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All Journal Indonesian Journal of Cancer Chemoprevention
Miralda Zahra
Undergraduate Program in Department of Pharmacy, Faculty of Science, Sumatera Institute of Technology, South Lampung 35365, Indonesia
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Bioinformatic and Molecular Docking Study of Zerumbone and Its Derivates against Colorectal Cancer Riri Fauziyya; Winni Nur Auli; Nisa Yulianti Suprahman; Sarmoko Sarmoko; Arif Ashari; Kalista Alsadila; Lanita Agustin; Safia Fazila; Miralda Zahra; Esteria Christina Pane; Sukrasno Sukrasno
Indonesian Journal of Cancer Chemoprevention Vol 14, No 1 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss1pp39-48

Abstract

The prevalence of colorectal cancer (CRC) is ranked third among all cancer types in both men and women, highlighting the urgency for drug exploration. Zerumbone and its derivatives have gained attention for their ability to inhibit angiogenesis, invasion, and metastasis and have been tested for their efficacy against various cancer cells. This study aimed to investigate the potential targets and mechanism of action of zerumbone derivatives in colon cancer invasion and migration. Bioinformatic analysis was conducted using STITCH and STRING to identify potential target genes, and molecular docking was used to search for anticancer candidates from 20 zerumbone derivatives. The results revealed that six proteins were targeted by zerumbone derivatives, including XIAPBIR3 (1TFT), AKT1 (3O96), JAK2 (6VGL), HASP90AA (2XJX), MDM2 (4MDN), and XIAPBIR2 (4KJU). Compound 4 was found to have a lower binding energy than zerumbone as well as AZD5363 (pan-Akt inhibitor) when interacting with the protein target AKT1. This makes it the most promising candidate among the zerumbone derivatives for treating colorectal cancer. Further development, such as the addition of an amine functional group, is expected to improve the potency of this molecule through the formation of hydrogen bonds and other interactions with lower bond energy.Keywords: Bioinformatic, molecular docking, zerumbone derivatives, colorectal cancer.
Co-Authors Arif Ashari Aulia, Winni Nur Esteria Christina Pane Fauziyya, Riri Kalista Alsadila Lanita Agustin Nisa Yulianti Suprahman Safia Fazila Sarmoko Sarmoko Sukrasno Sukrasno