journal of Basic Medical Veterinary
Vol. 8 No. 2 (2019): Journal of Basic Medical Veterinary, December 2019

EFFECT OF Polygonum minus (KESUM) LEAVES ETHANOLIC EXTRACT ON HISTOPATHOLOGICAL CHANGES ON THE WALL AORTA OF MICE (Mus musculus) INDUCED BY CADMIUM CHLORIDE ANTIOXIDANT

Putri Anggraheni Kusumaningrum (Fakultas Kedokteran Hewan Universitas Airlangga)
Lita Rakhma Yustinasari (Fakultas Kedokteran Hewan Universitas Airlangga)
Iwan Sahrial Hamid (Fakultas Kedokteran Hewan Universitas Airlangga)
Sri Agus Sudjarwo (Fakultas Kedokteran Hewan Universitas Airlangga)
Kuncoro Puguh Santoso (Fakultas Kedokteran Hewan Universitas Airlangga)
Chairul Anwar (Fakultas Kedokteran Hewan Universitas Airlangga)

Article Info

Publish Date
02 Jul 2020

Abstract

This study was conducted to investigate the protective effect Polygonum minus leaves extract on the histopathological changes on aorta wall of mice (Mus musculus) induced by cadmium chloride. Thirty male mice were divided into five groups and were administered via intragastric gavage with different treatments for 21 days. The treatment were Negative Control (CMC Na 0.5% solution + aquadest), Positive Control (CMC Na0.5% solution + 8 mg/kg bw of mercuric chloride), Treatment 1, 2, and 3 (200, 400, and 800 mg/kg bw of Polygonum minus leaves extract respectively + 8 mg/kg bw of cadmium chloride). The microscopec examine followed analyzed by One Way ANOVA continued with Duncan test for counting the amount of foam cell and the histopathological changes of wall aorta were examined by using Ifora Scoring method was analysed using Kruskal Wallis and continued with Mann-Whitney test. The result showed Polygonum minus leaves extract could protect wall aorta of mice from the damage effect of cadmium chloride. The best dose of Polygonum minus on this research was 400 mg/kg bw.

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Journal Info
journal of Basic Medical Veterinary
Website

Abbrev

JBMV

Publisher

Universitas Airlangga

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary

Description

This journal published original articles, review articles, and case studies in Indonesian or English, in the scope of JBMV has a broad coverage of relevant topics across veterinary basic medical sciences which includes: preclinical and paraclinical disciplines like Anatomy, Physiology, Biochemistry, ...