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Uji Potensi Daya Hambat Ekstrak Metanol Biji Jintan Hitam (Nigella Sativa L.) Terhadap Bakteri Streptococcus Guntur Satrio Pratomo; Nurul Chusna; Muhammad Priyadi
Jurnal Surya Medika (JSM) Vol 6 No 1 (2020): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v6i1.1615

One of the plants that are often used as medicinal plants is Black Seed, Black Seed is a medicinal plant known in Indonesia by the name of black cumin. Black cumin seeds and essential oils (Nigella sativa L.) have been widely used in traditional medicine. Many studies have proven the effects of Nigella sativa extract. In various studies, black cumin seed oil shows efficacy as an anti-cancer, anti-free radical and immunomodulator, analgesic, antimicrobial, anti-inflammatory, a spasmolytic, bronchodilator, hepatoprotective, and anti-hypertensive Advanced chemical analysis found that Black Seed contains carotene that is converted into vitamin A by heart. The purpose of this study was to determine the potential inhibition of methanol extract of black cumin seeds (Nigella Sativa L.) against Streptococcus. This research uses a quantitative approach with an experimental method. This research was conducted in the Pharmacognition and Microbiology Laboratory of the Faculty of Health Sciences, Muhammadiyah University, Palangkaraya. The sample used was a sample of plant material, namely Black Cumin Seed (Nigella sativa L) which had been dried and pollinated and then extracted and then tested against bacteria. The results of testing the antibacterial activity showed that from low concentration to high concentration the diameter of the resulting inhibition showed that the activity could inhibit the bacteria streptococcus mutants. The highest inhibition at a concentration of 6% is 0.83 mm and the lowest concentration at a concentration of 3% against Streptococcus mutants.

Profil Fitokimia Ekstrak Etil Asetat Temu Kunci (Boesenbergia rotunda L.) dan Serai (Cymbopogon citratus) Muhammad Priyadi; Nurul Chusna; Isnawati Isnawati; Opi Indriani
Jurnal Pharmascience Vol 8, No 1 (2021): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i1.9725

Senyawa bahan alam yang terdapat pada tanaman memiliki banyak khasiat bagi kesehatan yang telah dibuktikan melalui pengobatan tradisional secara empiris. Identifikasi senyawa kimia sangat penting untuk mengetahui kemungkinan adanya senyawa yang dapat memiliki aktivitas farmakologi. Tanaman yang telah banyak digunakan oleh masyarakat termasuk pengobatan adalah temu kunci (Boesenbergia rotunda L.) dan serai (Cymbopogon citratus). Temu kunci dan serai diekstraksi menggunakan pelarut etil asetat. Uji fitokimia pada ekstrak etil asetat temu kunci dan serai dilakukan dengan uji kualitatif pereaksi warna dan pengendapan serta kromatografi lapis tipis untuk melihat gambaran pemisahan senyawa kimia yang terkandung. Ekstrak etil asetat temu kunci dan serai mengandung senyawa golongan alkaloid, terpenoid, flavonoid, fenol, dan kuinon. Senyawa pada temu kunci dan serai dapat dipisahkan menggunakan kromatografi lapis tipis dengan fase gerak etil asetat : n-heksan (8:2). Kata Kunci: Fitokimia, Temu Kunci, Serai, Ekstrak Etil Asetat, Kromatografi Lapis Tipis Natural compounds found in plants have many health benefits that have been proven through empirically traditional medicine. Identification of chemical compounds is very important to determine the possibility of compounds having pharmacological activity. Plants that have been widely used by the community, including medicinal plants, are Temu Kunci (Boesenbergia rotunda L.) and serai or lemongrass (Cymbopogon citratus). Temu Kunci and lemongrass were extracted using ethyl acetate as a solvent. Phytochemical test on ethyl acetate extract of temu Kunci and lemongrass was carried out by qualitative test using color reagent and deposition and thin layer chromatography to see the description of the separation of the chemical compounds contained. Temu Kunci and lemongrass ethyl acetate extracts contain alkaloids, terpenoids, flavonoids, phenols, and quinones. Compounds in Temu Kunci and lemongrass can be separated using thin layer chromatography with ethyl acetate: n-hexane (8: 2) as mobile phase.

