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MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan
Published by Universitas Muhammadiyah Semarang
ISSN : 24070505     EISSN : -     DOI : https://doi.org/10.26714/magnamed
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Magna Medica is a medical journal of APKKM contains papers and scientific articles created as a form of realization Tridharma college. The journal is published every six months, April and October of three articles in the form of: - Research article - Case report - Literature review The scope of this journal is all the field of medicine such as: -Internal medicine (including Pulmonary medicine and cardiovascular medicine) -Surgery (including urology, orthopaedic and traumatologic, plastic surgery, neurosurgery) -Anesthesia and Emergency Medicine -Neurology -Dermatology -Obstetric and Gynecologic -Forensic and Medicolegal -Clinical Pathology -Anatomical Pathology -Psychiatric -Ophthalmology -Otolaryngology -Pediatric -Radiology -Microbiology and parasitology -Basic Science of Medicine (including biochemistry, physiology, anatomy and Histology) -Public health and Health Management
Arjuna Subject : Kedokteran - Review dan Referensi, Kedokteran
Articles 13 Documents
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Search results for , issue "Vol 10, No 1 (2023): February" : 13 Documents clear
Association Between LMP-1 and p16 Expression with Prognostic Factor of Nasopharyngeal Carcinoma Rizki Widya Nur; Vega Karlowee; Awal Prasetyo
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 10, No 1 (2023): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.10.1.2023.9-18

Abstract

Background:  LMP-1 and p16 expression are potential biomarkers for nasopharyngeal prognostic factors. EBV interferes with intracellular signaling processes related to cell cycle regulation and LMP-1, inactivating p16 expression and increasing cell proliferation. LMP-1 has been also reported to remove the promoter of p16 via methylation and inactivation of the p16 gene leads to uncontrolled proliferation of cell tumors.Objective: To analyze the association between LMP-1 and p16 expression with prognostic factors of nasopharyngeal carcinoma.Methods: This is a cross-sectional design analyzed that LMP-1 and p16 expression based on immunostaining of nasopharyngeal carcinoma. The patient clinical data used as prognostic factors are histopathological type, quality of life, TNM, and tumor stage. Statistical analysis used chi-square and spearman correlation.Results: Of the 61 patients, 49 were non-keratinizing carcinoma, undifferentiated type (80,3%). About 54 (88.5%) of the 61 samples are LMP-1 positive, 47 of which were non-keratinizing carcinoma. We figured out the significant association between the p16 expression with lymph node involvement (p=0.026) and staging (p = 0.196) in nasopharyngeal carcinoma.  No correlation between LMP and p16 expression (p=0,134) (r=-0,194).Conclusion: p16 overexpression is associated with lymph node involvement and advanced stage in nasopharyngeal carcinoma
Relationship of Exclusive Breastfeeding with The Incidence of Acute Respiratory Infections in Toddlers at The Ringinarum Health Center Kendal Regency Izza Alya Ardana Putri; Astin Prima Sari; Ika Dyah Kurniati
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 10, No 1 (2023): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.10.1.2023.60-66

Abstract

Background: Acute Respiratory Infection (ARI) is an acute infection affecting the nose, paranasal sinuses, pharynx, trachea, bronchi, lungs, and epiglottis. ARI is the main cause of mortality and morbidity in toddlers in the world. The incidence of ARI can be prevented by exclusive breastfeeding.Objective: To prove the correlation of exclusive breastfeeding with the incidence of ARI in toddlersMethods: This case-control study conducted on December 2021 at the Ringinarum Health Center Kendal Regency. Sampling was conducted by purposive sampling method and was conducted based on inclusion and exclusion criterias.Results: The total samples obtained in this study were 124 samples. This study showed that the characteristics of toddlers with ARI among others the most frequent age is 24-35 months (30,6%), most of them were male (61,3%) and weren’t exclusively breastfed (69,4%). Futhermore, this study also found that there was a correlation between exclusivity of breastfeeding and the incidence of ARI in toddlers (p<0,05). Toddlers who weren’t exclusively breastfed had 5,5 times greater risk of ARI than those who were exclusively breastfed (OR>1).Conclusion: There is a correlation between exclusive breastfeeding with the incidence of acute respiratory infections in toddlers.
The Correlation Between Light Intensity, Age, And Working Period With Eye Fatigue In Computer Users Raden Ayu Tanzila; Dinda Arista
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 10, No 1 (2023): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.10.1.2023.1-8

