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All Journal Medical Laboratory Technology Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) UMI Medical Journal
Mansyur Arif
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Correlation Between Onset of Diabetes Mellitus and Nitric Oxide Levels in Patient with Type 2 Diabetes Mellitus Theosobia Grace Orno; Mansyur Arif; Irfan Idris
Medical Laboratory Technology Journal Vol. 4 No. 1 (2018): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (930.985 KB) | DOI: 10.31964/mltj.v4i1.175

Abstract

Type 2 diabetes mellitus (DM) is associated with increased risk of endothelial dysfunction if it lasts a long time without control. This study aims to connect the Onset of Diabetes Mellitus (DM) with Nitric Oxide levels in patients of type 2 diabetes mellitus. The study used cross-sectional study method. The samples were 86 subjects, consisting of 38 subjects of Type 2 DM controlled and 48 subjects of Type 2 DM uncontrolled. The results of the Kruskal-Wallis statistical test showed no significant difference between the Onset of DM and Nitric Oxide levels in the categories of 4-6 years (19.4 ± 10.1), 7-9 years (17.3 ± 9.3) and 10-12 years (13.3 ± 8.5) (p=0.06). Furthermore, the Spearman correlation test revealed a negative correlation between the Onset of DM and Nitric Oxide level in patients with Type 2 DM with and without control (r =-0.217). The level of Nitric Oxide (NO) can consider as a predictor of long-term complication in patients with type 2 DM.
Analisis Antibodi Ireguler pada Reaksi Inkompatibel Darah Transfusi Irna Diyana Kartika; Hilma Yuniar Thamrin; Rachmawati Muhiddin; Mansyur Arif; Ibrahim Abdul Samad
UMI Medical Journal Vol 5 No 2 (2020): UMI Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/umj.v5i2.93

Abstract

Latar belakang: Terjadi kasus inkompatibilitas karena pemberian darah yang inkompatibel dapat disebabkan oleh dua hal, yang pertama akibat ketidakcocokan golongan darah saat melakukan transfusi sehingga terjadi reaksi hemolisis intravaskular akut dan juga dapat disebabkan oleh reaksi imunitas antara antigen dan antibodi karena adanya golongan darah lain atau antibodi ireguler. Penelitian ini bertujuan untuk menganalisis antibodi ireguler pada hasil inkompatibilitas darah transfusi uji silang serasi darah transfusi. Metode: Penelitian ini merupakan penelitian observasional dengan menggunakan metode cross sectional. Sampel penelitian sebanyak 70 sampel inkompatibel uji silang serasi yang ditemukan di Unit Bank Darah RSUP Dr. Wahidin Sudirohusodo Makassar dan Unit Donor Darah PMI Makassar. Dilakukan pemeriksaan golongan darah dan uji silang serasi jika sampel yang telah di lakukan uji silang serasi dan hasilnya terjadi reaksi inkompatibel golongan darah maka sampel tersebut diambil kemudian di lanjutkan ke Direct antiglobulin test. Sampel yang Direct antiglobulin test positif dilanjutkan dengan pemeriksaan monospesifik yaitu tes IgG dan C3d. Analisis data menggunakan Metode analitik, yaitu dengan uji Chi Square untuk menilai variabel yang berhubungan dengan antibodi ireguler. Hasil: Penelitian menunjukkan bahwa, dari 70 sampel yang mengalami reaksi inkompatibilitas ternyata hanya 7 sampel yang positif memiliki antibodi ireguler, di antaranya Anti E 3 (4,29%), anti CDEd 1 (1,42%), dari ketujuh sampel yang positif terdapat 2 (2,86%) sampel yang positif semua pada sebelas sel panel tersebut dan terdapat 1 (1,42%) sampel yang positif pada sel panel kecil (sel 1 dan sel 2) untuk skrining antibodi. Kesimpulan: Kejadian inkompatibel golongan darah sebagian besar bukan karena adanya antibodi ireguler, hanya sekitar 10% inkompatibel akibat antibodi ireguler terjadi maka skrining antibodi ireguler belum menjadi urgensi di setiap Unit pelayanan Transfusi darah maupun di unit Bank darah Rumah sakit.
THE MORPHOLOGICAL FEATURES OF ERYTHROCYTES IN STORED PACKED RED CELLs Dewi Sri Kartini; Rachmawati Muhiddin; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 2 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i2.1128

