Jurnal Pendidikan Kimia (JPKim)
Vol 13, No 1 (2021): April

Synthesis and characterization of capsule shells non gelatin grass jelly leaves-seaweed as drug delivery system material

Micha Mahardika (Sekolah Tinggi Analis Kimia Cilegon, Cilegon, Banten, Indonesia)
Fauzan Amin (Sekolah Tinggi Analis Kimia Cilegon, Cilegon, Banten, Indonesia)
Ika Agustia Umami (Sekolah Tinggi Analis Kimia Cilegon, Cilegon, Banten, Indonesia)
Boima Situmeang (Sekolah Tinggi Analis Kimia Cilegon, Cilegon, Banten, Indonesia)
Agus Malik Ibrahim (Sekolah Tinggi Analis Kimia Cilegon, Cilegon, Banten, Indonesia)



Article Info

Publish Date
01 Apr 2021

Abstract

Drug delivery system is a system that describes the journey of a drug to its target location.  The main component of the drug delivery system is gelatin. The leaves of grass jelly-seaweed are needed as a raw material for gelatin. The main component of gelling agents in grass jelly leaves and seaweed is a low-methoxy pectin polysaccharide. Pectin from previous study is used as a synthesis material for hard capsule shells with the addition of other ingredients, which are Na-CMC, sorbitol, and water. The characterization results of capsule shells with variations in the composition of grass jelly-seaweed leaves 0: 4, 1: 3, 2: 2, 3: 1, and 4: 0 (A, B, C, D and E) have a disolving time of 12 minutes 45 seconds; 15 minutes 53 seconds; 23 minutes 10 seconds; 15 minutes 35 seconds and 18 minutes 12 seconds. The swelling degree test each of 200%;  266,7%;  303.3%;  586.7% and 643.3%. Furthermore, the shells of grass jelly-seaweed leaf capsules were tested for their material performance in the cefadroxyl disolving test with variations in sampling time of 10, 20, and 30 minutes.Keywords: Cefadroxyl, Drug delivery system, Green grass jelly leaves, Non-gelatin capsules, Seaweed

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Journal Info

Abbrev

jpk

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science

Description

Jurnal Pendidikan Kimia (JPKim) yang dikelola Program Pascasarjana Universitas Negeri Medan terbit 3 kali setahun, yakni bulan April, Agustus dan Desember. JPKim menerbitkan artikel ilmiah hasil-hasil penelitian pendidikan kimia dan kimia fundamental. JPKim juga menerbitkan artikel Review terkait ...