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Gambaran Leukosit Pro Inflamasi pada Status Asmaticus di RSUD Kebumen Rahayu, Ester Tri; Arjana, Adika Zhulhi; Juwariyah, Juwariyah; Yuantari, Rahma; Irfan, Rozan Muhammad
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 18 No 1: January 2018
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.180108

Asma merupakan kondisi penyempitan jalan nafas yang selama ini hanya dianggap sebagai reaksi hipersensitifitas tipe 1 karena pada kondisi lain juga dapat disebabkan oleh inflamasi dan koagulasi. Pada hipersensitifitas tipe 1 terdapat peran neutrofil dan eosinofil dan dalam penelitin ini akan dipetakan fenotip asma berdasarkan aktifitas eosinof dan neutrofil yaitu eosinofilik dan neutrofilik pada serangan akut asma. Penelitian dilakukan dengan desain observasional retrospektif terhadap data sekunder pasien asma dewasa, dalam waktu 1 tahun kebelakang dengan sampel sebanyak 91 orang di RSUD Kebumen. Pengambilan data menggunakan data rekam medis. Analisis data menggunakan uji ANOVA untuk data terdistribusi normal, dan uji rerata Kuskal-Wallis untuk data tidak normal. Karakteristik subyek sejumlah 91 orang, dengan 31 subyek pria dan rerata umur 38 tahun. Delapan puluh empat persen subjek adalah asma derajat ringan, 4 % berat dan sisanya sedang. Pada uji rerata eosinofil dan neutrofil, terdapat berbedaan rerata antar derajat serangan namun tidak signifikan secara statistik. Subyek asma neutrofilik lebih mendomasi dibandingkan eosinofilik. Walaupun begitu, belum dapat diambil kesimpulan hubungan kadar eosinofil dan neutrofil terhadap derajat asma karena belum ada hasil statistik yang signifikan.

UTILISASI INDEKS TROMBOSIT SEBAGAI PREDIKTOR KEPARAHAN PADA KASUS FEBRIS CURIGA DEMAM DENGUE Arjana, Adika Zhulhi; Yuantari, Rahma; Devita, Ninda; Irfan, Rozan Muhammad
Biomedika Vol 12, No 1 (2020): Biomedika Februari 2020
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v12i1.9725

ABSTRAKIndeks trombosit memiliki karakteristik yang mengarah pada kondisi cairan dan trombosit tubuh. Penelitian mengenai hubungan indeks trombosit pada penentuan derajat keparahan demam dengue membuka peluang menjadikan indeks trombosit sebagai factor prognostik. Tujuan penelitian ini untuk mngetahui hubungan indeks trombosit sebagai prediktor keparahan pada kasus febris curiga demam dengue. Penelitian ini bersifat non eksperimental analitik. Data diambil dengan metode cohort prospektif. Subjek penelitian adalah pasien febris curiga dengue di RS X, Y, dan Z Yogyakarta dan sekitarnya. Subjek kemudian diambil darah untuk diperiksa indeks trombosit pada saat masuk dan hari ketiga perawatan. Penentuan derajat keparahan dengue dinilai pada hari ketiga perawatan. Hubungan antara hasil indeks trombosit dengan diagnosis dianalisis dengan ANOVA sedangkan korelasi antara indeks trombosit saat admisi dan hari ketiga dengan uji korelasi dengan bantuan software Medcalc. Sebanyak 56 subyek masuk dalam penelitian). Analisis ANOVA menunjukkan adanya perbedaan yang signifikan untuk mean platelet volume (MPV) dan platelet distribution width (PDW) antar derajat infeksi dengue (p=0.01 dan p=0.017). Analisis ANOVA untuk plateocrit menunjukkan tidak ada perbedaan yang signifikan (p=0.055). Uji korelasi hasil antar indeks trombosit menunjukkan hubungan yang signifikan. Adanya perbedaan MPV dan PDW pada berbagai derajat infeksi dengue sehingga dapat digunakan untuk memprediksi keparahan infeksi dengue.Kata Kunci: Dengue, Indeks Trombosit, Resusitasi CairanABSTRACTPlatelet index has characteristics that lead to the condition of body fluids and platelets. Study on relationship of platelet index in the determining severity of dengue fever opens the opportunity to make the platelet index as a prognostic factor. The aim of this study was to know the correlation of platelet index with predictors of severity of febrile suspected dengue fever. This study was non-experimental and cohort prospective study. The subjects were febrile patients suspicious of dengue in X, Y, and Z Hospital in Yogyakarta and surrounding areas. Subjects were collected blood sample to be examined for platelet index at admission and third day after. Severity of dengue was assessed on third day after admission. Relationship between platelet index with severity was analyzed by ANOVA while correlation between platelet index was analyzed by correlation test with Medcalc software. A total of 56 subjects were included in the study. ANOVA analysis showed a significant difference in mean platelet volume (MPV) and platelet distribution width (PDW) between the degrees of dengue infection (p= 0.01 and p= 0.017). ANOVA analysis for plateocrit showed no significant difference (p = 0.055). Correlation test results between platelet indices show a significant relationship. The results of this study indicate differences in MPV and PDW in various degrees of dengue infection so that it can be used to predict severity of dengue fever.Keywords: dengue, platelet index, fluid resuscitation

