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All Journal Indonesian Journal of Science and Technology UNEJ e-Proceeding Majalah Farmasetika
Fauzia Azzahra
Program Studi D3 Farmasi, Politeknik Meta Industri, Jln. Inti 1 Blok C1 No 7 Lippo Cikarang, Jawa Barat, Indonesia
Computer Science & IT Education Environmental Science Medicine & Pharmacology

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EFFECT OF PARTICLE SIZE AND SURFACE CHARGE ON THE UPTAKE AND IMMUNE RESPONSE OF OVALBUMIN-ALGINATE MICROSPHERES Dewi Melani Hariyadi; Idha Kusumawati; Fauzia Azzahra
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Microspheres as one of drug and protein deliverysystem have some advantages such as producingsmall particles; protect extreme conditions andother benefits. Microspheres as one ofparticulate systems have benefits in vaccinedelivery systems for enhancing immune responsethrough several mechanisms. As vaccine deliverysystem, the particles can through phagocytosisdeliver antigens to Antigen Presenting Cells (APC)(Foged et al, 2005). Particulate antigens mightmediate the induction of both humoral andcellular immunity.The particle size, surface charge andphysicochemical properties are factors that affectthe uptake of particles from the gut. Zetapotential may also influence the drug releaseprofiles, stability and physicochemical properties.Microparticles or nanoparticle surface is a veryimportant consideration in drug delivery ystem,especially in targeting drug delivery. Surfacemodification of micro/nano-drug delivery systemsis the most common strategy to controlling theopsonization process and thus sustains thesystems for longer period in the blood stream.Zeta potential is one of important propertieswhich contribute to the effectiveness. Zetapotential can be defined as the electrokineticvalue associating a realistic magnitude of surfacecharge and its unit is usually millivolt.There are some investigations that showed thatthe surface charge of nano/microparticles has aneffect on the stimulation of the immuneresponse. Some studies showed that antigenloaded cationically charged particles could bebeneficial for gut up take (Honary S and Zahir F,2013).Peyer's patches (PP) is the main target of oraldelivery systems in the small intestine as a placefor the transport of pathogens to the lymphoidtissue. This function is carried out by M-cellswhich are located between epithelial cells,bringing antigens and microparticles measuringless than 10 μm (Lubben et al, 2001).This study used alginate microspheres containsafe and biodegradable polymer and CaCl2 nontoxic crosslinking agent produced by gelationionotropic technique by aerosolisation. Thistechnique had the advantage of spherical shape,smooth with a small particle size that meets therequirements of particle size for oral deliverysystems (Hariyadi et al, 2014). Maltodextrinlyoprotectant were found to stabilizemicrospheres (Hariyadi et al, 2015). Ovalbuminwas used as model antigen.The hemagglutination assay was used to evaluatethe formation of antibody and ability to stimulateimmune response. Uptake microspheres werestudied using fluorescent label microscopically. Inthe present study we addressed the importanceof particle size and surface charge for efficientinteractions and effect on the immune response.
In-Vitro Anticancer Activity of Chemical Constituents from Etlingera alba Poulsen against Triple Negative Breast Cancer and in silico Approaches towards Matrix metalloproteinase-1 Inhibition W. Wahyuni; Ajeng Diantini; Mohammad Ghozali; Anas Subarnas; Euis Julaeha; Riezki Amalia; Adryan Fristiohady; Andini Sundowo; Sofa Fajriah; Yuni Elsa Hadisaputri; Raden Maya Febrianti; Fauzia Azzahra; Agung W.M. Yodha; I. Sahidin
Indonesian Journal of Science and Technology Vol 7, No 2 (2022): IJOST: VOLUME 7, ISSUE 2, September 2022
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/ijost.v7i2.50547

Abstract

Etlingera alba (EA) is one of the endemic plants grown in Sulawesi. We determined the cytotoxic and anti-metastatic activity of isolates obtained from EA rhizome extract. IC50 value for 1,7-diphenyl-6-heptene-3-one, sitostenone, sinapyl alcohol diacetate, and sinapyl alcohol acetate were 134.59; 170 ; 128.11; and 161.96 μg/mL, respectively. The compounds also had anti-migration activity. 200-μg/mL Sitostenon exhibited the lowest migration rate (3.32%). The free bond energies of sitostenon, 1,7-diphenyl-6-heptene-3-one, sinapyl alcohol acetate, and sinapyl alcohol diacetate were -11.81; -8.25; -6.64; and -6.28 kcal/mol, respectively. All compounds were more effective in stabilizing the Matrix metalloproteinase 1 complex. Isolation from EA rhizomes have the potential to be developed as anti-metastatic for Triple-Negative Breast Cancer.
Daun Kelor (Moringa oleifera) : Aktivitas Tabir Surya Ekstrak dan Formulasi Sediaan Lotion Fauzia Azzahra; Vina Fauziah; Wartini Nurfajriah; Stanly William Emmanuel
Majalah Farmasetika Vol 8, No 2 (2023)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v8i2.43662

Abstract

Paparan sinar UV dapat mengakibatkan dampak negatif untuk kulit antara lain kulit terbakar, penuaan dini dan kanker kulit. Salah cara untuk meminimalisir dampak tersebut yaitu penggunaan tabir surya. Tabir surya dengan bahan filter sintetik memiliki efek samping, maka dari itu diperlukan alternatif bahan lain sebagai tabir surya. Daun kelor (Moringa oleifera) mengandung flavonoid seperti kuersetin, memiliki aktivitas antioksidan kuat yang mampu menetralkan radikal bebas, sehingga berpotensi sebagai tabir surya. Formulasi ekstrak etanol daun kelor dalam bentuk lotion dapat mengoptimalkan potensinya sebagai tabir surya. Sebelum di formulasikan dalam sediaan lotion, dilakukan penapisan fitokimia dan penentuan nilai SPF dari ekstrak Moringa oleifera menggunakan metode spektrofotometri. Formulasi sediaan lotion menggunakan ekstrak dengan konsentrasi 0,075% (F1), 0,15% (F2) dan 0,3% (F3). Evaluasi fisik yang dilakukan adalah organoleptis, daya sebar, pH dan viskositas. Pada penelitian ini didapatkan nilai SPF ekstrak daun kelor pada 250 ppm, 500 ppm dan 750 ppm yaitu 8,54 ± 0,23 (Ekstra), 16,27 ± 0,27 (Ultra) dan 23,34 ± 0,43 (Ultra) secara berturut-turut. Hasil uji daya sebar dari semua formula berada pada rentang 6,2 – 6,3 cm telah memenuhi syarat daya sebar yang baik yaitu berdiameter 5 – 7 cm. Hasil pengukuran pH dari semua formula berada pada rentang 7,29 – 7,30 dan nilai viskositas berada pada rentang 8300 – 8417 mPa.s telah memenuhi persyaratan sesuai dengan SNI 16-4399-1996. Berdasarkan hasil tersebut, diketahui bahwa ekstrak daun kelor (Moringa oleifera) berpotensi sebagai tabir surya dan dapat diformulasikan dengan baik dalam sebagai lotion. 
Co-Authors Adryan Fristiohady Agung W.M. Yodha Anas Subarnas Andini Sundowo Dewi Melani Hariyadi DIANTINI, AJENG - Euis Julaeha I. Sahidin Idha Kusumawati Mohammad Ghozali Raden Maya Febrianti Riezki Amalia Sofa Fajriah Stanly William Emmanuel Vina Fauziah W. Wahyuni Wartini Nurfajriah Yuni Elsa Hadisaputri