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ISM (Intisari Sains Medis) : Jurnal Kedokteran

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Published by Universitas Udayana

ISSN : 25033638 EISSN : - DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.

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Search results for , issue "Vol. 10 No. 3 (2019): (Available online: 1 December 2019)" : 78 Documents clear

Uji efektivitas ekstrak kunyit (Curcuma longa) terhadap daya hambat pertumbuhan bakteri Streptococcus mutans I Nyoman Candra Kumara; I Gusti Agung Sri Pradnyani; I Gusti Ayu Fienna Novianthi Sidiarta
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: Dental caries is a multifactorial disease characterized by dental tissue damage caused by the production of bacterial acids. The bacteria play the most role in the occurrence of caries is Streptococcus mutans. Turmeric extract (Curcuma longa) has been studied can inhibit bacterial growth because it contains essential oils and curcumin. The purpose of this study was to determine the inhibitory power of turmeric extract 5%, 10%, 20%, and 40% on the growth of Streptococcus mutans bacteria.Methods: Studies with true experimental design using a post test only control group design have been carried out on Streptococcus mutans bacteria. Turmeric extract was made by maceration method into 96% ethanol so that the required concentration was obtained (5%, 10%, 20%, dan 40%). The inhibition testing is done by the disk-diffusion method. Data were analyzed using the Kruskal-Wallis test on SPSS version 20 due to the data were not normally distributed.Results: The results showed that phytochemical assessment of turmeric extract showed positive results on phenol, essential oil, saponins, tannins, and flavonoids. The average value of the inhibitory zone diameter of Streptococcus mutans bacteria formed in turmeric extract concentrations of 5%, 10%, 20%, and 40% is 0 mm where there are significant differences compared to positive controls (P < 0.05)Conclusion: Various doses of turmeric extract couldnâ€™t inhibit the growth of Streptococcus mutans bacteriaÂ

Aktivitas secara in vitro dan in vivo kombinasi ekstrak daun kelor (Moringa oleifera lam.) dan pegagan (Centella asiatica (l.). Urb.) sebagai gel anti jerawat Ninik Setya Hastuti; Shelly Taurhesia; Agung Eru Wibowo
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: Acne is a skin problem that is common in everyday life. Expressions of acne can cause psychological problems because of appearance. Moringa leaf extract and herbs contain alkaloid compounds, flavonoids, saponins, tannins and phenolics that can be used as antibacterial, reduce inflammation, reduce sebum glands and moisturize the skin. The purpose of this study was to conduct an in vitro and in vivo analysis of gel activity in combination of Moringa Oleifera L. leaf extract and Centella asiatica (L.). Urb.) Herb or KEKP gel as an anti-acne gel.Method: Activities carried out in vitro with an antibacterial effect on P. acnes, in vivo are carried out by clinical observation and measurement of sebum secretion. The gel contains the same combination of extracts. Twelve volunteers who met the inclusion and exclusion criteria followed the in vivo test to determine the safety and benefits of KEKP gel.Results: At a concentration of 0.78% dilution shows a diameter of 10.4 mm inhibitory power. Medikline as a positive control gives better results compared to KEKP gel with a minimum inhibition diameter of 16.6 mm. Clinical improvement was assessed by reduced signs of inflammation, the number of papules, pustules, nodules and changes in sebum levels measured using a skin analysis tool.Conclusion: The results showed that KEKP antifungal gel invitro had antibacterial activity, and in vivo showed real clinical differences

