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All Journal VALENSI BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan KOVALEN: Jurnal Riset Kimia Jurnal Pendidikan Kimia (JPKim) Indonesian Journal of Pure and Applied Chemistry Jambura Journal of Chemistry
Boima Ramses Situmeang
Departmen Of Chemistry, Sekolah Tinggi Analis Kimia Cilegon, Banten, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science

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Isolasi Senyawa Triterpenoid dari Ekstrak Etil Asetat Pirdot (Saurauia vulcani. Kurth) Boima Ramses Situmeang; Achmad Rante Suparman; Murtihapsari kadarusman; Apriani sulu parumbak; Tati Herlina
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 4, No. 2, November 2018
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (21.168 KB) | DOI: 10.15408/jkv.v4i2.7272

Abstract

Pirdot plant(Saurauia vulcani. Kurth)is a plant that grows naturally in a tropical climate. During this decoction pirdot leaves plants are used by the people to treat diabetes disease. The purpose of this study was to isolate triterpenoid compound from ethyl acetate extract of pirdot leaves. The sample extraction was performed by total of maceration method using ethyl acetate as a solvent. The separation and purification of the compound was carried out by column chromatography method followed by stain pattern analysis with thin layer chromatography (TLC). Structure characterization of pure compound was determined using UV, IR, 1H-NMR, 13C-NMR, DEPT 135º, HMQC, HMBC, 1H-1H COSY and MS spectroscopies including compared with various literatures. Based on the analysis result, the pure isolate obtained was identified as a pentacyclic triterpenoid compound, 3-hydroxy acid, 12(13)-en,28-oleanolate acid with the molecular formula C30H48O3. The triterpenoid compound of pentacyclic oleanolic acid is the first reported from the pirdot plant (Saurauia vulcani. Kurth). 
Antibacterial Diterpenoid Against Pathogenic Oral Bacteria of Streptococcus Mutans ATCC 25175 Isolated From Sarang Semut (Myrmecodia Pendans) Mieke H Satari; Boima Situmeang; Indah Permata Yudha; Dikdik Kurnia
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 5, No. 2, November 2019
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (61.465 KB) | DOI: 10.15408/jkv.v5i2.8864

Abstract

Discovery of new antibacterial agent to treat oral disease caused by pathogenic oral bacteria is an attracted focus to more pay attention of researcher. The tropical natural product is the promising sources of new bioactive as antibacterial compounds. The epiphyte plant of Sarang Semut (M. pendans) empirically has been used as a drug to treat various diseases. Our previous research found that ethyl acetate extract of Sarang Semut inhibited the bacteria growth of Enterococcus faecalis. This study aims to isolate, structure determination and antibacterial activity evaluation of active compound against Streptococcus mutans ATCC 25175. The isolation by combination chromatography on normal and reverse phase resulted an antibacterial compound 1. Based on the analysis of the spectroscopic data including IR, FTIR, 1H-NMR, 13C-NMR, 2D-NMR as well as by mass spectroscopic (MS) and compare to reported data, structure of compound 1 was suggested as terpenoid type diterpene derivative. Antibacterial activity evaluation by Kirby-Bauer method of compound 1 against S. mutans ATCC 25175 showed inhibition zone values were 17.8, 14.5 and 11.1 mm at 10000, 5000 and 1000 ppm, respectively, while the MIC and MBC values were 18.125 ppm with MBC of 2500 ppm, respectively.
THE EFFECT OF FERMENTATION TIME ON ANTIOXIDANT AND ORGANOLEPTIC ACTIVITIES OF BIDARA (Zizipus spina CRISTI L.) KOMBUCHA DRINK Boima Situmeang; Muhammad Mutfi Amin Shidqi; Firman Rezaldi
BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan Vol 10, No 1 (2022): JURNAL BIOTIK
Publisher : Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/biotik.v10i1.11370

