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All Journal Nusantara Science and Technology Proceedings Binawan Student Journal Indonesian Journal of Health Science Sahabat Sosial: Jurnal Pengabdian Masyarakat
Arianto, Steven
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Agriculture, Biological Sciences & Forestry Humanities Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Analisis Kadar Mirisetin Pada Ekstrak Daun Myrica Javanica Reinw. Ex Bl. Dengan Metode HPLC: Quantitative Analysis Of Myricetin In Extract Leaf Myrica Javanica Reinw. Ex Bl. Using HPLC Arianti, Varda; Arianto, Steven; Maulina, Devi; Adiana, Sylvi
Binawan Student Journal Vol. 5 No. 3 (2023)
Publisher : Direktorat Penelitian, Pengabdian Masyarakat, Dan Kerjasama Universitas Binawan (DPPMK Universitas Binawan)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54771/bsj.v5i3.1355

Abstract

Tanaman Myrica javanica mengandung senyawa mirisetin yang berkhasiat sebagai: antiinflamasi, analgesik, antitumor, hepatoprotektor, antidiabetes dan antibakteri. Metode yang digunakan pada penelitian ini High Performance Liquid Chromatography (HPLC). Pengujian ini dilengkapi dengan validasi metode pengujian, yaitu Linearitas, Akurasi, Presisi, LOD dan LOQ. Hasil penelitian ini didapatkan pengujian linearitas adalah nilai r2 yaitu 0.9981 (r = 0.999). Persen (%) akurasi adalah 100,53%. Nilai presisi yaitu 0,98%. Nilai LOD diperoleh sebesar 1,93 dan nilai LOQ sebesar 6,43. Hasil uji kadar mirisetin pada yang diperoleh pada konsentrasi ekstrak 5000 ppm adalah sebesar 6,104.
Pemeriksaan Skrining Alternatif PAP SMEAR Parwati, Dewi; Arianto, Steven; Pannyiwi, Rahmat; Rahmat, Rezqiqah Aulia; Sabriana, Riska; Rosida, Rosida
Sahabat Sosial: Jurnal Pengabdian Masyarakat Vol. 1 No. 4 (2023): Sahabat Sosial: Jurnal Pengabdian Masyarakat (September)
Publisher : Asosiasi Guru dan Dosen Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59585/sosisabdimas.v1i4.169

Abstract

The incidence of cervical cancer in Indonesia reached 20,928 and cervical cancer is in second place after breast cancer. Pap smear is a microscopic examination of cells obtained from a cervical smear to detect early changes or abnormalities in the cervix before the cells become cancer and can be carried out by health workers other than gynecologists. The purpose of a pap smear is: a). Try to find cells that are not normal and can develop into cervical cancer. b). A tool to detect pre-cervical cancer symptoms for someone who has not yet suffered from cancer. c). Know the abnormalities that occur in cervical cancer cells. d). To determine the level of malignancy of the cancer cells, the examination is carried out by looking at the cervix which has been treated with 3-5% acetic acid inspectively. The methods used with the descriptive approach include: Conducting counseling about early detection of cervical cancer, Carrying out questions and answers about cervical cancer and the IVA test, Carrying out initial screening, namely no menstruation during the IVA test, no intercourse for 2 days, Carrying out an anamnesis on each - each respondent. Carrying out IVA tests in communities that have met the requirements for IVA tests. The number of respondents who met the requirements for the IVA test was 86 respondents. This IVA test was carried out for 3 days in three different locations, then the results of 46 people were obtained with positive IVA results. Conclusion: It is hoped that the IVA test carried out on the target group that has been held will be able to raise the target group's awareness of the importance of reproductive health.
Epigenetik Pada Sindrom Ovarium Polikistik: Gangguan Proses Folikulogenesis Yang Melibatkan Gen Reseptor Androgen, Reseptor Follicle-Stimulating Hormone Dan Reseptor Luteinizing Hormone Arianto, Steven; Radhina, Afifa; Shari, Amalia; Jannah, Insani Fitrahulil; Sari, Mike Permata
Indonesian Journal of Health Science Vol 4 No 1 (2024)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v4i1.683

