Article Per Year (5 Year)
p-Index From 2019 - 2024
2.739
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences AL KAUNIYAH Perfecting a Video Game with Game Metrics Journal of Tropical Biodiversity and Biotechnology Jurnal Biodjati Caraka Tani: Journal of Sustainable Agriculture Biosaintifika: Journal of Biology & Biology Education JPM PAMBUDI Jurnal Surya Masyarakat SIMBIOSA Proceeding Biology Education Conference Gunung Djati Conference Series Depik Jurnal Ilmu-Ilmu Perairan, Pesisir dan Perikanan Depik Jurnal Ilmu-Ilmu Perairan, Pesisir, dan Perikanan JPM Pambudi
Kurniawan, Isma Dwi
Department Of Biology, Faculty Of Science And Technology, UIN Sunan Gunung Djati Bandung, Bandung
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Social Sciences Other

Published : 16 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Jurnal Biodjati

 1 
Pharmacophore Analysis of Monoterpene Melaleuca leucadendra as an Inhibitor for 3CLPro of the SARS-CoV-2 Ismi Farah Syarifah; Yani Suryani; Ghea Gema Adzani; Isma Dwi Kurniawan; Opik Taupiqurrohman
Jurnal Biodjati Vol 7, No 2 (2022): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v7i2.20496

Abstract

The monoterpene compound has been reported to have antiviral activities . This study aimed to test the monoterpene compound in Melaleuca leucadendra to inhibit the SARS-CoV-2 virus. The monoterpenes tested were α-Pinene, β-Pinene, Linalool, α-Terpineol, and Terpinene-4-Ol. The method used was computational through pharmacophore analysis. The indicator for the quality of the compound was the fit score. A fit score of more than 50% indicates a good-quality compound, while a fit score of less than that indicates a  poor-quality compound. Based on the analysis results, the monoterpene compound in Melaleuca leucadendra can potentially inhibit the SARS-CoV-2 virus directly through the inhibition of 3C-like protease. The linalool showed a fit score of 55% with interactions of hydrophobic, electrostatic, and hydrogen bonds. All the compounds did not inhibit the metabolic process and were safe, possibly having no side effects based on ADMET analysis.
Co-Authors Adisty Virakawugi Darniwa Ahmad Zaenal Ependi Ana Widiana Andy Setiabudi Anggita Rahmi Hafsari Anggita Rahmi Hafsari Anggita Rahmi Hafsari Ardi, Tiara Esti Astuti Kusumorini Ateng Supriyatna Ayuni Adawiyah Ayuni Adawiyah Bayu Pamungkas Birama Satria Budi Dwisetiyani Cahyo Rahmadi Cahyo Rahmadi Cahyo Rahmadi, Cahyo Edi Dwi Atmaja Farhan Fauzan Fezaa Ashelia Zakia Ameliee Ghea Gema Adzani Hasbi Yasin Hilda Ayu Emalia Ida Kinasih Ida Kinasih Intan Suhartini Ismi Farah Syarifah Liberty Chaidir M. Agus Salim Mentari Kusuma Wardani Mohamad Agus Salim Muhammad Tahmid Musa'adah Musa'adah Nasrullah, Ridwan Nida Hidayaturrohmah Omar Calva Opik Taupiqurrohman Rahmat Taufik MA Rahmat Taufiq M.A Rahmat Taufiq Mustahiq Akbar Rahmat Taufiq Mustahiq Akbar Rasyid Wisnuaji Rezzy Eko Caraka Risda Arba Ulfa Risda Arba Ulfa Sakhinah Abu Bakar Sawaludin Iqbal Sella Nur Devi Siska Tridesianti Tri Cahyanto Ucu Julita Willyanto, Muhammad Iqbal Yani Suryani Yani Suryani Yuni Kulsum Zikri Imanudin