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All Journal CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Jurnal Kimia (Journal of Chemistry) Buletin Veteriner Udayana Buletin Udayana Mengabdi Jurnal Farmasi Udayana Indonesia Medicus Veterinus Syntax Literate : Jurnal Ilmiah Indonesia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Ilmiah Medicamento Jurnal Kesehatan Qamarul Huda

Dewa Ayu Swastini

Program Studi Farmasi FMIPA Universitas Udayana, Bukit Jimbaran, Bali

Author-ID : 398358

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Penurunan Kadar Glukosa Darah dan Gambaran Histopatologi Pankreas dengan Pemberian Gula Aren (Arenga pinnata) pada Tikus Jantan Galur Wistar yang Diinduksi Aloksan Swastini, Dewa Ayu; Shaswati, Gusti Ayu Prianka Adi; Widnyana, I Putu Sudiatmika; Amin, Amirul; Kusuma, Lalu Angga Sadi; Putra, Anak Agung Rai Yadnya; Samirana, Putu Oka
Indonesia Medicus Veterinus Vol 7 (2) 2018
Publisher : Faculty of Veterinary Medicine, Udayana University

Gula aren (Arenga pinnata) merupakan hasil pengolahan dari nira aren. Gula aren berpotensi sebagai agen antidiabetes. Pengujian ilmiah terhadap potensi antidiabetes yang dikandung oleh gula aren belum tersedia, sehingga dilakukan penelitian mengenai pengujian aktivitas antidiabetes gula aren. Pemodelan diabetes mellitus dibuat dengan menggunakan tikus jantan galur wistar yang diinduksi aloksan dengan dosis 120 mg/kgBB secara intraperitonial. Pengujian dilakukan dengan membagi tikus menjadi 6 kelompok perlakuan, antara lain: kontrol normal, kontrol negatif (Aquades), kontrol positif (Glibenklamid 0,45 mg/kg BB), dan tiga kelompok perlakuan (variasi dosis pemberian gula aren (Arenga pinnata)2,57 mg/kg BB, 5,14 mg/kg BB, 10,28 mg/kg BB) diberikan selama 28 hari. Selanjutnya diukur kadar glukosa darah tikus menggunakan uji glukosa pada hari ke-7, 14, 21 dan 28 serta pengamatan diameter pulau Langerhans secara histopatologi. Berdasarkan hasil pengujian, selisih rata-rata kadar gula darah sesaat setelah induksi aloksan dan setelah 28 hari, gula aren mampu menurunkan kadar gula darah secara signifikan (p<0,05) dibandingkan dengan kontrol negatif dan memiliki rata-rata selisih lebih besar dibanding kontrol positif. Hasil pengamatan secara histopatologi menunjukan bahwa pemberian gula aren pada tikus jantan galur Wistar yang diinduksi aloksan belum mampu memperbaiki kondisi pulau Langerhans

UJI PENAPISAN DAN PENETAPAN KADAR MORFIN DAN KODEIN DALAM PLASMA MENGGUNAKAN HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY- SPEKTROFOTODENSITOMETRI I Made Agus Gelgel Wirasuta; Dewa Ayu Swastini; Ni Made Pitri Susanti
CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Vol 7 No 2 (2019): volume 7, Nomor 2, 2019
Publisher : Magister Program of Applied Chemistry, Udayana University, Bali-INDONESIA

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ABSTRAK: Uji skrining dan konfirmasi kandungan morfin dan kodein dalam plasma telah dikembangkan menggunakan high-performance thin-layer chromatography (HPTLC)-Spektrofotodensitometri. Penetapan kadar morfin dan kodein pada plat HPTLC dideteksi pada panjang gelombang 212 nm. Ekstraksi morfin dan kodein dari plasma menggunakan campuran kloroform dan isopropanol, dengan menggunkan metanol atau isopropanol sebagai pengendap protein. Uji konfirmasi dengan teknik di atas belum memberikan hasil yang kurang tajam. Batas dekteksi morfin adalah 48,8 ng dan kodein 70,2 ng. Diperoleh variasi batas deteksi dan batas kuantisasi analit yang sangat besar antar plat HPTLC walaupun memberikan persamaan regrasi yang hampir sama. Kata Kunci: Uji skrining, Konfirmasi, morfin, kodein, HPTLC ABSTRACT: Screening and confirmation test for morphine and codeine by high-performance thin-layer chromatography-densitometry technique has been carried out. The determination test consist of limit detection (LOD) and limit quantification (LOQ) of the analyte using HPTLC scanned on wave length of 212 nm. The morphine and codeine were extracted by liquid-liquid extraction using mixture of chloroform and isopropanol from plasma. The screening and confirmation test based on corrected hRf – value and insitu UV-spectrum of analyte delivered a not convenient result. The LOD of morphine and codeine was 48,8 and 70,2 ng. The determination of opiate by HPTLC-densitometry was obtained a great range of LOD and LOQ between plat of HPTLC, although had a fast equal of linear regression-coefficient.

