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Antibacterial activity of the combination of Mentha spicata and Allium sativum extracts on the growth of Mycobacterium tuberculosis clinical isolates Yunan Jiwintarum; Maruni Wiwin Diarti; I Gede Angga Adnyana; Hady Anshory
Jurnal Ilmiah Farmasi Vol. 18 No. 1 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss1.art10

Abstract

Background: Tuberculosis (TB) is a disease with a high mortality rate in the world, including in Indonesia. In addition, the problem of Mycobacterium tuberculosis resistance to antibiotics is getting higher. Mint leaves and garlic have been shown its the ability to kill M. tuberculosis. However, it has never been studied how the combined effect the M. tuberculosis growth.Objective: The major objective of this study was to investigate the anti-mycobacterial activity of mint leaves-garlic combination to growth inhibition of clinical culture M. tuberculosis.Method: Extraction of mint leaves and garlic was carried out by maceration using ethanol as a solvent. M. tuberculosis cultures were obtained from clinical samples of patients diagnosed with new tuberculosis (TBB) and MDR- tuberculosis (TBB). The growth inhibition activity test was carried out using the agar dilution method on Lowenstein Jensen (LJ) media.Results: Mint and garlic extracts, and their combination can inhibit the growth of M. tuberculosis clinical culture from TBB and TBM patients with minimal inhibitory concentration (MIC) of 3 mg/mL.Conclusion: Mint and garlic extracts, and their combination are effective in inhibiting the growth of M. tuberculosis clinical culture and can be used as an alternative treatment for tuberculosis disease.Keywords: mint leaves (Mentha spicata), garlic (Allium sativum), Mycobacterium tuberculosis, multidrug-resistant (MDR)-Tuberculosis Intisari Latar belakang: Tuberkulosis (TBC) merupakan penyakit dengan tingkat kematian yang tinggi di dunia, termasuk Indonesia. Selain itu, masalah resistensi bakteri terhadap antibiotik semakin tinggi. Daun mint (Mentha spicata) dan bawang putih (Allium sativum) telah terbukti dapat membunuh bakteri M. tuberculosis. Namun belum pernah diteliti bagaimana efek kombinasi keduanya dalam membunuh atau menghambat pertumbuhan bakteri M. tuberculosis. Tujuan: Mengetahui aktivitas kombinasi ekstrak daun mint dan bawang putih dalam menghambat pertumbuhan bakteri M. tuberculosis isolat klinik.Metode: Ekstraksi daun mint dan bawang putih dilakukan secara maserasi menggunakan pelarut ethanol. Bakteri uji M. tuberculosis diperoleh dari sampel klinik pasien terdiagnosis tuberkulosis baru (TBB) dan tuberkulosis multidrug resistant (TBB). Uji aktivitas penghambatan pertumbuhan dilakukan menggunakan metode dilusi padat pada media Lowenstein Jensen (LJ).Hasil: Ekstrak daun mint dan bawang putih serta kombinasi keduanya dapat menghambat pertumbuhan bakteri M. tuberculosis isolat klinik dari pasien TBB maupun TBM dengan konsentrasi terkecil 3 mg/mL.Kesimpulan: Ekstrak daun mint dan bawang putih serta kombinasi keduanya efektif menghambat pertumbuhan bakteri M. tuberculosis isolat klinik dan berpotensi untuk digunakan sebagai alternatif pengobatan tuberkulosis.Kata kunci: daun mint (Mentha spicata), bawang putih (Allium sativum), Mycobacterium tuberculosis, multidrug-resistant (MDR)-TB
Hubungan Kualitas Tidur Dengan Kadar Glukosa Darah Sewaktu Pada Pasien Diabetes Melitus Tipe 2 Muhamad Sasiar Tajiwalar; I Gede Angga Adnyana; Made Rika Anastasia Pratiwi
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.3029

