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All Journal Medical Laboratory Technology Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) UMI Medical Journal Journal of Health Science Community Ebers Papyrus
Mansyur Arif
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Correlation Between Onset of Diabetes Mellitus and Nitric Oxide Levels in Patient with Type 2 Diabetes Mellitus Theosobia Grace Orno; Mansyur Arif; Irfan Idris
Medical Laboratory Technology Journal Vol. 4 No. 1 (2018): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (930.985 KB) | DOI: 10.31964/mltj.v4i1.175

Abstract

Type 2 diabetes mellitus (DM) is associated with increased risk of endothelial dysfunction if it lasts a long time without control. This study aims to connect the Onset of Diabetes Mellitus (DM) with Nitric Oxide levels in patients of type 2 diabetes mellitus. The study used cross-sectional study method. The samples were 86 subjects, consisting of 38 subjects of Type 2 DM controlled and 48 subjects of Type 2 DM uncontrolled. The results of the Kruskal-Wallis statistical test showed no significant difference between the Onset of DM and Nitric Oxide levels in the categories of 4-6 years (19.4 ± 10.1), 7-9 years (17.3 ± 9.3) and 10-12 years (13.3 ± 8.5) (p=0.06). Furthermore, the Spearman correlation test revealed a negative correlation between the Onset of DM and Nitric Oxide level in patients with Type 2 DM with and without control (r =-0.217). The level of Nitric Oxide (NO) can consider as a predictor of long-term complication in patients with type 2 DM.
Analisis Antibodi Ireguler pada Reaksi Inkompatibel Darah Transfusi Irna Diyana Kartika; Hilma Yuniar Thamrin; Rachmawati Muhiddin; Mansyur Arif; Ibrahim Abdul Samad
UMI Medical Journal Vol 5 No 2 (2020): UMI Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/umj.v5i2.93

Abstract

Latar belakang: Terjadi kasus inkompatibilitas karena pemberian darah yang inkompatibel dapat disebabkan oleh dua hal, yang pertama akibat ketidakcocokan golongan darah saat melakukan transfusi sehingga terjadi reaksi hemolisis intravaskular akut dan juga dapat disebabkan oleh reaksi imunitas antara antigen dan antibodi karena adanya golongan darah lain atau antibodi ireguler. Penelitian ini bertujuan untuk menganalisis antibodi ireguler pada hasil inkompatibilitas darah transfusi uji silang serasi darah transfusi. Metode: Penelitian ini merupakan penelitian observasional dengan menggunakan metode cross sectional. Sampel penelitian sebanyak 70 sampel inkompatibel uji silang serasi yang ditemukan di Unit Bank Darah RSUP Dr. Wahidin Sudirohusodo Makassar dan Unit Donor Darah PMI Makassar. Dilakukan pemeriksaan golongan darah dan uji silang serasi jika sampel yang telah di lakukan uji silang serasi dan hasilnya terjadi reaksi inkompatibel golongan darah maka sampel tersebut diambil kemudian di lanjutkan ke Direct antiglobulin test. Sampel yang Direct antiglobulin test positif dilanjutkan dengan pemeriksaan monospesifik yaitu tes IgG dan C3d. Analisis data menggunakan Metode analitik, yaitu dengan uji Chi Square untuk menilai variabel yang berhubungan dengan antibodi ireguler. Hasil: Penelitian menunjukkan bahwa, dari 70 sampel yang mengalami reaksi inkompatibilitas ternyata hanya 7 sampel yang positif memiliki antibodi ireguler, di antaranya Anti E 3 (4,29%), anti CDEd 1 (1,42%), dari ketujuh sampel yang positif terdapat 2 (2,86%) sampel yang positif semua pada sebelas sel panel tersebut dan terdapat 1 (1,42%) sampel yang positif pada sel panel kecil (sel 1 dan sel 2) untuk skrining antibodi. Kesimpulan: Kejadian inkompatibel golongan darah sebagian besar bukan karena adanya antibodi ireguler, hanya sekitar 10% inkompatibel akibat antibodi ireguler terjadi maka skrining antibodi ireguler belum menjadi urgensi di setiap Unit pelayanan Transfusi darah maupun di unit Bank darah Rumah sakit.
LIPID PROFILE ANALYSIS ON REGULAR AND NON-REGULAR BLOOD DONORS (Analisis Profil Lipid di Pendonor Darah Reguler dan Non-Reguler) Waode Rusdiah; Rachmawati Muhiddin; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 1 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i1.1180

