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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 8 Documents
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Search results for , issue "Vol 16, No 3 (2010)" : 8 Documents clear
ANALISIS BAHAN BAKU AIR MINUM DAN PRODUK OLAHANNYA SERTA ELIMINASI TERHADAP PENCEMARAN HORMON STEROID DAN LOGAM BERAT L. Mahaputra; SI Zadjuli; M. Ansori; Prihatin .; Sugianto .; Ismudiono .; H Callo
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 3 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i3.1033

Abstract

Steroid hormone and alloy could contaminate the drinking water which danger to human, because make bad side effect on the health. Steroid hormon may cause diseases ie. malignancy particularly of gen mutation and and heavy alloy may cause discrepancies oforgan among others: lever, kidneys, brain and the others. The objective of this research was to identify quantitatively either steroid sexhormones or heavy metal contaminants in drinking water. The water examination of PDAM, household and mineral water was doneby ELISA method to steroid hormones in Laboratory of veterinary obstetric and endocrine UNAIR .The alloy were analyzed by Atomicabsorption method in Dept. Of Chemistry in ITS laboratory. The data were analyzed by descriptive statistic show that all kinds of drinkingwater samples were not contaminated neither heavy metal such as Cd and Pb nor male sex hormone. But unfortunately contaminationof heavy metal mainly cuprum (Cu) spread it out for all kind of drinking water and its product so then the highest contamination foundin dig-land-water was 87%. The other hand more frequent female sex hormone contaminated drinking water there was estrogen and secondly followed with progesterone hormone. Examination of contaminant steroid hormone in drinking water, water supply of PDAM, Vendors water and mineral water didn’t contaminate with alloy (Cd and Pb) ,also they didn’t contaminate with testoteron hormonehowever almost water reservoir and more over dig-land-water of Mamuju Regency contaminated with Cu more than 0.02 ppm
PERAN ANTIGEN NS1 DENGUE TERHADAP PENGHITUNGAN TROMBOSIT DAN PENAMPAKAN (MANIFESTASI) KLINIS PENJANGKITAN/PENULARAN (INFEKSI) VIRUS DENGUE J Nugraha; T.E Widijatmoko
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 3 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i3.1038

Abstract

Dengue virus infection has become the major health problem in Indonesia. Dengue haemorrhagic fever is a part of dengue virus infection. 95% of this disease commonly affects children less than 15 years. However, in the last five years the incidence of DHF hasalso increased in adults. In 2008, the case fatality rate of DHF was 0.99% in East Java and 0.47% in Surabaya. The diagnosis of DHFis based on the 1997 WHO criteria. Thrombocytopenia is a haematological abnormality occurring in DHF. There is a hypothesis aboutthe role of non-structural 1 antigen (NS1 antigen) during initial virus replication leading to immunological reaction manifestationin thrombocytopenia. To analyze the role of NS1 antigen dengue to platelet count and clinical manifestations to know the degree ofdengue virus infection. This study used a cross-sectional design. The samples are comprised of 52 patients with dengue fever anddengue haemorrhagic fever grade I until III hospitalized at Tropical Disease Ward, Dr.Soetomo Hospital, and Surabaya. Data wereanalyzed using Mann-Whitney test, t-two sample test (p = 0.05). The result of this study using Mann-Whitney test show no difference between NS1 antigen dengue with the clinical manifestations in dengue virus infection (p = 0.882). Analysis using t-two sample test showed a significant difference between NS1 antigen dengue positive and NS1 antigen dengue negative with a change in platelet count (p = 0.006). Although, the test showed no significant difference between NS1 antigen dengue and the platelet count in dengue virusinfection (p = 0.062). There were found no significant association between NS1 dengue antigen with platelet count and clinicalmanifestations in dengue virus infection.
KADAR PENGHAMBAT PENGURAIAN FIBRIN OLEH TROMBIN YANG TERGIATKAN (THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR) DI PASIEN KEGEMUKAN DENGAN DAN TANPA DIABETES MELLITUS Mansyur Arif; Ichwani Meinard; Winni Agustiani
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 3 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i3.1035