Abstract

Background: Disturbances in the quantity and quality of sleep will trigger impaired glucose tolerance and reduce insulin sensitivity, affecting blood glucose levels. This situation can worsen the condition of people with type 2 Diabetes Mellitus. Objective: To determine the relationship between sleep quality and blood glucose levels in patients with type 2 diabetes mellitus at the Praya Public Health Center. Research method: Analytical research uses an observational approach with a cross sectional research design. The sample used was type 2 Diabetes Mellitus patients totaling 181 people taken by purposive sampling technique by measuring blood sugar levels while using the glucotest and providing a Pittsburgh Sleep Quality Index (PSQI) sleep quality questionnaire in data collection. Data were analyzed using spearman's rho. Result: The results of the study of respondents based on blood glucose levels at <200 (89 people) consisted of good sleep quality 96.6% and bad 3.4% while >200 (92 people) with good sleep quality 17.4% and bad 82.6 %. This shows that respondents experience hyperglycemia if the quality of sleep is poor. The analysis using Spearman's rho showed a significant relationship between sleep quality and blood glucose levels (p-value = 0.01) in type 2 Diabetes Mellitus patients at the Praya Health Center. Conclusion: There is a relationship between sleep quality and blood glucose levels in patients with type 2 diabetes mellitus at the Praya Public Health Center.
Paparan Asap Rokok Konvensional dan Elektrik bagi Manusia Serta Solusinya melalui Daun Bidara Deny Sutrisna Wiatma; I Gede Angga Adnyana; Rusmiatik Rusmiatik; Ana Andriana
Jurnal Keperawatan Vol 15 No 1 (2023): Jurnal Keperawatan: Maret 2023
Publisher : Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (377.768 KB) | DOI: 10.32583/keperawatan.v15i1.576

Abstract

Perilaku merokok adalah kebiasaan yang sangat sulit dihentikan pada sebagian besar perokok. Saat ini rokok elektrik diproduksi dan dipasarkan untuk mengganti rokok konvensional, namun US (FDA) menganalisis bahwa rokok elektrik mengandung sejumlah racun, karsionogen dan bahan lainnya yang diduga berbahaya bagi manusia. Penelitian ini bertujuan untuk membuktikan pemberian ekstrak etanol daun Ziziphus mauritiana dapat menghambat peningkatan kadar interleukin-8 dan kerusakan alveolus paru setelah paparan asap rokok konvensional dan elektrk pada mencit (Mus Musculus) jantan galur BALB/C. Penelitian ini merupakan penelitian true eksperimental dengan menggunakan raondomized post test only control group design. Sampel penelitian menggunakan mencit. Hasil penelitian menunjukkan bahwa mencit pada kelompok perlakuan K2 dan K3 tidak menunjukkan kadar IL-8 lebih rendah terhadap kelompok paparan K4 dan K5 secara statistik dengan p-value (p>0,05), begitu juga analisis derajat kerusak alveolus mencit pada kelompok perlakuan K2 dan K3 tidak menunjukkan perbaikan histologis jaringan paru terhadap kelompok paparan K4 dan K5 secara statistik dengan p-value (p>0,05). Ekstrak etanol daun bidara (Ziziphus mauritiana) dengan dosis 2mg dalam 0.5ml aquabides setiap hari selama 14 hari belum mampu menunjukkan kadar IL-8 lebih rendah dan belum mampu memperbaiki kerusakan alveolus paru secara signifkan (p<0.05) terhadap kelompok papran uap rokok elektrik dan asap rokok konvensional pada mencit (Mus Musculus) jantan galur BALB/C.
Faktor yang Mempengaruhi Kejadian Diare pada Wisatawan: A Systematic Review Kadek Dwi Pramana; I Putu Dedy Arjita; Rozikin Rozikin; Ayu Anulus; I Gede Angga Adnyana
Jurnal Keperawatan Vol 15 No 1 (2023): Jurnal Keperawatan: Maret 2023
Publisher : Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (273.474 KB) | DOI: 10.32583/keperawatan.v15i1.577