UTILISASI INDEKS TROMBOSIT SEBAGAI PREDIKTOR KEPARAHAN PADA KASUS FEBRIS CURIGA DEMAM DENGUE Adika Zhulhi Arjana; Rahma Yuantari; Ninda Devita; Rozan Muhammad Irfan
Biomedika Vol 12, No 1 (2020): Biomedika Februari 2020
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v12i1.9725

ABSTRAKIndeks trombosit memiliki karakteristik yang mengarah pada kondisi cairan dan trombosit tubuh. Penelitian mengenai hubungan indeks trombosit pada penentuan derajat keparahan demam dengue membuka peluang menjadikan indeks trombosit sebagai factor prognostik. Tujuan penelitian ini untuk mngetahui hubungan indeks trombosit sebagai prediktor keparahan pada kasus febris curiga demam dengue. Penelitian ini bersifat non eksperimental analitik. Data diambil dengan metode cohort prospektif. Subjek penelitian adalah pasien febris curiga dengue di RS X, Y, dan Z Yogyakarta dan sekitarnya. Subjek kemudian diambil darah untuk diperiksa indeks trombosit pada saat masuk dan hari ketiga perawatan. Penentuan derajat keparahan dengue dinilai pada hari ketiga perawatan. Hubungan antara hasil indeks trombosit dengan diagnosis dianalisis dengan ANOVA sedangkan korelasi antara indeks trombosit saat admisi dan hari ketiga dengan uji korelasi dengan bantuan software Medcalc. Sebanyak 56 subyek masuk dalam penelitian). Analisis ANOVA menunjukkan adanya perbedaan yang signifikan untuk mean platelet volume (MPV) dan platelet distribution width (PDW) antar derajat infeksi dengue (p=0.01 dan p=0.017). Analisis ANOVA untuk plateocrit menunjukkan tidak ada perbedaan yang signifikan (p=0.055). Uji korelasi hasil antar indeks trombosit menunjukkan hubungan yang signifikan. Adanya perbedaan MPV dan PDW pada berbagai derajat infeksi dengue sehingga dapat digunakan untuk memprediksi keparahan infeksi dengue.Kata Kunci: Dengue, Indeks Trombosit, Resusitasi CairanABSTRACTPlatelet index has characteristics that lead to the condition of body fluids and platelets. Study on relationship of platelet index in the determining severity of dengue fever opens the opportunity to make the platelet index as a prognostic factor. The aim of this study was to know the correlation of platelet index with predictors of severity of febrile suspected dengue fever. This study was non-experimental and cohort prospective study. The subjects were febrile patients suspicious of dengue in X, Y, and Z Hospital in Yogyakarta and surrounding areas. Subjects were collected blood sample to be examined for platelet index at admission and third day after. Severity of dengue was assessed on third day after admission. Relationship between platelet index with severity was analyzed by ANOVA while correlation between platelet index was analyzed by correlation test with Medcalc software. A total of 56 subjects were included in the study. ANOVA analysis showed a significant difference in mean platelet volume (MPV) and platelet distribution width (PDW) between the degrees of dengue infection (p= 0.01 and p= 0.017). ANOVA analysis for plateocrit showed no significant difference (p = 0.055). Correlation test results between platelet indices show a significant relationship. The results of this study indicate differences in MPV and PDW in various degrees of dengue infection so that it can be used to predict severity of dengue fever.Keywords: dengue, platelet index, fluid resuscitation

