Majalah Patologi Indonesia
Vol 23 No 1 (2014): MPI

Aplikasi Metode Whole Chromosome Painting untuk Mendeteksi Aberasi Kromosom pada Tumor Padat

Ecie Budiyanti (Unknown)
Des Suryani (Unknown)
Jeanne Adiwinata Pawitan (Unknown)

Article Info

Publish Date
26 Nov 2015

Abstract

In solid tumor, conventional cytogenetic method usualy fails to detect chromosomal aberation due to failure in obtaining good quality metaphases. Therefore, special technique is required to get the karyotype of solid tumors. Whole chromosome painting (WCP) is a method to paint the chromosomes using Fluorescence In Situ Hybridization (FISH) technique. Application of WCP, both using one and multiple colors (mFISH or SKY) or their modifications can be used to identify chromosomal aberrations, which are valuable in helping to attain a diagnosis, to determine the prognosis and management, and to predict the response to therapy. Key words: chromosomal aberation, FISH, solid tumor, whole chromosome painting.

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Journal Info
Majalah Patologi Indonesia
Website

Abbrev

patologi

Publisher

Perhimpunan Ahli Patologi Indonesia

Subject

Health Professions Public Health

Description

Majalah Patologi Indonesia (MPI) digunakan sebagai wahana publikasi hasil penelitian, tinjauan pustaka, laporan kasus dan ulasan berbagai aspek di bidang patologi manusia. Tujuannya ialah menghadirkan forum bagi permakluman dan pemahaman aneka proses patologik serta evaluasi berbagai penerapan cara ...