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All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Jurnal Kreativitas PKM Jurnal Sains dan Kesehatan
Aulia, Winni Nur
Department Of Pharmacy, Faculty Of Science, Sumatera Institute Of Technology, South Lampung 35365, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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The performance of derivate FTIR spectrophotometry method compared to colorimetry for tranexamic acid tablet content determination Nugrahani, Ilma; Aulia, Winni Nur
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (470.896 KB) | DOI: 10.12928/pharmaciana.v8i1.8227

Abstract

Recently, FTIR reported has been established as a direct content determination for some tablet dosage forms. In the method, infrared transmittance spectra was converted into the derivated absorbance form. In this present research, the method’s performance was investigated to quantified tranexamic acid in its tablet dosage form directly. The result then was compared to the colorimetry, which has been developed by another researcher. Correlations between the two methods were analyzed using t-test. The good linearity was shown at concentration range of 0.5 - 1.75% w/w at the wave number of NH group. Furthermore, the recovery, intra- and inter-day precision also fulfilled the validation requirement. Meanwhile, LOD and LOQ of the method were 0.0531%w/w and 0.1770%w/w. These methods were compared with colorimetry has been established before. Afterwards, the t-test proved no significant difference of content determination yielded, between these two methods. In conclusion, FTIR can be used for quantify the content of tranexamic tablet, more accurately than colorimetry, which has been developed before. Moreover, FTIR method also has advantages such as easier, simpler, faster and cheaper than the colorimetry method.  
The performance of derivate FTIR spectrophotometry method compared to colorimetry for tranexamic acid tablet content determination Ilma Nugrahani; Winni Nur Aulia
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (470.896 KB) | DOI: 10.12928/pharmaciana.v8i1.8227

Abstract

Recently, FTIR reported has been established as a direct content determination for some tablet dosage forms. In the method, infrared transmittance spectra was converted into the derivated absorbance form. In this present research, the method’s performance was investigated to quantified tranexamic acid in its tablet dosage form directly. The result then was compared to the colorimetry, which has been developed by another researcher. Correlations between the two methods were analyzed using t-test. The good linearity was shown at concentration range of 0.5 - 1.75% w/w at the wave number of NH group. Furthermore, the recovery, intra- and inter-day precision also fulfilled the validation requirement. Meanwhile, LOD and LOQ of the method were 0.0531%w/w and 0.1770%w/w. These methods were compared with colorimetry has been established before. Afterwards, the t-test proved no significant difference of content determination yielded, between these two methods. In conclusion, FTIR can be used for quantify the content of tranexamic tablet, more accurately than colorimetry, which has been developed before. Moreover, FTIR method also has advantages such as easier, simpler, faster and cheaper than the colorimetry method.  
The effect of partially pregelatinized cassava starch as disintegrant for paracetamol tablet Okta Nama Putra; Winni Nur Auli; Musa Musa; Derina Paramitasari; Gabriela Kasih Mawarni
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (691.913 KB) | DOI: 10.12928/pharmaciana.v12i3.24343

Abstract

The use of partially pregelatinized starch in tablet formulations is entirely various; one of them is disintegrant. Present pregelatinized starch is imported from another country, which is relatively expensive. In contrast, many plants can be used as starch sources, including cassava which is relatively abundant in Indonesia. This study aimed to determine the effect of using partially pregelatinized starch from cassava as a disintegrant in paracetamol tablets. In this study, seven formulas were used with different disintegrants, three formulas using partially pregelatinized starch from cassava with concentrations of F1 5%, F2 10%, and F3 15%, three formulas using Starch 1500 with the same concentration as partially pregelatinized starch from cassava and one control formula without disintegrant. The tablet was made using the wet granulation method. The tablets produced were tested for physical properties (hardness, disintegration, and dissolution). In addition, compact ability of partially pregelatinized starch from cassava was compared with Avicel, Starch 1500, and cassava starch. Based on the results of the study showed that partially pregelatinized starch from cassava produced tablets that tended to be capping with less hardness than tablets with Starch 1500 and control tablets. The compact ability test results showed that the compact ability of partially pregelatinized starch from cassava was better than Starch 1500 and cassava starch. The disintegration test results showed that tablets with partially pregelatinized starch from cassava had faster disintegration than tablets with Starch 1500 and control tablets. The dissolution profile of tablets with partially pregelatinized starch from cassava is also better than other formulas. 
Bioinformatic and Molecular Docking Study of Zerumbone and Its Derivates against Colorectal Cancer Riri Fauziyya; Winni Nur Auli; Nisa Yulianti Suprahman; Sarmoko Sarmoko; Arif Ashari; Kalista Alsadila; Lanita Agustin; Safia Fazila; Miralda Zahra; Esteria Christina Pane; Sukrasno Sukrasno
Indonesian Journal of Cancer Chemoprevention Vol 14, No 1 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss1pp39-48

