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All Journal Jurnal Buana Farma Prosiding Seminar Nasional dan Call For Paper Kebidanan Universitas Ngudi Waluyo Jurnal Dedikasi Masyarakat
Hasna
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Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Social Sciences Other

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Journal : Jurnal Buana Farma

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REVIEW ARTIKEL: PENINGKATAN KELARUTAN SENYAWA OBAT ANTIMALARIA MENGGUNAKAN METODE MODIFIKASI KO-KRISTAL Hasna; Faizal Hermanto
Jurnal Buana Farma Vol. 4 No. 3 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i3.1134

Abstract

Malaria is an infectious disease caused by the Plasmodium parasite that infects humans through the bite of female Anopheles mosquitoes. Most antimalarial drugs have limitations in terms of solubility. Drug solubility is a very important parameter that determines the effectiveness of the drug, with good drug solubility, the drug can achieve optimal bioavailability and pharmacological effects, based on this, efforts are needed to overcome these problems in order to provide effective and efficient therapy to patients using existing antimalarial drugs that have been modified in their physicochemical properties so that their solubility increases. The purpose of this study was to review various studies that used the co-crystal modification method to increase the solubility of antimalarial drug compounds. This study was designed using the Narrative Review method, article searches were carried out using two databases, namely Google Scholar and PubMed, with the keywords "Co-crystal" OR "Antimalaria". In this study, 7 articles were found that met the inclusion and exclusion criteria. The selected articles are articles that discuss antimalarial drugs (artesunate, artemisinin, pyrimethamine) developed by the co-crystal method which experienced a multi-fold increase in solubility compared to its pure preparation. The co-crystal method can be a solubility enhancing solution for antimalarial drugs that have low solubility in water, increasing the solubility of antimalarial drugs causes the bioavailability of the drug to increase, so that the drug can provide good therapeutic effects.
Co-Authors Andi Dihya Baiduri Musfira Saad Donela, Ardenia Faizal Hermanto Gresloan, Anny Idawati Kartika Sari Muh Ainul Fitrah Muhammad Adrian Muhammad Aidil Ramadhan Syafruddin Nur Abidah Pereira Doro, Noviana Rini Anggraeni Saskia Aulia Ashar Selviana, Riska Sri Wahyuni Sultan Hazanuddin