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All Journal Jurnal Ilmu Dasar INDONESIAN JOURNAL OF PHARMACY JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat

Paramita, Diajeng Putri

Fakultas Farmasi Universitas Airlangga

Author-ID : 750135

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Control & Systems Engineering Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Public Health Social Sciences

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Articles

PHYSICAL CHARACTERIZATION OF IBUPROFEN-STEARIC ACID BINARY MIXTURE DUE TO COMPRESSION FORCE Setyawan, Dwi; Isadiartuti, Dewi; Betari, Sita Desti; Paramita, Diajeng Putri
Indonesian Journal of Pharmacy Vol 27 No 1, 2016
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Aim of this research is to determine physical characteristic of ibuprofen-stearic acid due to compression force. Binary mixture of ibuprofen-stearic acid with weight ratio of 4:6, 5:5, and 6:4 was compressed under various compression force using hydraulic press with 13mm diameter flat punch.Identification of solid state interaction between these two components was performed by Hot Stage Microscopy (HSM). Physical characterization has been studied byDifferential Thermal Analysis (DTA), X-ray Powder Diffraction (XRPD), Scanning Electron Microscopy (SEM), and (Fourier Transform Infrared (FT-IR) spectroscopy. According to hardness measurement, 4:6 weight ratio has the highest tensile strength on 170.6N/cm2 under 19.93kN compression force. Interaction identification by HSM showed single blank line that indicates eutectic formation. Thermal analysis of DTA also revealed eutectic formation upon compression whichthe endotermic peak of ratio of 4:6has the lowest melting temperature of 53.2°C. X-ray diffraction of three peaksgenerally showed that peak intensity decreases as compression force increases, but at particular point it begins to increase again. Sintering phenomenon at the surface of compressed tablet was observed from SEM analysis. FT-IR study confirms the formation of simple eutectic. Key words: ibuprofen, stearic acid, binary mixture, compression force, physical characterization

Optimization of Povidone K-30 and Sodium Starch Glycolate on Levofloxacin Tablet by Factorial Design Dwi Setyawan; Widji Soeratri; Mahrus Naufal Nuruddin; Diajeng Putri Paramita; Bambang Widjaja
Jurnal ILMU DASAR Vol 21 No 1 (2020)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

The aim of this study was to determine the effect of binder and disintegrant excipients toward tablet properties of levofloxacin as the latter tends to suffer brittle fracture upon compression. The excipients used were povidone K-30 as the binder and sodium starch glycolate (SSG) as the disintegrant which the tablets were formulated according to factorial design 22 with two factors and two levels on each factor. Four formulas were prepared by wet granulation method using 2 and 4% of each povidone K-30 and sodium starch glycolate in various compositions. Tablet properties were evaluated for its hardness, friability, and disintegration time as well as dissolution profile. The data obtained was statistically analyzed using Minitab® 17 software to optimize the formulation and resulted in different impacts caused by each excipient. Povidone K-30 exhibited an increment in hardness, friability, disintegration time but a decrease indissolution profile of levofloxacin tablet. SSG decreased hardnessand disintegration time, but increased friability and dissolution profile of levofloxacin tablet. Overlaid contour plot showed that the optimal formula regarding tablet properties of friability, disintegration time, and dissolution profile is in composition of 2.01% povidone K-30 and 2.01% sodium starch glycolate. Keywords: levofloxacin tablet, povidone K-30, sodium starch glycolate, factorial design.

The Improvement of Food Additives and Good Food Production Method Knowledge on Sumba Island Noor Erma Nasution Sugijanto; Juni Ekowati; Heinrich Dengi; Asri Darmawati; Dewi Isadiartuti; Catur Dian Setiawan; Diajeng Putri Paramita; Melanny Ika Sulistyowati; Putri Hamidah Khairunnisa; Imamatin Nufus Melania; Muhammad Ilham Royyan Nafi; Sugijanto Kartosentono
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol 7 No 2 (2022): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v7i2.2783

In order to ensure good health and well-being in the community during the pandemic, especially in the food business in Sumba, several problems for MSME partners have been identified, namely related to food production, consumption, and misunderstanding of regulations in the food and beverage business which can be a problem for the health community. The solutions offered to overcome these problems are training in webinars and talk shows on Food Business Production Orders; Knowledge of Food Additives; Good Food Production Methods; Household Food Industry Product Licensing (CPPB-IRT); and Simple Marketing for the Food Business. This community service aims to improve MSMEs' quality and business capacity on Sumba Island, which is increasing and has become a model for similar MSME communities because they have not received similar guidance from any agency. The pre and post-test analysis results showed an increase in knowledge, especially on aspects of the types of food that were not allowed to receive SPP-IRT, food coloring, permitted food additives, how to get Halal certification, and spot tests to find out hazardous materials. The implementation evaluation showed that more than 58% stated that the material was acceptable. More than 99% stated that the registration was carried out well. For delivering materials and discussions, 99% said they were delighted. This webinar activity concludes that the material topics have been as needed, there is an increase in partner knowledge, and the implementation has been carried out well, based on pre-post test evaluation data and evaluation of the implementation of activities agency.