Abstract

The prevalence of colorectal cancer (CRC) is ranked third among all cancer types in both men and women, highlighting the urgency for drug exploration. Zerumbone and its derivatives have gained attention for their ability to inhibit angiogenesis, invasion, and metastasis and have been tested for their efficacy against various cancer cells. This study aimed to investigate the potential targets and mechanism of action of zerumbone derivatives in colon cancer invasion and migration. Bioinformatic analysis was conducted using STITCH and STRING to identify potential target genes, and molecular docking was used to search for anticancer candidates from 20 zerumbone derivatives. The results revealed that six proteins were targeted by zerumbone derivatives, including XIAPBIR3 (1TFT), AKT1 (3O96), JAK2 (6VGL), HASP90AA (2XJX), MDM2 (4MDN), and XIAPBIR2 (4KJU). Compound 4 was found to have a lower binding energy than zerumbone as well as AZD5363 (pan-Akt inhibitor) when interacting with the protein target AKT1. This makes it the most promising candidate among the zerumbone derivatives for treating colorectal cancer. Further development, such as the addition of an amine functional group, is expected to improve the potency of this molecule through the formation of hydrogen bonds and other interactions with lower bond energy.Keywords: Bioinformatic, molecular docking, zerumbone derivatives, colorectal cancer.
Pelatihan Pengolahan Umbi Porang Menjadi Produk Jelly di Pekon Bumiayu, Kabupaten Pringsewu Tantri Liris Nareswari; Kiki Yuli Handayani; Zada Agna Talitha; Refsya Azanti; Winni Nur Auli; Salsabila Fauziah; Lulu Zaqia; Nadia Nur Syakilla; Intan Kusuma Wardani; Nabila Ahlika Ulya; Keisya Aurora Natasha Chairunisa; Dzaki Arrafif; Dina Putri Agustina; Natasya Armelia Putri
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 6, No 10 (2023): Volume 6 No 10 2023
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v6i10.12054

Abstract

ABSTRAK Umbi porang memiliki kadar glukomanan tinggi, sehingga berpotensi untuk dikembangkan menjadi produk yang bermanfaat dalam menjaga kolesterol. Namun, selama ini hasil pertanian umbi porang belum diolah dan langsung dijual ke pengepul dengan harga yang sangat murah. Masyarakat juga enggan memanfaatkannya karena kandungan kalsium oksalat yang ada di porang menyebabkan gatal dan iritasi pada kulit. Oleh karena itu, kegiatan pengabdian kepada masyarakat (PkM) ini dilakukan untuk memberikan penyuluhan manfaat porang bagi kesehatan, pelatihan pengolahan umbi porang menjadi pangan fungsional yaitu gummy jelly, jelly drink, dan jelly siap seduh, serta pendampingan digital marketing agar produk yang dihasilkan dapat dipasarkan dengan baik dan luas. Peserta yang mengikuti kegiatan ini adalah sebanyak 22 orang dari PKK Pekon Bumiayu, Kabupaten Pringsewu, Provinsi Lampung. Setelah mengikuti kegiatan, 100% peserta memiliki peningkatan pengetahuan terkait cara pengolahan porang dan pembuatan produk. Kegiatan PkM ke Ibu-Ibu PKK Pekon Bumiayu, Kabupaten Pringsewu, telah dilaksanakan dengan baik dan diharapkan dapat dilaksanakan berkelanjutan. Ibu-Ibu PKK Pekon Bumiayu telah mengetahui manfaat kesehatan, cara pengolahan umbi porang, dan cara pembuatan produk jelly yang bermanfaat untuk membantu menurunkan kolesterol. Kata Kunci: Porang, Pengabdian Masyarakat, Anti Kolesterol, Kudapan, Jelly  ABSTRACT Porang tubers have the potential to be turned into products that are useful in maintaining cholesterol since they contain significant levels of glucomannan. The agricultural products of porang tubers, however, have not yet been processed and are instead being sold directly to collectors at extremely low costs. Additionally, because porang contains calcium oxalate, which irritates and itches the skin, people are hesitant to use it. In order to help the community, this service project is being carried out to provide information on the health benefits of porang, training on how to turn porang tubers into functional foods like gummy jelly, jelly drink, and ready-to-drink jelly, as well as assistance with digital marketing so that the products made can be sold. Twenty-two women from PKK of Pekon Bumiayu, Pringsewu Regency, Lampung Province, participated in the activity. After joining the activity, 100% of the participants had increased knowledge regarding how to process porang and make products. PkM activities for PKK Pekon Bumiayu women, Pringsewu Regency, have been successfully carried out and are anticipated to continue in a sustainable manner. The women of PKK Pekon Bumiayu are already aware of the advantages to health, how to prepare porang tubers, and how to make cholesterol-lowering jelly products. Keywords: Porang, Community Service, Anti-Cholesterol, Snacks, Jelly
Studi In Silico Potensi Antikanker Leukemia Limfositik Senyawa Alkaloid Indol terhadap Protein BCL-2: Study of In Silico Anticancer Action Potentials of Lymphocytic Leukemia Indole Alkaloid Compounds Against on BCL-2 Protein Bulan Rosita Sari; Winni Nur Auli; Vita Julia Saputri; Okta Dinata Saputri; Alika Putriyana Boru Tumanggor; Dhea Anggun Ferlinda; Fira Anggraini; Fatonah Fatonah
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1880