Abstract

Bidara leaves contain antioxidants that are good for the body because they play a role in warding off free radicals. Kombucha made with bidara leaves is an innovative tea variant product that comes from the symbiotic culture of fermentation between bacteria and fungi. The purpose of this study is to determine the effect of fermentation time on antioxidant and organoleptic activity of kombucha and to determine the value of antioxidant activity of kombucha. The parameters measured were the antioxidant activity using the DPPH (2,2- diphenyl-picrilhydrazine) radical method and the organoleptic test with the hedonic scale including taste, aroma and color. The analysis showed that the length of fermentation time affected both the antioxidant activity and organoleptic test which included the taste, aroma and color of kombucha leaves of bidara. Based on the mean value of DPPH radical scavenging percentage, the antioxidant activity at fermentation time of 1, 8 and 12 days are 24,72%; 35,98%; and 7,05% with the highest antioxidant activity of kombucha made with bidara leaves occurred at 8 days fermentation is 35.87%. The IC50 value of kombucha made  with bidara leaves product at fermentation time of 1, 8 and 12 days are 524,63 ppm; 441,03 ppm; and 1442,3 ppm Keywords: Antioxidant Activity, Kombucha, Leaf of Bidara, Organoleptic
Aktivitas Antidiabetes dari fraksi Sauauria bracteosa pada Tikus dengan Metode Induksi Aloksan Murtihapsari Murtihapsari; Boima Situmeang; Achmad Rante Suparman; Apriani Sulu Parubak; Radite Yogaswara; Yasmiwar Susilawati; Tati Herlina
Jambura Journal of Chemistry Vol 4, No 1 (2022): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v4i1.11659

Abstract

Penderita diabetes mellitus disebabkan oleh kurangnya sekresi insulin yang diperkirakan mengalami peningkatan dari 8,4 menjadi 21,3 juta jiwa pada 2000 hingga 2030 mendatang. Seiring dengan semakin meningkatnya penderita penyakit diabetes mellitus, maka perlu dilakukan pencarian berbagai alternatif obat herbal dari tumbuhan. Salah satu tumbuhan yang berpotensi sebagai pengobatan diabetes mellitus seperti Sauauria bracteosa yang banyak tumbuh liar di daerah tropis. Tujuan dari penelitian ini menguji aktivitas antidiabetes dari fraksi S. bracteosa diujikan lebih lanjut ke hewan percobaan (tikus). Metode pengujian aktivitas antidiabetes dilakukan dengan metode induksi aloksan terhadap fraksi tumbuhan S. bracteosa dengan dosis 250 mg/kg BB tikus. Induksi aloksan dosis 175 mg/kg BB tikus pada hari ke 0-6. Hasil pengujian aktivitas antidiabetes fraksi n-heksana memiliki aktivitas antidiabetes yang lebih tinggi 43,05% dibandingkan dengan fraksi etil asetat sebesar 33,22% dan fraksi air sebesar 8,88%. Persentase penurunan kadar glukosa kelompok fraksi n-heksana dan fraksi etil asetat pada dosis 100 mg/kgBB menunjukkan penurunan yang lebih tinggi daripada kelompok kontrol positif sebesar 20,93% yang diberikan glibenklamid dosis 0,5 mg/kg BB. Hal ini menunjukkan bahwa tumbuhan S. bracteosa berpotensi kuat sebagai penurun gula darah terutama fraksi n-heksana dan fraksi etil asetat.
Analysis of secondary metabolite compounds from leaves extract kesambi (Schleichera oleosa) and antioxidant activity test Boima Situmeang; Weny Nuraeni; Agus Malik Ibrahim; Saronom Silaban
Jurnal Pendidikan Kimia (JPKim) Vol 8, No 3 (2016): Desember
Publisher : Pascasarjana Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (411.191 KB) | DOI: 10.24114/jpkim.v8i3.4479

Abstract

Abstract. Kesambi (Schleichera oleosa) is one of plants that have the potential to treat various deasease. Kesambi plant or kusum widely spread in Asia such as India, Nepal, Malaysia and Indonesia. In Indonesia, this plant widely available in Java precisely Cilegon and Jember area. This study aimed to analyze the content of secondary metabolites from plants kesambi extract and antioxidant activity test of hexane, ethyl acetate and water fraction. Analysis of secondary metabolites is done with phytochemical and GC-MS test methods. Extraction was done by using maceration and fractionation methods. Antioxidan tactivity test using DPPH methods. The content of secondary metabolites contained in leaves kesambi (Schleichera oleosa) are flavonoids, alkaloids, tannins, phenols, and steroids. Based on IC50 values were obtained from three fraction, ethyl acetate fraction had a strong radical inhibition rate than the fraction of water and n-hexane. IC50 fraction of ethyl acetate, water, and n-hexane successively are: 206.0851; 272.2891 and 425,1143 ppm respectively. Keyword: kesambi, schleichera oleosa, DPPH, antioxidant
Synthesis and characterization of capsule shells non gelatin grass jelly leaves-seaweed as drug delivery system material Micha Mahardika; Fauzan Amin; Ika Agustia Umami; Boima Situmeang; Agus Malik Ibrahim
Jurnal Pendidikan Kimia (JPKim) Vol 13, No 1 (2021): April
Publisher : Pascasarjana Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (395.857 KB) | DOI: 10.24114/jpkim.v13i1.24138

