Garuda - Garba Rujukan Digital

All

Jurnal Farmasi Indonesia

farmasi-indonesia
Website

Published by Universitas Setia Budi

ISSN : 16938615 EISSN : 23024291 DOI : -

Core Subject : Health, Science, Engineering,

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.

Arjuna Subject : -

Articles 10 Documents

Search results for , issue "Vol 13 No 1 (2016): Jurnal Farmasi Indonesia" : 10 Documents clear

Toksisitas Akut Ekstrak Sembukan (Paederia scandens (Lour.) Merr. pada Mencit (Mus musculus L.) Galur Swiss Ida Fitriana; Agustina Dwi Wijayanti; Puspa Wikan Sari
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Sembukan (Paederia scandens (Lour.) Merr. belonging to Rubiaceae family that grows wild, sometimes was used as animal feed and traditional herbal medicine. Therefore, it is important to determine the safety of sembukan when consumed or used as a herbal medicine. This study aimed to determine the potential acute toxicity of the extract of sembukan using Organisation for Economic Co-operation and Development (OECD) 423 method which measured the clinical symptoms caused, and histopathologic of liver, kidney, and heart disease due to oral administration. Fifteen female Swiss Webster mouse weighing 25-35 gram used in this study. The procedure of this study followed the OECD method 423 using an initial dose of 300 mg/kg BW sembukan extract. Histopathological examination was done hematoxylin-eosin staining. The observation of histopathology and clinical toxicity symptoms were analyzed descriptively, while data changes on body weight of animals, organ weights, and the amount of feed intake was analyzed statistically. The results showed sembukan extract is safe to use. According to the Globally Harmonized System Classification (GHS), the potential for acute oral toxicity of the extract sembukan included in category 5 (not clarified) with LD50 cut-off > 2000-5000 mg/kg BW. Giving the test preparation did not affect body weight, feed intake, clinical symptoms of toxicity,and there was no pathological changes in the heart organ.

Penggunaan Obat Off Label di Instalasi Rawat Inap Rumah Sakit Kahyangan Happy Elda Murdiana
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Off label drug use is defined as prescriptions for indications or dosage form that did not pass the approval process asociations Food and Drug Administration (FDA). The main reason the off label use of the drug in pregnant women is to avoid complications such as premature birth problems womb, labor, pre-eclampsia and eclampsia or increase the capacity of postnatal adaptation that may occur for example, sepsis or respiratory distress. The purpose of this studywas to determine the type and percentage of drugs used off label installed hospital inpatient heavenly. The research method using the cross section for the retrieval of data from medical records and descriptive analysis. The results obtained was 9.8% lidocaine for perineal sewing anestesi therapy, 5.6% misoprostol for induction of labor and 8.5% issue of abortion, ondancetron 59.1% for the prophylaxis of nausea and vomiting due anestesi cesarean section, bupivacaine 59.1 % The FDA does not approve the use of spinal anestesia, analgesic ketorolax 59.1% cesarean surgery, dexamethasone 1.4% for fetal lung maturation has not been quite the month. So there were six kinds of off label drug used that all off label indications already mentioned above.

Pengaruh Pemberian Ekstrak Etanolik Daun Pandan Wangi (Pandanus amaryllifolius Roxb.) Terhadap Kadar Enzim Alp Pada Tikus Putih Yang Diinduksi Isoniazid Dan Rifampisin Angga Adi Rahmawan; Supriyadi Supriyadi; Tri Wijayanti
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Pandan leaves are medicinal plants that contain alkaloids, saponins, flavonoids, tanins and poliphenols compounds that have high antioxidant activity and potential as hepatoprotective. This research was conducted to determine the effect of ethanol extract pandan leaves (Pandanus amaryllifolius Roxb.) on the rate of ALP in to determine potency extract ethanol pandan leave inhibit necrosis cell of liver in white rats isoniazid and rifampisin induced. This research was used thirty rats were divided in 6 groups. Group I as a normal group. Group II as a hepatotoxic group. Group III as a drug group was given Curcuma 3,6 mg/200 g BW. Group IV, V, and VI as the treatment group given test solution ethanol extract pandan leaves 8,64 mg/200 g BW, 17,28 mg/200 g BW and 25,92 mg/200 g BW for 28 days. All groups except group I were induced by isoniazid and rifampisin 10,8 mg/200 g BW. All groups on day 0, 14th and 28th set ALP rate. Results obtained were analyzed by One Way ANOVA test. The results showed that ethanol extract pandan leaves at a dose of 8,64 mg/200 g BW, 17,18 mg/200 g BW, and 25,92 mg/200 g BW can inhibit ALP in to determine potency ethanol extract pandan leave inhibit necrosis cell of liver in white rats isoniazid and rifampisin induced. Dose of the ethanol extract pandan leaves was the most effective is 25,92 mg/200 g BW.