Abstract

Diare merupakan suatu keadaan di mana terjadi peningkatan respons buang air besar sebanyak 3 kali atau lebih per hari dengan konsistensi feses/tinja yang cair. Diare dapat menyebabkan berbagai masalah seperti kekurangan cairan (dehidrasi) yang parah, bahkan sampai kematian. Penelitian ini tujuan untuk melakukan review terhadap perkembangan terbaru dari faktor-faktor lingkungan serta personal wisatawan terhadap angka kejadian diare pada wisatawan. Metode penelitian ini adalah tinjauan sistematis. Basis data yang digunakan antara lain PubMed, ProQuest, Google Schoolar. dan Clinical key dari tahun 2015-2018. Kata kunci yang digunakan dalam pencarian artikel ini adalah “diarrhea AND traveller” dan “diarrhea OR traveller”, OR street food, OR hand washing, OR stay length, OR income, dan OR food hygiene. Berdasarkan kata kunci yang digunakan, diperoleh 7.626 artikel terkait. Berdasarkan hasil proses pencarian artikel dari berbagai database, diperoleh 67 artikel yang relevan. Dari studi tinjauan sistematis yang diperoleh, menunjukkan bahwa Diare pada wisatawan dipengaruhi oleh beberapa faktor diantaranya faktor lingkungan, personal, dan agent. Pada faktor lingkungan diare wisatawan dapat disebabkan oleh negara tujuan dengan risiko kejadian diare dan kualitas kebersihan makanan yang ada di destinasi. Pada faktor personal diare dapat disebabkan oleh negara asal wisatawan, usia, kebiasaan PHBS.
Interleukin-6 (IL-6), Interleukin-8 (IL-8), and Tumor Necrosis FactorAlpha (TNF-a): Their Role in the Development and Metastasis of Tumor Cells Adnyana, I Gede Angga
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 10, No 2 (2019): July-December 2019
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (607.731 KB) | DOI: 10.30659/sainsmed.v10i2.4184

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ABSTRACT: Cancer is a disease caused by uncontrolled and excessive cell division. The death caused by cancer is largely due to the cancer cell metastasis process. Cancer metastasis process is a consequence of molecules signaling pathways and interactions amongst cells in the body. Molecules involved and attributable to cancer metastasis are IL-6, IL-8, and TNF-α. This article aimed to describe the roles of IL-6, IL-8, and TNF-α in the process of various cancer cases.
HUBUNGAN INFEKSI NEMATODA USUS DENGAN STATUS GIZI PADA ANAK USIA 7 SAMPAI 10 TAHUN DI SDN 40 CAKRANEGARA KOTA MATARAM PROVINSI NUSA TENGGARA BARAT I Putu Ryan Aryadana; Rusmiatik; Fahriana Azmi; I Gede Angga Adnyana
Nusantara Hasana Journal Vol. 2 No. 11 (2023): Nusantara Hasana Journal, April 2023
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v2i11.823

Abstract

According to the results of the intestinal nematode infections survey in 10 provinces in Indonesia in 2014, the average national intestinal nematode infections prevalence was 30.35%. West Nusa Tenggara (NTB) is one of the provinces in Indonesia with quite high cases of intestinal nematode infections in school children with a total proportion of 69.03% and 73.45%. intestinal nematode infections in Mataram City is 87.54%. Intestinal nematode infections which cannot be treated immediately can cause a high risk of nutritional deficiencies, growth retardation, and a decreased ability to think and manage thoughts and behavior. This study was conducted to analyze the association between intestinal nematode infections with nutritional status in children aged 7 to 10 years. Observational analytic study with a cross-sectional study design was used. The sampling technique used was purposive sampling. The study was conducted in SDN 40 Cakranegara with a sample number of 38 respondents. The data obtained were analyzed by Fisher Exact Test The significance value limit was ρ-value >0.05. The characteristics of respondents were dominated by male elementary school-age children, and the highest height was 131-140 cm. with the age of most respondents aged 8 to 9 years, based on the most classes were respondents who occupied grade 2 elementary school, and with the most weight in the weight range of 20-30 kg. In bivariate analysis, it was found that there was no association between intestinal nematode infections and nutritional status, indicated by the ρ-value 0,49 (>0.05). In this study, there was no association between intestinal nematode infections and nutritional status, with a percentage of intestinal nematode infections at 5.3%, and respondents who were not infected had a prevalence of 94.7%.
Immunological Profile of Patients with Controlled and Uncontrolled Type 2 Diabetes Melitus in Mataram City, West Nusa Tenggara I Putu Dedy Arjita; I Gede Angga Adnyana; Ayu Anulus; I Putu Bayu Agus Saputra; Maruni Wiwin Diarti
JURNAL INFO KESEHATAN Vol 21 No 2 (2023): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol21.Iss2.933

