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All Journal Alchemy : Journal of Chemistry CHEMPUBLISH JOURNAL Molekul: Jurnal Ilmiah Kimia Bubungan Tinggi: Jurnal Pengabdian Masyarakat Jurnal Farmasi dan Sains Indonesia (JFSI)
Rizki Rachmad Saputra
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, Universitas Palangka Raya, Palangka Raya 7311, Central Kalimantan
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Social Sciences Other

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POTENSI BIOAKTIF EKSTRAK ALGA MERAH (Gracillaria verrucosa) TERHADAP KADAR MALONDIALDEHIDA (MDA) DAN GAMBARAN HISTOLOGI PARU TIKUS PUTIH (Rattus novergicus) PASCA INDUKSI FORMALIN Anggun Tanduwinata; Helmi Auliyah Istiqomah; Jamilah Jamilah; Ni Luh Kemmy Caesaria; Rizki Rahmat Saputra; Aulanni'am Aulanni'am
Molekul Vol 10, No 2 (2015)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.85 KB) | DOI: 10.20884/1.jm.2015.10.2.8

Abstract

Indonesia merupakan negara megabiodiversitas yang banyak mengandung kekayaan alam, salah satunya alga merah. Alga merah (Glacillaria verrucosa) mengandung senyawa fikosianin, fikoeretin dan karotenoid yang berperan sebagai antioksidan. Penelitian ini dilakukan untuk mengetahui potensi bioaktif ekstrak alga merahuntuk terapi hewan coba tikus putih (Rattus novergicus) berdasarkan kadar malondialdehida (MDA) dan gambaran histologi paru. Metode penelitian yang dilakukan meliputi ekstraksi alga merah dan karakterisasi, induksi  hewan coba (R. novergicus) dengan formalin, kemudian terapi ekstrak alga merah dengan variasi dosis. Berdasarkan uji fitokimia, analisis dengan FTIR dan LCMS, ekstrak alga merah mengandung senyawa flavonoid, terpenoid, alkaloid, β-karoten , β-apo-8’-carotenal dan α-tokoferolyang berperan sebagai antioksidan. Formalin dapat meningkatkan kadar MDA serta menyebabkan kerusakan sel epitel bronkus dibandingkan dengan keadaan normal. Pemberian terapi dengan dosis yang sesuai akan menurunkan kadar MDA dan memperbaiki keadaan sel epitel bronkus. Berdasarkan pengamatan parameter penelitan, diketahui bahwa dosis optimum yang sesuai untuk terapi kanker paru adalah 100 mg/kg BB
Study Natural Compound of Eleutherine americana as a SaR-CoV-2 Therapeutic Agent : In Silico Approach Mokhamat Ariefin; Rizki Rachmad Saputra
ALCHEMY:Journal of Chemistry Vol 11, No 1 (2023): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v11i1.18018

Abstract

Sar-CoV-2 (COVID-19) has rapidly spread globally where it has killed thousands of individuals and infected almost 1,016,395 others. Numerous people have died as a result of what the World Health Organization (WHO) has deemed a top worldwide health issue, which has also had severe detrimental social and economic impacts. Some Eleutherin americana are said to possess antiviral effects. Children's colds and nasal congestion can be treated with eleutherin americana. Naphthalene, anthraquinone, and naphtoquinone are the three main chemical families that have been identified from E. americana. Eleutherol, hongconin, isoeleutherol, and eleutherin were the compounds that were identified from E. Americana. Drug-receptor interactions are simulated using computational techniques toward 14 compounds isolated from E. americana. The docking method has been validated by redocking the N3 molecule as a native ligand to the Mpro of Sar-CoV-2 (PDB ID: 7BQY) as a receptor protein. The smaller the RMSD value 0.651 Å, the better the pose obtained through the docking process. Compound 12 has a more negative binding energy are showed -8.6 kcal mol-1, regarding to hydrogen bond interaction toward Thr26, His41, Leu141, Asn142, Gly143, Ser144, His163. The stability of the association between the ligand and receptor increases with decreasing binding energy value (∆G). On the other hand, Compounds 11 and 2 are depicted -8.2 kcal mol-1 and -8.1 kcal mol-1 respectively which close to N3 -8.3 kcal mol-1. Undergoing hydrogen bond interaction between 11 with Gly143,Thr26, Leu141, Glu166, Ser144, Cys145, His163, and less hydrogen bond interaction 2 toward Arg188 and Asn 142. Those result resembling hydroxy group have the best interaction with 7BQY. According to fulfilled data from three candidates 2, 11, 12, it can be expected that compound with many hydroxy groups are within realm of possibility as antiviral agent for Sar-CoV-2 through inhibit replication of this virus.
Anticaries Potential of Temu Kunci-Serai Ethyl Acetate Extract Combination: In Vitro and Molecular Studies Approach Muhammad Priyadi; Rizki Rachmad Saputra
CHEMPUBLISH JOURNAL Vol. 7 No. 1 (2023): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v7i1.26098