Efek Antihiperkolesterolemia Ekstrak Etanol Herba Alfafa (Medicago sativa) Pada Tikus Putih Jantan Ika Puspitaningrum; Lia Kusmita; Wahyuning Setyani
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Hypercholesterolemia is a disorder characterized by an increased concentration of cholesterol in the blood. Alfalfa (Medicago sativa) is one of the plants that are believed to control blood cholesterol. This study aims to determine antihypercholesterolemia effect of herb alfafa ethanol extract and the effective dose. Test antihypercholesterolemia ethanol extract of herb alfalfa using male Wistar rats as many as 30 individuals were divided into 6 groups. Group 1 (normal control) was given standard feed. Group 2 (negative control) was given CMC Na 0,5%. Group 3 (positive control) was given Simvastatin. Groups 4, 5 and 6 was given herb alfafa ethanol extract 270, 540 and 1080 mg/kg rat. All treatments are given 7 days orally. Induction hypercholesterolemia with high-fat feed a mixture of standard rat food with lard and egg yolk duck (3:1), as well as fructose 1.8 g/kg rat. Induction was given to all groups for 50 days, except for the normal control. Measurement of total blood cholesterol levels was done on days 0, 51 and 58. Cholesterol levels were obtained calculated % decline further tested with SPSS statistical release 16. The test results showed a statistically significant difference between the negative control group with the ethanol extract of herb Alfalfa three doses. While the comparison between the positive control with the ethanol extract of the herb alfalfa three doses showed no significant differences. It was provided that the ethanol extract of the herb alfalfa could affected antihypercholesterolemia, but not comparable to Simvastatin. The effective dose of ethanol extract of alfalfa as antihypercholesterolemia was 270 mg/kg rat.

Pengembangan dan Evaluasi Formulasi dari Tablet Kunyah Nanopartikel Mebendazol Muhammad Dzakwan; Widodo Priyanto
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Mebendazole is a benzimidazole derivative with broad spectrum anthelminthic activity and excellent tolerability. Orally it is rapidly absorbed and metabolized to sulfoxide and sulfone, which may be responsible for its anthelminthic action. This research aimed to formulate mebendazole nanoparticle chewable tablet to increase its dissolution velocity and impact saturation solubility. Mebendazole nanoparticle chewable tablets (300 mg) were prepared by direct compression. The tablets prepared by this method were evaluated by different parameters such as average weight, hardness, friability, disintegration, drug content and in vitro dissolution etc. All the parameters were found within the specifications. The study on the dissolution profile revealed that F1 had better dissolution rate while compared to F2, F3 and mebendazole microparticle, respectively. Assay values were within the limits of 90% to 110%.

Optimasi Proporsi Polisorbat 80 dan Sorbitan 80 dalam Formulasi Krim Ekstrak Etil Asetat Daun Jengkol (Pithecollobium lobatum Benth) Sebagai Antibakteri dengan Metode Desain Faktorial Ghani Nurfiana Fadma Sari; Ilham Kuncahyo; Mamik Ponco Rahayu
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Jengkol leaves ethyl acetate extract shows to have antibacterial activity because it contains saponins, flavonoids and tannins. The use of jengkol leaves ethyl acetateextract directly assessed less well, so that it made cream preparations to make it more convenient to use. This study aimed to obtain the optimum formula of cream of jengkol leavesethyl acetate extract using additional materials polysorbate 80 and sorbitan 80 by Factorial Design method. The Jengkol leaves extract obtained by soxhletation using n-hexane solvent followed by ethyl acetate was then evaporated to obtain a viscous extract. Jengkol leaves extract ethyl asetat cream was made four made in four formulas based on factorial design method. The resulting cream conducted stability tests including organoleptic test, viscosity, adhesiveness, and dispersive power. Optimum formulation parameters based on physical properties, namely: viscosity, viscosity shift, and dispersive power, using Design EaseÂ® Software version 7.1.6. Optimum formula was determined the physical properties and the data were analyzed using t-test. Antibacterial activity was tested by diffusion method. Optimum formula cream of jengkol leaves ethyl acetate extract obtained from proportion polysorbate 80 of 0.44 g and sorbitan 80 of 1.15 g with the physical properties of the response of the optimum formula predictions and experimental result showed no significant difference. Optimum cream showed antibacterial activity presented as inhibition diameter of 14 mm after one day incubation, more potential than formulation 1 (12.8 mm), formulation A (13,8 mm), formulation B (13,2 mm), and formulation AB (13 mm) against Staphylococcus aureus bacteria.