Abstract

Obesity will cause the development of insulin resistance and endothelial dysfunction through fat metabolism hormones and cytokines products. The metabolic disorders is hallmarked by the decrease of insulin function and will cause disorders of coagulation andfibrinolysis. Thrombin-activatable fibrinolysis inhibitor (TAFI) is a newly found glycoprotein that has a role in the balance of coagulationand fibrinolytic process. The aim of this study was to analyze the TAFI level in obese subjects with and without diabetes mellitus. A crosssectional study was carried out by collecting data from TAFI level measurements at Prodia Clinical Laboratory Jakarta and Makassarduring January-March 2008. The data was analyzed using t test with SPSS version 12.0. From 80 samples that match with the criteria,was found in four (4) diabetes mellitus patients and 76 subjects without diabetes mellitus. The mean TAFI level in obese subjects withdiabetes mellitus was 7.67 ug/ml and in obese subjects without diabetes mellitus was 8.10 ug/ml. The result of t test showed p = 0.58.There was no significant difference between TAFI level in obese subjects with and without diabetes mellitus.
EPIDEMIOLOGI DAN DIAGNOSIS KEDOKTERAN LABORATORIK INFEKSI VIRUS H1N1 Sembiring, J; Sianipar, O
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 3 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i3.1040

Abstract

H1N1 virus is an influenza virus family orthomyxoviridae, which clinical symptoms consist of: fever, cough, sore throat and headache. The virus can spread from person to person through airborne droplets and so a good infection control in the community or in healthworkers is needed, for instance by washing hands properly and PPE (Personal Protective Equipment). In October 4, 2009 there were over375.000 reported cases in which 4500 people were died. On June 11, 2009 the WHO stairs announced that H1N1 is the first pandemicin the 21st century. (The Indonesia people province was infecting by H1N1with 20 deaths until August 5, 2009). The purpose of thisarticle is to find out the epidemiological aspects as well as the diagnosis of influenza A H1N1 virus. From the website was found about1.110.000 sources, and after downloading them are selected as they are written only in the bibliography. From the searched informationobtained, it was known that H1N1 infection diagnosis begins with the discovery of heat (temperature ≥ 100° F [37.8° C]) and cough or sore throat. No cause other than influenza that is called with ILI was found. The informed laboratory examination is divided into three parts are confirmed if ILI was found as well as the virus in the throat or nasal swab by RT-PCR and/or virus culture; probably the ILIhas positive results of influenza A RT-PCR, but if the results are negative including the laboratorial findings, the basis of epidemiologyin this case was only suspected. Laboratory plays an important role in the establishing of the H1N1 infection diagnosis Rapid diagnosisis important to reduce infection, to protect patients from complications by antiviral treatment in the right time and also to provideimmediate information for the public.
PENGGUNAAN ANTIBIOTIKA BAGI PENDERITA BALITA PNEUMONIA DAP. Rasmika Dewi; Dewa Ayu Swastini
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 3 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i3.1037

Abstract

Pneumonia is a major cause of morbidity and mortality of children under 5 years old (toddlers). The number of antibiotics use as a therapeutic treatment of pneumonia has caused bacterial resistance, medicinal side effect, and increasing medication cost. Thisresearch was carried out intended to know the relationship between antibiotic regimens used for pneumonia therapy and the outcome ofparameters, such as body temperature and respiratory rate (RR), as well as the length of stay. This study is carried out in a retrospectivedescriptive design, using pneumonia patient’s medical record (children under 5 years old), during the period from the 1December 2008. It was shown in this study that the dose of antibiotics given to pneumonia children under 5 years old are in single,combination, and transition form. The single antibiotics most widely used is Cefotaxime (87.5%), and the combination is Ampicillin–Chloramphenicol (94.4%) while transitional is Ampicillin –Chloramphenicol to Cephalosporin group (58.3%). The use of antibiotics forpneumonia among children under five patients either single, combination, and transition was successful in obtaining therapy outcome,including decreasing body temperature from > 38° C to normal body temperature, is 36° C–38° C and decreasing RR value with theaverage length of stay for five (5) days. st January – 31st
HIPERURISEMIA SEBAGAI FAKTOR RAMALAN PERJALANAN PENYAKIT (PROGNOSIS) GEJALA KLINIK STROK INFARK Fenty .; Harjo Mulyono; Siti Muchayat
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 3 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i3.1034