Abstract

Background: In the 21st century, many jobs involve using computers, estimated at around 75%, and there are 90 million adults who use computers daily. The use of technology often results in harmful effects, mainly if it is not appropriately managed. Factors affecting eye fatigue are work equipment, work environment (light intensity), work design, work duration, individual characteristics (age), or refraction.Objective: This study aims to determine the correlation between light intensity, age, and work duration with eye fatigue complaints in computer users at PT Bank X Palembang.Methods: This research is analytically observational. The population was all computer users at PT Bank X Palembang. Sampling was conducted in 40 samples that met the inclusion and exclusion criteria. Data were obtained by questionnaires and measuring lux meters. Data were analyzed bivariate using the chi-square test.Results: showed that 24 respondents (60%) worked with poor light Intensity and 27 respondents (67.5%) complained of eye fatigue. Based on statistical tests, there was a significant correlation between light Intensity (p = 0.027), there was no significant correlation between age (p = 1.000) and years of services (p = 1.000), and complaints of eye fatigue in user's computers at PT Bank X Palembang.Conclusion: poor light intensity can cause eye fatigue in computer users.
The Effect of Citrus amblycarpa Hassk Extract Against Rattus norvegicus Body Weight with High-Fat Diet Roselina Panghiyangani; Juliyatin Putri Utami; Lena Rosida; Dewi Indah Noviana Pratiwi
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 10, No 1 (2023): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.10.1.2023.67-72

Abstract

Background:  Obesity is a complex disease that is generally accompanied by insulin resistance and increased oxidative stress and the expression of inflammatory markers that contribute to the accumulation of body fat mass. Lemons contain high levels of flavonoids and essential oils so that they have the potential to control appetite and play a role in fat breakdown. Purpose: to determine the effect of Citrus amblycarpa Hass extract on weight loss of rats fed a high-fat diet.Objective: Rattus novergicus Wistar strain aged 2-3 months and randomly divided into 6 groupsMethods: The dried Citrus amblycarpa Hass peel was extracted by maceration method with 70% ethanol as solvent. Variations in the dose of Citrus amblycarpa Hass peel extract given were 200, 300 and 400 mg/kg BW. There were 6 groups of treated rats with 30 rats total sample. The weight of the mice from each treatment group was measured for 6 weeks and then the average body weight of each group was analyzed using Kruskall Wallis with the Mann-Whitney further test.Results: The data showed that administration of Citrus amblycarpa Hass peel extract had a significant effect on weight loss of Wistar rats fed a high-fat diet with p= 0.00 (p <0.05). The average body weight of the 300 mg/kg BW and 400 mg/kg BW extract treated rats was significantly different from the control group that was not given the C. amblycarpa Hass peel extract, but the average body weight in the 200 mg/kg BW dose group did not show a significant difference.Conclusion: There is an effect of C. amblycarpa Hass peel extract in reducing the body weight of Wistar rats fed a high-fat diet significantly at doses of 300 mg/kg BW and 400 mg/kg BW.
Effects of The Combination of Seluang Fish (Rasbora spp.) and Pasak Bumi (Eurycoma Longifolia Jack) on Systemic Inflammation and Neurotransmitter in Stunting Model Rat (Rattus Novergicus) Didik Dwi Sanyoto; Hendra Nur&#039;amin; Triawanti Triawanti; Dimas Ikhsan Airlangga; Gastin Gabriel Jangkang
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 10, No 1 (2023): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.10.1.2023.27-39