Perbandingan Kadar NT-proBNP Serum Pasien PGK eGFR Made Padma Puspita; Widodo Widodo; Agus Subagio
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: N-terminal-proBNP (NT-proBNP) is one of the most important biomarkers in diagnosing heart failure (HF). The excretion of NT-proBNP is affected by the decline of kidney function, thus the interpretation of serum levels of NT-proBNP in chronic kidney disease (CKD) patients to diagnose HF needs to be assessed carefully. Therefore, the purpose of this study is to investigated the difference between NT-proBNP levels in CKD patient with and without heart failure.Method: This observational analytic with cross-sectional study examined primary data of the serum level of NT-proBNP in predialyzed CKD patients with and without HF in outpatient clinic in Dr. Soetomo hospital, Surabaya between August and September 2018. Kidney function in predialyzed patients were classified into five stages using the Cockcroft Gault formula of estimated glomerular filtration rate (eGFR). Patients with eGFR <60mL/min/1.73m2 were included in this study. The differences between NT-proBNP levels in predialyzed CKD patients with and without heart failure were then analyzed using univariate and bivariate analysis.Results: The study population consisted of 50 predialyzed CKD patients which include 25 patients with HF and 25 patients without HF. The NT-proBNP mean in HF patients was [23,082 pg/mL (22,413)] and in patients without HF was [815 pg/mL (651)]. There was significant difference in NT-proBNP level between patients with HF and without HF (p<0,001).Conclusion: This study showed that there was significant increase in NT-proBNP level of predialyzed CKD patients with HF compare to patients without HF.

Gambaran faktor risiko dan tingkat risiko stroke iskemik berdasarkan stroke risk scorecard di RSUD Klungkung Ni Made Trismarani Sultradewi Kesuma; Dion Krismashogi Dharmawan; Heni Fatmawati
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Latar Belakang: Indonesia memiliki angka beban stroke terbanyak kedua setelah Mongolia yaitu sebanyak 3.382,2/100.000 orang berdasarkan DALYs (disability-adjusted life-year). Berdasarkan profil kesehatan provinsi Bali, tipe stroke yang memiliki tingkat prevalensi yang tinggi adalah stroke iskemik. Strategi praktis dalam mengatasi beban akibat stroke harus difokuskan pada pencegahan dan penanganan berdasarkan faktor risiko. Tujuan penelitian ini adalah untuk mengetahui hubungan antara faktor-faktor risiko dengan tingkat risiko penderita stroke iskemik yang rawat inap di RSUD Klungkung Bali periode Oktober 2017 sampai dengan September 2018.Metode: Penelitian ini merupakan penelitian analitik observasional dengan desain cross sectional. 65 Subyek penelitian yang sesuai dengan kriteria inklusi, diambil dari data rekam medis pasien stroke iskemik yang rawat inap di RSUD Klungkung. Variabel yang diteliti dalam penelitian ini yaitu usia, jenis kelamin, tekanan darah, kadar kolesterol, riwayat merokok, indeks massa tubuh (IMT), aktivitas fisik, riwayat diabetes, riwayat fibrilasi atrium, dan riwayat stroke dalam keluarga.Hasil: Dari total 65 pasien stroke iskemik yang rawat inap di RSUD Klungkung, paling banyak berada pada kelompok usia â‰¥ 55 tahun â€“ 64 tahun dengan usia rerata 61,45 Â± 12,016 tahun. Pasien berdasarkan jenis kelamin didominasi oleh laki-laki dengan perbandingan kejadian stroke iskemik antara laki-laki dan perempuan sebesar 2,4:1. Hasil penilaian tingkat faktor risiko dengan Stroke Risk Scorecard (SRS), 51 orang (78,5%) memiliki risiko tinggi, 9 orang (13,8%) memiliki risiko sedang, dan 5 orang (7,7%) memiliki risiko rendah.Simpulan: Uji statistik chi-square menunjukkan adanya hubungan yang signifikan antara tingkat risiko stroke iskemik dengan indeks massa tubuh, tekanan darah, riwayat merokok, riwayat diabetes, dan kadar kolesterol (p<0,005).Introduction: Indonesia is the second highest country of stroke burden after Mongolia, which are 3,382.2 / 100,000 people based on DALYs (disability-adjusted life-year). Based on the health profile of the province of Bali, the type of stroke that has high prevalence rate is ischemic stroke. Practical strategies in overcoming the burden of stroke must be focused on prevention and treatment based on risk factors. The study aims to determine the relationship between risk factors and the level of risk of ischemic stroke patients hospitalized at RSUD Klungkung Bali.Methods: This study is observational analytic study with a cross sectional design that includes 65 patients taken from the medical records. The variables studied are age, gender, pressure blood, cholesterol levels, smoking history, body mass index (BMI), physical activity, history of diabetes, history of atrial fibrillation, and history of stroke in the family. Data analysis techniques used were univariate analysis and bivariate analysis.Result: The most characteristics based on age group is â‰¥ 55 years - 64 years with an average age of 61.45 Â± 12.016 years. Patients are dominated by men (2,4:1). The assessment of the level of risk factors in each sample using the Stroke Risk Scorecard (SRS), 51 people (78.5%) had a high risk, 9 people (13.8%) had moderate risk, and 5 people (7.7%) has a low risk of ischemic stroke.Conclusion: The chi-square statistical analysis showed a significant relationship between the risk level of ischemic stroke with body mass index, blood pressure, smoking history, history of diabetes, and cholesterol levels (p<0,005).

