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All Journal MNJ (Malang Neurology Journal)
Dalhar, Mochamad
Malang Neurology Journal
Neuroscience

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PARKINSON AND STEM CELL THERAPY Gunawan, Gerry; Dalhar, Mochamad; Kurniawan, Shahdevi Nandar
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (719.145 KB) | DOI: 10.21776/ub.mnj.2017.003.01.7

Abstract

Parkinson's disease is a neurodegenerative disorder that is progressive about the movement or control of movement. The disease often occurs in people over the age of 60 years. The etiology of Parkinson's disease caused by a combination of genetic and environmental factors. Because overall life expectancy increases, the number of people with Parkinson's disease will increase in the future. Treatment of Parkinson's disease can be used with pharmacological therapy and nonpharmacological therapy. Pharmacological therapy can use levodopa, monoamine oxidase-B inhibitors, dopamine agonists, anticholinergics and amantadine, while nonpharmacological therapies may use the method of stem cell therapy. Stem cells are master cells that have two important characteristics that can perform self-renewing through cell division and can be induced to become cells with specific functions. The aim of Stem cell therapy in Parkinson's disease to replace the damaged dopaminergic cells.
PATHOPHYSIOLOGY AND MANAGEMENT OF CEREBRAL EDEMA Husna, Ully; Dalhar, Mochamad
Malang Neurology Journal Vol 3, No 2 (2017): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (604.425 KB) | DOI: 10.21776/ub.mnj.2017.003.02.7

Abstract

Cerebral edema comprehensively defined as a pathological increase of water in the whole brain that leads to an increased of brain volume. Cerebral edema can be classified into focal or global topography. According to the etiology, it can be categorized as cytotoxic, vasogenic, interstitial, or a combination. The symptoms of cerebral edema are not specific and are associated with secondary effects of mass, vascular compression and herniation. Clinical and radiological changes are usually reversible in the early stages during the underlying cause is corrected. Cerebral edema need to be discussed more specifically in the pathophysiology and management. By understanding the pathophysiology and management quickly and accurately will be able to improve the prognosis of patients with cerebral edema.
THE INFLUENCE OF SAMPLING TIME TO SERUM GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) LEVELS IN ACUTE STROKE Raisa, Neila; Sujuti, Hidayat; Purnomo, Hari; Rahayu, Masruroh; Dalhar, Mochamad
Malang Neurology Journal Vol 5, No 1 (2019): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.01.5

Abstract

Background: Serum Glial Fibrillary Acidic Protein (GFAP) is a great potential for biomarker that is widely studied as a diagnostic biomarker of acute stroke. Sampling within 6 hours after onset is the best time window, but in Indonesia, stroke patients often arrive late more than 6 hours.Objective: To identify the difference in time of blood sampling with serum GFAP levels within 24 hours onset of ischemic stroke (IS) patients and intracerebral hemorrhage (ICH) strokes.Methods: Cross-sectional analysis with purposive sampling, sampling in IS and ICH strokes that arrive at the ER within 24-hour on-site. The serum GFAP examination was performed with ELISA.Results: In this study, 41 acute stroke patients with 24-hour onset of each stroke were grouped into group 1 (<6 hours), group 2 (6-12 hours) and group 3 (12-24 hours). One Way ANOVA and Tukey's analysis showed no significant difference in GFAP levels among the three groups in both IS and ICH. Conclusion: There was no significant difference in GFAP levels in samples <6 hours, 6-12 hours, and 12-24 hours in ischemic strokes and ICH strokes.
Co-Authors Gerry Gunawan, Gerry HARI PURNOMO Hidayat Sujuti Husna, Ully Masruroh Rahayu, Masruroh Raisa, Neila Shahdevi Nandar Kurniawan, Shahdevi Nandar