Abstract

Background:  Stunting causes growth and development issues which are characterized by a systemic inflammatory response and neurotransmitter disorder. The South Kalimantan natural resources i.e. extracts of Pasak Bumi (Eurycoma longifolia Jack) and seluang fish have the potential as a modified therapy for stunting management.Objective: To analyze the effect of Pasak Bumi and seluang fish administration in overcoming systemic inflammation and neurotransmitter disorders in the stunting rats model.Methods: Rats were divided into six group i.e Positive Control (KP): Stunting rats + placebo + standard feed; (P1): stunting rats + 70% EPB 15 mg/kg body weight (BW) + standard feed; (P2): Stunting rats + DHA 1 mg/kg BW + standard feed; (P3): Stunting rats + EPB 15 mg/kg BW + DHA 1 mg/kg BW + standard feed; (P4): Stunting rats + seluang fish; (P5): Stunting rats + EPB 15 mg/kg BW + seluang fish for 5 weeks; Parameters measured were levels of IL-6, TNF-α, and serotonin.Results: There were significant differences in levels of TNF-α (p = 0.000) and serotonin (p = 0.000).Conclusion: The administration of Pasak Bumi extract and seluang fish was able to inhibit systemic inflammation and neurotransmitter dysregulation.
The Impact of the Covid-19 Pandemic on Eating Behavior among Adults Poles Agnieszka Panasiuk; Kamil K. Hozyasz
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 10, No 1 (2023): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.10.1.2023.73-92

Abstract

Background: Due to the outbreak of coronavirus disease (COVID-19), many restrictions and temporary lockdown were carried out. As a result, previous lifestyle, including diet, were disrupted.Objectives: The aim of this review was to assess changes in eating behavior during the COVID-19 compared to the period before pandemic in Poland. Methods: In the review involved original studies concerning adults Poles (aged ≥ 18), including changes in their eating behavior.Results: The COVID-19 pandemic and the social isolation periods had ambiguous influence on diet in Poland. The changes were dependent on many factors e.g. age, sex, education, occupation, or body weight. In general, regular diet pattern was followed. In case of changes, positive and negative eating habits were observed. Improper eating behavior such as the increase of total food and junk food intake was noticed, however improvement of the diet also was observed. Consumption of healthy food, such as vegetables and fruit went up. The significant increase of home cooking also was noticed.Conclusions: The present review indicates the need for future strategies to assess nutrition in cases of alarming situations. Promoting healthy eating behavior appears to be essential, especially during the pandemic.
Diabetic Wound Healing Activity of Anabas testudineus Fish Scales Erwin Rosadi; Lia Yulia Budiarti; Bhisma Ridho Romadhon; Nida Nurkhalishah; Nur Salsabila Apriliani Risma Putri; Nur Azmina Aisyah; Isnaini Isnaini
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 10, No 1 (2023): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.10.1.2023.40-47

Abstract

Background:  Anabas testudineus fish scales are part of the fish that has not been used optimally. Fish scales contain chitin. Chitin which undergoes deacetylation, produces chitosan. Chitosan is an efficacious compound for antibacterial and diabetic wound healing.Objective: This study aimed to extract chitosan from fish scales and test the diabetic wound healing activity of fish scale extract gelMethods: Extraction of fish scales using 0.3 M NaOH, 0.55 M HCl, and 50% NaOH. FTIR will analyze the extraction results to see the functional groups of the extract. Activity test of fish scale extracts diabetic wound healing gel was carried out on Rattus novergicus Wistar strain for 14 days. There were five treatments: negative control, positive control given octenillinR, and fish scale extract gel conc. 5%, 10%, and 15%.Results: The results showed that the fish scales extract contained chitosan, and gel extract fish scale conc 5% have diabetic wound healing activity better than 10% and 15%. Conclusion: A. testudineus fish scale extract contains chitosan, as seen from the FTIR results.
Sedentary Lifestyle Phenomenon and Obesity Risk on Students at School and College during Transitions from Conventional School to Online School Diana Putri Wibowo; Kartika Prahasanti; M. Reza Utama; Aprilia Paramitasari; Absa Secka
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 10, No 1 (2023): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.10.1.2023.93-108

