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Journal of Pharmaceutical and Medicinal Research Sekolah Tinggi Ilmu Farmasi Makassar Perintis Kemerdekaan Street KM 13.7 90242 Makassar-Indonesia
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INDONESIA
Journal of Pharmaceutical and Medicinal Sciences
Published by Sekolah Tinggi Ilmu Farmasi Makassar
ISSN : 25282824     EISSN : 2580328X     DOI : -
Core Subject : Health,
Medicine & Pharmacology
The Journal of Pharmaceutical and Medicinal Sciences (JPMS) pISSN 2528-2824; eISSN 2580-328X dedicated to publish original research papers, original research notes, invited topical reviews, mini-reviews, editorial commentary and news. Medicinal resources about exchange of information and understandings about people's use of plants, fungi, animals, microorganisms, minerals, their biological and pharmacological effects based on the principles established through international conventions. Pharmaceutical including drugs, pharmacokinetics, biopharmaceutics, pharmacodynamics, pro-drug developments, metabolic disposition of bioactive agents, dosage form design, protein-peptide chemistry and biotechnology specifically as these relate to pharmaceutical technology and targeted drug delivery.
Arjuna Subject : -
Articles 90 Documents
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Physical Stability Profile Of Curcuma xanthorrhiza Roxb Extract Gel With Various Carbomer® 940 Concentration Jainer Pasca Siampa, Abdul Halim Umar, Muhammad Afif
Jurnal Farmasi dan Ilmu Pengobatan Vol 1 No 2 (2016): JPMS
Publisher : STIFA Makassar

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Abstract

Curcuminoid is a compound contained in turmeric (Curcuma xanthorrhiza Roxb) that act as antioxidants, anti-inflammatory, hepatoprotective and antibacterial. This research aimed to obtain a gel formula from ethanol extract of Curcuma xanthorrhiza Roxb that has good physical stability by using Carbomer® 940 as a gelling agent. Gel made in six formulas with extract and various concentration of Carbomer® 940 and evaluated physically such as organoleptic, homogeneity, viscosity, pH, spreading power, and adhesion before and after accelerated test. The data were analyzed using paired T-test. The result showed that formula 6 with 2% Carbomer is the best and physically stable before and after the stress condition. Formula 6 showed a homogeny gel with brownish yellow color, specific odor, texture soft and viscous. The value of viscosity, pH, spreading power, and adhesion respectively was 185,000 mPas; 6.8; 6.8 cm; and 44.16 seconds
Identifikasi dan Eksplorasi Etnomedisina pada Suku Samin di Kabupaten Bojonegoro, Jawa Timur Alifia Putri Febriyanti , Siti Jazimah, Praditya Widya Pariwara
Jurnal Farmasi dan Ilmu Pengobatan Vol 1 No 2 (2016): JPMS
Publisher : STIFA Makassar

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Abstract

Indonesia merupakan negara yang kaya akan sumber daya alam, yang dapat digunakan sebagai obat tradisonal. Beberapa cara pengobatan hilang karena metode pengajarannya secara lisan dan empiris menyebabkan berkembangnya etnomedisin di Indonesia. Pengobatan tradisional identik dengan masyarakat asli (suku). Salah satu suku di Indonesia adalah suku Samin, yang masih menggunakan pengobatan tradisional seperti pengolahan bahan dari tanaman, hewan, dan bahan lain yang dapat dikembangkan untuk pengobatan modern. Tujuan dilakukan penelitian ini adalah mengidentifikasi dan mengeksplorasi cara penggunaan tumbuhan, hewan, dan bahan lain yang dimanfaatkan Suku Samin sebagai bahan obat tradisional. Pengambilan data dilakukan dengan menggunakan metode wawancara dengan alat kuisioner, dan didapat hasil berupa nama tanaman, hewan, dana bahan lain yang digunakan serta cara pakainya dalam pengobatan tradisional di Suku Samin. Dari hasil penelitian dapat disimpulkan penggunaan obat tradisional pada masyarakat Suku Samin Bojonegoro dari 40 narasumber telah diidentifikasi 19 jenis penyakit dengan 21 tumbuhan, 4 jenis hewan dan 4 bahan mineral alam. Bahan-bahan yang digunakan sebagai obat tradisional oleh Suku Samin sebagian besar sudah diteliti dan mempunyai khasiat obat, sehingga memiliki prospek untuk dikembangkan menjadi bahan baku industri obat tradisional. Cara penggunaan tumbuhan, hewan, dan bahan mineral pada Suku Samin sebagai obat tradisional sangat sederhana antara lain: campuran bahan atau bahan tunggal ditumbuk, diremas-remas, atau direbus kemudian diminum atau dioleskan pada bagian tubuh yang sakit.
Uji Aktivitas Antioksidan Ekstrak Etanol Daging Buah Asam (Tamarindus indica L.) Asal Kota Bima Nusa Tenggara Barat Dengan Metode DPPH Imrawati, Muzakkir Baitz, Mar’atun Jannah
Jurnal Farmasi dan Ilmu Pengobatan Vol 1 No 2 (2016): JPMS
Publisher : STIFA Makassar