Abstract

Drug delivery system is a system that describes the journey of a drug to its target location.  The main component of the drug delivery system is gelatin. The leaves of grass jelly-seaweed are needed as a raw material for gelatin. The main component of gelling agents in grass jelly leaves and seaweed is a low-methoxy pectin polysaccharide. Pectin from previous study is used as a synthesis material for hard capsule shells with the addition of other ingredients, which are Na-CMC, sorbitol, and water. The characterization results of capsule shells with variations in the composition of grass jelly-seaweed leaves 0: 4, 1: 3, 2: 2, 3: 1, and 4: 0 (A, B, C, D and E) have a disolving time of 12 minutes 45 seconds; 15 minutes 53 seconds; 23 minutes 10 seconds; 15 minutes 35 seconds and 18 minutes 12 seconds. The swelling degree test each of 200%;  266,7%;  303.3%;  586.7% and 643.3%. Furthermore, the shells of grass jelly-seaweed leaf capsules were tested for their material performance in the cefadroxyl disolving test with variations in sampling time of 10, 20, and 30 minutes.Keywords: Cefadroxyl, Drug delivery system, Green grass jelly leaves, Non-gelatin capsules, Seaweed
Antimalarial activity and phitochemical analysis from Suruhan (Peperomia pellucida) extract Nurhayati Bialangi; Moh Adam Mustapa; Yuszda K Salimi; Ari Widiantoro; Boima Situmeang
Jurnal Pendidikan Kimia (JPKim) Vol 8, No 3 (2016): Desember
Publisher : Pascasarjana Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (565.757 KB) | DOI: 10.24114/jpkim.v8i3.5817

Abstract

Abstract. Infectious and parasitic diseases is one of various disease that the most common. Based on data from the World Health Organization (WHO) in 2011, infectious and parasitic diseases become the third largest cause of death in the world. One of the plants that have potential as an antimalarial is suruhan (Peperomia pellucida). The purpose of this study is to test antimalarial activity against Plasmodium falciparum and analysis photochemistry consituen from extract suruhan. Antimalarial activity test using Desjardin method. Extraction was done by using maceration wuth methanol as a solvent and fractionation using partition methods. Results of phytochemical screening revealed the presence of alkaloids, flavonoid, steroid, saponins and triterpenoid test results antimalarial activity fraction of n-hexane, ethyl acetate and water show IC50 values are 12.80, 2.90 and 10.74 mg/ mL respectively.Keyword: Peperomia pellucida, suruhan, antimalarial
Utilization of leaf and fruit extracts of kedondong (Spondias dulcis Forst) as a supporting material for energy conversion in dye sensitized solar cells and electrochemical cells Agus Malik Ibrahim; Boima Situmeang; Ahmad Rifa’i; Afif Hidayatul Mustafid
Jurnal Pendidikan Kimia (JPKim) Vol 13, No 1 (2021): April
Publisher : Pascasarjana Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (480.491 KB) | DOI: 10.24114/jpkim.v13i1.24140