Abstract

Profil lipid merupakan petunjuk untuk menilai faktor kebahayaan penyakit jantung koroner, terutama jika terdapat bukti adanyaperoksidase lipid. Beberapa laporan telah mengaitkan donor darah secara regular dengan menurunnya tolok ukur profil lipid. Donordarah secara regular akan menurunkan kadar zat besi dan pada gilirannya akan menurunkan peroksidase lipid. Penelitian ini bertujuanmengetahui kadar profil lipid di pendonor darah regular dan non-regular, menggunakan pendekatan secara potong lintang denganmengambil sampel darah di UTD Transfusi Darah Dinas Kesehatan Propinsi Sulawesi Selatan. Diperoleh sebanyak 60 sampel darah yangberasal dari donor regular 30 orang (50,0%) dan non-reguler 30 orang (50,0%). Rentang umur 18–40 tahun 27 orang (45,0%) dan41-60 tahun 33 orang (55,0%). Di telitian ini kelompok pendonor darah regular rerata memiliki kolesterol total 157,93 mg/dL dan LDL95,33 mg/dL yang lebih rendah dibandingkan dengan kelompok non-regular dan menunjukkan perbedaan bermakna secara statistik(ρ=0,001). Kadar HDL secara bermakna lebih tinggi (ρ=0,015) di kelompok non-regular 43,20 mg/dL dibandingkan dengan kelompokregular 35,50 mg/dL. Kadar Trigliserida (ρ=0,673) menunjukkan tidak terdapat perbedaan bermakna antara kelompok regular dannon-regular. Donor secara teratur dapat memberikan perlindungan terhadap penyakit kardiovaskular seperti yang tercermin dari nilairerata kolesterol total dan kadar LDL yang secara bermakna lebih rendah di pendonor darah regular daripada non-reguler.
ANGKA BANDING NETROFIL/LIMFOSIT DI POPULASI DEWASA MUDA Arie Yanti; Uleng Bahrun; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 2 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i2.1110

Abstract

Previous studies have shown that neutrophil/lymphocyte ratio in bacteremia is higher than nonbacteremia, therefore it could beused as a marker to distinguish both conditions in patients with sepsis .Another study on oncology patients in ICU showed a correlationbetween the severity of clinical course and the increase of neutrophil/lymphocyte ratio. In physiological condition, neutrophil/lymphocyteratio <5, while in pathological conditions (severe infection or systemic inflammation) neutrophil/lymphocyte ratio increases >6.Neutrophil/lymphocyte ratio is a sensitive, fast, cost effective and applicable laboratory test for routine use, therefore this test result canbe used as the parameter to assess clinical condition of patients. However, a reference value of neutrophil/lymphocyte ratio has neverbeen defined, especially in Makassar City, South Sulawesi Province. The aim of this study was to know the neutrophil/lymphocyte ratioin a healthy young adult population. A cross sectional study was conducted from March to April 2014, involving residents (specialisticcandidates in Medical Faculty, Hasanuddin University, who underwwent medical checkup and voluntarily joined this study. Samplesconsisted of 198 persons who fulfilled the inclusion criteria with an age range between 24-40 years old, comprising 84 males (42.42%)and 114 females (57.58%). The neutrophil/lymphocyte ratio for all samples was 1.95 (1.15-4.74). Mann Whitney test showed thatthere was no significant difference of neutrophil/lymphocyte ratio between males and females, 1.88 (1.25-4.74) vs 1.95 (1.15-4.12),p=0.65 and neither between the age group 21-30 years old and 31-40 years old, 1.95 (1.21-4.74) vs 1.94 (1.15-4.09), p=0.82.
THE ANALYSIS OF CALCIUM LEVEL IN STORED PACKED RED CELLS Suryani Jamal; Rachmawati Muhiddin; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 3 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i3.1194