PELATIHAN PEMBUATAN SABUN ANTISEPTIK CAIR BERBAHAN DASAR TANAMAN RAMBUSA KALIMANTAN TENGAH Evi Mulyani; Nurul Chusna; Muhammad Priyadi
JMM (Jurnal Masyarakat Mandiri) Vol 6, No 1 (2022): Februari
Publisher : Universitas Muhammadiyah Mataram

Abstrak: Pandemi COVID-19 telah mengubah kebiasan kehidupan di masyarakat termasuk menjaga kebersihan tangan melalui cuci tangan termasuk di lingkungan sekolah. Keterbatasan dalam mendapatkan akses pendidikan dan pelatihan selama pandemi ini melanda menjadikan siswa sekolah memerlukan kegiatan di luar sekolah untuk meningkatkan keterampilan sebagai bekal tambahan. Pengabdian ini bertujuan untuk meningkatkan pengetahuan siswa SMA dalam pembuatan sabun antiseptik cair dengan bahan dasar tanaman rambusa Kalimantan Tengah. Pengabdian dilakukan kepada siswa/i SMA Muhammadiyah 1 Palangka Raya dengan melakukan pelatihan pembuatan sabun antiseptik cair secara daring dan luring terhadap 24 peserta. Evaluasi kegatan dilakukan melalui asessmen awal dan akhir berupa pemberian instrumen kuisioner kepada peserta pelatihan. Hasil menunjukkan telah terjadi peningkatan pengetahuan siswa/i SMA Muhammadiyah 1 Palangka Raya sebesar 30,4%.Abstract: The COVID-19 pandemic has changed the habits of life in the community, including maintaining hand hygiene through hand washing, including in the school environment. Limitations in getting access to education and training during this pandemic have made school students need activities outside of school to improve skills as additional provisions. This service aims to increase the knowledge of high school students in making liquid aniseptic soap with plant-based ingredients typical of Central Kalimantan. The service was carried out to students of SMA Muhammadiyah 1 Palangka Raya by conducting online and offline training on making liquid antiseptic soap for approximately 24 participants. Activity evaluation is carried out through initial and final assessments in the form of giving a questionnaire instrument to the training participants. The results show that there has been an increase in knowledge of students at SMA Muhammadiyah 1 Palangka Raya by 30.4%.

EDUKASI TENTANG VIRUS CORONA DAN PEMBUATAN JAMU EMPON – EMPON UNTUK PENANGANAN VIRUS CORONA DI JUNJUNG BUIH III KOTA PALANGKARAYA Nurul Chusna; Evi Mulyani; Muhammad Priyadi; Ade Irawati; Drenikha Sikhe R; Rismadani Safitri
JMM (Jurnal Masyarakat Mandiri) Vol 5, No 1 (2021): Februari
Publisher : Universitas Muhammadiyah Mataram

Abstrak: Seluruh dunia saat ini tengah dihebohkan dengan Corona Virus Disease (COVID-19) yang tak pernah disangka akan menyebabkan pandemi global dengan jumlah total kasus yang sangat banyak dan terus menyebar ke seluruh dunia termasuk hingga mencapai Kota Palangka Raya, Indonesia. Penyebaran informasi yang keliru saat pandemi dapat membuat masyarakat bingung, resah dan takut sehingga diperlukan upaya edukasi maupun sosialisasi agar masyarakat menjadi paham dan tenang. Pengabdian ini bertujuan untuk melakukan edukasi tentang penanganan virus corona/COVID-19, pembuatan jamu empon-empon agar dapat mengurangi dan mencegah terjadinya risiko penyebaran corona di Junjung Buih III Kota Palangka Raya dengan melibatkan mitra ketua RW dan perkumpulan ibu-ibu. Kegiatan ini dilakukan melalui 3 tahapan yaitu persiapan (observasi), pelaksanaan kegiatan (edukasi dan sosialisasi) dan evaluasi. Hasil dari kegiatan ini adalah kegiatan ini diikuti oleh 32 warga Junjung Buih III yang mampu meningkatkan pemahaman dan kesadaran warga dalam pencegahan virus corona yang terlihat pada penggunaan masker, hand sanitizer, mencuci tangan maupun mengkonsumsi jamu empon-empon yang dibuat langsung di rumah. Abstract: The whole world is currently in shock with the Coronavirus Disease (COVID-19) which was never expected to cause a global pandemic with a very large number of cases and continues to spread throughout the world including reaching Palangka Raya City, Indonesia. The dissemination of misinformation during a pandemic can make people confused, anxious, and afraid so that educational and socialization efforts are needed so that people understand and are calm. This activity aims to provide education about the handling of the coronavirus/COVID-19, making herbal medicine jamu empon-empon in order to reduce and prevent the risk of spreading corona in Junjung Buih III, Palangka Raya City by involving RW chief partners and women's associations. This activity is carried out in 3 stages, namely preparation (observation), implementation of activities (education and socialization), and evaluation. The result of this activity was that this activity was attended by 32 residents of Junjung Buih III who were able to increase people's understanding and awareness of the prevention of the coronavirus which can be seen in the use of masks, hand sanitizers, washing hands, and also consuming jamu empon-empon made directly at home (home made).