Abstract

This study aims to obtain a dye sensitized solar cell (DSSC) prototype and a voltaic cell prototype using the kedondong plant (Spondias dulcis Forst). Kedondong leaves as a source of chlorophyll were deliberately chosen to be in line with the use of kedondong fruit as a material for electrochemical cells, so that two research results could be obtained from the kedondong plant. This research is for the application of scientific development, increasing the added value of kedondong plant, and as support for the use of environmentally friendly energy. Research methods in general are chlorophyll extraction, citric acid isolation, chlorophyll testing, DSSC assembly, electrochemical cell assembly, and performance testing for both DSSC and electrochemical cells. The analysis results show that typical peaks appear for the functional groups in chlorophyll at certain wave numbers. Hydroxyl (-OH) groups appear in the range of 3650 - 3200 cm-1, the C=C group at 1700 - 1500 cm-1, the C-N group at 1350 - 1000 cm-1, and the C-O group at 1300 - 1000 cm-1. Quantitative testing used a UV-Vis spectrophotometer at 645 nm and 633 nm, the results obtained were chlorophyll a was 4.52 mg/L, chlorophyll b was 8.43 mg/L, and total chlorophyll was 12.95 mg/L. The DSSC prototype performance test with a size of only 2.5 cm2, can produce a minimum voltage of 30.1 mV and a maximum of 280 mV. The electrochemical test of kedondong citric acid extract showed that the value of the electric voltage ranged from 121 to 630 mV.Keywords: Kedondong, Chlorophyll, DSSC, Citric acid, Electrochemical cells
Antioxidant Potential of Ethanol Extract from Mango Parasite (Dendrophthoe petandra) to Maintain Crude Palm Oil (CPO) Quality Ninik Triayu Susparini; Rohmatulloh; Boima Situmeang; Isna Lailatusholihah; Siti Rohmiyati
KOVALEN: Jurnal Riset Kimia Vol. 8 No. 2 (2022): August Edition
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/kovalen.2022.v8.i2.15954

Abstract

The present study aimed to determine the effectiveness of adding natural antioxidants from ethanolic extract of mango parasite (Dendrophthoe petandra) to oxidation stability of crude palm oil (CPO) during storage. The parameters tested were levels of free fatty acid (FFA), acid values, and deterioration of bleachability index (DOBI). The antioxidant activity of D. petandra extract obtained was IC50 of 6.369 ppm. Concentrations of D. petandra extract range from 200 to 1000 ppm. Based on the results, the ethanolic extract of D. petandra was able to reduce the FFA and acid value and increase the DOBI compared to the negative control. The lowest FFA levels and acid numbers were obtained from samples with addition of 1000 ppm natural antioxidants with FFA of 4.2% and acid value of 7.4 mg KOH/g, while the DOBI value increased to 1.300.
POTENSI FRAKSI ETIL ASETAT KULIT BATANG KESAMBI SEBAGAI ANTIBAKTERI TERHADAP Escherichia coli THE POTENTIAL OF ETHYL ACETATE FRACTION OF KESAMBI STEM AS ANTIBACTERIAL AGAINST Escherichia coli Afif Hidayatul Mustafid; Yeyen Maryani; Sri Agustina; Boima Situmeang
Indonesian Journal of Pure and Applied Chemistry Vol 6, No 2 (2023)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v6i2.63497

Abstract

In our previous research, ethyl acetate extract of kesambi stem bark have the highest antibacterial activity against Escherichia coli compared with n-hexane and methanol extract. In our present study, we report the antibacterial activity of fractions from ethyl acetate extract against Escherichia coli. The method of fractionation used coloumn and thin lawyer chromatography. The Antibacterial activity uses Kirby Bauer methods. The characterization of active fractions used spectrometer infrared. The result showed fractions 6 and 7 have the highest antibacterial activity with inhibition zone 11.65 and 7.1 mm. The characterization of fractions 6 and 7 showed fungtional groups C=O, O-H, and C=C. The ethyl acetate fraction has the potential as antibacterial materials.
Co-Authors Achmad Rante Suparman, Achmad Rante Afif Hidayatul Mustafid Afif Hidayatul Mustafid Ahmad Rifa’i Apriani Sulu Parubak Apriani sulu parumbak Ari Widiantoro Dian Susvira Dikdik Kurnia Fauzan Amin Firman Rezaldi Hafidz Al Asad Holisha Widiyanto Ibrahim, Agus Malik Ika Agustia Umami Indah Permata Yudha Isna Lailatusholihah Micha Mahardika Mieke H Satari Moh Adam Mustapa Muhammad Mutfi Amin Shidqi Murtihapsari, Murtihapsari Nurhayati Bialangi Radite Yogaswara Rohmatulloh Saronom Silaban Siti Rohmiyati Sri Agustina Sriwijayanti Susparini, Ninik Triayu Tati Herlina Tati Herlina Weny Nuraeni Yasmiwar Susilawati Yeyen Maryani Yuszda K. Salimi