Abstract

Penelitian ini bertujuan mengetahui; pengaruh penyimpanan terhadap kadar kalsium pada darah simpan Packed Red Cells (PRC);menentukan kadar kalsium pada hari ke-7, hari ke-21 dan hari ke-35 dan membandingkan kadar kalsium hari ke-7 dan hari ke-21,hari ke-7 dan hari ke-35, hari ke-21 dan hari ke-35. Penelitian ini dilaksanakan di Bank Darah dan Laboratorium Patologi Klinik RSUPDr. Wahidin Sudirohusodo. Metode yang digunakan dalam penelitian ini adalah observasional dengan pendekatan potong lintang.Pengambilan sampel dilakukan di semua darah simpan Packed Red Cells (PRC) yang disalurkan di Bank Darah RSUP Dr. WahidinSudirohusodo. Data dianalisis dengan uji statistik Repeated Anova Test. Hasil penelitian menunjukkan bahwa terdapat perbedaanbermakna kadar kalsium darah simpan PRC akibat pengaruh penyimpanan pada hari ke-7 dan hari ke-21, pada hari ke-7 dan harike-35 serta hari ke-21 dan hari ke-35. Penurunan kadar kalsium terjadi karena eritrosit sudah mulai terjadi lisis.
KADAR KOLESTEROL HDL TERUKUR MENGGUNAKAN REAGEN CHOLESTEST N HDL DAN HDL-C PLUS GENERASI KETIGA Ichwan Meinardi; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 2 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i2.971

Abstract

The using of the open reagent system tools gives the possibility to choose the best quality of reagents including the reagent for HDLcholesterol concentration test. Hitachi 902 (Roche) as an open reagent system tool may used Cholestest N HDL (Daichi) as the firstHDL reagent and HDL-C plus 3rd generation reagent (Roche). The aim of this study was to know the correlation of HDL cholesterolconcentrations using Cholestest N HDL and HDL-C plus 3rd generation reagents measured by Hitachi 902. A cross sectional study wasdone from April to June 2008 at Ratulangi Medical Centre Laboratory, Makassar. The HDL cholesterol concentration was measured byHitachi 902 using Cholestest N HDL and HDL-C plus 3rd generation reagents. Sample was analyzed with SPSS 14 for Windows Programusing T test and Pearson Correlation. Among 80 samples we found the mean HDL concentration using Daichi reagent was 46.19 mg/dlranging from 34.99 mg/dl to 57.39 mg/dl and the mean using Roche 3rd reagent was 48.35 mg/dl ranging from 35.18 mg/dl to 61.52mg/dl, with p = 0.098 and Pearson Correlation was r = 0.967 with p = 0.000.There was no difference between HDL concentrationdetected by Cholestest N HDL and HDL-C plus 3rd generation reagents.
LEUKEMIA SEL BERAMBUT Reini Meilani Isbach; Agus Alim Abdullah; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 2 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i2.1069

Abstract

Hairy cell leukaemia (HCL) is a neoplastic disorder of B lymphocytes originally described by Bouroncle et al. in 1958. HCL clinicalmanifestations varies, generally characterized by various degrees of splenomegaly, pancytopenia, or emphasis only on the two cell lines(bisitopenia), with the hairy cells in varying amounts in the peripheral blood smear and bone marrow. HCL is a very rare case, there areonly about 2% of all leukaemias more frequently in men than women (4:1) with the average age of disease onset between 50–55 years.The etiology of HCL is still not known. A case of HCL Leukaemia in a female patient, aged 55 years is reported which was a rare case.HCL diagnosis in this patient was based on the clinical manifestation (splenomegaly), and laboratory results (bisitopenia, neutropeniaand monositopenia) and about 80% hairy cells were found in peripheral blood smears. Definite diagnosis of HCL should be made by bonemarrow examination, immunophenotyping and cytogenesis.
PENGUKURAN DAN APLIKASI KLINIK THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.1032

Abstract

Cross regulation of coagulation and fibrinolysis plays an important role in preserving a balanced hemostatic process. These process are exquisitely regulated and protect the organism from excessive blood loss or excessive fibrin deposition. Identification of ThrombinActivatable Fibrinolysis Inhibitor (TAFI) as an inhibitor of fibrinolysis and one of the main intermediates between coagulation andfibrinolysis, greatly improved our understanding of cross regulation of coagulation and fibrinolysis. As TAFI is an enzyme that is activatedby thrombin generated by the coagulation system, its activation is sensitive to the dynamics of the coagulation system. This review willdiscuss the role of TAFI and characterize it with respect to its activation, regulation, and clinical application.
HEMOSTASIS BERLANDASKAN SEL HIDUP (IN VIVO) Liong Boy Kurniawan; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 3 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i3.421

