Jurnal Farmasi Indonesia
Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.
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<![CDATA[PENGGUNAAN OFF-LABEL DRUG PADA PASIEN GERIATRI DENGAN PENYAKIT DEGENERATIF DI APOTEK WILAYAH SURAKARTA ]]>
<![CDATA[Nila Darmayanti Lubis]]>;
<![CDATA[Santi Dwi Astuti]]>
<![CDATA[ Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Setia Budi ]]>
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DOI: 10.31001/jfi.v18i1.642
<![CDATA[ABSTRACT Off-label drug use in geriatric patients who have degenerative diseases has the potential to cause medication errors or adverse drug reactions but off-label is not always bad and harmful. The purpose of this study was to determine the prevalence of off-label drug use in the categories of indication, dosage, contraindication and age in geriatric patients with degenerative diseases. This study used a descriptive design. Data were collected by retrospectively. Samples were taken with a purposive sampling technique from several Pharmaceutical Installation in the Surakarta that served prescriptions with inclusion criteria for geriatric patients with degenerative diseases, prescriptions were written by specialists, prescriptions were redeemed at pharmacies that had collaborated with specialist doctors, prescriptions that had complete information, prescriptions that entered the pharmacy in April-May 2019 and matched the information on the use of the drug with the medicine leaflet. The evaluation results of the use of off-label drugs in geriatric patients with degenerative diseases in pharmacies in the Surakarta region are the prevalence of the use of off-label drug indicative categories of 7.6%; the prevalence of off-label drug use in the dose category is 33.92%; the prevalence of off-label drug use is contraindicated and age category is 0%.]]>
<![CDATA[Penggunaan Kontrasepsi Oral dan Risiko Obesitas Pada Wanita Usia Subur ]]>
<![CDATA[Iqlima Den Firza]]>;
<![CDATA[Nurmainah Nurmainah]]>
<![CDATA[ Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Setia Budi ]]>
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DOI: 10.31001/jfi.v18i1.793
<![CDATA[Oral contraception is a method that can be used to support family planning programs. However, there are some side effects that can be caused by the use of oral contraceptives, one of which is weight gain, which is a major risk factor for obesity. Obesity is known as a factor in the development of hypertension and diabetes mellitus. This research aimed to analyze the correlation between duration of use and type of oral contraception that is alleged to have a risk of obesity. This study using an observational method with an analytic cross-sectional study design. The data was taken based on acceptors’ medical records for the period January 2018-March 2019. Data collection techniques using purposive sampling with samples that comply with the inclusion and exclusion criteria is 68 samples. The results showed that the longer used of oral contraception, the higher the risk of obesity in oral contraception acceptors (p = 0.001; OR = 20.7; CI95% = 4.87-87.95). Using the type of combined oral contraceptives also has a higher risk of obesity in oral contraception acceptors (p = 0.011; OR = 10.2; CI95% = 1.25-82.87). The conclusion of this study that duration of use and type of oral contraception has a correlation with the risk of obesity.]]>
<![CDATA[Efektivitas Kombinasi Dua Obat Antihipertensi Pasien Hipertensi Rawat Jalan RSUD Karanganyar ]]>
<![CDATA[Tri Wulandari]]>;
<![CDATA[Anindhita Yudha Cahyaningtyas]]>
<![CDATA[ Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Setia Budi ]]>
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DOI: 10.31001/jfi.v18i1.811
<![CDATA[The aim of hypertension treatment was to manage and control blood pressure so that the risk of cardiovascular disorders and other complications can be minimized. Blood pressure control can be achieved faster with combination treatment than monotherapy. The use of drugs combination was more effective than inertia therapy and prevented the risk of cardiovascular damage. The purpose of this study was to analyze the effectiveness of combination therapy of 2 drugs that have the highest target achievement for controlling blood pressure in patients with hypertension age ≥ 60 years is <150/90 mm Hg, for patients <60 years is <140/80 mm Hg. The design of this study was retrospective and observational analytic with a cross-sectional approach. Data collection was conducted by reviewing the record of patients. The study samples were outpatients in Karanganyar District Hospital who suffer from hypertension and received the same drug combination therapy for three months successively. The patient's blood pressure was measured during inspection every month. The number of samples in this study was 59 respondents. The results showed that the combination of two antihypertensive drugs most widely used by the CCB + ARB group with achievement target by 92.3% and the lowest achievement target from the combination of diuretic + ARB groups by 20%. The P-value of this research is 0.001 indicated that there were significant differences in the selection of an antihypertensive combination of 2 drugs.]]>