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Abstract

Antioxidant are compounds neutralizing free radicals. Based on the previous research, in the flesh of tamarind fruit contains flavonoids that act as antioxidant. This research aimed to determine the antioxidant activity on the extract of tamarind fruit flesh (Tamarindus indica L). Antioxidant activity was done using the reduction method of free radicals by DPPH (1,1- DiPhenyl-2-Picryl Hidrazil). Antioxidant assay of the tamarind fruit flesh extract was measured using UV-VIS Spectrophotometer at the maximum wavelength 0f 515,23 nm with various concentrations of 50, 100, 200, 250 and 300 ppm. The comparison used was quercetin with concentrations of 1, 2, 3 and 5 ppm. The calculation showed that the tamarind fruit flesh has antioxidant activity with IC50 values 740,833 µg/mL and the quercetin has IC50 values 1,045 µg/mL.
Formulasi Losio Emolien dari Ekstrak Etanol Sarang Semut (Myrmecodia pendens) dengan Menggunakan Emulgator Anionik dan Nonionik Astri Syamsuddin, Iskandar Zulkarnain, Nursiah Hasyim
Jurnal Farmasi dan Ilmu Pengobatan Vol 1 No 2 (2016): JPMS
Publisher : STIFA Makassar

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Abstract

Myrmecodia (Myrmecodia pendens) is an epiphytic plant with several active chemical constituents as antioxidants including flavonoids, tocopherol, and tannins. This research aimed to obtain the formula of emolien lotion of the ethanol extract was obtained by soxhletation method using ethanol 96%. In the initial stage of formulation the emulsifier used was first optimized, then formulated and tested its physical stability, such as other organoleptic test, pH, homogeneity, emulsion type, creaming, dispersiibility, viscosity, and the determination of the type of flow before and after the stressed conditions. The data obtained were processed by anova two replication in Microsoft Excel worksheet 2010. The result of myrmecodia extraction were obtained the rendamen of 26,00078%, while the result of the optimization showed that TEA-Stearat 3-7% and Tween 80-Span 80 5% more stable. The results of stability test showed that the anionic emulsifier formula (TEA-Stearat 3-7%) and nonionic emulsifier (Tween 80-Span 80 5%) were physically stable.
Formulasi Emulgel Antiinflamasi dari Ekstrak Temulawak (Curcuma xanthorrhiza Roxb) Radhia Riski, Abdul Halim Umar, Rismadani
Jurnal Farmasi dan Ilmu Pengobatan Vol 1 No 2 (2016): JPMS
Publisher : STIFA Makassar

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Abstract

Ginger extract are known to have antiinflamatory effect at a dose of 200 mg. In order to be applied to the skin, ginger extract must be formulated into stable emulgel. This study aims to formulate and evaluate the physical stability of emulgel from ginger extract using carbomer® 940 as gelling agent with concentration variation 0,5%, 1%, 1,5% and 2%. Physical stability evaluation was conducted including organoleptic test, pH, spreading test, adhesion test and viscosity test. From the research result it is obtained yellow and distinctive odor of emulgel. pH of all emulgel formula were 6. Adhesion test result of formula 5, 6, 7, 8 were 00.63, 19.03, 50.84 and 60.50 respectively. Spreading test result from formula 5, 6, 7, 8 were 5,725, 4,875, 4,325 and 3,85 respectively. Viscosity test result were 2.200, 3.720, 4.000 and 7.720 for formula 5, 6, 7 and 8 respectively. According to paired sample T-test there was not significant differences between formula on pH test, viscosity test, adhesion test (p>0,05), before and after accelerated storage condition. In spreading test result showed a significant difference 0,000 (0<0,05) before and after accelerated storage condition.
Uji Sinergisme Aktivitas Antibakteri Kombinasi Minyak Atsiri Syzygium aromaticum L. dan Myristica fragrans Houtt. Terhadap Bakteri Staphylococcus aureus ATCC 25923 Serta Profil Kimianya Dewi Winni Fauziah; Endang Darmawan
Jurnal Farmasi dan Ilmu Pengobatan Vol 2 No 2 (2017): JPMS
Publisher : STIFA Makassar