Abstract

Infarction stroke is a leading cause mortality and disability in the world. Appropriate management of acute infarction stroke will be able to reduced morbidity and mortality of the disease. Many laboratory parameters which can be done for detecting risk of prognosticfactors, one of them is serum uric acid concentration. The aim of this study is to know if hyperuricemia is prognostic factor for clinicaloutcome in acute infarction stroke.A prospective cohort study was carried out, compare between two groups of exposed and non-exposedgroup. Subjects who meet inclusion and exclusion criteria was involved in the study. The exposed group was a group of acute infarctionstroke patients who exposed to hyperuricemia, in other hand, patient who do not have hyperuricemia was separated as the non-exposedgroup. Inception cohort was applied when patient admits to emergency unit during 48 hours of onset, age ≥ 40 years old, man orwoman, have signed informed consent are inclusion criteria. Gadjah Mada Stroke Scale and serum uric acid concentration was measured on admission. Patient with haemorhage stroke and who are taking medicine that cause decrease uric acid are excluded. Test of serum uric acid concentration was performed by using Vitros 250, dry chemistry system. Patients were followed up 7 days in Neurology Unitand the outcome were measured by evaluating a score of Gadjah Mada Stroke Scale. Prognostic factor hyperuricemia has RR= 2.159(95% CI: 0.684-6.816), p= 0.158 for outcome. Hyperuricemia is not be evident as prognostic factor in acute infarction stroke.
DAN MYELOPEROxIDASE) DAN DISFUNGSI ENDOTEL (ASIMETRIK DIMETILARGININ) DI KEGEMUKAN (OBESITAS) Joko Widodo; Burhanuddin Bahar; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 3 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i3.1039

Abstract

Obesity is a pathological condition in which there is an excess body fat due to imbalance energy expenditure. Its association with oxidative stress could cause other metabolic disorders such as endothelial dysfunction, atherosclerosis, and cardiovascular disease. Theaim of this study was to assess the correlation of oxidative stress (F2-Isoprostane, Superoxide dismutase and Myeloperoxidase) andendothelial dysfunction (Asymmetric dimethylarginine) which happened in central obese men. A cross sectional study was carried outin 62 central obesity male subjects with ages range between 30−60 years. The researcher determined SOD activity, concentration ofMPO as well as ADMA. In this study was found a significant correlation of F2-Isoprostan (r = 0.333, p = 0.008), MPO (r = 0.386; p = 0.008) and ADMA but not with SOD. The elevated concentration of F2-Isoprostane occur 3.5 times (p = 0.02; 95%; CI = 1.19–10.19), elevated MPO occur 3.7 times (p = 0.023; 95%; CI = 1.16–11.56) while combination of elevated F2-Isoprostane-MPO occur6.7 times (p = 0.011; 95%; CI = 1.33-33.24) will increase the risk of endothelial dysfunction. There was a significant correlation of oxidative stress with endothelial dysfunction, and the increase concentration of F2-Isoprostane and MPO indicates the occurrence of endothelial dysfunction in central obesity.
IDIOPATHIC THROMBOCYTOPENIC PURPURA Alvina .; Diana Aulia
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 3 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i3.1036

Abstract

Idiopathic thrombocytopenic purpura is an autoimunne disease with low platelet count and bleeding manifestation like purpura, echymosis, petechie, mucosa membrane bleeding. The cause of ITP is platelet coated with specific thrombocyte autoantibody. Idiopathicthrombocytopenic purpura is classified as primary or secondary. The primary ITP is classified as acute and chronic.. Children and adultonset idiopathic thrombocytopenic purpura are different. An Acute ITP can be found in children and chronic onset can be found in adult.The duration of bleeding may help to distinguish acute and chronic idiopathic thrombocytopenic purpura. The diagnosis of idiopathicthrombocytopenic purpura remains one of exclusion after other thrombocytopenic disease are ruled out based on history and needanamnesa, physical examination, thrombocyte count, perifer blood smear examination, bone marrow smear examination. The treatmentis to raise the platelet count into a hemostatically safe range. This article presented a study case of idiopathic thrombocytopenic purpuraon an old woman with DIC which caused her death.

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