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All Journal Majalah Obat Tradisional Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Majalah Farmaseutik SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Al-Khidmah Journal Syifa Sciences and Clinical Research (JSSCR) Poltekita: Jurnal Pengabdian Masyarakat Jurnal Insan Farmasi Indonesia Indonesian Journal of Pharmaceutical Education Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Ropiqa, Meri
Jurusan Farmasi, Fakultas Kedokteran, Universitas Tanjungpura, Kota Pontianak, Indonesia
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Journal : Majalah Obat Tradisional

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Screening of Extraction Process and The Estimation of Total Alkaloids in Carica papaya Linn. Leaf Sisca Devi; Meri Ropiqa; Yosi Bayu Murti; Akhmad Kharis Nugroho
Majalah Obat Tradisional Vol 25, No 2 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.52184

Abstract

The papaya leaf decoctions have been widely used as a traditional treatment for malaria. The alkaloid of papaya leaves, carpaine, is reported to have the antiplasmodial activity in vitro. The industrial-scale commercial product development requires the quantification of the carpaine, and total alkaloids in the papaya leave as the raw materials. This study aims to optimize the extraction process leading to the highest yield and total alkaloids. The extraction process was carried out using different methods and solvents. The first method was maceration with the water-miscible solvent of ethanol: distilled water: HCl 37% (89: 10: 1 v/v/v). The second method was maceration with the water-immiscible solvent of dichloromethane solvents in pH 8-9 with ammonium hydroxide. The third method was digestion with acid water solvent of 0.05 N HCl. The identification of alkaloids employed the analysis using Thin Layer Chromatography (TLC) and Dragendroff reagent. The quantification of carpaine used a densitometer, while the spectrophotometric method was used to estimate the total alkaloids. The results showed that despite the extraction methods used, the tested extracts confirm the alkaloids content with the highest yield of 3.09% (84.72% of total alkaloids).
Co-Authors Ade Damhuzi Akhmad Kharis Nugroho Budi Suryana Dian Kartikasari Dian Kartikasari Dwi Nur Oktavianti Erwan kurnianto Fajar Nugraha Fajriaty, Inarah Fathiah Fathiah Hadi Kurniawan Hadi Kurniawan Hairunisa Hairunisa Hairunisa Hairunisa, Hairunisa Ika Ristia Rahman Indah Purwaningsih Muhammad Rafly Agustriangga Risa Indriyani Shoma Rizkifani Sisca Devi Sisca Devi Siti Nani Nurbaeti Sri Wahdaningsih Suhaimi Suhaimi Sunarsieh Sunarsieh Tiara Bella Pratiwi Yosi Bayu Murti Yosi Bayu Murti