Penghambatan Interaksi Eutektik Akibat Energi Kompresi dengan Penambahan Pati Jagung Dwi Setyawan; Noorma Rosita; Diajeng Putri Paramita; Dicky Pratama
Jurnal Sains Farmasi & Klinis Vol 5, No 1 (2018): J Sains Farm Klin 5(1), April 2018
Publisher : Fakultas Farmasi Universitas Andalas

This research has been carried out to study inhibition of eutectic interaction which occurs on compressed binary mixture of ibuprofen-stearic acid by addition of corn starch. Corn starch was mixed into binary mixture of 40:60 (% b/b) ibuprofen-stearic acid with composition 10, 20, and 30% (w/w) and then compressed into tablet form. The physical characterization was conducted using tensile strength test, differential thermal analysis (DTA), powder X-ray diffraction (PXRD), Fourier transform infrared (FT-IR), and scanning electron microscope (SEM). According to tensile strength test, the value was reduced upon addition of 10 and 20% corn starch compared to the compressed binary mixture. Addition 20% corn starch to compressed binary mixture shifted the eutectic diffraction peaks with a decline in intensity during PXRD study. Thermal analysis of compressed binary mixture-20% corn starch exhibited an increase in eutectic point, and FT-IR spectrum was observed no difference compared to the compressed binary mixture. SEM analysis indicated that 20% corn starch addition was able to inhibit sintering phenomena by dispersed on particle’s surfaces. Physical characterizations result in the conclusion that corn starch can inhibit the eutectic interaction between ibuprofen and stearic acid upon compression

Pengaruh Komponen Hidrofobik Elastis terhadap Karakteristik Fisik dan Laju Disolusi Tablet Eritromisin Stearat Diajeng Putri Paramita; Dwi Setyawan
Jurnal Sains Farmasi & Klinis Vol 6, No 3 (2019): J Sains Farm Klin 6(3), Desember 2019
Publisher : Fakultas Farmasi Universitas Andalas

Eritromisin stearat (ERS) telah diketahui menunjukkan fenomena sintering ketika dikempa dan ini berpotensi menyebabkan masalah pada kualitas sediaan mengingat ERS umum dipasarkan sebagai tablet. Pembuatan campuran biner ERS dengan parasetamol (PRS) dan asam mefenamat (ASM) dilakukan untuk menelaah pengaruh karakter hidrofobik elastis kedua senyawa tersebut terhadap sintering dari ERS. Karakterisasi fisik tablet campuran biner meliputi uji kekuatan mekanis, difraksi sinar-X serbuk (DSXS), scanning electron microscope (SEM), differential thermal analysis (DTA), spektrofotometri inframerah, dan terakhir dilakukan uji disolusi. Keberadaan PRS dan ASM meningkatkan nilai kekuatan tarik tablet ERS dan ASM memberikan peningkatan yang lebih tinggi. Superimposisi pola difraksi ERS dengan PRS maupun ASM teramati dari difraktogram sinar-X campuran biner. Fotomikrograf SEM memperlihatkan batas-batas antarpartikel pada permukaan dan patahan tablet campuran biner yang lebih jelas terlihat pada tablet ERS-ASM. Spektra inframerah dan termogram DTA tidak menunjukkan adanya puncak baru akibat interaksi pada sampel campuran biner, hanya teramati transformasi polimorfik dari PRS. Tablet campuran biner ERS-PRS dan ERS-ASM menghasilkan profil disolusi lebih baik dari pada tablet ERS. Berdasarkan hasil karakterisasi tersebut di atas dapat disimpulkan bahwa kemampuan PRS dan ASM dalam mencegah fenomena sintering dari ERS tidak melibatkan adanya interaksi dan dapat memengaruhi profil disolusinya.

Co-Authors Asri Darmawati Bambang Widjaja Betari, Sita Desti Dewi Isadiartuti Dicky Pratama Dwi Setyawan Heinrich Dengi Imamatin Nufus Melania Juni Ekowati Mahrus Naufal Nuruddin Melanny Ika Sulistyowati Muhammad Ilham Royyan Nafi Noor Erma Nasution Sugijanto Noorma Rosita Putri Hamidah Khairunnisa SETIAWAN, Catur Dian Sugijanto Kartosentono Widji Soeratri

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