Optimasi Formula Gel Ekstrak Buah Mengkudu (Morinda Citrifolia L.) Sebagai Antioksidan Dengan Metode Simplex Lattice Design Dewi Ekowati; Evie Yuliaswari; Endang Sri Rejeki
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Noni Fruit (Morinda citrifolia L.) contains polyphenols, flavonoids, saponins, which plays a role as an antioxidant. Noni fruit extract is formulated in gel dosage form for the comfortness and convenience of topical use. This research aims to obtain the optimum formula noni fruit gel which effective as an antioxidant. Gel formula was optimazed by method of Simplex Lattice Design (SLD). design-expert 8.0.6.1. Gel formula was preparated using CMC-Na base (A) and (B) Carbopol 940 so it was obtained 3 formula, i.e. F1 (100% A:0% B), F2 (50% A:50% B), F3 (0% A:100% B) and then was optimized based on physical properties of viscosity, adhesivity, power spread and the shift of viscosity. The SLD's equation was used to make the gel with the response a total of physical prop erties of the gel the most optimum. Optimum gel tested antioxidant activity by using DPPHmethod. Antioxidant activity the ï¬ maximum and operating time so the IC50 values were obtained through analysis of probit with the use of vitamin C as a comparison. The optimum formula of noni fruit extract gel obtained by SLD method was the formula contained CMC-Na 78,92% : carbopol 940 21,08% with the desirability value of 0,511. The t-test results of viscosity, power latched onto, power spread and the shift of viscosity shows no significant difference. The results demonstrated the optimum gel fruit noni had antioxidant activity with IC50 value of 92,875 ppm.

Penentuan Kadar Vitamin C dan Aktivitas Antioksidan Buah Carica (Vasconcellea cundinamarcensis) Wonosobo Hery Muhamad Ansory; Rinda Binugraheni; Argo Khoirul Anas
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

The content of vitamin C information in carica fruit is very important because it can improvethe marketability of this fruit. The potential of Carica fruit as antioxidants agent hasn’t beenstudied by the researchers. It’s made Carica fruit are interesting to be studied, so theresearchers conducted this study to determine the vitamin C contain and the antioxidant activityof Carica fruit that grows in Wonosobo.This study was started by the preparation of the Carica fruit to obatined Carica fruitsolution. So that the total content of organic acids, ascorbic acid, and antioxidant activity ofCarica fruit solution could be analyzed. The organic acid content analysis of Carica fruit solutionwas performed by alkalimetric method. The ascorbic acid content analyses were performed byUV-Vis Spectrophotometry, and analysis of antioxidant activity were performed with DPPHmethod.The organic acids total concentration of Carica fruit solution was equal to 0,4 N. Theascorbic acid concentration of Carica fruit solution was 1560 ppm and The C50 value of Caricafruit obtained from sample solution by 118x dilution or equivalent to 17 gram of Carica fruit.