PROFIL BIOAUTOGRAFI DAN UJI PENANGKAP RADIKAL 2,2-DIFENIL-1-PIKRIHIDRAZIL OLEH EKSTRAK ETANOL DAUN BINAHONG (Anredera scandens (L.) Moq.) DAN FRAKSI-FRAKSINYA P. O. Samirana; D. A. Swastini; A. A. G. R. Y. Putra; I P. W. Kusuma; N. P. A. Y. Pratiwi; V. A. Setiawan
Jurnal Kimia (Journal of Chemistry) Vol.14 No.1 Januari 2020
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Free radicals are atoms or molecules that have one or more unpaired electrons and are highly reactive. Antioxidants can inhibit the excessive oxidation reaction. The leaves of binahong (Anredera scandens (L.) Moq.) are one part of plants which contain flavonoid compounds and tannins that have scientific activity as antioxidants.This study aims to determine the bioautographic profile and to test the antioxidant activity of the ethanol extract of the leaves of Anredera scandens (L.) Moq. useing 2.2-diphenyl-1-pikrilhidrazil radical capture method. The extraction process produced 19.22% yield, 14.68% (14.684 grams) chloroform fraction, 11.22% (11.224 grams) n-hexane fraction, 3.09% (3.094 grams) ethyl acetate fraction, and 23.90% (23.904 grams) n-butanol fraction. The results of bioautographic profile test using KLT densitometry method proved that ethanol extract, chloroform fraction and ethyl acetate fraction have DPPH radical capture activities. The determination of total flavonoid content found that ethyl acetate fraction contained higher total flavonoids than other fractions. In the ethyl acetate fraction, high total flavonoid level and low IC50 values were obtained, while the n-hexane fraction had low flavonoid level and high IC50 values. Keywords: antioxidants, binahong leaves, free radicals, flavonoids, IC50.

SCREENING FITOKIMIA DAN AKTIVITAS ANTIRADIKAL BEBAS EKSTRAK METANOL DAUN GAHARU (Gyrinops versteegii) I Made Mega; Dewa Ayu Swastini
Jurnal Kimia (Journal of Chemistry) Vol. 4, No. 2 Juli 2010
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

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It has been done screening fitokimia and the determination of free antiradical activity extract methanol ofgaharu leaf. The screening fitokimia determined by the colour test and free antiradical activity determined bydiphenyl pykril hydrazil (DPPH) method according to sphectrophotometry UV-Vis, before that the honey was dilutedwith methanol and then the absorbance was measured on 497nm, 517 nm, and 537 nm. The result showed thatmethanol extract of gaharu leaf contain phenol, flavonoid and terpenoid compound and the free antiradical activityshowed inhibitor percent is 106,32 % (5”) and 111,31 % (60’).

UJI AKTIVITAS PENURUNAN KOLESTEROL PRODUK MADU HERBAL YANG BEREDAR DI PASARAN PADA TIKUS PUTIH DIET LEMAK TINGGI Ni Putu Ariantari; Sagung Chandra Yowani; Dewa Ayu Swastini
Jurnal Kimia (Journal of Chemistry) Vol. 4, No. 1 Januari 2010
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

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The research aims to investigate hypocholesterolemic activity of two marketed herbal honey products forhypocholesterolemia, mentioned as product A and B on Wistar albino rats with hypercholesterolemic diet.Hypocholesterolemic activity test was conducted with Enzymatic Photometric Test CHOD-PAP (CholesterolOxidase Phenol Aminoantipyrin) method. The result revealed that product A administered orally to Wistar albino ratswith hypercholesterolemic diet, at 0.15 mL/200g BW dose once daily, did not show hypocholesterolemic activity. Onthe other hand, product B at 0.5 mL/200g BW dose showed hypocholesterolemic activity similar to simvastatin.