Gambaran karakteristik fraktur radius distal di RSUP Sanglah Tahun 2013-2017 Irene Natalia Tantri; A. A. Gde Yuda Asmara; Agus Roy Rusly Hariantana Hamid
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: Radius distal fracture is the most common fracture seen in emergency department which involves the upper extremity. Radius distal fracture can occur in any age, ranging from children, teenager until elderly patients. There is an increasing trend of radius distal fracture. However, the research on radius distal fracture characteristic, especially in Bali, is still limited.Method: This study was a descriptive-retrospective study which aims to find out the characteristic of radius distal fracture at Sanglah General Hospital, Denpasar, Bali. For data collection, we used total sampling technique using secondary data from patientsâ€™ medical records. The study sample was all patient diagnosed with radius distal fractures between the year 2013-2017 with incomplete medical record as the exclusion criteria.Result: This study obtained 677 radius distal fracture samples. Most of the patients were male [434 cases (64,1%)] with the most common age range was between 20-29 years old [147 cases (21,7%)]. The most common etiology of radius distal fracture was traffic accident [322 cases (47,6%)]. Fracture of the other upper extremity parts, in addition to radius distal, was the most common complaints accompanying radius distal fractures [333 cases (49,2%]. Based on the length of stay, 84% patients were hospitalized less than 5 days.Conclusion: Distal radial fracture was commonly seen in men with the age range between 20-29 years old. Traffic accident was the most common cause of distal radial fracture with the average length of stay less than 5 days.