<![CDATA[Pengaruh Corona Virus Disease terhadap Penjualan Produk Suplemen Kesehatan ]]>
<![CDATA[Khotimatul Khusna]]>;
<![CDATA[Rita Septiana]]>;
<![CDATA[Ghani Nurfiana Fadma Sari]]>;
<![CDATA[Isma Rosida]]>
<![CDATA[ Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Setia Budi ]]>
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DOI: 10.31001/jfi.v18i1.937
<![CDATA[Corona Virus Disease-19 (COVID-19) has been declared a pandemic by the World Health Organization (WHO) on March 11, 2020, previously on March 2, 2020 Indonesia has reported 2 confirmed cases of COVID-19. Immunomodulators that can increase the body's resistance to the COVID-19 virus by stimulating the immune system. The purpose of this study was to determine the effect of COVID-19 on the sale of health supplement products in a pharmacy in Surakarta.This research is an analytical observational research. Data was collected from sales records at pharmacies in the 3 months before the COVID-19 pandemic and 3 months at the beginning of the COVID-19 pandemic. Data analysis using statistical tests.Sales of health supplement products for 6 months were 17843 pcs. There were 4773 health supplement products sold before the pandemic, while 13070 pcs were sold during the pandemic. The results of the normality test showed that the data were not normally distributed. The Wilcoxon test results show that the significant value is 0.028 (<0.05), meaning that there is a difference in sales before and after the determination of the pandemic. The conclusion of this study is that COVID-19 has an effect on the sale of health supplement products in a pharmacy in Surakarta.]]>
<![CDATA[Efek Reaksi Isomerisasi Pada Miristisin Terhadap Potensinya Sebagai Tabir Surya Secara in-vitro ]]>
<![CDATA[Hery Muhamad Ansory]]>;
<![CDATA[Ika Nur Fitriani]]>
<![CDATA[ Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Setia Budi ]]>
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DOI: 10.31001/jfi.v18i1.1094
<![CDATA[Myristicin has an alkenyl benzene structure with a double bond that is not conjugated with a benzene ring with good sunscreen activity, the change of the double bond to the conjugated position can be done by an isomerization reaction. This change will result in the molecule having longer delocalized double bonds and is expected to increase its activity as a sunscreen. The purpose of this study was to see the effect of changes in myristicin structure on its activity as a sunscreen. The isomerization reaction was carried out by reflux method using 20% KOH catalyst in ethanol for 5 hours. Sunscreen activity test was carried out in-vitro using a UV spectrophotometer. The results of the isomerization reaction obtained isomyristicin in the form of a clear light yellow liquid that dissolves in ethanol (1: 1) with a% yield of 84% and a purity of 90% E: Z (6: 1). The results of the sunscreen activity test showed changes that were not much different between myristicin and isomyristicin, which indicated that the isomerization reaction had no significant effect on sunscreen activity.]]>
<![CDATA[Uji Toksisitas Subakut Ekstrak Etanol Daun Asam Jawa Dosis Efektif Sebagai Antihiperglikemia Terhadap Kadar AST, ALT, dan Kreatinin Tikus (Rattus norvegicus) ]]>
<![CDATA[Sitti Rahimah Rachman]]>;
<![CDATA[Dzulkifli Dzulkifli]]>;
<![CDATA[Suwahyuni Suwahyuni]]>;
<![CDATA[Rahmad Aksa]]>;
<![CDATA[Mirnawati Salampe]]>;
<![CDATA[Akbar Awaluddin]]>
<![CDATA[ Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Setia Budi ]]>
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DOI: 10.31001/jfi.v18i1.1096
<![CDATA[The toxicity test is one of the pharmacological testing stages that must be carried out to assess the use of a drug. Research on the activity test of the ethanol extract of Tamarind leaves (Tamrindus indica L) at a dose of 14 mg / 200 g BW as an antihyperglycemia in experimental animals gave results that were not significantly different from the standard drug activity of Glibenclamide as an antidiabetic mellitus, so this study was conducted with the aim of looking at the ethanol of tamarind leaves. (Tamrindus indica L) for 30 days on levels of the enzymes AST, ALT, and creatinine in rats (Rattus norvegicus). This sub-acute toxicity test used 14 test animals divided into 2 groups, each group consisting of 7 rats. Group I was given 0.5% Na CMC treatment as a control and group II was treated with the ethanol extract of tamarind leaves at a dose of 14 mg / 200 g BW for 30 days. On the 31st day, blood serum measurements were taken with AST, ALT and creatinine parameters using a humalyzer. The results of the subacute toxicity test showed that giving tamarind leaves ethanol extract as an antihyperglycemia did not cause an increase in the AST, ALT AND creatinine enzymes beyond normal limits.]]>