Strategi Pengembangan Akreditasi Manajemen Penggunaan Obat Dengan Metode Hanlon Di IFRSUD Sultan Imanuddin Pangkalan Bun Poppy Dwi Citra Jaluri; R.A. Oetari; Gunawan Pamudji Widodo
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

To improve the quality of services and improve patient safety in providing hospital services needed hospital accreditation. The purpose of this study was to determine the level of conformity seven accreditation standards MMU based from KARS and strategy development pharmacy installation with Hanlon method. This study is a non-experimental research design in Hospital Pharmacy Installation Sultan Imanuddin Pangkalan Bun, Central Kalimantan, data collection conducted by using a questionnaire instrument to 28 respondents are Pharmacists and TTK. After the problem was found in each element and then analyzed using the Hanlon method. Research concluded that the level suitability to the accreditation standards of pharmacy service MMU is MMU1 85.36%, 92.39% MMU2, MMU3 78.75%, 88.57% MMU4, MMU5 50.24%, 72.32% MMU6, and MMU7 42.62% and development strategy appropriate priorities to be applied in IFRSUD Sultan Imanuddin Pangkalan Bun, Central Kalimantan are still does not meet the maximum standards.

Pengaruh Superoksida Dismutase Rekombinan Staphylococcus equorum Terhadap Viabilitas Sel dan Deposisi Kolagen Pada Sel Fibroblas 3T3 Yang Dipaparkan UVA Ana Indrayati; Sukmadaja Asyarie; Tri Suciati; Debbie Soefie Retnoningrum
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

UVA is the main external factors causing skin aging. UVA increase matrix metalloproteinase (MMP) synthesis that degrade collagen indirectly through reactive oxygen species. Superoksida dismutase (SOD) catalyzes the conversion of superoxide anions to hydrogen peroxide and oxygen. SOD can be used as a cosmeticâ€™s component to prevent skin aging. The objective of this research to determine rSOD S. equorum ability to increase collagen deposition using fibroblast 3T3 against UVA. The research was initiated by the confirmation of E. coli BL21(DE3) carrying pJExpressÂ®414-sod. rSOD was overproduced in E. coli BL21(DE3) by IPTG induction to a final concentration of 1 mM for 4 hours at 37oC. rSOD purification was done using an Ni-NTA affinity column with gradient imidazole concentrations for elution. Various concentrations of rSOD was added to fibroblast 3T3 cell culture after UVA irradiation to determine its role in collagen deposition. The effect of rSOD was analyzed by fibroblast viability using Alamar blue and collagen deposition with picro sirius red. The results showed that fibroblast cell viability exposed with UVA for 45 minutes in the presence of 4, 8, and 16 unit rSOD was not significantly affected, however, the collagen deposition was significantly increased about 3.02%; 20.03% and 35.75% respectively compared to cell without rSOD. This result indicates that rSOD is a good candidate for an anti photoaging agent.

Page 1 of 1 | Total Record : 10

Filter by Year

2016 2016

Filter By Issues

All Issue Vol 21 No 1 (2024): Jurnal Farmasi Indonesia (in Press) Vol 20 No 2 (2023): Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia Vol 17 No 1 (2020): Jurnal Farmasi Indonesia Vol 16 No 2 (2019): Jurnal Farmasi Indonesia Vol 16 No 1 (2019): Jurnal Farmasi Indonesia Vol 15 No 2 (2018): Jurnal Farmasi Indonesia Vol 15 No 1 (2018): Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia Vol 14 No 1 (2017): Jurnal Farmasi Indonesia Vol 13 No 2 (2016): Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia Vol 12 No 2 (2015): Jurnal Farmasi Indonesia Vol 12 No 1 (2015): Jurnal Farmasi Indonesia Vol 11 No 2 (2014): Jurnal Farmasi Indonesia Vol 11 No 1 (2014): Jurnal Farmasi Indonesia Vol 10 No 2 (2013): Jurnal Farmasi Indonesia Vol 9 No 1 (2012): Jurnal Farmasi Indonesia Vol 8 No 2 (2011): Jurnal Farmasi Indonesia Vol 8 No 1 (2011): Jurnal Farmasi Indonesia Vol 7 No 2 (2010): Jurnal Farmasi Indonesia Vol 7 No 1 (2010): Jurnal Farmasi Indonesia Vol 6 No 3 (2009): Jurnal Farmasi Indonesia Vol 6 No 1 (2009): Jurnal Farmasi Indonesia More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kota surakarta,

Jawa tengah

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name -

Contact Email -

Phone -

Journal Mail Official -

Editorial Address -

Location Kota surakarta, Jawa tengah INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kota surakarta,

Jawa tengah

INDONESIA