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Nursalam Hamzah
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ad-Dawaa : Journal of Pharmaceutical Sciences
Published by Universitas Islam Negeri Alauddin Makassar
ISSN : 26547392     EISSN : 26546973     DOI : 10.24252/djps
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
ad-Dawaa Journal of Pharmaceutical Sciences (DJPS) merupakan jurnal yang terbit dua kali dalam setahun, yaitu setiap Juni dan Desember. Jurnal ini fokus pada seluruh bidang terkait ilmu farmasi, termasuk biologi farmasi, farmakokimia, farmakologi, farmasi klinik dan teknologi farmasi. Jurnal ini juga mempublikasikan artikel terkait integrasi Islam dengan ilmu farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 8 Documents
 1 
Search results for , issue "Vol 3 No 2 (2020)" : 8 Documents clear
The Effect of Papaya (Carica Papaya L.) Leaves on Adolescents with Dysmenorrhea Desy Aulia Rahmah; Mukti Priastomo; Laode Rijai
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 2 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i2.16478

Abstract

Papaya leaves (Carica papaya L.) contain active compounds of flavonoids and alkaloids which have the function of reducing dysmenorrhea. Dysmenorrhea is a condition that occurs at any time during menstruation that experiences pain or pain in the abdominal and pelvic area so it can interfere with activities and require treatment. This study aims to determine the effect of the effectiveness of offering papaya leaf herbal drink in reducing dysmenorrhea. The research design used in this study was a pre-experimental research design with a pre-experimental test design with accidental sampling technique. Measurement of pain intensity using pain scale measurements (Pre-Test) and final pain (Post-test using a numerical rating scale, time of incidence on the first and second day of menstruation (77%), location of lower abdominal dysmenorrhea (92%), symptoms of dysmenorrhea, namely abdominal pain (75%), moderate pain scale (48%)], and treatment was resting (63%). Based on the results of the study, subjects who were given a papaya leaf herbal drink were able to reduce the pain scale of dysmenorrhea with a large difference in pain scale reduction in the treatment group of chopped papaya leaf stew by 3,2.
Bioavailability Study of Propranolol Patch Muh Ikhlas Arsul; Latifah Rahman; Agnes Lidjajah
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 2 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i2.19498

Abstract

Bioavailability is a measure of the rate and amount of drug or active ingredient that is absorbed by a drug product and available at the site of action. By definition, the bioavailability of a drug when administered intravenously is 100%. However, when a drug is given by a different route of administration, its overall bioavailability will decrease (since the drug is not completely absorbed and metabolized first pass effect) or may vary from patient to patient. Bioavailability is very important in pharmacokinetics. One of them is that bioavailability needs to be taken when calculating the doses for administering a drug other than by intravenous route. The aim of this study was to describe the bioavailability of propranolol in patch preparations. Propranolol is made in patch formulations using menthol, PEG, and various combinations of PVP and Eudragit. PVP and Eudragit each dissolved in alcohol and then mixed until homogeneous. Propranolol was dissolved with a menthol solution and then mixed into a solution of PVP and Eudragit. Finally, PEG is added to the solution and stirred until homogeneous and then poured into the patch mold. The patches produced were then measured for each patch and bioavailability assay. The patch formula produced can be used transdermally, but of the three formulas, the F3 formula with a ratio of PVP K30 and Eudragit RS-100 3: 7 gives the best results with a tmax of 2 hours, Cmax 79.33 µg / ml and AUC 49.07 µg hours / ml.
Administered of Lavender (Lavandula Angustifolia) Aromatherapy To Improve Sleep Quality for the Elderly Ni Made Maharianingsih; A.A Sagung Istri Iryaningrat; Dhiancinantyan Windidaca Brata Putri
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 2 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i2.17926

Abstract

Elderly people are age group with a higher incidence of disease or disorders than adults because of physical or psychological changes such as insomnia or decreased quality of sleep. Around 35 % of the total population decreased in sleep quality in the world and in Indonesia around 50%. Aromatherapy that using essential oils can be used as an alternative therapy besides drugs to treat sleep difficulties such as lavender Lavender contains linalool and linalyl acetate which can improve sleep quality and has a calming effect. The purpose of this study was to see the effect of lavender aromatherapy to improve sleep quality elderly. This research design used a pre-experimental design with one group pretest-posttest design method. Respondents were 42 elderly which taking with purposive sampling who resides in panti werda. Data analysis used a non-parametric test, namely the Wilcoxon test. The results obtained were that before using lavender aromatherapy there were 42 respondents (100%) who experienced a decrease in sleep quality. After giving lavender aromateraphy, 38 respondents (90.47%) experienced an increase in sleep quality and 4 respondents (9.53%) did not experience any changes, with p = 0.000. Improved sleep quality can be seen from the difference in the value of subjective sleep quality parameters, sleep latency, sleep duration, sleep efficiency, sleep disturbances, and daytime dysfunction based on the difference between the pretest and posttest scores. It can be concluded that giving lavender aromatherapy can improve the quality of sleep in the elderly.
The Effect of NaOH Concentration on Cellulose Levels of Kepok Banana Hump (Musa paradisiaca L.) Surya Ningsi; Nurshalati Tahar; Nur Azizah Syahrana; Yuri Erika Arifin
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 2 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i2.20146

Abstract

The high cellulose content of Kepok banana hump has great potential to be used as a pharmaceutical excipient. This research aims to determine the effect of NaOH concentration on cellulose levels from kepok banana hump. NaOH solution was made in five concentrations, namely 5%; 7.5%; 10%; 12.5% and 15%. Cellulose levels were analyzed using the Chesson method. The research results showed that the NaOH solution with a concentration of 5%; 7.5%; 10%; 12.5% and 15% yielded cellulose content of 12.5%, 15.9%, 64.9%, 60.7% and 41.9%. The highest cellulose content is produced at a concentration of 10% NaOH solution.
Antiproliferation potential of Botto-botto (Chromolaena odorata L.) leaves methanol extract fraction against HeLa Cell Line Muhammad Rusdi; Haeria Haeria; Nursalam Hamzah; Afrisusnawati Rauf; Faradibha Amriani
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 2 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i2.14051

