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All Journal JUARA: JURNAL WAHANA ABDIMAS SEJAHTERA Jurnal AKAL: Abdimas dan Kearifan Lokal Jurnal Kedokteran Gigi Terpadu
Endriyana, Jessica
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Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Transportation

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Journal : Jurnal Kedokteran Gigi Terpadu

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Peran igf-1 dan let-7 dalam morfogenesis gigi ditinjau dari sel punca mesenkimal pulpa gigi Endriyana, Jessica; Aryani Hayuningtyas, Ria
Jurnal Kedokteran Gigi Terpadu Vol. 6 No. 1 (2024): Jurnal Kedokteran Gigi Terpadu
Publisher : Fakultas Kedokteran Gigi Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/jkgt.v6i1.19136

Abstract

Tooth development is a complex process involving the interaction between dental epithelium and mesenchymal tissues. IGF-1 plays a crucial role in regulating cell proliferation, differentiation, apoptosis, and migration. Its significance is particularly notable during the proliferation and differentiation stages of root development, as well as in the stem cells derived from the apical papilla responsible for root pulp and dentin formation. IGF-1 exhibits osteoconductive potential in bone healing by modulating osteoclasts in bone resorption and osteoblasts in bone formation. Stem cells from dental pulp or apical papilla represent a mesenchymal stem cell or progenitor population that forms calcium nodules in osteo/odontogenic media. This study aims to elucidate the roles of IGF-1 and Let-7 in tooth morphogenesis, utilizing the PRISMA guidelines for data collection. A total of 12 literature sources were identified, with 3 articles published in the last 5 years. Only 5 articles were selected for inclusion in this study. Further exploration of IGF-1/IGF-1R/hsa-let-7c modulation in odonto/osteogenic differentiation holds promise for future tooth regeneration. IGF-1 enhances the size of tooth bud cultures, suggesting potential applications in genetic engineering for tooth morphogenesis. IGF-1 plays a crucial role in odontogenic proliferation and differentiation.
Insights into periodontitis: pathogenesis, host response, and antibiotic strategies Aryani Hayuningtyas, Ria; Endriyana, Jessica; Natassya, Priska
Jurnal Kedokteran Gigi Terpadu Vol. 6 No. 1 (2024): Jurnal Kedokteran Gigi Terpadu
Publisher : Fakultas Kedokteran Gigi Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/jkgt.v6i1.19185

Abstract

This paper provides a comprehensive exploration of periodontitis, a persistent and multifaceted inflammatory condition impacting tooth-supporting structures. The authors investigate the intricate relationship between causative factors, local microbiota, and the host immune response. The disarrayed regulation of cytokines, specifically IL-1, IL-6, and TNF, is highlighted for its pivotal role in triggering or hastening periodontitis onset. The study delves into the host response, emphasizing the delicate equilibrium needed between the immune system and microbiota. The categorization of periodontal pathogenic bacteria, with a focus on the highly pathogenic Phorphyromonas gingivalis and its virulence factors, is explored. Antibiotic efficacy in the context of rising resistance is discussed, encompassing commonly used antibiotics and proposing alternative strategies like plant extracts and bacteriocins. The study advocates for comprehensive therapeutic approaches that integrate antibiotics with alternative methods to effectively address the complex nature of periodontal diseases
Co-Authors Adrian , Nova Arianne Dwimega Aryani Hayuningtyas, Ria Dipankara, Jackson Eddy Louisa, Marie Luki Astuti Melaniwati Natassya, Priska Niko Falatehan Panjaitan, Caesary Cloudya Sri Lestari