Hubungan jumlah konsumsi jeruk terhadap kejadian batu ginjal di RSUP Sanglah Denpasar Made Wahyu Krisnandewi; I Wayan Gede Sutadarma; Desak Made Wihandani
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Latar Belakang: Batu ginjal merupakan penyakit ketiga terbanyak di bidang urologi setelah penyakit kelenjar prostat dan infeksi saluran kemih. sitrat merupakan salah satu inhibitor yang penting dalam pengumpulan kalsium oksalat dan berhubungan dengan kejadian batu ginjal. Tujuan studi ini adalah mengetahui hubungan jumlah konsumsi jeruk terhadap kejadian batu ginjalMetode: Penelitian analitik dengan metode cross sectional (potong lintang) dan menggunakan data primer dan sekunder.Â Pengambilan data dilakukan di Rumah Sakit Umum Pusat Sanglah dari Januari sampai dengan Oktober 2018. Sebanyak 93 data dikoleksi dan dianlisis univariat, bivariat dan multivariate. Univariat menggunakan uji frekuensi, normlaitas dan tabulasi silang. Uji korelasi dan chisquare sebagai uji bivariat dan uji multivarait menggunakan regresi logistikHasil: Subjek penelitian terdiri atas 66.7% laki-laki dan 33.3% perempuan. Jangkauan usia pada sampel berkisar antara 15 tahun hingga 87 tahun, dengan rerata usia 52.38 + 11.3 tahun. Jenis kelamin laki-laki menunjukkan kecenderungan untuk memiliki batu ginjal bilateral (r= -0,258; p= 0.019). Korelasi negatif antara konsumsi jeruk dan batu ginjal dan tidak signifikan secara statistik (r= -0.024; p=0.533). regresi logistic menunjukkan jenis kelamin memilki hubungan yang disignifikan (p=0.0021; IK95%: 0.07-0.83).Simpulan: Batu ginjal disebabkan multifaktorial dan konsumsi jeruk tidak berkorelasi secara stastitikIntroduction: Kidney stone is the third most common disease in the disease of urology after prostate gland disease and urinary tract infections. Citrate is one of the important inhibitors of accumulation of calcium oxalate and associated with the incidence of kidney stones. This study aimed to determine the relationship of the amount of orange consumption to the incidence of kidney stonesMethod: The research is an analytical study with the cross-sectional method and using either primary or secondary data. Data collection was collected at the Sanglah hospital from January until October 2018. 93 data were collected and analyzed by univariate, bivariate and multivariate. Univariate uses frequency test, normalization, and cross-tabulation. Correlation and chi-square test as a bivariate test and multivariate test using logistic regressionResult: The study subjects consisted of 66.7% men and 33.3% women. The age range in samples from 15 to 87 years, with mean 52.38 + 11.3 years. The male sex showed a tendency to occur bilateral kidney stones (r = -0.258; p = 0.019). The correlation between the consumption of oranges and kidney stones was negatively and not statistically significant (r = -0.024; p = 0.533). Logistic regression states sex was a significant relationship (p = 0.0021; IK95%: 0.07-0.83)Conclusion: Kidney stones were caused by multifactorial and consumption of citrus was not statistically correlated.

Gambaran persepsi ibu terhadap obesitas pada anak usia sekolah dasar di Kecamatan Canggu, Kabupaten Badung, Bali tahun 2018 Putu Eksa Bidja Yudha Putri; Komang Ayu Kartika Sari; Luh Putu Ariastuti
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Latar Belakang: Obesitas adalah suatu keadaan terjadinya penumpukan lemak tubuh yang berlebih, sehingga berat badan seseorang jauh melebihi norma. Pemasalahan gizi lebih di Indonesia harus mendapatkan perhatian, prevalensi obesitas pada anak di indonesia terus meningkat. Pada tahun 2007 sebesar 7,95%, di tahun 2013 meningkat menjadi 18,8%.Metode: Penelitian ini merupakan penelitian deskrtitif dengan rancangan penelitian cross sectional yang bertujuan untuk menggambarkan persepsi ibu terhadap obesitas pada anak usai sekolah dasar. Sempel dari penelitian ini adalah sebanyak 92 responden, dengan teknik pengambilan sempel random sampling dan penelitian ini menggunakan alat ukur kuesionerHasil: Ibu yang memiliki persepsi positif terhadap obesitas pada anak sebanyak 56,5% sedangkan ibu yang memiliki persepsi negatif terhadap obesitas pada anak sebanyak 43,5%Simpulan: Masih banyak ibu yang menganggap bahwa obesitas pada anak bukan maslah bagi ksehatan anak.Â Introduction: Obesity is a condition where there is excess body fat accumulation so that a person's weight is far above normal. The current problem of overnutrition in Indonesia must get attention; the prevalence of obesity in children in Indonesia continues to increase in 2007 by 7.95% and increased to 18.8% in 2013.Method: This study is a descriptive study with a cross sectional study design that aims to describe mothers' perceptions of obesity in children after primary school. The samples from this study were 92 respondents, with random sampling technique and the research using a questionnaire measuring instrument.Result: Mothers who have a positive perception of obesity in children as much as 56.5% while mothers who have a negative perception of obesity in children as much as 43.5%.Conclusion: Based on these results it can be concluded that there are still many mothers who consider that obesity in children is not a problem for children's health.