Abstract

Morfologi eritrosit Packed Red Cells (PRC) akan mengalami perubahan selama penyimpanan di suhu 2°–8°C. Eritrosit dalammempertahankan viabilitasnya membutuhkan adenosine triphosphate (ATP). Apabila kadar ATP intraseluler menurun, terjadi kerusakanlipid membran, penumpukan Natrium dan Kalsium intraseluler, penurunan kadar Kalium dan air intraseluler, dehidrasi sel, membranmenjadi kaku dan bentuknya berubah dari cakram menjadi sel krenasi, sferosit dan bite cell. Penelitian ini bertujuan untuk melihatpersentasi bentuk eritrosit crenated cell, sferosit dan bite cell PRC simpan pada hari ke-3 yang digunakan sebagai pembanding, hari ke-7,ke-14 dan ke-21 dari tanggal aktaf kantong darah. Penelitian observasional dengan pendekatan kajian kohort dilakukan pada bulanAgustus 2015 di BDRS RSUP Dr. Wahidin Sudirohusodo Makassar. Sampel sebanyak 30 selang kantong darah menjadi 120 hapusandarah slide. Dari 30 sampel kantong darah dengan golongan darah A 26,6%, B 13,3%, AB 16,6% dan O 43,3%, didapatkan peningkatanpersentase jumlah crenated cell, sferosit dan bite cell setelah penyimpanan hari ke-3, ke-7, ke-14 dan ke-21. Penyimpanan hari ke-3dijadikan pembanding. Data diolah dengan menggunakan uji Fiedman dan Wilcoxon dengan nilai kemaknaan p<0,001. Terdapatpeningkatan persentase perubahan morfologi eritrosit (crenated cell, sferosit dan bite cell) seiring dengan lamanya penyimpanan darahPRC. Pemakaian darah PRC dianjurkan tidak boleh melebihi 21 hari penyimpanan.
TALASEMIA BETA HEMOGLOBIN E (Hemoglobin E Beta Thalassemia) Viviyanti Zainuddin; Agus Alim Abdullah; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 3 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i3.1286

Abstract

Thalassemia is a quantitative abnormality of the hemoglobin marked by inadequate hemoglobin synthesis due to the lack orabsence of synthesis of one or more globin polypeptide chains. Hemoglobin variant is a qualitative abnormality due to the presence ofthe abnormal amino acid sequence of one or more globin polypeptide chains. HbE β thalassemia is a disorder of hemoglobin that resultsfrom the fusion between the gene β-thalassemia allele from one parent with a gene HbE allele from another parent. In this case, HbEβ-Thalassemia patient was a 4.8 year girl diagnosed with hemoglobin E-beta thalassemia based on history and clinical manifestations;pale, the presence of splenomegaly and hepatomegaly. Laboratory tests were Hb: 7.7 g/dL, MCV: 52.9 fl, MCH: 17.7 pg, MCHC: 33.5g/dL and ferritin: 1012 ng/mL. Peripheral blood smear evaluation showed a microcytic hypochromic anemia with hemolytic signs andinfected features of leukocytes. Hb electrophoresis using HPLC showed a Hb F: 37.7% and HbA2 52.4%, indicating that HbA2 was falsehigh due to coeluating with HbE. The patient was treated by blood transfusion and received additional therapy such as folic acid, ironchelation and vitamin E.
ANGKA BANDING NETROFIL/LIMFOSIT DI POPULASI DEWASA MUDA Arie Yanti; Uleng Bahrun; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 2 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i2.1110

Abstract

Previous studies have shown that neutrophil/lymphocyte ratio in bacteremia is higher than nonbacteremia, therefore it could beused as a marker to distinguish both conditions in patients with sepsis .Another study on oncology patients in ICU showed a correlationbetween the severity of clinical course and the increase of neutrophil/lymphocyte ratio. In physiological condition, neutrophil/lymphocyteratio <5, while in pathological conditions (severe infection or systemic inflammation) neutrophil/lymphocyte ratio increases >6.Neutrophil/lymphocyte ratio is a sensitive, fast, cost effective and applicable laboratory test for routine use, therefore this test result canbe used as the parameter to assess clinical condition of patients. However, a reference value of neutrophil/lymphocyte ratio has neverbeen defined, especially in Makassar City, South Sulawesi Province. The aim of this study was to know the neutrophil/lymphocyte ratioin a healthy young adult population. A cross sectional study was conducted from March to April 2014, involving residents (specialisticcandidates in Medical Faculty, Hasanuddin University, who underwwent medical checkup and voluntarily joined this study. Samplesconsisted of 198 persons who fulfilled the inclusion criteria with an age range between 24-40 years old, comprising 84 males (42.42%)and 114 females (57.58%). The neutrophil/lymphocyte ratio for all samples was 1.95 (1.15-4.74). Mann Whitney test showed thatthere was no significant difference of neutrophil/lymphocyte ratio between males and females, 1.88 (1.25-4.74) vs 1.95 (1.15-4.12),p=0.65 and neither between the age group 21-30 years old and 31-40 years old, 1.95 (1.21-4.74) vs 1.94 (1.15-4.09), p=0.82.
ESTIMATED BLOOD LOSS IN OPEN HEART SURGERY (Taksiran Kehilangan Darah di Bedah Jantung Terbuka) Riesti Ekasanti; Rachmawati Muhiddin; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 3 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i3.1232