Uji Aktivitas Antibakteri Kombinasi Minyak Kelapa Murni dan Arang Aktif terhadap Streptococcus mutans Nurul Chusna; Muhammad Priyadi
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.12704

Streptococcus mutans merupakan bakteri penyebab masalah pada karies gigi. Penggunaan bahan alami dipercaya menjadi salah satu terapi infeksi yang dapat digunakan sebagai antibakteri. Beberapa penelitian menunjukkan adanya potensi bahan alami seperti minyak kelapa murni dan mineral arang aktif dapat mengobati karies gigi. Hal ini mendorong untuk mengetahui aktivitas antibakteri kombinasi antara minyak kelapa murni dan arang aktif terhadap S. mutans. Pengujian antibakteri dilakukan dengan metode difusi cakram dengan mengukur diameter zona hambat. Kelompok sampel uji terdiri dari kombinasi minyak kelapa murni : arang aktif (konsentrasi 10% v/v : 5% b/v, 5% v/v : 5% b/v, dan 5% v/v : 10% b/v) dan amoksisilin 30 µg sebagai kontrol positif. Hasil menunjukkan kombinasi minyak kelapa murni : arang aktif (10% v/v : 5%b/v, 5% v/v : 5% b/v, dan 5% v/v : 10% b/v) dan amoksisillin memiliki besaran zona hambat berturut-turut sebesar 8,50 mm; 6,90 mm; 6,90 mm dan 30,04 mm. Hasil uji penelitian yang dilakukan menunjukkan bahwa kombinasi antara minyak kelapa murni dan arang aktif memiliki aktivitas antibakteri yang lemah terhadap bakteri S. mutans. Selanjutnya, perlu dilakukan penelitian lanjutan aktivitas minyak kelapa murni maupun bahan-bahan alami lainnya pada penanganan infeksi gigi dan mulut. Kata Kunci: Antibakteri, Minyak Kelapa Murni, Arang Aktif, Karies Gigi, Streptococcus mutans Streptococcus mutans is bacteria that causes problems in dental caries. The use of natural ingredients is believed to be one of the infection therapies that can be used as antibacteria. Several studies have shown the potential of natural ingredients such as virgin coconut oil and activated charcoal minerals to treat dental caries. It is encouraging to know the antibacterial activity of the combination of virgin coconut oil and activated charcoal against S. mutans. Antibacterial testing was carried out by disc diffusion method to know the diameter of the inhibition zone. The test sample group consisted of a combination of virgin coconut oil: activated charcoal (10% v/v : 5% w/v, 5% v/v : 5% w/v, and 5% v/v : 10% w/v ) and amoxicillin as a positive control. The results showed that the combination of virgin coconut oil: activated charcoal (10% v/v : 5% w/v, 5% v/v : 5% w/v, and 5% v/v : 10% w/v) and amoxicillin 30 µg had the size of the inhibition zone was 8.50 mm, 6.90mm, 6.90 mm and 30.04 mm, respectively. The results of the research conducted showed that the combination of virgin coconut oil and activated charcoal had weak antibacterial activity against S. mutans. Furthermore, it is necessary to conduct further research on the activity of virgin coconut oil and other natural ingredients in the treatment of dental and oral infections.

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETIL ASETAT DAUN RAMBUSA DAN DAUN KARAMUNTING TERHADAP Streptococcus mutans Muhammad Priyadi; Nurul Chusna; Guntur Satrio Pratomo
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.875

Empirically, many natural ingredients have been used in preventive care for the treatment of dental and oral disorders. Chronic conditions on the teeth with the appearance of plaque and tooth decay are referred to as dental caries which are characterized by toothache and also digestive disorders. Streptococcus mutans is known as the bacteria that most often causes dental caries. Karamunting and rambusa plants have enough potential as antibacterials because there have been many studies that have shown their potential as antibacterial activities. The purpose of this study was to determine the antibacterial activity of ethyl acetate extract of karamunting leaves and rambusa leaves against Streptococcus mutans. Antibacterial activity test using well diffusion method by measuring the diameter of the inhibition zone. The results showed that the ethyl acetate extract of karamunting leaves 1%, 5%, 10%, 15%, 20% had inhibition zone diameters of 4.6 mm, 4.1 mm, 0 mm, 0 mm, 0 mm, respectively while rambusa leaves 1%, 5%, 10%, 15%, 20% had inhibition zone diameters of 4.4 mm, 8.7mm, 9.4 mm, 5.3mm and 8.8mm respectively. The ethyl acetate extract of karamunting and rambusa leaves is known to have weak antibacterial activity in the resistant category.