Abstract

Background: Online School was actively carried out during the COVID-19 pandemic in order to reduce social interaction, minimize outdoor activities, and decreasing airborne virus transmission. This activities mainly uses virtual media. During activities, students are advised and ordered to stay inside their house, which causes reduction towards physical activities. Said actions, causes a significant change in their lifestyle and can increase the risk of obesity.Objective: To find out the phenomenon of obesity in conventional education school students, from elementary to high school, during the transition from face-to-face learning to long distance learning.Methods: Reviewing several published scientific articles regarding the phenomenon of increased risk of obesity due to online school during the COVID-19 Pandemic.Results: There is a relationship between online school that increased risk of obesity where are sedentary behavior, stress, and diet. This is because online school makes decreased physical activity, increased screen time, irregular sleep patterns, and stress. This can be experienced by any students.Conclusion: Online learning during the COVID-19 pandemic is proven to escalate risks in students becoming obese, according to an additional increase in their sedentary lifestyle. Hence a modification in their lifestyle and routine is highly needed. 
Effectiveness of Bitter melon (Momordica charantia L) Extract on Growth of Trichopyton rubrum: In Vitro Study Vika Pangesty; Ika Dyah Kurniati; Kanti Ratnaningrum
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 10, No 1 (2023): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.10.1.2023.19-26

Abstract

Trichophyton rubrum is type of fungus that most often causes superficial fungal infections. Development of herbal ingredients as antifungal therapy is carried out to find alternative therapies for fungal infections. Bitter melon contains various compounds that have potential to be used as antifungals, including flavonoids and saponins. The aim of this study was to determine the effect of bitter melon extract (Momordica charantia L) on the growth of Trichopyton rubrum. This study used bitter melon extract at concentrations of 5%, 25%, 50%, 75% and 100%. Ketoconazole concentrations of 2% was used as a positive control. Pure cultures of Trichopyton rubrum were diluted using physiological NaCl. Fungal growth was observed microscopically and macroscopically. Results showed that Trichopyton rubrum grew at a concentration of 5% while at concentrations of 25%, 50%, 75% and 100% there was no Trichopyton rubrum growth. Bitter melon extract at a concentration of 25% had similar effect as ketoconazole 2%. Conclusion Bitter melon extract at concentrations of 25%, 50%, 75% and 100% had a similar effect to 2% ketoconazole in inhibiting the growth of Tricophyton rubrum.
Mature Teratoma of The Lung : A Case Report Priangga Adi Wiratama; Alphania Rahniayu; Vira Yasmina Ramadhani
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 10, No 1 (2023): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.10.1.2023.109-116

Abstract

Background:  Mature teratoma is a germinal cell tumor that is commonly found in ovaries and testis. Mature teratoma in the lung region is a rare case. According to the literature there are only 67 cases worldwide starting from 1939 to 2007. There were one cases in Dr. Soetomo general hospital during January 2013 – December 2017.Objective: Mature teratoma in the lung region is a rare case. Presenting in a case report would be beneficial for pathology databaseCase Presentation: A 19 years old man came to hospital with shortness of breath within 3 months ago. It was followed with hemoptysis, trichoptysis and coughing out tooth. CT Scan examination showed an irregular walled cavity with semisolid component and calcification along with a description of "air cresent sign". In thoracotomy tumor excision obtained multilobulated mass size 8.5x6,8x5,6 cm, yellowish-gray white color, and firm consistency. There were also hair and tooth components. The microscopic representation shows pieces of lung tissue with tumor growth coated with squamous epithel with a stroma containing adnexal skin glands, fatty tissue, cartilage tissue, and serous glands (asinar). Discussion: Mature teratoma of the lung is one of the rare tumors, with symptoms of chest pain, hemoptysis, and trichoptysis. Mature teratoma of the lung is generally cystic and multiloculated, but can also be solid, encapsulated. On microscopic examination, shows a picture of various components of ectoderm, mesoderm and endoderm.Conclusion: Mature teratoma of the lung is a rare tumor. Diagnosis was based from clinical findings, radiologic examination, and confirmed with histopathology and immunohistochemistry.

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