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Paundralingga, Obed Trinurcahyo Kinantyo
Malang Neurology Journal
Neuroscience

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EFFECTS OF ACUTE STRESS DURATION ON THE RAT BRAIN MAST CELL ACTIVATION Paundralingga, Obed Trinurcahyo Kinantyo; Darkim, Darmawan; Munir, Badrul; Daeng, Bonaventura Handoko
Malang Neurology Journal Vol 3, No 2 (2017): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (429.995 KB) | DOI: 10.21776/ub.mnj.2017.003.02.4

Abstract

Background. Stress of varying duration and types are known to affect the number and activation level of cerebral mast cells (MCs) via plasma CRH. Although MC number is known not to be increased in acute stress, elevated plasma CRH might still activate brain MCs.Objective. To investigate the effect of acute stress of incremental duration to the activation level of thalamic and hippocampal mast cells using elevated platform test to elicit stress in male Wistar rats.Methods. This research used randomized post-test only control group design with 4 control group of 30, 60, and 90 minute stress exposure. Mast cell activation of the regiotalamus and hippocampus is assessed by histomorphometrics.Results. In the hippocampus, we found a significant difference of MC activation between control and experimental groups (p=0.014; p<0.05) but not among the incremental duration of acute stress. However, MC activation was not different between control and experimental groups in the thalamus.Conclusion. Acute stress exposure increases MC activation without recruiting further MCs in specific cerebral region but the duration of acute stress itself does not affect the activation level.
NEURAL PAIN PATHWAY TRACING OF RABBIT ISCHEMIC HEART BY DOUBLE-RETROGRADE NEUROTRACING Dapamede, Theodorus; Paundralingga, Obed Trinurcahyo Kinantyo; Rahayu, Masruroh; Soemantri, Bambang
Malang Neurology Journal Vol 1, No 1 (2015): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (439.297 KB) | DOI: 10.21776/ub.mnj.2015.001.01.3

Abstract

Background. Myocardial ischaemia leads to angina pectoris or referred pain, whichhappens because of the inability of the brain to distinguish the visceral afferent inputs from the somatic afferent inputs since they run along a common pathway via the dorsal root ganglia.Objective. To distinguish specific areas of the rabbit heart that are projected to specific dorsal root ganglia, which then associates to its specific dermatomes.Methods. A double-retrograde neurotracing method was used, with True Blue and Nuclear Yellow as the neurotracers. Rabbits were divided into 3 groups, which the first and second groups were ligated at the left anterior descending artery and at the left circumflex artery, respectively.The third group acted as the control group, without ligation.Results. There is significant association between the site of ligation to the projection of the neurotracers at specific dorsal root ganglia (p<0.05). The first group showed high tendency to be projected to T2 and the second group showed a high tendency to project to T1.Conclusion. This study shows that the rabbit heart can be specifically projected neuronally to specific dorsal root ganglia, following coronary artery ligation.
EFFECTS OF GENISTEIN EXPOSURE TOWARD INITIAL DEVELOPMENT OF CENTRAL NERVOUS SYSTEM IN CHICKEN EMBRYO MODEL (GALLUS GALLUS) AGE 48 HOURS Rahayu, Indriati Dwi; Paundralingga, Obed Trinurcahyo Kinantyo; Sari, Vidia Purnama
Malang Neurology Journal Vol 4, No 1 (2018): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (445.117 KB) | DOI: 10.21776/ub.mnj.2018.004.01.3

Abstract

Background. The safety of genistein consumption in the first trimester of pregnancy and its effect on embryonic development, especially in the development of Central Nervous System (CNS) is still not widely known.Objective. To determine the effect of genistein exposure to the early development of the Central Nervous System.Methods. The animal model used in this research is chick embryo (Gallus gallus). Genistein at a dose of 5 µM, 10 µM and 20 µM in ovo injected into the yolk sac of the eggs before incubation. The eggs were then incubated for 48 hours at a temperature of from 37.50 to 38.50 C. After 48 hours, broken egg shell, embryos are taken and carried out using Toluidine Blue staining. The evaluation was done on the neural tube, anterior neuropore, posterior neuropore and somites.Results. It was found neural tube defects in the group treated with genistein more than the control group but the result was not statistically significant.Conclusion. For the somites, in the group treated with a dose of 10 µM genistein, the number of somites more than the control group and statistically the number is significant.
Co-Authors Badrul Munir, Badrul Bambang Soemantri, Bambang Daeng, Bonaventura Handoko Darkim, Darmawan Indriati Dwi Rahayu Masruroh Rahayu, Masruroh Sari, Vidia Purnama Theodorus Dapamede, Theodorus