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INDONESIA
Jurnal Ilmiah Manuntung
Published by SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA
ISSN : 2443115X     EISSN : 24771821     DOI : -
Core Subject : Agriculture,
Agriculture, Biological Sciences & Forestry
Jurnal Media Pertanian dipublikasikan dalam Bahasa Indonesia dan diterbitkan dua kali dalam setahun. Jurnal ini mempublikasikan artikel hasil penelitian dan artikel review bidang ilmu Agronomi secara luas. Semua tulisan yang masuk hendaknya bukanlah hasil plagiat dan belum dipublikasikan. Artikel akan di review oleh editor dan hasilnya akan di komunikasikan dengan penulis.
Arjuna Subject : -
Articles 16 Documents
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Search results for , issue "Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung" : 16 Documents clear
ANALISIS EFEKTIVITAS BIAYA KEMOTERAPI PADA PASIEN KANKER PAYUDARA DI RSPAD GATOT SOEBROTO JAKARTA Musnelina, Lili; Pontoan, Jenny; Martin, Clara Jesica
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

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Abstract

Breast cancer is a disease of malignant neoplasm which is an abnormal growth of tissue that is different from the surrounding tissue. Various used of chemotherapy in the process of achieving management in cancer that causes the use of benefits and costs. This study aims to determine a more effective therapy in breast cancer patients at RSPAD Gatot Soebroto in 2017. This study was non experimental with comparative study into two group chemotherapy is single group (chemotherapy bondronat) and combination group (chemotherapy doxorubicin-paclitaxel). This study use secondary data from medical records patients on retrospectively. The results showed a decrease in the scale of single chemotherapy (Bondronat) was 82,61% with an average direct medical cost of IDR 9,3 million where as in combination chemotherapy (Doxorubicin-Paclitaxel) 95,65% with an average direct medical cost of IDR 7,6 million. The ACER value in single chemotherapy was IDR 11,3 million and combination chemotherapy was IDR 7,9 million. The ICER value in the two treatment groups was IDR 13,5 million. The conclusion is the combination of chemotherapy of Doxorubicin-Paclitaxel is the most cost-effective than Bondronate single chemotherapy.
ANALISIS FRAGMENTASI GC-MS SENYAWA AKTIF ANTIKANKER LEUKEMIA FRAKSI KLOROFORM UMBI BAWANG TIWAI (Eleutherine bulbosa (Mill.) Urb) Lestari, Dwi; Kartika, Rudi; Marlina, Eva; Syamsul, Eka Siswanto
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

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Abstract

Tiwai Onion (Eleutherine bulbosa (Mill.) Urb.) is an Iridaceae tribe which is a typical plant of Borneo. Its used by the Dayak community, among others, for colon cancer, breast cancer, diabetes mellitus, hypertension, lowering cholesterol, strokes, boils, anti-bleeding and abdominal pain. The purpose of this study was to determine the components of anticancer compounds of chloroform fraction by GC-MS method. The results of GC-MS spectrum analysis based on the base peak equation of the chloroform fraction contain 9,12-Octadecadienoic Acid, and 1- (2,3,5,6-Tetramethyl phenyl) Ethanone which has the potential as an anticancer.
OPTIMASI CAMPURAN PATI JAGUNG DAN AVICEL PH 101 SEBAGAI BAHAN PENGHANCUR PADA TABLET EKSTRAK BUAH PARE (Momordica charantia L.) SECARA GRANULASI BASAH Saryanti, Dwi; Ismawati, Heny; Setiawan, Iwan
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

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Abstract

Bitter melon fruit (Momordica charantia L.) can be used as traditionally to reduce blood sugar levels. Avicel PH 101 and corn starch are efficacious as fillers, disintegration excipient and binders. The combination of Avicel PH 101 with corn starch is expected to be able accelerate the tablet disintegration time of tablet. This research was aimed to get the optimum formula tablets of  bitter melon extract tablets using combination of corn starch and avicel PH 101. Bitter melon extract was formulated in tablet with wet granulation method. Bitter melon extract was obtained by maceration with ethanol 70% as solvent. Tablet formula based on the Simplex Lattice Desaign method uses Design Expert software version 11 with parameters that are used weight uniformity, hardness, friability and disintegration time. The results obtained from the simplex lattice design compared with the results of testing using the SPSS 18 program using the One Sample T-Test with a confidence level of 95%. The result  of this research indicate bitter melon extract was made by tablets with wet granulation method with a combination of Avicel PH 101and corn starch, a formula with a ratio of 51% : 49% selected as the optimum formula with weight uniformity, hardness, friability and disintegration time meeting the requirements.   Keywords : bitter melon extract, tablets, corn starch, avicel PH 101, simplex lattice design  
PEMBUATAN DAN UJI SIFAT FISIK GEL ANTINYERI KOMBINASI MINYAK ATSIRI BUNGA CENGKEH ( Syzygium aromaticum(L.) Merr.&Perry ) DAN SEREH (Cymbopogon nardus L. Rendle) Purgiyanti, Purgiyanti; Tivani, Inur
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