Pengaruh Durasi DM Tipe 2 Terhadap Angka Leukosit dan Hitung Jenis Leukosit Pada Tikus Wistar Pasca Bilateral Common Carotid Artery Occlusion (BCCAO) Ety Sari Handayani; Farah Jasmine Dianita; Rahma Yuantari Yuantari
Smart Medical Journal Vol 5, No 1 (2022): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v5i1.42787

Pendahuluan: Stroke iskemik merupakan masalah kesehatan yang sering ditemui di dunia terutama Indonesia. BCCAO merupakan teknik yang dapat digunakan untuk menginduksi iskemia serebral. Salah satu faktor risiko stroke iskemik yaitu diabetes melitus tipe 2 dimana dapat meningkatkan agregasi leukosit dan aktivasi aterosklerosis. Mengetahui pengaruh durasi diabetes melitus tipe 2 terhadap angka leukosit dan hitung jenis leukosit pada tikus pasca ligasi BCCAO.Metode: Jenis penelitian berupa kuasi eksperimental. Subjek penelitian ini yaitu tikus jantan dewasa (Rattus norvegicus) galur Wistar. Tikus dikelompokkan menjadi 4 kelompok perlakuan, masing-masing terdiri dari 6 ekor tikus. Kelompok 1 merupakan kelompok sham operated, kelompok 2 merupakan kelompok iskemik (diligasi BCCAO selama 20 menit dan reperfusi 7 hari), kelompok 3 merupakan kelompok perlakuan DM-iskemik (DM selama 2 minggu dengan BCCAO), dan kelompok 4 merupakan kelompok DM-iskemik (DM selama 3 minggu dengan BCCAO. Analisis data menggunakan uji ANOVA dan Kruskal Wallis.Hasil: Angka leukosit dan hitung jenis leukosit pada DMT2 durasi 3 minggu memiliki nilai Neutrofil yang signifikan (23,53x 5,57; p = 0,014, p <0,05) dan Limfosit (66,68 x 6,16; p = 0,028, p <0,05) setelah induksi stroke iskemik.Kesimpulan: Terdapat pengaruh durasi diabetes melitus tipe 2 terhadap hitung jenis leukosit yaitu neutrofil dan limfosit pada tikus pasca ligasi BCCAO.Kata Kunci: Durasi DM, BCCAO, angka leukosit, hitung jenis leukosit

Pengembangan dan Validasi Kuesioner untuk Menilai Miskonsepsi tentang Pengobatan pada Hipertensi dan Diabetes Melitus dengan Kejadian Gagal Ginjal Irwan Nuryana Kurniawan; Rahma Yuantari; Endang Sulistyowatiningsih; Ani Khotul Faizah; Vitarani Dwi Ananda Ningrum
Jurnal Sains Farmasi & Klinis Vol 7, No 3 (2020): J Sains Farm Klin 7(3), Desember 2020
Publisher : Fakultas Farmasi Universitas Andalas