Abstract

Taksiran kehilangan darah merupakan perkiraan kehilangan darah di setiap tindakan pembedahan. Permintaan darah untukpersiapan pembedahan elektif sering tidak sesuai dengan jumlah darah yang ditransfusikan selama tindakan tersebut karena belum adapanduan mengenai jumlah permintaan darah untuk tata langkah bedah. Penelitian ini bertujuan untuk mengetahui taksiran kehilangandarah pada pembedahan jantung terbuka dan kesesuaian dengan permintaan darah dalam kegiatan tersebut. Penelitian dilakukan secaraobservasional retrospektif seraya mengambil data rekam medis di Instalasi Rekam Medik RSUP dr. Wahidin Sudirohusodo Makassarantara bulan Januari 2009−Desember 2012. Sebanyak 32 pasien yang menjalani bedah jantung terbuka didapatkan dengan presentasilaki-laki sebanyak 22 pasien (68,75%) dan perempuan sebanyak 10 orang (31,25%). Jumlah taksiran kehilangan darah bedah jantungterbuka rerata 2,80 kantong darah lengkap (980 mL) dan permintaan darah untuk kegiatan tersebut rerata sebanyak 4,00 kantong(1400 mL). Antara jumlah permintaan darah persiapan bedah dan taksiran kehilangan darah (p=0,149) terdapat ketidaksesuaian.Taksiran kehilangan darah di bedah jantung terbuka di RSUP dr. Wahidin Sudirohusodo Makassar di RSUP dr. Wahidin SudirohusodoMakassar adalah 2,80 kantong darah lengkap (980 mL), yang tidak sesuai dengan jumlah permintaan darah persiapan bedah.
DIAGNOSIS TIROID (Diagnosis of Thyroid) Liong Boy Kurniawan; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 3 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i3.1285

Abstract

Thyroid disease often causes unspecific or mild symptoms, so laboratory tests are needed to confirm the functional diagnosis of thethyroid disorder. The laboratory tests which are important to establish the diagnosis of thyroid disorder include: total and free thyroidhormones, its related (thyroid) hormone binding proteins and auto antibodies. The thyroid hormone tests are mostly measured withcompetitive or sandwich immunoassays and each method can be interfered by several factors. Some drugs may increase or decrease thethyroid functional tests and several factors such as: underlying diseases, age, pregnancy, occurrence of heterophil antibody and autoantibodies may also interfere the thyroid tests results. The interpretation of an unusual combination from thyroid stimulating hormonesuch as free thyroxin and tri-iodothyronine results needs confirmation of underlying condition for establishing the right diagnosis. Thisreview is aimed to evaluate several factors which may influence the thyroid tests and interpretation.
TURNAROUND TIME UJI COCOK SERASI DI PELAYANAN BANK DARAH (Turnaround Time Cross Match in the Blood Bank) Glent Nurtanio; Rachmawati Muhiddin; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 1 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i1.1220

Abstract

Turnaround Time (TAT) is the time between the blood request form arriving at the blood bank and when it is issued by the bloodbank. Blood Bank RSWS standard on the TAT of Stat blood service is <45 minutes and is regularly <60 minutes. The aim of this researchwas to know the TAT of blood services at the Blood Bank of the Dr Wahidin Sudirohusodo Hospital, Makassar. The research was carriedout by cross sectional study between August until November 2013. The data were divided into two (2) categories, which were Stat andregular blood service. The blood service was divided into three (3) service times, morning (08:00–14:00), afternoon (14:00–21:00) andevening (21:00–08:00). The statistical method used was Independent Samples T Test. There were 1.366 blood services consisting of 831Stat blood service with average TAT about 37.15 minutes (82.9% complied to standard) and 535 regular blood service with averageTAT about 45.73 minutes (96.1% complied to standard). There were significant differences between morning and afternoon (p=0.000)and between afternoon and evening Stat TAT (p=0.003), but there was no significant difference between morning and evening StatTAT (p=0.196). No significant difference was found in regular TAT between the morning and afternoon session (p=0.915), as well asnoon and evening (p=0.490); and morning and evening session (p=0.428). The TAT blood service at the Dr. Wahidin SudirohusodoHospital Blood Bank which was carried out by gel method should shorten the waiting time of Stat and regular blood service, but not upto 100% yet. Based on this study, the researchers recommended to do some regulation changes in the blood service system especiallyfor the morning and evening Stat sessions.
HUBUNGAN DERAJAT PERLEMAKAN HATI NON-ALKOHOLIK DENGAN AKTIVITAS AMINOTRANSFERASE SERUM Nyoman Trisna Yustiani; Mutmainnah .; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.1027

