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Fahriani Istiqamah Jafar
Laboratorium Penelitian dan Pengembangan Kefarmasian “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Kalimantan Timur, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Uji Efek Antidiare Ekstrak Rimpang Kunyit Hitam (Curcuma caesia Roxb.) terhadap Mencit (Mus musculus): Antidiarrheal Effect of Black Turmeric Rhizome Extract (Curcuma caesia Roxb.) on Mice (Mus musculus) Icha Safitri; Riski Sulistiarini; Fahriani Istiqamah Jafar
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 18 (2023): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v18i1.706

Abstract

Diarrhea is a disease characterized by increased frequency of defecation and decreased stool consistency caused by impaired absorption of air and electrolytes in the intestine. Black turmeric is a plant that has properties as a traditional medicine for types of diseases, one of which is diarrhea. The aim of this study was to determine the antidiarrheal effect of black turmeric rhizome extract and the best dose of reducing defecation frequency and increasing stool consistency in diarrheal mice. This research was carried out using 40 mice that were induced by diarrhea using Ricini oleum. Mice were divided into 8 groups, the normal group without treatment, the positive control was given Loperamide HCl, the negative control was given 1% NaCMC, the test control group was given 5 variations of doses of black turmeric rhizome extract 50 mg/KgBW, 150 mg/KgBW, 250 mg/KgBW, 300 mg/KgBW, and 500 mg/KgBW. The results showed that black turmeric rhizome extract could reduce the frequency of defecation and increase stool consistency with a significant value (p<0.05). Black turmeric rhizome extract at a dose of 250 mg/KgBW is the best dose because it can reduce the frequency of defecation and increase stool consistency better than Loperamide HCl. Keywords: Antidiarrheal, Black turmeric, Oleum ricini Abstrak Diare merupakan penyakit yang ditandai dengan peningkatan frekuensi defekasi dan penurunan konsistensi feses disebabkan oleh gangguan absorpsi air dan elektrolit di dalam usus. Kunyit hitam disebut sebagai tanaman yang memiliki khasiat sebagai obat tradisional untuk berbagai jenis penyakit salah satunya diare. Tujuan penelitian ini adalah untuk mengetahui efek antidiare ekstrak rimpang kunyit hitam dan dosis terbaik dalam memberikan efek penurunan frekuensi defekasi dan peningkatan konsistensi feses pada mencit diare. Penelitian ini dilakukan dengan menggunakan 40 ekor mencit yang diinduksi diare menggunakan oleum ricini 0,75 ml. Mencit dibagi menjadi 8 kelompok yaitu kelompok normal tanpa perlakuan, kontrol positif diberi Loperamide HCl, kontrol negatif diberi NaCMC 1%, kelompok kontrol uji diberi 5 variasi dosis ekstrak rimpang kunyit hitam 50 mg/KgBB, 150 mg/KgBB, 250 mg/KgBB, 300 mg/KgBB, dan 500 mg/KgBB. Hasil penelitian menunjukkan bahwa ekstrak ekstrak rimpang kunyit hitam dapat menurunkan frekuensi defekasi dan meningkatkan konsistensi feses dengan nilai signifikasi (p<0,05). Ekstrak rimpang kunyit hitam dosis 250 mg/KgBB merupakan dosis terbaik karena dapat menurunkan frekuensi defekasi dan meningkatkan konsistensi feses dengan hasil lebih baik dari Loperamide HCl. Kata Kunci: Antidiare, Kunyit hitam, Oleum ricini
Kajian Metabolit Sekunder dan Potensi Antibakteri Daun Banitan (Monocarpia kalimantanensis): Study of Secondary Metabolites and Antibacterial Potential of Banitan Leaves (Monocarpia kalimantanensis) Nugra Ilmahdi; Fahriani Istiqamah Jafar; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 18 (2023): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v18i1.716