<![CDATA[Penghambatan Enzim Asetilkolinesterase Pada Penyakit Alzheimer Dari Ekstrak Etanol Daun Kelor (Moringa oleifera Lam.) ]]>
<![CDATA[Yonathan Tri Atmodjo Reubun]]>
<![CDATA[ Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Setia Budi ]]>
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DOI: 10.31001/jfi.v18i1.1105
<![CDATA[Moringa leaves have been recognized by the public as a treatment. One such disease is Alzheimer's disease where the way this plant works is to inhibit the damage that occurs in the nervous system in the brain. The purpose of this study was to obtain ethanol extract of Moringa leaves by carrying out a phytochemical screening process to determine the chemical content contained in these plants. The moringa leaves obtained were subjected to a grinding process to obtain simplicia powder. After that, the extraction is done by soaking the Moringa leaves with 96% ethanol for 11 times until the extract is perfect. After that, the concentration is done with a Rotary Evaporator until you get a thick extract of Moringa leaves. After that, the thick extract is followed by the Freeze Drying process to get a thick extract that is stable and can hold in storage. After that, the extract was tested against the inhibition of the acetylcholinesterase enzyme based on the Ellman method, the IC50 yield of Moringa leaf extract was 819.7517 ppm. Meanwhile, Eserin positive control with an IC50 value of 5.010 ppm. Acetylcholinesterase inhibition kinetics were competitive. So it is said that Moringa oleifera extract has an effect on the treatment of Alzheimer's disease.]]>
<![CDATA[Analisis Biaya Langsung Medis Terapi Seftriakson Dibandingkan Dengan Levofloksasin Pada Pasien Pneumonia Komunitas di Rumah Sakit Pemerintah X NTB ]]>
<![CDATA[Cyntiya Rahmawati]]>;
<![CDATA[Baiq Leny Nopitasari]]>
<![CDATA[ Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Setia Budi ]]>
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DOI: 10.31001/jfi.v18i1.1117
<![CDATA[Pneumonia is a respiratory tract infection with the highest number of cases in Government Hospital X in NTB in 2018. The worst impact of pneumonia are death and high cost of health services risk. So management of costs is needed for effectively and efficiently. The therapeutic choice for community acquired pneumonia (CAP) used in X Hospital is ceftriaxone and levofloxacin which have a high price difference. This study aims to calculate the average direct medical costs in hospitalized CAP patients who use ceftriaxone and levofloxacin therapy at Government Hospital X in NTB in 2018. This research type is quantitative analysis using secondary data that compares the average direct medical costs of two alternative treatments for CAP with the BPJS Kesehatan perspective. The cost component are cost of medicine, care, doctor, emergency room, accommodation, and laboratory. The number of samples was 65 patients. The results showed: (1) The average direct medical costs using ceftriaxone was Rp.3.034.965, while levofloxacin was Rp.1.594.053; (2) There is significant difference in the average direct medical cost of Rp.1.440.912 perpatient; (3) Levofloxacin provide the lowest rupiah than ceftriaxone in community acquired pneumonia patients.]]>
<![CDATA[Pengembangan Molecular Imprinted Polymer Untuk Pemisahan Vitamin C dalam Sediaan Multivitamin ]]>
<![CDATA[Untung Gunawan]]>;
<![CDATA[Eko Adi Prasetyanto]]>;
<![CDATA[Shannen Ivanka Gunardi]]>
<![CDATA[ Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Setia Budi ]]>
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DOI: 10.31001/jfi.v18i1.1155
<![CDATA[Vitamin C has chromophore group that can be analyzed using UV-Vis spectrophotometry, however if the complex matrix to be analyzed like multivitamins, a selective separation method is required to eliminate matrix interferences. One of the selective separation methods is Molecular Imprinted Polymer (MIP) which which hasn’t been widely used in multivitamin samples. The purpose of this study was to obtain selective MIP for separation of vitamin C in multivitamins.. Research methods included interaction observation of vitamin C with functional monomers using UV spectrophotometry, MIP was synthesized using bulk method for 24 hours at 60 °C. MIP was characterized using spectrophotometry, infrared and scanning electron microscopy MIP selectivity were determined by determination of imprinting factor and its recovery with the liquid-liquid extraction method (LLE) and SPE C18 for separation of vitamin C in multivitamin samples on the market using a validated method. Hypsochromic shift showed interaction between vitamin C and functional monomers, which hydrogen bonds were taking role in MIP synthesis. Imprinting factor more than 1 and recovery value close to 100% indicated MIP selectivity to vitamin C. MIP-1 had the highest selectivity compared to the ECC and SPE C18 methods for separation of vitamin C in multivitamin samples with recovery of 98.17 ± 2.31%, 69.42 ± 3.01%, and 93.26±4.24% respectively. Synthesized MIP-1 was selective for the separation of vitamin C in multivitamins.]]>
