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All Journal journal of Basic Medical Veterinary
Putri Anggraheni Kusumaningrum
Fakultas Kedokteran Hewan Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary

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EFFECT OF Polygonum minus (KESUM) LEAVES ETHANOLIC EXTRACT ON HISTOPATHOLOGICAL CHANGES ON THE WALL AORTA OF MICE (Mus musculus) INDUCED BY CADMIUM CHLORIDE ANTIOXIDANT Putri Anggraheni Kusumaningrum; Lita Rakhma Yustinasari; Iwan Sahrial Hamid; Sri Agus Sudjarwo; Kuncoro Puguh Santoso; Chairul Anwar
Journal of Basic Medical Veterinary Vol. 8 No. 2 (2019): Journal of Basic Medical Veterinary, December 2019
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/.v8i2.20408

Abstract

This study was conducted to investigate the protective effect Polygonum minus leaves extract on the histopathological changes on aorta wall of mice (Mus musculus) induced by cadmium chloride. Thirty male mice were divided into five groups and were administered via intragastric gavage with different treatments for 21 days. The treatment were Negative Control (CMC Na 0.5% solution + aquadest), Positive Control (CMC Na0.5% solution + 8 mg/kg bw of mercuric chloride), Treatment 1, 2, and 3 (200, 400, and 800 mg/kg bw of Polygonum minus leaves extract respectively + 8 mg/kg bw of cadmium chloride). The microscopec examine followed analyzed by One Way ANOVA continued with Duncan test for counting the amount of foam cell and the histopathological changes of wall aorta were examined by using Ifora Scoring method was analysed using Kruskal Wallis and continued with Mann-Whitney test. The result showed Polygonum minus leaves extract could protect wall aorta of mice from the damage effect of cadmium chloride. The best dose of Polygonum minus on this research was 400 mg/kg bw.
Co-Authors Chairul Anwar Hamid, Iwan Sahrial Kuncoro Puguh Santoso Lita Rakhma Yustinasari