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Abstract

Clove and lemongrass are agricultural commodities that have high economic value. One of the natural compounds produced from both and is usually obtained by distillation is essential oil. The use of clove oil and citronella oil that has often been used by the public is as an analgetics. The purpose of this study was to make an analgetics gel from a combination of essential oils of clove and citronella oil with variations in the concentration of CMC-Na as a gelling agent and to determine the gel that wasmost preferred by respondents. This research is an experimental research, the method of document collection uses qualitative and quantitative data from laboratory experiments. The resulting gel is then tested for physical properties of the preparation which includes organoleptic test, homogeneity, pH, clarity, dispersion , protection power, and adhesion. Test of preference for 10 respondents to determine the most preferred gel. The results showed that the gel combination of clove and citronella oil with 2% CMC-Na concentration was the best formula seen from the physical test and preference test.
ANALISIS RISIKO REAKSI OBAT YANG TIDAK DIKEHENDAKI PADA PASIEN HIPERTENSI GERIATRI DI RSUD ARIFIN ACHMAD PROVINSI RIAU Muharni, Septi; Pratiwi, Erniza; Iswari, Yuwanda
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

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Abstract

Adverse Drug Reaction (ADR) is every adverse event related to the use of a drug in humans. Geriatrics have a 7 times greater risk of developing ADR. Hypertension is the most common disease suffered by geriatric patients. The purpose of this study was to analyze the risk of ADR occurrence in geriatric hypertension patients and also to analyze the relationship of demographic data with the incidence of ADR. This study was carried out in an observational manner which was descriptive analytic with a cross sectional approach in 88 medical record samples of geriatric hypertension patients in inpatient installations using gerontoNET scores. Based on the ADR risk variable according to the gerontoNET score, there was 1 patient with ?4 comorbid, 45 patients had heart failure, 5 patients had liver disorders, 19 patients received 6-7 drugs and 37 patients received ?8 drugs, no patients with ADR history, and 28 patients developed kidney problems. From the results of this study, there are 37 patients who have a high risk of ADR events which are marked by gerontoNET score ?4. Based on the correlation analysis of gender and age range on ADR risk obtained a weak relationship and no significant correlation (r = 0.116, p = 0.116; r = 0.017, p = 0.847), so that gender and age in geriatric hypertension patients are not related to the risk of ADR.
FORMULASI SEDIAAN PASTA GIGI KARBON AKTIF DENGAN BASIS Virgin Coconut Oil (VCO) Maesaroh, Imas; Silviani, Silva
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

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Abstract

Activated carbon is defined as carbon that has a great absorptive capacity of anions, cations, and molecules in the form of organic and inorganic compounds, either in the form of solutions or gases. Activated carbon has been highly used for various things, mainly to absorb dirt or toxins. The pores formed on this activated carbon will bind the impurities on the tooth surface. Therefore, cleaning the yellowish substances on the teeth will be easier. The aim of this research is to make dentifrice formulation with variety of activated carbon concentrate as the active substance and Virgin Coconut Oil (VCO) as the basis to get best tooth paste formula, or to meet toothpaste quality requirement.The concentrate of activated carbon used was12.5%, 15%, 17.5%, 20% and the Virgin Coconut Oil (VCO) concentrate used was 10%, 12.5%, 15%, 17.5% , 20%. Other additives that were also used were calcium carbonate, sorbitol, glycerol, Na.CMC, saccharin, sodium benzoate, sodium lauryl sulphate, menthol and aquades. The result of research indicated that the nifty basis of VCO was F3 with 15% VCO concentrate and  15% of F1 activated carbon toothpaste formula, which fulfilled toothpaste quality requirement. This formula was used to test gray organoleptic test, delicate texture, and homogeneous. It also had a pH of 8 which was corresponding to the pH value requirement for dentifrice preparations according to SNI 12-3524-1995 ie 4.5 -10.5 and typical menthol odor and fresh taste. The toothpaste does not contain of air bubbles, separated lumps and particles, and foreign objects are not visible.
FORMULASI DAN EVALUASI LIP BALM LIOFILISAT BUAH TOMAT (SOLANUM LYCOPERSICUM L.) SEBAGAI PELEMBAB BIBIR Yusuf, Nurul Arfiyanti; Hardianti, Besse; Lestari, Indah Ayu; Sapra, Amriani
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