Abstract

The prevalence of DM disease in West Nusa Tenggara Province is not much different from that in Indonesia. DM cases in NTB are included in the ten most non-communicable illnesses suffered by the community and the incidence continues to increase from year to year. An increase in the levels of pro-inflammatory cytokines in the body is one of the causes of insulin resistance in cells which can further develop into type 2 diabetes. This study involved diabetic patients at the Mataram Community Health Center, who were assigned into 2 groups, namely the controlled diabetes group and the uncontrolled diabetes group and involved a standard group which was a group consisted of healthy people. Each group was examined for Fasting Blood Glucose (FBG) and HbA1c levels. The results of the examination in the standard group, controlled diabetes group and uncontrolled diabetes group obtained the FBG levels of 89.22 mg/dl, 110.0 mg/dl, and 245.80 mg/dl, respectively. Furthermore, the results of the HbA1c test in the standard group, controlled diabetes group and uncontrolled diabetes group were 5.44%, 6.03%, and 10.49%, respectively. The results of the examination of IL-6 levels in the standard group, controlled diabetes group and uncontrolled diabetes were 329.36 pg/ml, 331.52 pg/ml, and 320.33 pg/ml, respectively. The results of the IL-10 test in the standard group, controlled diabetes group and uncontrolled diabetes were 71.80 pg/ml, 116.60 pg/ml, and 128.10 pg/ml, respectively. Based on the results of the study, there was no significant difference in the levels of interleukin 6 and interleukin 10 between respondents with diabetes mellitus and healthy respondents (p>0.05). It can be concluded that there were no differences in interleukin 6 and 10 levels between healthy people with patients with controlled and uncontrolled diabetes.
Methanol Extract Inhibition’s Effectiveness of Kawista Fruit Var. Dompu on E-Coli Through in-Vitro Ardian Ansari; Ana Andriana; Rozikin Rozikin; I Gede Angga Adnyana
Indonesian Journal of Multidisciplinary Science Vol. 2 No. 7 (2023): Indonesian Journal of Multidisciplinary Science
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/ijoms.v2i7.479

Abstract

Diarrhea is an endemic disease that causes individuals to excrete feces with a liquid consistency that have frequency of three or more times a day. The disease is caused by gastrointestinal infection due to the introduction of disease agents that can be transmitted through food, water, eating utensils, hands and flies. One of the causative agents of diarrhea is Escherichia coli. The use of various types of diarrhea drugs is basically to prevent the proliferation of Escherichia coli bacteria in the gastrointestinal tract, such as the use of Kawista fruit pulp and seeds by local people as a cure for diarrhea. The purpose of this study was to test the inhibitory activity of methanol extract of Kawista fruit pulp and seeds (Limonia acidissima L. ) Dompu variant with 4 concentrations, 25%, 50%, 75% and 100% extract concentrations. Testing antibacterial activity using the agar well diffusion method, which is done by measuring the inhibition zone around the wells. The methanol extract of Kawista fruit pulp and seeds (Limonia acidissima L. ) Dompu variant was significantly able to inhibit the growth of Escherichia coli at extract concentrations of 25%, 50%, 75% and 100% with inhibition zone diameter respectively 14.5 mm, 20.5 mm, 25.25 mm and 26.75 mm. The 100% extract concentration is classified as the concentration with the highest effectiveness in inhibiting the growth of Escherichia coli bacteria. Based on the results obtained, it can be concluded that the methanol extract of Kawista fruit pulp and seeds (Limonia acidissima L) 
Pengaruh Susu Kuda Liar Sumbawa Terhadap Kadar TNF-a pada Tikus Gastritis yang Diinduksi Indometasin Musyarrafah, Musyarrafah; Wanadiatri, Halia; Merta, Putu Demas Ardina; Adnyana, I Gede Angga; Rozikin, Rozikin; Luktiana, Metha
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 6, No 4: December 2021
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (677.007 KB) | DOI: 10.30604/jika.v6i4.1031