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Abstract

Infeksi dapat disebabkan oleh bakteri yang salah satunya adalah Staphylococcus aureus yang merupakan bakteri gram positif. Pengobatan infeksi bakteri banyak dilakukan dengan menggunakan antibiotika atau minyak dari bahan alam. Minyak atsiri dari Syzygium aromaticum L. dan Myristica fragrans Houtt memiliki aktivitas antibakteri terhadap bakteri gram positif. Penelitian ini bertujuan untuk mengetahui sinergisme aktivitas antibakteri kombinasi minyak atsiri dari Syz dan Myr terhadap bakteri S. aureus ATCC 25923. Uji sinergisme aktivitas antibakteri dilakukan menggunakan metode mikro dilusi checkerboard dengan penambahan MTT sebagai indikator pertumbuhan bakteri. Efek kombinasi dilihat dari indeks FIC dan Isobologram sedangkan komponen kimia minyak atsiri dari kedua tanaman tersebut dianalisis dengan GC-MS. Hasil uji aktivitas sinergisme memperlihatkan efek aditif terlihat pada perbandingaan Myr/Syz sebesar 2/5 dan 8/5 dengan indeks FIC sebesar 0,75; akan tetapi pada perbandingan Myr/Syz sebesar 2/5 memperlihatkan hasil indifferent dengan indeks FIC sebesar 1,5. Perbandingan konsentrasi terbaik antara Myr dengan Syz adalah 1 : 2,5 (mg/mL). Hasil analisis GC-MS menunjukkan komponen senyawa kimia utama dari minyak atsiri Syz adalah caryophyllene dan eugenol; minyak atsiri Myr adalah alpha pinene, beta-pinene, sabinene, p-cymene, terpinene-4-ol, safrol, dan miristisin. Secara keseluruhan dapat disimpulkan bahwa kombinasi minyak atsiri kedua tanaman tersebut memiliki efek aditif dalam menghambat S. aureus ATCC 25923.
Uji Aktivitas Antioksidan Fraksi Etil Asetat Daun kersen (Muntingia calabura L.) Menggunakan Metode ABTS Imrawati Imrawati; Suwahyuni Mus; Sahibuddin A Gani; Kafita Inkristi Bubua
Jurnal Farmasi dan Ilmu Pengobatan Vol 2 No 2 (2017): JPMS
Publisher : STIFA Makassar

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Abstract

Kersen (Muntingia calabura L.) adalah salah satu tumbuhan yang berpotensi sebagai antioksidan alami. Penelitian tentang uji aktivitas antioksidan fraksi etil asetat daun M. calabura dengan menggunakan metode ABTS (2,2’-azino-bis-(3 etilbenzotiazolin)-6 sulfonate acid) telah dilakukan. Daun M. calabura diekstraksi dengan cara maserasi menggunakan pelarut etanol selanjutnya difraksinasi secara berturut-turut menggunakan pelarut air, n-hexan dan etil asetat. Uji golongan menunjukkan ekstrak etanol mengandung komponen kimia flavonoid, fenolik, dan steroid. Sedangkan hasil uji aktivitas antioksidan menggunakan metode ABTS menunjukan aktivitas antioksidan yang sangat kuat dengan nilai IC50 1,20 ppm yang sebanding dengan vitamin C (IC50 1,18 ppm). Sehingga dapat disimpulkan bahwa daun M. calabura berpotensi sebagai sumber oksidan alami.
Pengembangan Sari Buah Lemon (Citrus limon L.) Dalam Bentuk Facial Peeling Scrub Dengan Variasi Kosentrasi Tea-Stearat Hamsinah Hasan; Adinda Dwi Ayu D Rasyid; Ririn Ririn
Jurnal Farmasi dan Ilmu Pengobatan Vol 2 No 2 (2017): JPMS
Publisher : STIFA Makassar