Abstract

Understanding of hemostasis has developed substantially in the last century from stasis in vitro to in vivo concept. Hemostasis theory develops from classic theory, discovery of coagulation factors leading to cascade/waterfall theory, as well as to in vivo cell based theory which explains the limitations of cascade theory. Phases of cell based hemostasis theory include initiation, amplification, propagation and termination with the role of tissue factor, platelet activation and coagulation factors in thrombin and fibrin synthesis. Common hemostasis tests used nowadays are important in evaluating bleeding risk but this matter still can not explain cell based hemostasis theory comprehensively so we need to find new tests to evaluate in vivo hemostasis.
PERMINTAAN DARAH PERSIAPAN TINDAKAN BEDAH DI RSUP DR. WAHIDIN SUDIROHUSODO Herlinah Herlinah; Rachmawati Muhiddin; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 2 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i2.1115

Abstract

Surgical procedures frequently need blood transfusion. However, the blood demand is frequently excessive without an appropriateneed analysis. The high percentage of canceled and returned blood indicates the ineffective use of blood transfusion. To know theappropriateness of blood demand for surgery preparation at the Dr. Wahidin Sudirohusodo General Hospital the researchers analyzedhis matter. This study was an observational study with cross sectional approach. The data of the blood demand for surgery preparationwere obtained from the blood bank of the Dr. Wahidin Sudirohusodo General Hospital, Makassar during August up to November 2013.The data were grouped based on the number of blood demand and the quantity of canceled and returned blood, these were then analyzedby SPSS software. The total of samples which were identified was about 1599 with 3829 blood demands. The quantity of canceled bloodwas1915 and the returned blood was 730. The demand of blood products indicated that whole blood was 2340 (61.3%), PRC 1392(36.4%), platelets 83 (2.2%) and FFP 5 (0.1%). The highest blood demand was observed in the General Surgery Department 797(20.9%). The difference between blood demand and the returned blood quantity (for whole blood and PRC) was analyzed statisticallyand indicated a significant result (p=0.000), this meant that there was a mismatch between blood demand number and the returnedblood quantity. This matter could reflect the ineffective use of blood transfusion.
Co-Authors Agus Alim Abdullah Ani Kartini Arie Yanti Asvin Nurulita Baharuddin Baharuddin Burhanuddin Bahar Cyntia Kornelius D. Daud Darmawaty Rauf Darwati Muhadi Dewi Sri Kartini Fitrie Octavia Glent Nurtanio HAM Akil Hardjoeno Hardjoeno Hendra Rasubala herlinah herlinah Hilma Yuniar Hilma Yuniar Thamrin Hj. Darmawaty E.R, I Hutagalung I. Hutagalung Ibrahim Abd. Samad Ibrahim Abdul Samad Ibrahim Labeda Ichwan Meinardi Ichwani Meinard Idham Jaya Ganda Irawaty Irawaty Irfan Idris Irna Diyana Kartika Iwan Joseph Joko Widodo Juranah . Kusriny A.P. Lince Wijoyo Liong Boy Kurniawan, Liong Boy Muh Taufiq Mutmainnah . Nur Rahmi Raehaan Nurhayana Sennang Nursin Abd. Kadir Nyoman Trisna Yustiani Rachmawati A.M Rachmawati AM Rachmawati Muhiddin Rachmawati Muhiddin Raehana Samad Reini Meilani Isbach Riesti Ekasanti Rifai Amirudin Rima Yuliati Muin Rostina Rostina Sri Wahyunie S Suci Aprianti Sukmawaty Sukmawaty Sulina Yanti Wibawa Suryani Jamal Susi Sevianty Syahraswati Syahraswati Theosobia Grace Orno Uleng Bahrun Viviyanti Zainuddin Waode Rusdiah Winni Agustiani Wiwi Payung Yedid Lebang Yosep F. Tallulembang ZK Abdurahman Baizal