Faktor penyebab infertilitas pasien program IVF (In Vitro Fertilization) di Klinik Graha Tunjung RSUP Sanglah Ni Wayan Ariati Trisna Dewi; Anom Suardika; Ryan Saktika Mulyana
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Latar Belakang: Infertilitas adalah tidak mampu untuk hamil sesudah 12 bulan atau lebih tanpa menggunakan kontrasepsi dan bersifat primer dimana pasangan yang gagal untuk mendapatkan kehamilan untuk meneruskan keturunan. Infertilitas dapat disebabkan oleh faktor perempuan, laki-laki maupun keduanya. Sekitar 50-80 juta pasangan mengalami infertilitas di dunia, infertilitas di negara berkembang terjadi lebih tinggi yaitu sekitar 30%, di bandingkan negara maju hanya 5-8%.Metode: Penelitian ini merupakan suatu penelitian deskriptif cross sectional, Sumber data berasal dari data sekunder yaitu rekam medis pasien yang mengalami infertilitas di klinik graha tunjung RSUP Sanglah periode Januari 2016 -Desember 2017. Pengambilan data di ambil dengan metode Total Sampling. Distribusi variabel penelitian yaitu pada perempuan dengan faktor tuba, uterus dan ovarium sedangkan pada laki-laki yaitu faktor sperma.Hasil: Kejadian infertilitas di RSUP Sanglah Denpasar periode Januari 2016 -Desember 2017 sebanyak 38 kasus. Pada perempuan yaitu faktor satu tuba non-paten sebanyak 4 kasus (25,0%), dan responden dengan kedua tuba non-paten sejumlah 12 kasus (75,0%). Kasus denghan kelainan Faktor ovarium, yaitu Endometrioma sebanyak 2 kasus (12,5%). Tidak didapatkan kasus dengan kelainan faktor Uterus pada Perempuan. Infertilitas pada laki-laki berdasarkan faktor sperma: oligozoospermia 1 kasus (5,6%), Asthenozoospermia 2 kasus (11,1%), Teratozoospermia 1 kasus (5,6%), Oligo Astheno Teratozoospermia 11 kasus (61,1%) dan Azoospermia 3 kasus (16,7%).Simpulan: Faktor penyebbab infertilitas pada perempuan yang paling tinggi adalah kelainan pada tuba yaitu, kedua tuba non patten. Sedangkann penyebab infertilitas paling tinggi pada laki-laki yaitu kelainan pada sperma Oligo Astheno Teratozoospermia.Introduction: Infertility is the inability to get pregnant after 12 months or more without using contraception and is primary where the couple fails to get a pregnancy to continue the offspring. Infertility can be caused by factors of women, men or both. Around 50-80 million couples experience infertility in the world, infertility in developing countries is higher, which is around 30%, compared to developed countries, only 5-8%.Method: This research is a cross-sectional descriptive study. The source of the data comes from secondary data, namely medical records of patients experiencing infertility at the clinic visiting Sanglah Hospital for the period January 2016-December 2017. Data collection was taken by the Total Sampling method. The distribution of research variables is in women with tubal, uterine and ovarian factors whereas in men it is sperm factor.Result: Infertility events at Sanglah General Hospital Denpasar in January 2016 -December 2017 were 38 cases. In women, the factor of one non-patent tube were 4 cases (25.0%), and respondents with both non-patent tubes were 12 cases (75.0%). Ovarian factor abnormalities, Endometrioma were 2 cases (12.5%). There were no cases of Uterine factor abnormalities in Women. Infertility in men based on sperm factors: 1 case oligozoospermia (5.6%), Asthenozoospermia 2 cases (11.1%), Teratozoospermia 1 case (5.6%), Oligo Astheno Teratozoospermia 11 cases (61.1%) and Azoospermia 3 cases (16.7%).Conclusion: The highest factor of infertility in women is abnormalities in the tube, both tubal non-patent. The highest cause of infertility in men is an abnormality in sperm, Oligo-Astheno-Teratozoospermia.