KARAKTERISTIK DAN SKRINING FITOKIMIA EKSTRAK ETANOL 70% BATANG KEPUH (Sterculia foetida L.) N. P. S. E. Cahyani; J. Susiarni; K. C.S. Dewi; N. L.P. Melyandari; K. W.A. Putra; D. A. Swastini
Jurnal Kimia (Journal of Chemistry) Vol.13 No.1 Januari 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Kepuh (Sterculia foetida L) is a type of kapok plant that has been scientifically proven to have activity as an anti-inflammatory and analgesic. 70% ethanol extract of stem stem is obtained by maceration using 70% ethanol. Examination of the characteristics of 70% ethanol extract of kepuh stem included organoleptic, of moisture content and determination of residual solvent content. Phytochemical screening of 70% ethanol extract of kepuh bark includes: alkaloid, flavonoid, saponin, tannin , polyphenol, and examination of glycosides. The results of the examination of the characteristics of 70% ethanol extract of kepuh stem obtained water content of 8.66 ± 0.748%, the residual content of the solvent had a 0 (zero) ethanol level. The results of phytochemical screening showed 70% ethanol extract of stem stem containing steroid compounds, triterpenoids, flavonoids, saponins, tannins and polyphenols. The identification using UV-Vis spectrophotometry produced ? 212, the absorbance was 1.8601 and ? 284, the absorbance was 0.42186.

Studi Farmakokinetika Kodein Pada Kelinci Setelah Pemberian Intravena Bolus I Made Agus Gelgel Wirasuta; Ni Made Listiari; Dewa Ayu Swastini
Buletin Veteriner Udayana Vol. 11 No. 2 Agustus 2019
Publisher : The Faculty of Veterinary Medicine, Udayana University

The codeine has been used as a marker for illicit heroin uses, that for increasing differentiating illicit heroin uses, it needs the codeine pharmacokinetic data. Eleven rabbits have been injected 11.04 mg codeine (with body weight: ± 1.8 kg) via marginal vena. Blood has taken at every 5, 15, 30, 60, 90, and 120 minutes. Serum has stored at -20 0C before analyzed. Blood protein was predicated by isoprophanol. Codeine was extracted with chloroform-isopropanol (3:1) and buffer phosphate 0.2N pH 9.3 then separated by phase toluene-acetone-ethanol-ammonia (45:45:7:3) as mobile phase and aluminium sheet of silica thin layer chromatography Gel 60 F254 as the stationary phase. Codeine determined by spectrophotodensitometry at 215 nm. Limit of detection and limit of quantification of codeine was 184.43 ng and 563.62 ng per spot, respectively the percentage recovery of in vitro was 60.60%. Profile concentration of codeine after IV bolus showed decreasing concentration at the first terminal and increasing codeine concentration at the last terminal that indicated an enterohepatic cycle. Codeine pharmacokinetic followed the first compartment with the half time was 30.61 minutes and the distribution volume was 7760.50 mL. Enterohepatic cycle caused a prolonged lifetime of codeine at the rabbit

PENINGKATAN KUALITAS DAN NILAI FES NIRA AREN DI DESA TARO TEGALLALANG MELALUI DIVERSIFIKASI PRODUK OLAHAN D.A. Swastini; Y. Ramona; C.I.S. Arisanti
Buletin Udayana Mengabdi Vol 17 No 1 (2018): Buletin Udayana Mengabdi
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Sucrose, electrolyte, vitamin, as well as probiotic bacterial contents of palm juice (Arrenga pinnata Merr) areuseful for the maintenance of the healthiness of human body. Due to its low glycemic index, palm sugar issafe to consume and has high potential for use as an alternative companion sugar for diabetes mellituspatients. In Taro village, almost 90% of the people there manage palm sugar plantations, but their ability toprocess and distribute their products is still limited. This program of Science and technology for the Societyaims to improve the quality and value of FEs palm juice by applying revitalization and diversificationmethods. Revitalization was conducted by socializing pre and postharvest preparation techniques andprocedures and the outcomes were measured by questionnaires. Diversification methods were conductedthrough training and advisory preparation of isotonic and probiotic drinks, as well as production of sugarcrystal. The results of this socialization showed that there was an increase in average knowledge of farmersfrom 22.57% (before socialization) to 73.87% (after socialization). Product diversification did not onlyincrease the value of FEs palm juice, but also saved energy and time of processing. As the product wassupported by credible results of laboratory tests, this product is currently marketed in some touristdestinations, such as Tegallalang, Gianyar.

PENCEGAHAN STROKE DINI MELALUI PEMERIKSAAN TEKANAN DARAH, KADAR GULA DARAH DAN KOLESTEROL PADA PINANDITA DI DESA TARO KECAMATAN TEGALLALANG GIANYAR D.A. Swastini; I.A.D. Wiryanthini; N.P.A.D. Wijayanthi; P.O. Samirana
Buletin Udayana Mengabdi Vol 16 No 3 (2017)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

