhibiting PTEN activity, the insulin signaling pathway is expected to work properly. We have searched, read, analyzed, and summarized various studies regarding the potential of PTEN to reduce diabetes mellitus cases. In some research articles, the use of active compounds and therapy using stem cells to inhibit PTEN activity has shown good progress in the insulin signaling pathway. Based on these, it can be an option to make PTEN a target for diabetes mellitus therapy.
PTEN: The Potential Therapeutic Target of Diabetes Mellitus Ni Made Wiasty Sukanty; I Putu Bayu Agus Saputra; Lina Yunita
Poltanesa Vol 24 No 1 (2023): June 2023
Publisher : P2M Politeknik Pertanian Negeri Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51967/tanesa.v24i1.2004

Abstract

Diabetes mellitus is a metabolic disease characterized by high blood glucose levels. The cause of glucose control failure is decreased insulin production by pancreatic β-cells and insulin resistance. Both lead to the obstacle of glucose uptake into cells. The mechanism of glucose uptake into cells is crucial in carbohydrate metabolism. This mechanism aims to produce energy in the form of ATP. The main signaling pathway after the process of glucose uptake is the PI3K/Akt pathway. This pathway involves many proteins activated by phosphorylation mechanisms. One of the proteins involved in this pathway is PTEN, a PI3K regulator. PTEN activity can dephosphorylate PI3K so that the insulin signaling pathway becomes blocked and glucose cannot be uptaken into cells. It causes blood glucose levels to increase. The role of PTEN in inhibiting the PI3K/Akt pathway seems to be a crucial matter to observe. By inhibiting PTEN activity, the insulin signaling pathway is expected to work properly. We have searched, read, analyzed, and summarized various studies regarding the potential of PTEN to reduce diabetes mellitus cases. In some research articles, the use of active compounds and therapy using stem cells to inhibit PTEN activity has shown good progress in the insulin signaling pathway. Based on these, it can be an option to make PTEN a target for diabetes mellitus therapy.
Co-Authors Arjita, I Putu Dedy Ayu Anulus Dhika Juliana Sukmana Diani Sri Hidayati Hardani, H I Gede Angga Adnyana Lina Yunita Maruni Wiwin Diarti Ni Made Wiasty Sukanty