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Medicinus : Jurnal Kedokteran
  • Medicinus : Jurnal Kedokteran
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Published by Universitas Pelita Harapan
ISSN : 19783094     EISSN : 26226995     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.
Arjuna Subject : -
Articles 178 Documents
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GAMBARAN KLINIS DAN ANALISA CAIRAN SEREBROSPINAL PADA PASIEN MENINGITIS KRIPTOKOKUS DENGAN ATAU TANPA INFEKSI HUMAN IMMUNODEFICIENCY VIRUS DI RUMAH SAKIT SHLV Pricilla Yani Gunawan; Feliana Feliana; Cucunawangsih Cucunawangsih
Medicinus Vol 4, No 8 (2015): February 2015 - May 2015
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v4i8.1182

Abstract

Meningitis kriptokokus adalah infeksi sistem saraf pusat dengan onset subakut atau kronis, disebabkan oleh sel ragi berkapsul Cryptococcus neoformans. Pasien dengan MK biasanya adalah pasien imunodefisiensi/imunokompromais. Di negara-negara Asia Tenggara, penyakit infeksi oportunistik yang sering dijumpai pada pasien Human Immnunodeficiency Virus (HIV) stadium lanjut adalah MK. Meningitis kriptokokus juga ditemukan pada riwayat penggunaan steroid sistemik, terapi immunosuppresive, transplantasi organ, gagal ginjal, keganasan, penyakit reumatik, diabetes melitus, dan systemic lupus erythematosus atau bahkan pada pasien yang imunokompeten sekalipun. Penelitian ini merupakan studi deskriptif retrospektif potong lintang yakni pengambilan data rekam medis hasil pemeriksaan neurologis dan analisa carian serebrospinal (CSS) penderita MK yang dirawat di Siloam Hospitals Lippo Village dari bulan Januari 2009 hingga September 2014. Teknik pengumupulan data pada penelitian ini dengan mengumpulkan data dari rekam medis. Dari 8 subyek penelitian yang memenuhi kriteria inklusi diperoleh hasil: pasien meningitis kriptokokus dengan HIV (+) sebanyak 6 orang (75%) dan dengan HIV (-) sebanyak 2 orang (25%). Proporsi pria dan wanita sebesar 3:1. Rentang usia subyek dari 4 hingga 55 tahun dimana sebagian besar subyek penelitian berusia sekitar 20-40 tahun dengan hasil pemeriksaan HIV (+). Saat masuk rumah sakit, secara keseluruhan gejala yang paling sering ditemukan pada subyek berupa nyeri kepala (87.5%). Meskipun memiliki sejumlah kelemahan data hasil penelitian ini diharapkan dapat bermanfaat bagi perkembangan neurologi khususnya neuroinfeksi di Banten. Di masa yang akan datang diharapkan dapat dilakukan penelitian dengan skala yang lebih besar dan komprehensif.
ANTIBIOTIC SUSCEPTIBILITY IN UROPATHOGEN FROM INTENSIVE CARE PATIENTS WITH URINE CATHETER Angeline Nifiani M Wibowo; Cucunawangsih Cucunawangsih
Medicinus Vol 4, No 9 (2015): June 2015 - September 2015
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v4i9.1187

Abstract

Background: Multi-Drug Resistance Organisms (MDROs) are defined as organisms that acquired non-susceptibility to more than one antimicrobial agent. Intensive care patients are immune-compromised patients, using catheter and are given broad-spectrum antibiotics. Hence, the chance to develop microbial resistance is high. The aim of this study is to see the etiology and the microbial susceptibility pattern of catheter-associated urinary tract infection patients treated in intensive care.Materials and Methods: The urine samples were taken from catheterized patients admitted to intensive care in Siloam Lippo Village, Tangerang, Indonesia in a one year period from July 2013 until June 2014. We confirmed species identification with Vitex-2 Compact® from Biomérieux, France. The susceptibility of antibiotics is according to Clinical and Laboratory Standard Institute (CLSI). Results: We managed to get 113 urine culture results with mean of age 57.03 ± 18.505 (years). There were 67 males (59.3%) and 46 females (40.70%) that were acquired in the sample. The result of species identification showed that Escherichia coli was the dominant isolate from the urine culture (40.63%), followed by Klebsiella pneumoniae (12.5%). The percentage of MDRO was found to be 71.9%. The antibiotics susceptibility of Escherichia coli for Amoxicilin, Ampicillin/Sulbactam, Ciprofloxacin and Levofloxacin are 50%, 58%, 76% and 75% respectively. Meanwhile the susceptibility against Amikacin and Meropenem are 100% for Escherichia coli and Klebsiella pneumoniae. Conclusion: The proportion of Escherichia coli was the highest among with susceptibility of Meropenem was still high susceptibility for both gram negative and gram positive bacteria.  
Pendekatan Diagnostik Terhadap Leukemia Akut Vinson Hartoyo; Andree Kurniawan
Medicinus Vol 6, No 1 (2016): October 2016 - January 2017
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v6i1.1138