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Stroke merupakan merupakan penyebab kematian ketiga terbanyak di Indonesia. Hipertensi, diabetes mellitus, dan hiperkolesterol merupakan faktor resiko terbesar stroke yang dapat dimodifikasi, dimana diagnosanya dapat ditegakkan melalui pemeriksaan tekanan darah, kadar gula darah, dan kadar kolesterol, Maraknya kegiatan keagamaan berakibat pada perubahan aktivitas dan gaya hidup pinandita di Desa Taro Kecamatan Tegallalang Gianyar yang berpotensi menginduksi terjadinya stroke. Pemeriksaan meliputi pemeriksaan Tekanan Darah, Kadar Glukosa Darah Puasa (KGDP), kadar Glukosa 2 jam Makan (KGD2PP), dan Kolesterol Puasa. Pemeriksaan diikuti oleh 46 pinanditas se Desa Taro dengan sebaran umur peserta 27 sampai 63 Tahun. Hasil pemeriksaan menunjukkan rerata TD diatas normal 84.44 % dengan kisaran tertinggi pada 151-200mg/Hg, KGDP diatas 74.33% pada kisaran tertinggi 150-200mg/dl, KGD2PP 64.22% pada kisaran tertinggi 201-250mg/dl, serta Kolesterol Total 87.63% pada kisaran 250-300mg/dl, sehingga perlu dilakukan terapi lanjutan atas hasil dari pemeriksaan dengan mengkonsumsi obat anti hipertensi, obat oral diabetik dan penurun kolesterol.

Pemeriksaan Golongan Darah dan Rhesus Pelajar Kelas 5 dan 6 Sekolah Dasar di Desa Taro Kecataman Tegallalang Gianyar D.A. Swastini; A. A.W. Lestari; N.P.L. Laksmiani; E.I. Setyawan
Buletin Udayana Mengabdi Vol 15 No 1 (2016): Jurnal Udayana Mengabdi
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

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Examination of blood type has many benefits and shorten the identification time, in the interests of transfusion , right blood donor, and the identification in forensic cases such as the identification of criminal cases, in the other hand, blood type and rhesus checks also one of the prerequisites to attend junior high school from elementary school. Academic data of year 2014/2015 shows, none of the children in elementary school at Taro village, ever checked blood type or rhesus, so it is necessary to do this activity especially for 5 and 6 grade of students at elementary school. Examination includes blood type systems A, B , O and Rh. This examination followed by 139 students in grade 5 and 6 from SDN 1 , 2 , 3 , 4 of Taro, with the distribution age of the participants between 11 to 16 years. The test results showed 18.71 % of the participants have A blood type , 41.01 % with B blood type , 5.04 % AB blood type and 35.25 % with O blood type. All participants have a positive Rhesus ( Rh + ).

Co-Authors A. A. G. R. Y. Putra A. A. Ngurah Putra Riana Prasetya A. A. Raka Karsana A. A.W. Lestari Agestiawan, I. G. A. M. Amin, Amirul Anak Agung Gede Rai Yadnya Putra Ariadi, K. A. Astiti, I.A.G. Cokorda Istri Sri Arisanti Desta, I.G.A.G.P.C Dewa Ayu Putu Rasmika Dewi Dewantar I G.N.A. Dwi Mega Permatahati E.I. Setyawan I Gusti Ayu Nyoman Dyah Sukmawati I Made Agus Gelgel Wirasuta I Made Kardena I Made Mega I Nyoman Gede Piliarta I P. R. Ardinata I P. S. D Suarka I P. W. Kusuma I.A.D. Wiryanthini Ivanna Susila J. Susiarni Junior, I.K.P. K. C.S. Dewi K. W.A. Putra Kadek Nadia Martha Dewi Kartika I G. A. A. Komang Dirga Mega Buana Kusuma, Lalu Angga Sadi Laras A.A.I.S. Lestari A. A. W. Luh Pratiwi Diva Yanti Luh Putu Febryana Larasanty Made Krisna Adi Jaya Maryadhi N. M. D. D. N. L.P. Melyandari N. N. M Nesa, N. P. A. Y. Pratiwi N. P. S. E. Cahyani N. W. Satriani N.M. Rudiarta N.P.A.D. Wijayanthi Ni Kadek Ria Pratiwi Ni Kadek Warditiani Ni Made Listiari Ni Made Pitri Susanti Ni Putu Ariantari Ni Putu Eka Leliqia Ni Putu Linda Laksmiani Oviani, Gusti Ayu Puspitasari L Putra M.M. Putu Oka Samirana Putu Rika Jesika Putri Rini Noviyani S.A. Putri Sagun Chandra Yowani Setiawati Setiawati Shaswati, Gusti Ayu Prianka Adi Subratha I D. G. P. Y. Sugiarto, R. P. Udayana, N.K Utami, L. N. S. V. A. Setiawan Wardana M. Widnyana, I Putu Sudiatmika Wijayanti N.P.A.D. Yan Ramona Yanti, I G. A. A. D. Yanti, N.L.G.T

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