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Abstract

Buah lemon (Citrus limon L.) merupakan tanaman yang banyak mengandung vitamin C yang merupakan salah satu senyawa antioksidan alami. Telah dilakukan penelitian formulasi pengembangan perasan buah C. limon dalam bentuk facial peeling scrub dengan variasi konsentrasi TEA-stearat (FA= 1:2 dan FB= (2:1). Penelitian ini bertujuan untuk menetukan formulasi yang paling stabil dan memiliki aktivitas antioksidan dari krim perasaan buah C. limon yang diformulasikan kedalam bentuk facial peeling scrub. Sedian facial peeling scrub ini menggunakan scrub jagung dengan ukuran partikel 0,5 mm. Evaluasi kestabilan dilakukan dengan pengamatan uji organoleptik, volume krimming, homogenitas, pH, tipe emulsi, viskositas dan aliran sebelum dan sesudah kondisi dipaksakan selama 10 siklus pada suhu 5C dan 35C. Hasil penelitian menunjukkan bahwa FA dan FB stabil setelah penyimpanan kondisi dipaksakan. Aliran dari kedua formula menunjukkan aliran thiksoropi.
Identifikasi dan Karakterisasi Senyawa Aktif Ekstrak Daun Murbei (Morus alba L.) Subehan Lallo; Hamdayani L A; Besse Hardianti; Rizki Asmawati Bahar
Jurnal Farmasi dan Ilmu Pengobatan Vol 2 No 2 (2017): JPMS
Publisher : STIFA Makassar

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Abstract

Mulberry (Morus alba L.) is commonly use in the cultivation of silkworms and medicinal plants in Indonesia. Traditionally, the leave are used to decrease arterial blood pressure. This study has been carried out the identification and characterization of compounds that isolated from the M. alba leaves collected from South Sulawesi. Extraction was done by maceration of their leaves using ethanol 0%, separation and purification using chromatography method. The results of the stationary phase column chromatography with silica gel with the mobile phase n-hexane:ethyl acetate in a gradient system obtained fractions with the fraction showed clear spot at TLC was continued for isolation. The isolated compound was analyzed with IR and UV-VIS spectrophotometry. Analysis of IR spectrum indicated the presence of an O-H (2285 to 2385 cm-1), C-H (2854 to 2954 cm-1) and the C=C (1521 to 1577 cm-1), these isolates indicate the presence of flavanoid compounds and their functional group at wavenumber 1336; 3421; and 968-1273 cm-1 indicated the presence of C-N; N-H; and C-O functional groups, respectively. These data also indicated the possibility of alkaloids. In addition characterization with UV sprectrum showed absorption at a wavelength of 239 and 413 nm, they indicated the presence of flavonoid group.
Pengaruh Natrium Alginat Sebagai Polimer Terhadap Karakteristik Fisik Mikropartikel Liofilisat Daun Murbei (Morus alba L.) Aisyah Fatmawaty; Radhia Riski; Nurul Arfiyanti; Lukman Muslimin
Jurnal Farmasi dan Ilmu Pengobatan Vol 2 No 2 (2017): JPMS
Publisher : STIFA Makassar

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Abstract

The research about the effects of sodium alginate as the polymer to found a stable physical characteristic of microparticles of mulberry leaves (Morus alba L) has been conducted. The purpose of this study was to determine the effect of Na.alginate as the polymer to the physical characteristics of microparticles of M.alba. In this research, the formulation M. alba leaves in the form of microparticles in which the sodium alginate as a polymer with cross connector CaCl2. Microparticles with an ionic gelation method by dispersing mulberry leaf-sodium alginate into a solution of CaCl2. Formula microparticles made with mulberry leaves concentration ratio of sodium alginate (1: 1); (1: 1.5), and (1: 2). Microparticles characterized physically by the size, shape, and appearance by using SEM (scanning electron microscopy), and the adsorption efficiency. The yield on mulberry leaves microparticles obtained are not spherical morphology SEM and entrapment efficiency data cannot be calculated.

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