Abstract

Sindrom Ovarium Polikistik (SOPK) merupakan salah satu gangguan hormonal yang dialami oleh wanita. Gangguan ini menyebabkan disregulasi proses neuroendokrin dan mengganggu proses pembentukan folikel (folikulogenesis). Etiologi gangguan folikulogenesis pada Sindrom Ovarium Polikistik disebabkan oleh reseptor androgen, reseptor follicle stimulating hormone (FSH), dan reseptor luteinizing hormone (LH). Beberapa pendekatan ilmiah digunakan untuk memahami penyebab gangguan folikulogenesis pada Sindrom Ovarium Polikistik, salah satunya epigenetik. Faktor epigenetik seperti metilasi DNA dan modifikasi histon diduga menjadi salah satu penyebab gangguan pengaturan sinyal luteinizing hormone dan follicle stimulating hormone pada folikulogenesis. Sinyal luteinizing hormone dan follicle-stimulating hormone diatur oleh reseptor luteinizing hormone dan reseptor follicle stimulating hormone yang memiliki ekspresi messenger RNA (mRNA) yang berbeda dibandingkan dengan kondisi normal. Reseptor luteinizing hormone diekspresikan secara berlebihan pada sel teka dan sel granulosa, sedangkan reseptor follicle stimulating hormone mengalami represi ekspresi gen pada sel granulosa. Hiperandrogenisme yang dimediasi reseptor androgen juga diatur secara berbeda pada Sindrom Ovarium Polikistik.
Viroinformatic Study of Star Anise (Illicium verum) as Mpro Inhibitor in SARS-CoV-2 Infection Arianto, Steven; Lakoan, Milda Rianty; Arianti, Varda
Nusantara Science and Technology Proceedings The 1st International Conference of Health Institut Kesehatan Mitra Bunda 2024
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2024.4304

Abstract

The spread and infection of SARS-CoV-2 towards the end of 2019 started the COVID-19 outbreak. Additionally, the antiviral medications that are still missing. Spices were among the many traditional medicines used in Indonesia. This research aims to find possible bioactive compounds in star anise with antiviral qualities to treat COVID-19 against SARS-CoV-2 proteases through the in-silico approach. Samples were obtained from the Protein Data Bank (PDB) and PubChem (NCBI, USA). Then, drug-likeness analysis was performed on the SCFBIO web server using the Lipinski rule of five. Additionally, the binding activity and molecular interaction by PoseView web server and PyMol software v2.4.1 (Schrödinger, Inc., USA) were determined by the blind docking approach using PyRx 0.8 software. Using Lipinski's rule of five, the eighty-one bioactive chemicals in star anise were examined to see how similar they were to therapeutic compounds. The molecular docking procedure was then executed using PyMOL and PyRx 0.8 (Virtual Screening Tool) and its interaction with Mpro protein. Methylphenyl has been revealed to have the lowest binding energy for Mpro SARS-CoV-2 and great potential as an inhibitor of SARS-CoV-2 viral replication based on the comprehensive research conducted on these bioactive compounds. However, since the results are only computational, a wet lab study is required for validation. Of 38 drug-like bioactive chemicals of star anise, only methylphenyl has the lowest binding affinity, which can bind and function as inhibitor of the Mpro protease enzyme. A can obstruct the SARS-CoV-2 virus's reproduction. As a result, the SARS-CoV-2 virus cannot assemble its genetic material, capsids, and other body components. Viral replication can be stopped to lower the amount of genetic material copied from the virus.
Co-Authors Adiana, Sylvi Arianti, Varda Dewi Parwati Jannah, Insani Fitrahulil Lakoan, Milda Rianty Maulina, Devi Pannyiwi, Rahmat Radhina, Afifa Rahmat, Rezqiqah Aulia Rosida Rosida Sabriana, Riska SARI, MIKE PERMATA Shari, Amalia