ABSTRAK Jeruk manis (Citrus sinensis L.) tergolong buah penting. Permintaan jeruk terus bertambah dengan meningkatnya jumlah penduduk, kesadaran masyarakat akan kesehatan dan pola makan berimbang. Salah satu penyebab menurunnya produksi buah jeruk adalah serangan hama. Tujuan penelitian adalah untuk mengetahui respon tanaman jeruk manis terhadap pemberian ekstrak daun pepaya sebagai pestisida organik. Metode penelitian menggunakan pre-eksperimental designs dengan pola one-group pretest-posttest design. Metode analisis data menggunakan uji normalitas Shapiro-Wilk bertujuan untuk menentukan apakah data yang diambil dari populasi tergolong normal atau tidak. Uji lanjut menggunakan uji statistik paired sample test bertujuan untuk mengetahui apakah terdapat perbedaan rata-rata dari dua sampel yang berpasangan. Hasil analisa menunjukkan bahwa data penelitian pada pre-test dan post-test pada serangan hama pada tanaman jeruk manis terdistribusi normal dan terdapat perbedaan yang signifikan antara sebelum dan sesudah diberi perlakuan ekstrak pestisida organik daun pepaya (Carica papaya L.) pada tanaman jeruk manis. Respon tanaman jeruk manis setelah diberi perlakuan ekstrak pestisida organik daun pepaya tergolong baik (33.37%-66.66%) dan sangat baik (66.67%-100%). Pemberian ekstrak pestisida organik daun pepaya dapat mengurangi serangan hama pada tanaman jeruk manis. ABSTRAKSweet oranges (Citrus sinensis L.) are classified as important fruits. Demand for oranges continues to increase with increasing population, public awareness of health and a balanced diet. One of the causes of decreased citrus fruit production is pest attacks. The aim of the research was to determine the response of sweet orange plants to the application of pepaya leaf extract as an organic pesticide. The research method uses pre-experimental designs with a one-group pretest-posttest design pattern. The data analysis method uses the Shapiro-Wilk normality test which aims to determine whether the data taken from the population is classified as normal or not. Further tests using the paired sample test statistical test aim to find out whether there is a difference in the average of two paired samples. The results of the analysis showed that the research data on the pre-test and post-test on pest attacks on sweet orange plants were normally distributed and there was a significant difference between before and after treatment with organic pesticide extract of pepaya leaves (Carica papaya L.) on sweet orange plants. The response of sweet orange plants after being treated with organic pesticide extract from pepaya leaves was classified as good (33.37%-66.66%) and very good (66.67%-100%). Providing organic pesticide extract from pepaya leaves can reduce pest attacks on sweet orange plants.