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All Journal Jurnal Biologi Tropis
Zulfa Hasyimiyyah Ihtisyam
Universitas Mataram
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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The Potential of Saponin in Sea Cucumbers to Prevent Hyperlipidemia Talitha Syahla; Diki Wahyudi; Sima Smith; Yumna Iftinan Khalda; Zulfa Hasyimiyyah Ihtisyam; Dini Suryani
Jurnal Biologi Tropis Vol. 23 No. 4 (2023): October - December
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i4.5740

Abstract

Hyperlipidemia is the main risk factor for atherosclerosis which can cause death. The occurrence of hyperlipidemia is relatively high with a percentage of 45% globally and 35% in Indonesia.  The purpose of this article is to determine the potential of saponins in sea cucumbers as the ingredients used to prevent hyperlipidemia. The method used in this article is a literature study by collecting relevant and focused articles. The literature used were the National Center for Biotechnology Information (NCBI), the Multidisciplinary Digital Publishing Institute (MDPI), and Google Scholar. The results of the literature review carried out are that the saponins found in sea cucumbers are the main component as a lipid reducer compared to other compounds found in sea cucumbers. In conclusion, saponins in sea cucumbers influence lipid metabolism which ultimately prevents hyperlipidemia through various mechanisms.
Giant Cell Tumor: Pathogenesis and Clinical Manifestation Adinda Ilsa Maulida; Ali Ramzi; Amrullah Muliawan H; Baiq Ghassani Kayla; Clara Nadila; Dinda Salsabila; Febbi Anggy; Herodya Lajunee Fesmia; Jihan Alifa Rahma; Trisna Ayu Kurnia Putri; Wina Aryslia Fakar; Zulfa Hasyimiyyah Ihtisyam; Nurhidayati Nurhidayati
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i4b.5831

Abstract

A giant cell tumor of bone (GCTB) as known as a benign bone tumor (neoplasm) is aggressive locally and frequently recurs, and it is characterized by the growth of mononuclear stromal cells and datia cells that resemble osteoclasts. GCTB has varying incidence rates and has been shown to have high mortality. GCTB patients have several treatment options, but the majority of patients still experience recurrence and even metastasis to other organs. This literature review aims to explain more deeply about Giant Cell Tumor (GCT) starting from the definition, etiology, epidemiology, pathogenesis, clinical manifestations and treatment options so that patients get a better prognosis. This literature review was conducted using the keywords "Giant Cell Tumor AND pathogenesis AND clinical manifestation" from PubMed dan Google Scholar. The results of the literature review carried out are that the molecular and biological pathogenesis of GCTB consists of 4 processes, namely tumorigenesis of neoplastic mononuclear stromal cells, generation of reactive multinucleated giant cells, bone resorption/migration, and bone matrix remodeling for angiogenesis, invasiveness, and metastasis. Besides, the histological picture of GCTB contains "reactive" osteoclasts such as multinucleated giant cells (Giant Cells/GC), round cells such as macrophages and spindle stromal cells such as "neoplastic" fibroblasts (mononuclear stromal cells/SC) which are important findings in establishing the diagnosis. In conclusion, staging and management are very important to produce a better prognosis and reduce recurrence rates in GCTB patients.
Co-Authors Adinda Ilsa Maulida Ali Ramzi Amrullah Muliawan H Baiq Ghassani Kayla Clara Nadila Diki Wahyudi Dinda Salsabila Dini Suryani Febbi Anggy Herodya Lajunee Fesmia Jihan Alifa Rahma Nurhidayati Nurhidayati Sima Smith Talitha Syahla Trisna Ayu Kurnia Putri Wina Aryslia Fakar Yumna Iftinan Khalda