Anticaries Potential of Temu Kunci-Serai Ethyl Acetate Extract Combination: In Vitro and Molecular Studies Approach Muhammad Priyadi; Rizki Rachmad Saputra
CHEMPUBLISH JOURNAL Vol. 7 No. 1 (2023): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v7i1.26098

Dental caries is one of the problems in dental disorders suffered by many people. There have been many ways of handling such as using temu kunci and lemongrass plants. This study aims to determine the antibacterial activity of caries in vitro and predict the mechanism of action of the bacteria that cause caries Streptococcus mutans. Temu kunci and lemongrass were extracted using ethyl acetate solvent. antibacterial tests against Streptococcus mutans were carried out using diffusion tests with a combination treatment of temu kunci: serai extracts 5% b/v: 5% b/v, 5% b/v: 10% b/v, and 10% b/v: 5% b/v. The positive control used amoxicillin and DMSO as a negative control. Potency as an anticaries drug of drived compound from Temu Kunci and Serai were evaluated by molecular docking using glucosyltransferase (3AIC). The results showed that the combination of temu kunci and serai with concentration 10% b/v: 5% b/v has potential as anticaries against Streptococcus mutans. Molecular studies depicted that Panduratin A, Isopanduratin, and 1,3-O-di-p-coumaroylglycerol have great activity toward 3AIC, respectively. Especially for Panduratin A and Isopanduratin, those compound depicted great and similar binding affinity (-8.4 kcal mol-1) that lower than Acarbose as native ligand (-8.3 kcal mol-1). Furthermore, those compound binding similarity ilustrated activity mechanism similarly with native ligand toward receptor. Additionally, the profiling drug-target interaction suggested Temu Kunci’s derived compounds have great potential as anticaries treatment.

Phytochemical and Cytotoxic Test of Durio kutejensis Root Bark on MCF-7 Cells Muhammad Priyadi; Haryoto Haryoto; Amaliyah Dina Anggraeni; Heng Yen Khong
Borneo Journal of Pharmacy Vol. 4 No. 1 (2021): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v4i1.1443

Durio kutejensis has known potential as herbal medicine in Kalimantan. Many things can be explored from D. kutejensis related pharmacological activity in every part of the plant included root bark. This study investigated the phytochemical content with a qualitative test and tested cytotoxic activities of D. kutejensis root bark on MCF-7 cell lines. Cytotoxic activity tested on MCF-7 cells with MTT assay method. The result showed that D. kutejensis root bark contains flavonoid, tannin, terpenoid, phenol, and saponin. IC50 value for ethanol extracts of root bark, n-hexane fractions, ethyl acetate fractions, and doxorubicin on MCF-7 cells were 761.29; 280.5; 207.08; and 0.25 μg/mL, respectively. In conclusion, D. kutejensis root bark has some secondary metabolites but no cytotoxic activity on MCF-7 cells. Further research is needed to explore the anticancer activity of secondary metabolites on some other cancer cells and other pharmacological activities.

Aktivitas Psikostimulan Tanaman Bajakah (Spatholobus suberectus) : Studi In Silico Terhadap Protein 4M48-Dopamine Transporter Muhammad Priyadi; Rizki Rachmad Saputra; Yohanes Edy Gunawan; Shesanthi Citrariana; Decenly Decenly; Yahya Febrianto
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p149-154

Bajakah plants (Spatholobus suberectus) have been widely used by Dayak tribes in Kalimantan with various properties that are believed and have also been studied for various tests of phytochemical compound content and pharmacological tests. Secondary metabolite compounds from bajakah (Spatholobus suberectus) have potential as psychostimulant compounds. The purpose of this study was to investigate the psychostimulant activity of bajakah plants (Spatholobus suberectus) through analysis of the interaction between bajakah secondary metabolite compounds and the 4M48-Dopamine Transporter receptor (PDB: 4M48), which is one of the dopamine transporter proteins. Ligand and receptor interactions were analyzed using molecular docking method with Autodock Vina 4 application with nortriptyline compound as native ligand and 15 secondary metabolite compounds for testing. The results of docking analysis showed that the standard ligand nortriptyline compound has an affinity value of -10.2 kcal/mol. There are 3 compounds from bajakah that have affinity values close to the standard compounds plathymenin, butein and eriodictyol with affinity values of -9.7 kcal/mol, -9.4 kcal/mol and -9.2 kcal/mol respectively. Based on the analysis conducted, it can be concluded that bajakah plants (Spatholobus suberectus) have the potential to be developed as psychostimulant therapy.

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