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All Journal Nusantara Medical Science Journal Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Indian Journal of Forensic Medicine & Toxicology
Cangara, Husni
Department Of Anatomical Pathology, Medical Faculty Hasanuddin University, Makassar, Indonesia
Agriculture, Biological Sciences & Forestry Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Veterinary

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Journal : Indian Journal of Forensic Medicine

 1 
Circulating and Renal Endothelin-1 Expression Lead to Glomerular Impairment in High Fat-Induced Diet Wistar Rats Haslindah Dahlan1, Muhammad Husni Cangara2, Rina Masadah2, Irfan Idris3, Upik Anderiani Miskad2, And
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12910

Abstract

Objective: This study aimed to determinelevels of expression ET-1 in serum and renal tissue associated withchanges in kidney structure.Method: The rats were divided into two groups. The Obese group was given a high-fat-induced diet chowand a standard diet chow for the control group. ET-1 protein expression and localization in the glomerulusof the kidney were examined. The serum of blood checked for ET-Iusing ELISA method and assessed theET-1 expression of the glomeruliby Immunohistochemistry (IHC). Mesangial expansion is an indicator toevaluate the degree of glomerular damage by Periodic Acid–Schiff(PAS staining). Associations between theimmunoreactivity for ET-1 in glomeruli and the degree of kidney injury were examined.Results: Lee Index was significantly higher in the obese group than in the control group (p<0.05). ET-1immunoreactivity was considerably higher in the obese group than the control rat. It was a strong correlationwith enhancingmesangial expansion glomeruli using PAS staining of the renal tissue (rs=0.765; p= 0.001).Contrast to ET-1 levels in the serum revealed no significant in obese rat groups (p>0.05).Conclusion: These data confirm the role of ET-1 will provide changes in the levels of glomeruli impairment,but serum levels may well fail to reflect the local expression at the tissue level.
Co-Authors A Endang Kusuma Intan Arsyad, Muhammad Aryadi Desi Dwirosalia Suparman Dwi Kesuma Sari Fatimah Mappanyompa Ika Yustisia Ilhamjaya Patellongi Marinati A Manggau Rosdiana Natsir Sartini Natsir Yulia Yusrini Djabir