Iwan Saka Nugraha
Institut Teknologi dan Kesehatan Bintang Persada

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The Kajian Manfaat Tumbuhan Kepuh (Sterculia Foetida L.) Dan Terapi Yoga Sebagai Pengobatan Tradisional Ni Wayan Rika Kumara Dewi; Iwan Saka Nugraha; Made Prita Artika
Jurnal Yoga dan Kesehatan Vol 6 No 1 (2023): Volume 6 Nomor 1 Maret 2023
Publisher : UHN IGB Sugriwa Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25078/jyk.v6i1.2007

Abstract

Kepuh plant (Sterculia foetida L.) is one of the plants that have the potential as a source of new medicines which are rich in compounds used as modern medicines, pharmaceutical intermediates, and main compounds in natural medicinal ingredients. Traditional medicine in Bali is often called Usada which contains the science of diagnosing diseases, medicinal ingredients, and prayers. The community is also familiar with Ayurveda, namely the use of herbal medicines and yoga therapy. The development of traditional medicine into herbal medicine requires an analysis of the activity of primary metabolites present in the Kepuh plant (Sterculia foetida L.). In addition, it is also necessary to know the effect of yoga therapy on traditional medicine. This study uses a descriptive method using a structured article review method. Based on secondary data obtained from several scientific journals, it is known that the biological activities of secondary metabolites in the Kepuh plant (Sterculia foetida L.) are antibacterial, antioxidant, antifungal, antiprotozoal, cytotoxic, thrombolytic, anti-rheumatic, analgesic, antipyretic, antidiabetic, insecticidal, antifeedant, and microbicidal effects. So scientifically the Kepuh plant (Sterculia foetida L.) can be used as a source of new drugs which are rich in compounds used as modern medicines, pharmaceutical intermediates, and main compounds in natural medicinal ingredients. Likewise, the effect of giving yoga therapy to traditional medicine which is a non-pharmacological treatment can help the healing process in patients with certain diseases. However, it is necessary to carry out further research on the use of the Kepuh plant as a herbal medicine in combination with yoga therapy.
Andrografolid : Potensi Sebagai Antiaterosklerosis Pada Sitokin Il-1β Putu Yudha Ugrasena; Iwan Saka Nugraha; Ni Wayan Rika Kumara Dewi
Jurnal Ilmiah Kesehatan Sandi Husada Vol 12 No 1 (2023): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v12i1.991

Abstract

The focus is how the role of cytokines in atherosclerosis as a chronic inflammatory disease, as it is known that cytokines regulate complex inflammatory responses in atherosclerotic plaques, especially IL-1β. Sambiloto (Andrographis paniculata) is a plant with various pharmacological activities. Andrographolide (AND) is the main bioactive compound in the diterpene lactone group. This literature study aims to assess the potential of AND on the proinflammatory cytokine IL-1 β as an antiatherosclerosis. This type of research is a qualitative review of various studies using sambiloto plants or andrographolide compounds (AND). Search literature using the Google Scholar database. Keywords used "Andrographis paniculata, andrographolide, IL-1β, Atherosclerosis. The results showed that AND has effects as an anti-inflammatory, antiatherosclerosis as well as cardiovascular-related diseases. There are not many articles on the activity of AND in IL-1β against atherosclerosis, but AND can provide inhibitory activity of the cytokine IL-1β against inflammation. Not many researchers have discussed the pharmacological effects of AND as an antiatherosclerotic on IL-1β therapeutic targets, but from the results of the review AND has a strong potential in inhibiting IL-1 cytokine secretion β.