Abstract

Acute leukemia is the most common form of cancer in children, comprises approximately 30 percents of all childhood malignancies, with acute lymphoblastic leukemia (ALL) being five times more common than acute myeloid leukemia (AML)1. Despite the advance in the treatment of acute lymphobalstic leukemia, five-year event free survival rate still remain quite low in group of patient with advanced age of onset (40% or below in later age)2,3,4. A case of 17 year old girl presented with 3 day onset of profuse bleeding from her nostril, ear, gums and gastrointestinal tract (melena and hematemesis). Blood count and peripheral blood smear revealed a pancytopenia with 26% blast count lymphocyte dominant, and reticulocyte percentage of 0.26% which is signalling a bone marrow failure. The patient was planned to undergo a bone marrow transplant before finally died on third day of care.
Heart Involvement in Systemic Lupus Erythematosus Andree Kurniawan; Nata Pratama Hardjo Lugito
Medicinus Vol 6, No 2 (2017): February 2017 - May 2017
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v6i2.1143

Abstract

Pericardial effusion is considered as one of criteria to diagnose systemic lupus erythematosus (SLE) based on American Rheumatism Association (ARA) criteria. There is limited data about the incidence and characteristic pericardial effusion in SLE patients in our country. The aim of this study is to report and assess the incidence of and characteristic heart involvement in SLE. This is cross-sectional study conducted in secondary referral hospital in Tangerang county, west part of Jakarta, capital city of Indonesia. We evaluated from medical record and echocardiogram data from 2013-2015 patients diagnosed with SLE according to ARA criteria. From 33 SLE medical records reviewed, we found 13 patients (40%) with pericardial effusions. All patients were in active stage. Clinical assessment and transthoracic echocardiogram were used to diagnose pericardial effusions. Eighty percent pericardial effusion positive patients had minimal effusion. The others had moderate effusion. No tamponade patients were recorded. Ninety six percent patients were female with median age 24(13-51) years old. Three patients were reported having pulmonary arterial hypertension. One patient had thrombus in left ventricle. All patients had clinical symptoms of cardiac such as heart failure and chest pain. For the conclusion, the incidence of pericardial effusion in SLE patient was 40 percent. Eighty percent patients had minimal effusion. All patients had cardiac symptoms related.
Manifestasi Okular dan Non Okular Sindrom Rubella Kongenital Pada Penderita Katarak Kongenital Josiah Irma; Iwan Sovani; Maya Sari Wahyu; Feti Karfiati
Medicinus Vol 6, No 3 (2017): June 2017 - September 2017
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v6i3.1148

Abstract

Background: Maternal infection with rubella in the first trimester of pregnancy result in congenital rubella syndrome (CRS). It caused blindness, deafness, congenital heart dissease and mental retardation. One of the main cause of blindness in CRS is congenital cataract. Infant affected with CRS worldwide estimated 238.000 each year and 46.000 live in South East Asia.Objective: This study aimed to looked for other ocular and non ocular manifestation from 0-11months old congenital cataract infants based on World Health Organization (WHO) CRS case definiton: suspected, clinically confirmed and labaratory confirmed.Methods:This is a retrospective observational study. We colected all data from computer base medical record, patient with congenital cataract 0-11 months old that came to Pediatric Ophthalmology unit Cicendo Eye Hospital from January 2012 until December 2013. Age, sex, laterality, axial length, cataract morphology, retinopathy pigmentary, cardiac dissorder, hearing impairment, mental dissorder and laboratory serology rubella for IgM and IgG were recorded.Results: We found ninety three patients diagnosed with CRS from congenital cataract cases. Ocular manifestation include microphthalmia in 63 eyes (33.9%), microcornea in 30 eyes (16.1%), and pigmentary retinopathy in 1 eye (0.5%) . The most common type of cataract morphology was nuclear type (49.9%.). Non-ocular manifestation include cardiac dissorder in 16 cases (17.2%), hearing impairment in 1 case (1.1%) and mental retardation in 6 cases (6.4%). Case definition based on WHO criteria were 93 cases (100%) for suspected, 20 cases (25.8%) for clinically confirmed and 15 cases (42,8%) for laboratory confirmed.Conclusion: Ocular manifestation for CRS in congenital cataract 0-11 months old were microphthalmia, microcornea, pigmentary retinopathy. Other manifestation found were cardiac disorder, hearing impairment and mental retardation.
Aspek Histopatologik Adenokarsinoma Prostat Erna Kristiani
Medicinus Vol 5, No 2 (2016): February 2016 - May 2016
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v5i2.1166