Abstract

BCL-2 is an anti-apoptotic protein that can inhibit cell death, prolong cell survival time, and turn cells into malignant ones, which is one of the pathways targeted in the development of leukemia therapy by binding and inactivating the BH3 domain pro-apoptotic protein. Indole alkaloids have pharmacological activities and contribute to the development of new drug leads. This study aims to analyze the potential of insilico alkaloids against Bcl-2 in silico. The docking process initiated from preparing the ligand taken from the Pubchem website. The three-dimensional macromolecular structure of the protein used was BCL-2 retrieved from the RCSB Protein Data Bank (www.rcsb.org) with PDB ID number 6O0K. The validation and docking process was carried out using the AutodockTools software program from MGLTools 1.5.6. Chemical bond interaction analysis was carried out using BIOVIA Discovery Studio 2021 Client. The binding energy results from validating the native ligand venetoclax as existing drug is -14.46 kcal/mol. The results obtained from the three ligands, namely aspidodasycarpine, tetrahydroalstonine, and kopsamine have binding energies of -6.76, -7.92, -7.57 kcal/mol respectively. When compared with tetrahydroalstonine which has the smallest value among the three other ligands, it can be concluded that venetoclax is still smaller so that it becomes more potent than tetrahydroalstonine. Keywords:          Indole alkaloids, Cancer, Bcl-2, Docking   Abstrak BCL-2 adalah protein anti-apoptosis yang dapat menghambat kematian sel, memperpanjang waktu hidup sel, dan mengubah sel menjadi ganas, yang merupakan salah satu jalur yang ditargetkan dalam perkembangan terapi penyakit leukemia dengan mengikat serta menonaktifkan protein pro-apoptosis domain BH3. Alkaloid indol memiliki aktivitas farmakologi dan berkontribusi untuk pengembangan lead obat baru, dimana salah satu senyawa yang paling aktif memiliki berbagai aktivitas farmakologi, yaitu antikanker. Penelitian ini bertujuan untuk menganalisis potensi alkaloid indol terhadap Bcl-2 in silico. Proses docking dimulai dari penyiapan ligan yang diambil dari situs web Pubchem. Struktur makromolekul tiga dimensi protein yang digunakan dalam studi docking ini adalah BCL-2 yang diunduh dari RCSB Protein Data Bank (www.rcsb.org) dengan nomor ID PDB 6O0K. Proses validasi dan docking dilakukan menggunakan perangkat lunak program AutodockTools dari MGLTools 1.5.6. Analisis interaksi ikatan kimia dilakukan menggunakan BIOVIA Discovery Studio 2021 Client. Hasil energi ikatan dari validasi ligan bawaan venetoclax sebagai obat yang telah dikembangkan yaitu -14.46 kkal/mol. Diperoleh hasil dari analisis data energi ikatan dari tiga ligan, yaitu aspidodasycarpine, tetrahydroalstonine, dan kopsamine berurutan sebesar -6,76, -7,92, -7,57 kkal/mol. Apabila dibandingkan dengan tetrahydroalstonine yang memiliki nilai paling kecil diantara ketiga ligan lain maka dapat disimpulkan bahwa venetoclax masih lebih kecil sehingga menjadi lebih poten dibandingkan dengan tetrahydroalstonine. Kata Kunci:         Alkaloid indol, Kanker, BCL-2, Docking
Co-Authors Alika Putriyana Boru Tumanggor Arif Ashari Bulan Rosita Sari Derina Paramitasari Dhea Anggun Ferlinda Dina Putri Agustina Dzaki Arrafif Esteria Christina Pane Fatonah Fatonah Fauziyya, Riri Fira Anggraini Gabriela Kasih Mawarni Ilma Nugrahani Ilma Nugrahani intan kusuma wardani Kalista Alsadila Keisya Aurora Natasha Chairunisa Kiki Yuli Handayani Lanita Agustin Lulu Zaqia Miralda Zahra Musa Musa Nabila Ahlika Ulya Nadia Nur Syakilla Natasya Armelia Putri Nisa Yulianti Suprahman Okta Dinata Saputri Okta Nama Putra Refsya Azanti Safia Fazila Salsabila Fauziah Sarmoko Sarmoko Sukrasno Sukrasno Tantri Liris Nareswari Vita Julia Saputri Zada Agna Talitha