Abstract

Botto-botto (Chromolaena odorata L.) was one of plants that its leaves used empirically in South Sulawesi society as wound and anti-inflammatory drugs. This study aimed to determine the potential of Botto-botto toward cancer cells (HeLa Cells) and normal cells (Vero cells) using the MTT assay method (Microculture Tetrazolium Salt Method). Ethyl acetate extract from methanol extract being fractionated by vacuum liquid chromatography method by a different polarity level of solvent. Cytotoxic effect test was using MTT method to cancer cells (HeLa), and normal cells (Vero) with the percent parameter of cell growth inhibition. Selectivity index was determined from percentage of cancer cell growth inhibition ratio of cancer cells to normal cells. The results showed that A, B, C, D, E, F, and G fractions had a selectivity index on HeLa cells at 0.845, 3.387, 2.004, 1.508, 1.625, 1.284, 1.299. This result proved that B fraction of methanol extract of Botto-botto leaves had a potential to be developed as chemotherapy agents in increasing the effectiveness treatment of cervix cancer.
Efficacy of Sangkareho Leaves Ethanol Extract (Callicarpa longifolia l.) As Anti-Diarrhea Munifah Wahyuddin
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 2 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i2.20413

Abstract

Diarrhea is a public health problem in developing countries such as Indonesia, because it still often occurs in the form of Extraordinary Events (KLB), and is accompanied by high mortality, especially in Eastern Indonesia. Based on the results of Riskesdas in 2007, it was shown that diarrheal disease was the main cause of death in infants. This study aims to determine the concentration of how much extract from DaunSangkareho can provide antidiarrheal effects on male mice test animals by looking at the frequency and consistency of stool. 15 mice were used which were divided into 5 groups and each group consisted of 3 mice, the negative control group was given a 1% Na.CMC suspension, groups II, III, and IV were given extracts of 2%, 4%, and 6 respectively. % b / v, as a treatment group. And for group V was given positive control of the loperamid-HCl suspension as a comparison. All groups were injected with English saline solution orally as diarrhea inducers. Evaluation of antidiarrheal effects was carried out by observing the consistency of mouse stools every 1 hour for 10 hours. The results showed that Sangkareho Leaf Extract with a concentration of 2%, 4%, and 6% b / v, had an antidiarrheal effect on the gastric or intestinal mucosa caused by an English saline solution. Sangkareho Leaf Extract at a concentration of 6% b / v has an optimal antidiarrheal effect and is the same as giving Loperamid-HCl suspension as a comparison.
Antianemic Activity of Coconut (Cocos nucifera) Haustorium Waste Filtrate in Mice Induced by Sodium Nitrite Adzimahtinur Pradawahyuningtyas; Mukti Priastomo; Laode Rijai
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 2 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i2.16477

Abstract

This study aims to determine the antianemic activity of coconut haustorium (Cocos nucifera) waste against mice induced by sodium nitrite orally for 43 days. The condition of anemia was determined by calculating the hemoglobin level using the Point of Care Test (POCT) method with the easytouch® GCHb and the resulting Hb level was 7.96 ± 0.05 g/dL. After the anemia condition is achieved, the test treatment is given for 21 days by dividing the mice into four groups, each consisting of three mice. The blank group (I) was administered distilled water, the control group (II) was administered Inbion® supplements at a dose of 0.65 mg/20 g BW, groups III and IV were administered coconut haustorium filtrate at a dose of 5 and 15 g/kg, respectively. Then measured the hemoglobin level and the number of erythrocytes. Based on the results of the study, the average hemoglobin levels of the blank, control, I and II groups were 13,9; 15,4; 16,0; and 16.8 g / dL, respectively. The number of erythrocytes during anemia was 1,750,000 / mm3 and after giving coconut kentos was 8,260,000 / mm3. From this study it can be concluded that the highest anti-anemia activity showed by coconut haustorium waste filtrate at dose 15 g/kgBW and had a significant difference in hemoglobin levels (p <0.05) with the blank group.
Potential of Sweet Orange Peels (Citrus sinensis) Essential Oil as Sunscreen Isriany Ismail; Fatma Dewi; Ferawati Ferawati; Nursalam Hamzah
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 2 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i2.20720

Abstract

Telah dilakukan penelitian tentang uji efektifitas minyak atsiri kulit buah jeruk manis (Citrus sinensis) sebagai tabir surya secara spektrofotometer UV-VIS. Penelitian ini bertujuan untuk menentukan potensi dari minyak atsiri kulit jeruk manis sebagai tabir surya yang ditentukan dengan nilai SPF, transmisi eritema dan transmisi pigmentasi. Minyak atsiri jeruk diperoleh dengan mengekstraksi kulit buah jeruk manis dengan metode pengepresan/pemerasan. Pengujian dilakukan menggunakan metode spektrofotometri UV pada panjang gelombang 290 – 400 nm terhadap konsentrasi minyak atsiri 20, 40, 60, 80, 100, dan 120 bpj. Hasil analisis menunjukkan bahwa minyak atsiri kulit buah jeruk manis (Citrus sinensis) mengabsorbsi sinar UV B hingga UV A dengan nilai SPF 1,094 hingga 1,380. Persen eritema dan pigmentasi pada konsentrasi 120 bpj berturut-turut adalah 66,98% dan 65,54%.

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