Abstract

Fatty liver could be related to alcoholic or non-alcoholic. Mild to moderate elevation of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities are the most laboratories test ordered in patient with non-alcoholic fatty liver. This studyhas purposed to know the relation of degree non-alcoholic fatty liver’s with aminotransferase serum activity. A cross-sectional studywas done in 38 patients with non-alcoholic fatty liver aged 30 to 60 years at Clinical Pathology Laboratory Installation and RadiologyDepartment Dr. Wahidin Sudirohusodo Hospital in Makassar from March to July, 2008. Patient made to criteria done some laboratorytest for AST and ALT examination. Data was analyzed using T-Test in SPSS for windows version 11,5. In this study we found that therewere a significant difference between non-alcoholic fatty liver degree with AST and ALT activity in cutt off 18 (p < 0,05). From this studywe could conclude that the activity of AST and ALT serum can be used to predict probability of non-alcoholic fatty liver.
DAN MYELOPEROxIDASE) DAN DISFUNGSI ENDOTEL (ASIMETRIK DIMETILARGININ) DI KEGEMUKAN (OBESITAS) Joko Widodo; Burhanuddin Bahar; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 3 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i3.1039

Abstract

Obesity is a pathological condition in which there is an excess body fat due to imbalance energy expenditure. Its association with oxidative stress could cause other metabolic disorders such as endothelial dysfunction, atherosclerosis, and cardiovascular disease. Theaim of this study was to assess the correlation of oxidative stress (F2-Isoprostane, Superoxide dismutase and Myeloperoxidase) andendothelial dysfunction (Asymmetric dimethylarginine) which happened in central obese men. A cross sectional study was carried outin 62 central obesity male subjects with ages range between 30−60 years. The researcher determined SOD activity, concentration ofMPO as well as ADMA. In this study was found a significant correlation of F2-Isoprostan (r = 0.333, p = 0.008), MPO (r = 0.386; p = 0.008) and ADMA but not with SOD. The elevated concentration of F2-Isoprostane occur 3.5 times (p = 0.02; 95%; CI = 1.19–10.19), elevated MPO occur 3.7 times (p = 0.023; 95%; CI = 1.16–11.56) while combination of elevated F2-Isoprostane-MPO occur6.7 times (p = 0.011; 95%; CI = 1.33-33.24) will increase the risk of endothelial dysfunction. There was a significant correlation of oxidative stress with endothelial dysfunction, and the increase concentration of F2-Isoprostane and MPO indicates the occurrence of endothelial dysfunction in central obesity.
Co-Authors Agus Alim Abdullah Ani Kartini Arie Yanti Asvin Nurulita Baharuddin Baharuddin Burhanuddin Bahar Cyntia Kornelius D. Daud Darmawaty Rauf Darwati Muhadi Dewi Sri Kartini Fitrie Octavia Glent Nurtanio HAM Akil Hardjoeno Hardjoeno Hendra Rasubala herlinah herlinah Hilma Yuniar Hilma Yuniar Thamrin Hj. Darmawaty E.R, I Hutagalung I. Hutagalung Ibrahim Abd. Samad Ibrahim Abdul Samad Ibrahim Labeda Ichwan Meinardi Ichwani Meinard Idham Jaya Ganda Irawaty Irawaty Irfan Idris Irna Diyana Kartika Iwan Joseph Joko Widodo Juranah . Kusriny A.P. Lince Wijoyo Liong Boy Kurniawan, Liong Boy Misnah Misnah Mutmainnah . Nur Rahmi Raehaan Nurhayana Sennang Nursin Abd. Kadir Nyoman Trisna Yustiani Rachmawati A.M Rachmawati AM Rachmawati Muhiddin Rachmawati Muhiddin Raehana Samad Reini Meilani Isbach Riesti Ekasanti Rifai Amirudin Rima Yuliati Muin Rostina Rostina Sri Wahyunie S Suci Aprianti Sukmawaty Sukmawaty Sulina Yanti Wibawa Suryani Jamal Susi Sevianty Syahraswati Syahraswati Theosobia Grace Orno Uleng Bahrun Viviyanti Zainuddin Waode Rusdiah Winni Agustiani Wiwi Payung Yedid Lebang Yosep F. Tallulembang