Abstract

Gastritis is an inflammatory, irritating, or erosive condition that affects the mucosa submucosa of the stomach. Uncontrolled use of NSAIDs for a long time can cause excess stomach acid that will lead injury to the gastric lumen which results in the immune system release of pro-inflammatory factors, one of which is TNF-a. This study aims to determine the effect of Sumbawa’s mare milk (SMM) on TNF-a Levels in Wistar Rats with Indomethacin-induced gastritis. This study used 24 male Wistar rats which were divided into 4 treatment groups, namely negative control group (group 1), positive control group (group 2), SMM treatment group + Indomethacin (group 3), and SMM treatment group (group  4). Treatment was given for 14 days analyzed using an ELISA reader. Group 3 showed the highest levels of TNF-a (median=52.36). While group 4 got the lowest TNF-a level (median=24.49). In the control group, TNF-a levels were higher in group 1(median=35.14) than in group 2 (median=30.14). Results showed that SMM had a significant effect on TNF-a levels (p less than 0.05). Effects that can be given vary, either decreasing or increasing TNF-a depending on the conditions in the tissue. SMM has the potential not only as a preventive treatment but also as a curative treatment.Abstrak: Gastritis adalah kondisi inflamasi, iritasi, maupun erosif yang mengenai daerah mukosa dan submukosa lambung. Pemakaian NSAID yang tidak terkontrol dalam waktu lama dapat mengakibatkan asam lambung berlebih sehingga mukosa lambung terkikis. Perlukaan pada lumen lambung akan membuat sistem imun mengeluarkan faktor proinflamasi, salah satunya adalah TNF-a, sehingga terjadi gastritis. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian susu kuda liar Sumbawa terhadap kadar TNF-a pada Tikus Gastritis yang diinduksi Indometasin. Penelitian ini menggunakan 24 ekor tikus jantan galur Wistar yang dibagi menjadi 4 kelompok perlakuan yaitu kelompok kontrol negatif (kelompok 1), kelompok kontrol positif (kelompok 2), kelompok perlakuan SKL (Susu Kuda Liar) Sumbawa + Indometasin (kelompok 3), dan kelompok perlakuan SKL (kelompok 4). Perlakuan diberikan selama 14 hari dan dilakukan analisis menggunakan ELISA-reader. Kelompok 3 menunjukkan kadar TNF-a tertinggi (median=52,36). Sedangkan kelompok 4 mendapatkan kadar TNF-a terendah (median=24,49). Pada kelompok kontrol, kadar TNF-a lebih tinggi pada kelompok 1 (median=35,14) dibandingkan dengan kelompok 2 (median=39,74). Hasil penelitian menunjukkan bahwa susu kuda liar Sumbawa berpengaruh terhadap kadar TNF-a secara signifikan (p kurang dari 0,05). Pengaruh yang dapat diberikan beragam, baik menurunkan maupun meningkatkan kadar TNF-a tergantung dengan kondisi di jaringan tersebut. SKL Sumbawa tidak hanya berpotensi sebagai pengobatan preventif namun juga sebagai pengobatan kuratif.
The Relationship between Worm Infection and Stunting in Children in Central Lombok Regency, West Nusa Tenggara Province Ananta Fittonia Benvenuto; I Gede Angga Adnyana; Velia Maya Samodra; Fahriana Azmi
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No 2: June 2022
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (780.977 KB) | DOI: 10.30604/jika.v7i2.1483

Abstract

Stunting is a condition of weight that is not in accordance with the height for children his age, caused by internal factors, namely low nutrition, inadequate maternal nutritional intake during pregnancy and external factors, namely pregnancy infection in the mother and the presence of infectious diseases in children. Worm infection is one of the most common diseases in children. This study aims to determine the relationship between intestinal worm infection and the incidence of stunting in children and the risk factors associated with intestinal worm infection in Central Lombok district, NTB province. A cross-sectional survey was conducted on 170 children with stunting in Central Lombok Regency, West Nusa Tenggara Province. This research took place from January-March 2021. The sample of this study was children with stunting in 8 Puskesmas in Central Lombok Regency. This study used a purposive sampling method, the independent variable was intestinal worm infection and the dependent variable was stunting. The children's parents were given an informed consent form, a set of personal protective equipment in the form of a mask and a pair of handscones, a stool pot, plastic, and oil paper. Children were also taken blood for ELISA examination, the primary data obtained in this study. Data analysis with SPSS is univariate test. There were 19 (11.17%) of the total 170 subjects infected with intestinal worms in Central Lombok Regency with a mean age of 32.64±13.75. Intestinal worm species include Ascaris lumbricoides 18 (10.59%) and Trichuris trichiura 1 (0.58%). There was no significant risk factor between intestinal helminth infection and stunting in children (95% CI = 33.47-49.36, with p value = 0.695) on blood examination using the ELISA method for levels of IL-4 as a marker of intestinal worm infection and on stool examination by the Lugol method in children in Central Lombok Regency. However, there was a significant relationship between anemia and intestinal worm infection in stunted children (p = 0.029). There is a relationship between intestinal worm infection and stunting in children in Central Lombok Regency, NTB Province. Anemia is a risk factor associated with the incidence of intestinal worm infection. However, the small number of samples and the short time in this study showed insignificant results between the two variables.