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Abstract

The research on formulation and evaluation of lypholized tomato (Solanum lycopersicum L) as lip balm has been conducted. The objective of this research was to investigate the physical stability of lip balm formula from lypholized tomato that could enhance the lips? humidity. The formulation of lip balm was made into three concentration i.e 1%, 3%, and 5%. The physical stability evaluations that were performed before and after stress condition. Which is included organoleptic, homogeneity, and melting point test. The stable formula was then evaluated as skin moisture enhancer using skin analyzer. The results of this research showed that all three formula was physically stable. On the third formula (lypholized concentration of 5%) had the highest percentation of moisture enhancement with the significant difference among the three formulas.
IDENTIFIKASI METABOLIT SEKUNDER DAN POTENSI ANTIDIARE EKSTRAK DAUN CINCAU (Stephania capitata (Blume) Spreng) Mentari, Ika Ayu; Hairunisa, Indah; Ibrahim, Arsyik; Fridayanti, Aditya
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

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Abstract

Indonesia biodiversity has the second highest number of indigenous medical plants after the amazon rain forest, meanwhile Indonesian people usually used plants as a medicine source and some medicine plants have been developed as modern drugs. One of medicine plant in Indonesia that usually used as a refreshment was grass jelly (Stephania capitata (Blume) Spreng). This plant frequently found in Sumatra, Borneo and Java island and the leaf of grass jelly has been reported as a medicine against stomach complaint (diarrhea) and fevers. This research was designed to investigate the secondary metabolites and the efficacy of leaf extract of grass jelly as anti diarrhea. The leaves extraction was done by using maceration with ethanol solvent at room temperature. Meyer reagent, dagendroff reagent, methanol, magnesium band, hydrochloric acid, iron (III) chloride, anhydrous acetic acid, sulfuric acid, chloroform were used for identification of secondary metabolites from grass jelly leaves. For potency anti diarrhea, animals were divided into six group: diarrhea group, treatment group with loperamid HCl and treatment group of leaf extract of grass jelly. The results showed that the leaf extract of grass jelly contain saponin, phenol, sterol and triterpen and the treatment with leaf extract of grass jelly significantly decreasing time duration of diarrhea.
ANALISIS PENGARUH KUALITAS PELAYANAN TERHADAP KEPUASAN PASIEN RAWAT JALAN DI INSTALASI FARMASI RUMAH SAKIT X KOTA SURAKARTA Sulo, Habel Roy; Hartono, Elina; Oetari, R. A.
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

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Abstract

The development and improvement of pharmacy service has become consumer concern, since this quality of service will affect on consumer satisfaction. The study aimed at assessing the level of outpatient satisfaction at Department of Pharmacy X Hospital In Surakarta City. This study was a survey research, which was conducted using questionnaire by direct interview. A total of 323 respondent were recruited conveniently in the study. The obtained data was then analyzed using Gap analysis to assess the differences in level of quality services between customer perceptions and customer expectations. The study investigates the five dimensions of service quality and identifies the gap between the perception and expectation. The data was analyzed by using SPPS for windows. In general, the result shows that service quality was lower than the expectations of the patients in the studied hospital. The study finding indicated that gap or differences exist on various dimensions between perception and expectation in level quality services. The highest service quality gap was given to Responsiveness followed by Reliability, Empathy, Tangibles and Assurance with the value of - 0,129; - 0,125; - 0,115; - 0,114; and - 0,108 respectively. Patient satisfactions was influenced by health service quality, with the assurance and responsiveness dimensions as the greatest influence on patient satisfaction.
SITOTOKSISITAS EKSTRAK ETANOL 70% KULIT JENGKOL (ARCHIDENDRON JIRINGA (JACK). I.C. NIELSEN) TERHADAP PENGHAMBATAN SEL KANKER PAYUDARA MCF-7 DAN KANKER SERVIKS HELA Noviardi, Harry; Ratu, Antonius Padua; Tri R, Diah Ajeng
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

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Abstract

Jengkol (Archidendron jiringa (Jack).I.C. Nielsen) skin for this belongs to the organic wastes that do not provide economic value. Compounds of natural ingredients on the Jengkol Skin among others, alkaloids, flavonoids, tannins, saponins, and triterpenoids. Some of the molecular structures of the compound are thought to potentially in inhibiting the growth of cancer cells. This research aimed to determine the cytotoxicity effect of 70% ethanol extract of Jengkol Skin as anticancer. Jengkol Skin was macerated in ethanol 70% then extract was concentrated with a rotary vacuum evaporator and water bath. Cytotoxicity test was carried out using cells MCF-7 (breast cancer) and HeLa cells (cervical cancer) based upon the method of MTT assay. The parameter was the value measured inhibition concentration (IC50). Extracts of the Jengkol Skin showed activity against cytotoxicity MCF-7 cells with IC50 values of 51.76 ?g/mL and for the IC50 value of HeLa cells 39.618 ?g/mL. IC50 values of the cell were less than 100 ?g/mL, indicated categories of potential cytotoxicity. The Jengkol Skin extract could be used as anticancer agents.

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