Abstract

The Banitan plant (Monocarpia kalimantanensis) is a plant in the Annonaceae family that can be found in Samboja, East Kalimantan. The aim of this research is to identify and determine the content of secondary metabolite compounds and antibacterial activity contained in banitan leaves. The method used for antibacterial testing was well diffusion and the positive control used was Amoxicillin. The results obtained from this research were a yield with a value of 12.35%, then in secondary metabolites there were alkaloids, triterpenoids, flavonoids, phenolics, saponins and tannins. Antibacterial testing using well diffusion obtained the best results against Escherichia coli at a concentration of 15%. And for Staphylococcus aureus bacteria, the best concentration was found at 25%. Keywords: Banitan (Monocarpia kalimantanensis), phytochemicals, yield, antibacterial, well diffusion Abstrak Tanaman Banitan (Monocarpia kalimantanensis) merupakan tanaman berfamili Annonaceae yang dapat dijumpai di Samboja, Kalimantan Timur. Tujuan dari penelitian ini adalah mengidentifikasi dan mengetahui kandungan senyawa metabolit sekunder, dan Aktivitas antibakteri yang terdapat dalam daun banitan. Metode yang dilakukan pada pengujian antibakteri adalah difusi sumuran dan kontrol positif yang digunakan adalah Amoxicillin. Hasil dari penelitian ini yang didapat adalah hasil rendemen dengan nilai 12,35%, kemudian pada metabolit sekunder terdapat senyawa alkaloid, triterpenoid, flavonoid, fenolik, saponin, dan tannin. Pengujian antibakteri dengan difusi sumuran didapat hasil terbaik terhadap Escherichia coli pada konsentrasi 15%. Dan pada bakteri Staphylococcus aureus didapat konsentrasi terbaik pada 25%. Kata Kunci: Banitan (Monocarpia kalimantananensis), Fitokimia, Rendemen, Antibakteri, Difusi Sumuran
Aktivitas Antimikroba Ekstrak dan Fraksi Kulit Batang Banitan (Monocarpia kalimantanensis): Antimicrobial Activity from Extract and Fraction of Banitan Stem Bark (Monocarpia kalimantanensis) Otsuka Khaera Nurmala; Fahriani Istiqamah Jafar; Herman Herman
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 18 (2023): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v18i1.720

Abstract

Banitan (Monocarpia kalimantanensis) is a plant that grows in the Samboja area, East Kalimantan. Antimicrobial activity extract and fractions of banitan stem barks against Staphylococcus aureus, Escherichia coli, and Candida albicans has never been done. This study aims to determine the yield and antimicrobial activity produced by banitan bark extract and fractions (n-hexane, ethyl acetate and n-butanol) against Staphylococcus aureus, Escherichia coli, and Candida albicans. Antimicrobial activity was assayed by agar well diffusion method using 5 concentration groups of the extract and fractions of banitan stem bark, namely 0,625%; 1,25%; 2,5%; 5%; and 10% with chloramphenicol and ketoconazole as positive control and DMSO 10% as negative control. The diameter inhibition zone value of ethanol extract, n-hexane, ethyl acetate and n-butanol fractions at the concentration 10% for Staphylococcus aureus were 13,63; 9,08; 21,18; 6,05 mm, Escherichia coli were 14,46; 9,93; 21,97; 6,90 mm and Candida albicans were 11,85; 18,09; 19,36; 13,17 mm. The ethyl acetate fraction showed the highest inhibitory activity at a concentration of 10%. Keywords: Monocarpia kalimantanensis, antimicrobial Abstrak Banitan (Monocarpia kalimantanensis) adalah tanaman yang tumbuh di daerah Samboja, Kalimantan Timur. Aktivitas antimikroba ekstrak dan fraksi kulit batang banitan terhadap Staphylococcus aureus, Escherichia coli, dan Candida albicans belum pernah dilakukan. Penelitian ini bertujuan untuk mengetahui aktivitas antimikroba yang dihasilkan oleh ekstrak dan fraksi (n-heksana, etil asetat dan n-butanol) dari kulit batang banitan terhadap Staphylococcus aureus, Escherichia coli, dan Candida albicans. Aktivitas antimikroba diuji dengan metode difusi agar kertas cakram menggunakan 5 kelompok konsentrasi yaitu 0,625%; 1,25%; 2,5%; 5%; dan 10% dengan kloramfenikol dan ketokonazol sebagai kontrol positif dan DMSO 10% sebagai kontrol negatif. Ekstrak etanol, fraksi n-heksana, etil asetat dan n-butanol dengan konsentrasi 10% mampu menghambat pertumbuhan Staphylococcus aureus sebesar 13,63; 9,08; 21,18; 6,05 mm, Escherichia coli sebesar 14,46; 9,93; 21,97; 6,90 mm dan Candida albicans sebesar 11,85; 18,09; 19,36; 13,17 mm. Fraksi etil asetat menunjukkan aktivitas penghambatan paling tinggi pada konsentrasi 10%. Kata Kunci: Monocarpia kalimantanensis, antimikroba
Co-Authors Herman Herman Icha Safitri Laode Rijai Nugra Ilmahdi Otsuka Khaera Nurmala Riski Sulistiarini