Abstract

Introduction: Prostate carcinoma is the second most common tumor in male, 95% in which made up from adenocarcinoma. The diagnosis of prostate adenocarcinoma through a needle biopsy specimen plus the determination of tumor staging are paramount in selecting the therapy and management. This study is done to know the morphologic variation of prostate adenocarcinoma in the needle biopsy as well as to measure the grading compatibility between the needle biopsy and prostatectomy using Gleason scoring system.Materials and Method: This retrospective study is conducted through form and specimen slides compilement. The specimens, consisting of prostate adenocarcinoma’s needle biopsy and prostatectomy, were gathered from the archives of Pathological Anatomy Departement, Faculty of Medicine, University of Indonesia in the year of 2008-2013. The slides were re-read and the morphologic appearance’s variation was valued. Gleason scoring was also executed from the pairing specimen according to International Society of Urological Pathology (ISUP) 2010.Result: Out of 114 needle biopsy cases, the morphologic variation was found to be perineural invation (n=38), mucinous fibroplasia (n=1), glomerulation (n=1), mucinous basophilic (n=25), and eosinophilic crystal (n=5). The amount of patient that was performed both specimen is 11, and there is a compatibility between biopsy score and prostatectomy as much as 63.63% and the median is 7.Conclusion: It is requisite to know the morphological variation in prostate adenocarcinoma in the biopsy needle specimen to get an accurate diagnosis. Undergrading in biopsy specimen is as much as 36.36%, owing to the fact that prostate carcinoma can be manifested as mutifocal lesion, thus the higher grading can only be found in prostatectomy specimen, for the needle biopsy was inadequately taken.Keywords: prostate adenocarcinoma, morphological view, Gleason score
Clinical Characteristic of Young Indonesian Colorectal Cancer Patients: A Preliminary Study Nata Pratama Lugito
Medicinus Vol 5, No 3 (2016): June 2016 - September 2016
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v5i3.1171

Abstract

Introduction: Colorectal cancer (CRC) is generally a disease of persons aged above 40 year-old. Controversies still exist regarding clinical characteristics of CRC in young persons. The aim of this study is to know the clinical characteristics of young CRC patients in Siloam General Hospital, Karawaci, Banten.Material And Methods: A total of 14 patients with diagnosis of CRC from December 2013 to January 2014 in Siloam General Hospital, Karawaci, Banten were studied cross – sectionally.  The symptoms and signs, family history of cancer, diabetes, location of mass were collected and evaluated.Results: There were 5 (35.7%) cases of CRC patients aged below 40 year-old (young patients) and 9 (64.3%) above 40 years-old (old patients). The most common symptom was constipation followed by bloody diarrhea i.e. 57.1% and 42.9% consecutively. Constipation occurred in 2 and 6 young and old patients consecutively and in 3 and 3 young and old patients consecutively. In young patients, 2 (14.2%) had a history of cancer in the family compared to none in the old patients. According to the location of tumor in the colon 4 (28.5%) were in ascending colon with 2 and 2 in young and old patients consecutively, 3 (21.7%) were in descending colon with 2 and 1 in young and old patients consecutively, 8 (57.1%) were in rectum with 2 and 6 in young and old patients consecutively. One young patient had diabetes, and one other young patient had positive Clostridium difficile antigen and toxin.Conclusion: Approximately 35.7% cases CRC patient in our hospital was of young patients. Two patients were having family history of cancer. The location of mass was not specific for young CRC patients.Key words: colorectal cancer, young patients
Pengaruh P53 Dan YY1 Terhadap Terjadinya Kanker Serviks Jacobus Jeno Wibisono
Medicinus Vol 5, No 1 (2015): October 2015 - January 2016
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v5i1.1177