Gambaran pemeriksaan IgM anti-Salmonella thypi 09 pada penderita demam dan gangguan pencernaan, dengan atau tanpa gangguan kesadaran di Puskesmas Denpasar Timur I IGA Ayu Ratih Pradnyadewi; Ni Nyoman Mahartini; I Wayan Putu Sutirtayasa
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Latar Belakang: Demam tifoid merupakan penyakit endemik Indonesia, yang disebabkan oleh infeksi dari bakteri Salmonella typhi. Bakteri ini dapat ditularkan melalui makanan dan juga minuman yang terkontaminasi bakteri tersebut, bisa juga akibat dari terkontaminasi dari tinja maupun urin dari orang yang telah terinfeksi bakteri tersebut. Penegakan untuk diagnosis demam tifoid saat ini dapat dilakukan secara klinis maupun dengan cara pemeriksaan laboratorium. Salah satunya ialah uji serologis yang dapat digunakan dalam demam tifoid meliputi tes Tubex.Metode: Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross-sectional. Data dalam penelitian ini berasal dari sumber data primer berupa pengambilan serum pasien di Puskesmas Denpasar Timur I sejumlah 33 sampel.Hasil: Pasien yang berobat ke Puskesmas Denpasar Timur I didapatkan kelompok yang paling banyak ialah perempuan 81,9% sedangkan laki-laki 18,1%. Sebanyak 100% datang dengan keluhan demam, sebanyak 63,7% datang dengan keluhan mual dan muntah 9,0%.Simpulan: Hasil IgM anti-Salmonella thypi 09 positif sebanyak 9,1% dan IgM anti-Salmonella thypi 09 negatif sebanyak 90,9%.Introduction: Typhoid fever is an endemic disease in Indonesia, which is caused by an infection of the bacterium Salmonella typhi. These bacteria can be transmitted through food and beverages contaminated with these bacteria, can also be caused by contamination of feces and urine from people who have been infected with these bacteria. Enforcement for the diagnosis of typhoid fever can now be done clinically or by laboratory examination. One of them is the serological test that can be used in typhoid fever including the Tubex test.Method: This research is a descriptive study with a cross-sectional approach. The data in this study came from primary data sources in the form of taking serum of patients in the East Denpasar Health Center I with 33 samples.Result: Patients who went to the East Denpasar Public Health Center I, found the most group was women 81.9% while men 18.1%. As many as 100% came with complaints of fever, 63.7% came with complaints of nausea and vomiting were 9.0%.Conclusion: The positive results of anti-Salmonella thypi 09 were 9.1% and negative IgM anti-Salmonella thypi 09 as much as 90.9%.

Hubungan antara perubahan iklim dengan jumlah kasus demam dengue (DD) di Denpasar, Bali tahun 2010-2015 I Gusti Agung Bagus Arya Wiradarma; I Ketut Agus Somia
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: Dengue is one of tropical infectious disease that can give a serious public health problem in Denpasar. Several factors have been associated with the high prevalence of dengue fever; one of them is climate changes. This study aims to determine the relations between climate change and a number of dengue cases in Denpasar.Methods: The climate change and a number of dengue cases data take place in Denpasar from the year 2010-2015 using observational study. The Spearman correlation test was used to know the relation between climate change ( maximum and minimum temperature, rainfall, humidity, light duration, and wind velocity ) and a number of dengue cases. Data were analyzed using SPSS version 20 software for windows.Results: The highest prevalence of Dengue Fever infection was in 4,431 (38.16%) cases in 2010, followed by 1,837 (15,82%) cases in 2014, 1,766 (15.22%) cases in 2013, 1,576 (13.57%) cases in 2015, 1,009 (8.69%) cases in 2012, and 992 (8.54%) cases in 2011. Based on climate variables, rainfall has a weak significant relation affecting the number of dengue cases compared with others (r=0.247; p=0.036).Conclusion: Rainfall was the only climates variables significantly related to the high prevalence of dengue fever in Denpasar, Bali since 2010-2015. So, further efforts need to be done to prevent dengue cases on rainy season.

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