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Indonesian Journal of Science and Technology

Vol 7, No 2 (2022): IJOST: VOLUME 7, ISSUE 2, September 2022

W. Wahyuni (Universitas Padjadjaran)
Ajeng Diantini (Universitas Padjadjaran)
Mohammad Ghozali (Universitas Padjadjaran)
Anas Subarnas (Universitas Padjadjaran)
Euis Julaeha (Universitas Padjadjaran)
Riezki Amalia (Universitas Padjadjaran)
Adryan Fristiohady (Thammasat University)
Andini Sundowo (National Research and Inovation Agency (BRIN))
Sofa Fajriah (National Research and Inovation Agency (BRIN))
Yuni Elsa Hadisaputri (Universitas Padjadjaran)
Raden Maya Febrianti (Universitas Padjadjaran)
Fauzia Azzahra (Universitas Padjadjaran)
Agung W.M. Yodha (Politeknik Bina Husada)
I. Sahidin (Universitas Halu Oleo)

Publish Date
09 May 2022

Etlingera alba (EA) is one of the endemic plants grown in Sulawesi. We determined the cytotoxic and anti-metastatic activity of isolates obtained from EA rhizome extract. IC50 value for 1,7-diphenyl-6-heptene-3-one, sitostenone, sinapyl alcohol diacetate, and sinapyl alcohol acetate were 134.59; 170 ; 128.11; and 161.96 μg/mL, respectively. The compounds also had anti-migration activity. 200-μg/mL Sitostenon exhibited the lowest migration rate (3.32%). The free bond energies of sitostenon, 1,7-diphenyl-6-heptene-3-one, sinapyl alcohol acetate, and sinapyl alcohol diacetate were -11.81; -8.25; -6.64; and -6.28 kcal/mol, respectively. All compounds were more effective in stabilizing the Matrix metalloproteinase 1 complex. Isolation from EA rhizomes have the potential to be developed as anti-metastatic for Triple-Negative Breast Cancer.

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