Abstract

Cervical cancer is one of the most prevalent cancer in the world and caused by Human Papilloma Virus (HPV). The pathogenesis of cancer as whole (50%) is caused by gene mutation. HPV stimulates carcinogenesis on cervix epitel cells by HPV-Encoded viral oncoproteins, E6 and E7, which will inhibit tumor suppressor gene activation, such as p53 gene. HPV-encoded E6 oncoprotein  is able to directly attached on p53 causing degeneration via E6-AP-mediated ubiquitination pathway. Moreover, overexpression on YY1 gene has significant role on the progression of HPV on cervical cancer. YY1 inhibits p53 activation dan inhibits apoptosis on cells infected by HPV. Overexpression of YY1 induces reduction of endogenous p53, which will inhibit p53 function as tumor suppressor gene.Keywords: cervical cancer, HPV, P53, YY1
Hubungan Indeks Massa Tubuh dengan Lemak Tubuh dan Distribusi Tekanan Plantar saat berdiri dan berjalan pada anak usia 8-10 Tahun Stefanus Satria Sumali; Sasanty Kusumaningtyas; Tirza Z Tamin
Medicinus Vol 4, No 8 (2015): February 2015 - May 2015
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v4i8.1183

Abstract

Indeks massa tubuh (IMT) merupakan parameter seorang anak kurus, normal, gemuk ataupun obese. Kegiatan anak mempengaruhi kadar lemak tubuh karena konsumsi karbohidrat yang berlebihan tanpa disertai aktivitas yang seimbang menyebabkan penumpukan lemak sebaliknya bila energi tersebut tidak dapat memenuhi kebutuhan maka lemak akan digunakan untuk memenuhi kebutuhan tersebut yang mengakibatkan berkurangnya kadar lemak tubuh. Demikian juga dengan distribusi tekanan plantar karena anak obese dengan aktivitas rendah, tekanan plantar lebih tinggi dibandingkan anak obese dengan aktivitas tinggi sehingga aktivitas subyek penelitian harus dihomogenisasi untuk memperoleh hasil yang akurat. Penelitian ini bertujuan untuk mengetahui hubungan IMT (kurus, normal, gemuk dan obese) dengan lemak tubuh dan distribusi tekanan plantar saat berdiri dan berjalan pada anak usia 8-10 tahun. Metode : desain penelitian adalah observasional cross sectional / potong lintang dengan jumlah 33 anak sebagai subyek penelitian dengan lifestyle sedentary. Penelitian dilakukan dengan mengukur kadar lemak tubuh menggunakan timbangan Tanita dan puncak tekanan (peak pressure) dengan menggunakan alat Matscan. Tekanan plantar diukur saat berdiri dan berjalan. Anak dengan IMT gemuk mempunyai korelasi yang kuat dengan lemak tubuh (r=0,6333) dan anak dengan IMT obese  mempunyai korelasi yang sangat kuat  terhadap lemak tubuh (r=0,8) sedangkan anak dengan IMT kurus juga mempunyai korelasi terhadap lemak tubuh tetapi korelasinya lemah (r=0,2582). IMT juga berhubungan dengan distribusi tekanan plantar saat berdiri dan berjalan terutama daerah midfoot sedangkan untuk anak kurus ditemukan adanya peningkatan tekanan pada daerah hindfoot sewaktu heelstrike. IMT berhubungan dengan kadar lemak tubuh dan distribusi tekanan plantar terutama pada anak dengan IMT gemuk dan obese. 
GASTROINTESTINAL STROMAL TUMOR Jeremy Sebastian; Lucky Faizal Sobarna
Medicinus Vol 4, No 9 (2015): June 2015 - September 2015
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v4i9.1188

Abstract

Latar Belakang: Gastrointestinal Stromal Tumor (selanjutnya disebut GIST) adalah salah satu jenis neoplasma pada jalur gastrointestinal (GI) yang paling sering. Penyakit ini sering diketemukan secara tidak sengaja pada pemeriksaan radiologis, walaupun pada tumor berukuran besar gejalanya lebih nyata. Karena itu kami mengangkat topik ini dengan tujuan agar rekan – rekan petugas kesehatan dapat mengenali penyakit ini dengan lebih baik.Metode: Wanita 52 tahun dirawat dengan keluhan BAB berdarah menahun. Endoskopi menunjukkan adanya divertikel pada jejunum dan CT scan memperlihatkan adanya massa tumor di dinding ileus. Pada pasien kemudian dilakukan tindakan reseksi tumor. Paska operasi tidak ditemukan adanya komplikasi pada pasien dan tidak terdapat tanda – tanda rekurensi tumor.Diskusi: Penanganan GIST memerlukan pendekatan multidisiplin. Tumor yang terlokalisir memerlukan operasi sebagai terapi utama. Terapi adjuvant menggunakan imatinib diperlukan untuk mencegah rekurensi. Sedangkan pada tumor yang sudah berkembang atau sudah mengalami metastasis, imatinib merupakan terapi utama. Tindakan operasi pada tahap ini masih dipertimbangkan untuk mengurangi efek massa. Follow up pada pasien dilakukan secara berkala dan lamanya tergantung pada faktor prognosisnya.

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