Miskonsepsi tentang pengobatan menjadi salah satu faktor tingginya ketidakpatuhan pengobatan. Masyarakat beranggapan bahwa penggunaan obat rutin pada hipertensi dan diabetes mellitus (DM) dapat menyebabkan gagal ginjal. Penelitian ini bertujuan untuk menyediakan kuesioner valid dan reliabel yang dapat digunakan untuk mengukur miskonsepsi masyarakat tentang pengobatan jangka panjang pada hipertensi dan DM dengan kejadian gagal ginjal. Pengembangan kuesioner dilakukan dalam 5 tahap yakni konseptualisasi, konstruksi alat ukur, uji coba melalui studi 1 pada 240 mahasiswa/i medis dan non-medis, dan studi 2 pada 300 masyarakat di wilayah Kabupaten Sleman, tes revisi dan selanjutnya tahap analisis melalui uji reliabilitas alpha cronbach. Sementara itu, uji validitas dilakukan dengan membandingkan kuesioner ini dengan kuesioner terpercaya lainnya. Hasil skala pengetahuan tentang terapi hipertensi dan DM terkait kejadian gagal ginjal pada studi 1 dan studi 2 tersusun atas 4 variabel pengetahuan meliputi: pengetahuan terapi hipertensi dan DMT (α 0.742, α 823), miskonsepsi penggunaan obat rutin (α 0.835, α 0.805), pengetahuan obat penyebab gagal ginjal (α 0.582), (α 0.581), serta pengetahuan faktor risiko gagal ginjal (α 0.721, α 0.698). Hasil analisis ini menunjukkan bukti awal dan menyediakan instumen valid dan relevan untuk mengukur tingkat miskonsepsi masyarakat tentang pengobatan jangka panjang pada hipertensi dan DM terkait dengan gagal ginjal.

Prolonged severe acute respiratory syndrome of Corona Virus-2 positive with polymerase chain reaction: A case report Linda Rosita; Rahma Yuantari; Budi Mulyono; Umi Solekhah Intansari; Ingesti Bilkis Zulfatina
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 3, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss3.art12

COVID-19 continues to spread across the world, with more than 60 million confirmed cases in 220 countries. Since March 11, 2020, WHO announced the COVID-19 outbreak as a pandemic. Impacts caused by COVID-19 are not only on the health sector but also economic, social, and political sectors. In a diagnosing process, the SARS-CoV-2 PCR results for swab specimen are a gold standard in determining confirmed COVID-19 cases. Previously, 2 repeated results of negative SARS-CoV-2 PCR become criteria of being recovered from COVID-19. Therefore, based on the latest guidelines from the Indonesian Ministry of Health revised on July 13th 2020, patients with no symptoms, mild to moderate symptoms, and severe symptoms are declared to be recovered if the patients meet the requirements of finished periods of isolation based on a doctor’s assessment. Confirmed cases with severe or critical symptoms are specially declared with one negative result of the PCR test plus three days without showing any symptoms. This case study discussed a 52-years-old woman diagnosed with COVID-19. PCR test for this patient had been conducted 11 times during 64 days of treatment, and its results turned to be always positive, failing to fulfil the discharge criteria. Therefore, it needs to determine causes of prolonged positive PCR results and impacts of clinical condition of the patients, and prognosis of the patients.

Pengembangan Kuesioner Pengetahuan Masyarakat tentang Penyakit Ginjal Kronik Irwan Nuryana Kurniawan; Mursidha Rakhmi Salicha; Rahma Yuantari; Vitarani Dwi Ananda Ningrum
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1849

To reduce the prevalence of chronic kidney disease, a pillar of health paradigms through community empowerment has been introduced. Society with profound knowledge of such disease has proved to be able to raise awareness of kidney disease early detection. Meanwhile, limited data on public knowledge of chronic kidney disease make the education programs in health promotion seem ineffective. This study therefore aims to develop a questionnaire with high validity and reliability to assess public knowledge of this disease. The development included five stages of conceptualisation, instrument construction, a trial with Study 1 of 240 medical and non-medical students and Study 2 of 300 participants from Sleman Regency in Yogyakarta, a test of the revision, and an analysis using the Cronbachâ€™s alpha reliability test. A validity test compared this questionnaire with another reliable questionnaire. Both studies yielded a knowledge scale with two variables comprising kidney disease knowledge (risk factors, causes, symptoms, management) and kidney disease prevention knowledge with Cronbachâ€™s alpha of 0.623 and 0.703 (Study 1) and 0.361 and 0.545 (Study 2). This has proved that the preliminary psychometric evidence (factor structure, reliability, convergent validity) satisfied the requirements for an instrument used to measure public knowledge of chronic kidney disease.