Abstract

Dental caries is one of the problems in dental disorders suffered by many people. There have been many ways of handling such as using temu kunci and lemongrass plants. This study aims to determine the antibacterial activity of caries in vitro and predict the mechanism of action of the bacteria that cause caries Streptococcus mutans.  Temu kunci and lemongrass were extracted using ethyl acetate solvent. antibacterial tests against Streptococcus mutans were carried out using diffusion tests with a combination treatment of temu kunci: serai extracts 5% b/v: 5% b/v, 5% b/v: 10% b/v, and 10% b/v: 5% b/v. The positive control used amoxicillin and DMSO as a negative control. Potency as an anticaries drug of drived compound from Temu Kunci and Serai were evaluated by molecular docking using glucosyltransferase (3AIC). The results showed that the combination of temu kunci and serai with concentration 10% b/v: 5% b/v has potential as anticaries against Streptococcus mutans. Molecular studies depicted that Panduratin A, Isopanduratin, and 1,3-O-di-p-coumaroylglycerol have great activity toward 3AIC, respectively. Especially for Panduratin A and Isopanduratin, those compound depicted great and similar binding affinity (-8.4 kcal mol-1) that lower than Acarbose as native ligand  (-8.3 kcal mol-1). Furthermore, those compound binding similarity ilustrated activity mechanism similarly with native ligand toward receptor. Additionally, the profiling drug-target interaction suggested Temu Kunci’s derived compounds have great potential as anticaries treatment.   
Training on the Making of Eco-Enzyme Disinfectants as a Sustainable Strategy for Processing Organic Waste Retno Agnestisia; Erwin Prasetya Toepak; Yuliana Yuliana; Rizki Rachmad Saputra; Marvin Horale Pasaribu; Abed Nego Purba; Okta Prianus
Bubungan Tinggi: Jurnal Pengabdian Masyarakat Vol 6, No 2 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/btjpm.v6i2.10369

Abstract

The community in Habaring Hurung Urban Village, Bukit Batu District, Palangka Raya City, is grappling with the issue of accumulating household waste, primarily composed of organic waste. The prevalent practices of managing this waste, such as landfilling, burning, or haphazardly piling it around residential areas and roadsides, pose environmental and health risks. In response to this challenge, an initiative was undertaken to empower families in Habaring Hurung Urban Village through training sessions on creating disinfectants using eco enzymes derived from fermented organic waste. The method of implementing community service consists of the preparation stage, namely digging up information on training needs, and preparing materials and teaching aids; the implementation stage in the form of pre-final tests and training; and the last stage in the form of evaluation and reporting, took place on September 4, 2023, at the office hall of Habaring Hurung Urban Village. A total of 39 participants actively engaged in the training, displaying enthusiasm and a positive response. The results of the questionnaire also showed a fairly good level of satisfaction of all participants regarding the theme of the activity, the presentation was easy to understand, the participants' knowledge increased, and this activity should be continued by all participants where the percentage of participants who agreed showed a value of 56.4%. 51.3%, 66.7%, and 53% respectively. The ultimate goal of this initiative is to educate the local community on transforming organic waste into multifunction products for everyday use.
Aktivitas Psikostimulan Tanaman Bajakah (Spatholobus suberectus) : Studi In Silico Terhadap Protein 4M48-Dopamine Transporter Muhammad Priyadi; Rizki Rachmad Saputra; Yohanes Edy Gunawan; Shesanthi Citrariana; Decenly Decenly; Yahya Febrianto
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p149-154

Abstract

Bajakah plants (Spatholobus suberectus) have been widely used by Dayak tribes in Kalimantan with various properties that are believed and have also been studied for various tests of phytochemical compound content and pharmacological tests. Secondary metabolite compounds from bajakah (Spatholobus suberectus) have potential as psychostimulant compounds. The purpose of this study was to investigate the psychostimulant activity of bajakah plants (Spatholobus suberectus) through analysis of the interaction between bajakah secondary metabolite compounds and the 4M48-Dopamine Transporter receptor (PDB: 4M48), which is one of the dopamine transporter proteins. Ligand and receptor interactions were analyzed using molecular docking method with Autodock Vina 4 application with nortriptyline compound as native ligand and 15 secondary metabolite compounds for testing. The results of docking analysis showed that the standard ligand nortriptyline compound has an affinity value of -10.2 kcal/mol. There are 3 compounds from bajakah that have affinity values close to the standard compounds plathymenin, butein and eriodictyol with affinity values of -9.7 kcal/mol, -9.4 kcal/mol and -9.2 kcal/mol respectively. Based on the analysis conducted, it can be concluded that bajakah plants (Spatholobus suberectus) have the potential to be developed as psychostimulant therapy.
Co-Authors Abed Nego Purba Anggun Tanduwinata Aulanni'am Aulanni'am Citrariana, Shesanthi Decenly Decenly Erwin Prasetya Toepak Gunawan, Yohanes E Helmi Auliyah Istiqomah Jamilah Jamilah Marvin Horale Pasaribu Mokhamat Ariefin Muhammad Priyadi Ni Luh Kemmy Caesaria Okta Prianus Retno Agnestisia Yahya Febrianto Yuliana Yuliana