Implementation of the Posyandu Information System in Tirtorahayu Village Kapanewon Galur Kulon Progo Regency Rahadian Kurniawan; Sri Kusumadewi; Rahma Yuantari
KACANEGARA Jurnal Pengabdian pada Masyarakat Vol 6, No 1 (2023): Januari
Publisher : Institut Teknologi Dirgantara Adisutjipto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28989/kacanegara.v6i1.1271

Kalurahan Tirtorahayu is one of the villages that is highly receptive to the growth of information technology. No Posyandu Information System (SIP) has been implemented in the village to date; so, the management of maternal and child health data has encountered considerable obstacles. This activity was intended to develop and implement SIP in Tirtortahayu Village. The activities consist of four phases: 1) situation analysis; 2) application development; 3) system implementation; and 4) program evaluation. The situation analysis was conducted via FGDs and direct observation of Posyandu activity implementation. SIP development was done with direct user participation. Posyandu cadres who became pilots, village midwives, and personnel who handled health data received training in two phases. The first phase consists of a web-based SIP training, while the second phase focuses on maternal and child health data entry via an Android-based application. The results of the evaluation proved that the participants viewed this SIP as important and as needed immediate implementation. The successful implementation of this SIP were the support of the village government, the usability of the application, and the experience of participants in using information technology-based applications.

COFFEE CONSUMPTION MAY DECREASE THE SERUM CREATININE AND PLASMA MALONDIALDEHYDE LEVELS IN RATS WITH HYPERURICEMIA INDUCED BY A HIGH PURINE DIET Hilmi Ardian Sudiarto; Rahma Yuantari; Dwi Nur Ahsani
Jurnal Kedokteran Hewan Vol 15, No 2 (2021): June
Publisher : Universitas Syiah Kuala

The aim of this research was to determine the effect of coffee on creatinine and plasma malondialdehyde (MDA) level in rats fed on high purine diet. A total of 24 male Wistar rats divided into 4 groups of 6 rats each. Beef broth were given to 3 groups (K1, P1, P2) for thirty days. Beef broth administration were followed by giving coffee (caffeinated= P1 or by a decaffeinated= P2, 144 mg/200 g BW). Serum creatinine levels and plasma MDA were examined periodically on day 0, 15, and 30. Data were analyzed by multivariate analysis of variance or MANOVA test (CI= 95%, P0.05). Coffee administration (caffeinated and decaffeinated) may decrease the serum creatinine (day-30, K1= 3.17+ 0.69; P1= 1.63+0.11; P2= 1.14+0.08) and MDA levels (day-30, K1= 9.8+0.28; P1= 5.80+0.55, P2= 3.87+3.26) after 30 days of treatment (P= 0.000 for creatinine and MDA levels in K1, P1, P2 groups). A lower serum creatinine and MDA levels can be found in decaffeinated coffee grup. Coffee consumption for 30 days (especially decaffeinated) may decrease serum creatinine and plasma MDA in rat induced by a high purine diet.

The role of red-cell distribution width (RDW) and mean platelet volume (MPV) as biomarkers of community-acquired pneumonia (CAP) severity Edy Purwanto; Reza Ishak Estiko; Firdausia Rahma Putri; Linda Rosita; Rahma Yuantari
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art11

Community-acquired pneumonia (CAP) remains a leading cause of morbidity and mortality worldwide. Red-cell distribution width (RDW) and mean platelet volume (MPV) are two parameters included in complete blood count (CBC). It is simple, inexpensive, and widely available in any hospital. Many previous studies have shown that RDW and MPV can be used as supporting biomarkers for CAP, but the study in this area remains limited. This study aims to investigate the relationship between RDW and MPV with the severity of CAP and their potential as biomarkers. We conducted a scoping review of original articles using PubMed, Springer Link, Taylor and Francis, EBSCO, Cochrane Library, Google Scholar, Medline, Science Direct, Wiley, and Portal Garuda. Only articles published between 2012 and 2022 in English or Indonesian were included. Out of 11,852 articles reviewed, only 18 met the criteria for the focus on using RDW, MPV, or both as biomarkers for CAP. The details of these studies, including their research design, internal and external validity, and key results, are presented. The results show that increased RDW and MPV levels correlate with higher morbidity and mortality rates among CAP patients. Elevated levels of RDW (>14%) and MPV (>8.1 fL) can predict and acts as a biomarker of CAP severity. Thus, measuring RDW and MPV may give physicians a way to anticipate the outcomes for patients with CAP, helping them make and implement decisions, either alone or in combination with other established methods.

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