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All Journal ad-Dawaa : Journal of Pharmaceutical Sciences Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Sains dan Kesehatan

Mukti Priastomo

Laboratorium Penelitian dan Pengembangan Kefarmasian “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Author-ID : 4295861

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

Published : 11 Documents Claim Missing Document

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Aktivitas Antioksidan dan Tabir Surya Ekstrak Etanol Tanaman Crassocephalum crepidioides (Benth.): Antioxidant and Sunscreen Activity of Ethanol Extract of Crassocephalum crepidioides (Benth.) Rolan Rusli; Ismah Nuri; Mahdyya Afiana Ramadani; Vita Olivia Siregar; Mukti Priastomo; Muhammad Faisal
Jurnal Sains dan Kesehatan (J. Sains Kes.) Vol. 4 No. 3 (2022): Jurnal Sains dan Kesehatan (J. Sains Kes.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Crassocephalum crepidioides (sintrong) plant has secondary metabolites such as flavonoids, saponins, steroids, and tannins which are thought to have antioxidant and sunscreen activities. Antioxidant activity of the ethanol extract of the leaves and flowers of Sintrong was measured using Uv-Vis spectrophotometry obtained IC50 values of 23.558 ppm (flowers) and 0.62 ppm (leaves), and categories as very strong antioxidants. Based on %Te and %Tp values, ethanol extract of sintrong leaves was categories as sunblock, while ethanol extract of flowers of sintrong was categories as Fast Tanning (for %Te) and for %Tp was categories as suntan standard (for 200-300 ppm) and Extra Protection (for 400-600 ppm). The SPF of the ethanol extract of the leaves and flowers of sintrong is categories as minimal protection.

Uji Aktivitas Ekstrak Daun Sepat (Mitragyna speciosa) terhadap Penurunan Kadar Glukosa Darah Mencit (Mus musculus) Ayu Indah Cahyani; Mukti Priastomo; Adam M. Ramadhan
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 4 (2016): Proceeding of Mulawarman Pharmaceuticals Conferences (Prosiding Seminar Nasional Kefa
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Tumbuhan sepat merupakan tumbuhan dari famili rubiceae, yang biasa digunakan sebagai obat tradisional dalam menurunkan kadar glukosa darah. Daun sepat memiliki kandungan kimia alkaloid yang diduga memiliki efek dalam menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak daun sepat, mengetahui dosis terbaik dan mengetahui potensinya dalam menurunkan kadar glukosa darah mencit (Mus musculus). Metode penelitian yang digunakan adalah secara in vivo dengan menggunakan hewan coba mencit jantan yang diberikan beban sukrosa 50 % secara oral. Hewan coba dibagi menjadi 5 kelompok yaitu kelompok 1 (diberi suspensi Na CMC 0,5 %), kelompok 2 (glibenklamid), kelompok 3 (ekstrak dosis 100 mg/kg bb), kelompok 4 (ekstrak dosis 200 mg/kg bb), kelompok 5 (ekstrak dosis 400 mg/kg bb). Kadar glukosa darah mencit didapatkan dari pengukuran menggunakan alat glukometer. Dari hasil pengujian diketahui bahwa ekstrak daun sepat memiliki aktivitas dalam menurunkan kadar glukosa darah mencit. Dosis efektif ekstrak daun sepat dalam menurunkan kadar glukosa darah yaitu dosis 200 mg/kg bb.

Efek Perubahan Tekanan Darah Pada Manusia Dengan Pemberian Aroma dari Tanaman Kemangi (Ocimum basilicum L.) Delti Delaya Busa; Mukti Priastomo; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 6 (2017): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Tanaman kemangi (Ocimum basilicum L.) mengandung minyak atsiri yang dapat menghasilkan aroma khas. Aroma khas pada tanaman dapat mempengaruhi perubahan tekanan darah. Penelitian ini dilakukan untuk mengetahui perubahan tekanan darah pada manusia dengan pemberian aroma dari tanaman kemangi (Ocimum basilicum L.) Metode penelitian ini merupakan penelitian kuantitatif dengan menggunakan desain penelitian quasi eksperiment dengan rancangan one group pretest-posttest dengan jumlah sampel 5 orang. Hasil penelitian ini diketahui ada pengaruh pemberian aroma dari tanaman kemangi terhadap tekanan darah sistolik sebelum intervensi yaitu dengan rata-rata sebesar 112,4 mmHg dan setelah intervensi menjadi 107,26 mmHg, tekanan darah diastolik sebelum intervensi sebesar 74,46 mmHg dan setelah intervensi menjadi 76,13 mmHg, serta denyut jantung sebelum intervensi sebesar 83,53 kali/menit dan setelah intervensi menjadi 77,26 kali/menit. Hasil penelitian ini menunjukkan bahwa aroma tanaman kemangi terbukti dapat mempengaruhi perubahan tekanan darah yaitu menurunkan tekanan darah sistolik.

Studi Penggunaan Antibiotik pada Pasien Demam Tifoid di RS SMC Periode 2017 Khoirunnisa Hazimah; Mukti Priastomo; Rolan Rusli
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 7 (2018): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Penyakit demam tifoid merupakan infeksi akut pada usus halus yang disebabkan oleh bakteri Salmonella typhi dengan gejala demam lebih dari satu minggu. Terapi utama pengobatan demam tifoid yaitu menggunakan antibiotik, yang dapat menyebabkan resistensi. Sehingga dibutuhkan studi terkait penggunaan antibiotik pada pasien demam tifoid. Penelitian dilakukan dengan pendekatan retrospektif pada 79 data pasien demam tifoid. Hasil penelitian menunjukkan bahwa penderita demam tifoid terbanyak adalah perempuan (53,16%) dengan usia kanak–kanak (6-11 tahun) dan masa dewasa awal (26-35 tahun) sebesar 17,72%. Penggunaan antibiotik terbanyak digunakan adalah adalah golongan sefalosporin (56,96 %) yakni seftriakson, dengan frekuensi pemberian yaitu sekali dalam sehari. Selain penggunaan antibiotik, diberikan pula terapi suportif seperti antipeuretik, H-2 bocker dan anti mual muntah.

Potensi Ekstrak Buah Libo (Ficus variegate, Blume ) Sebagai Hepatoprotektor pada Tikus (Rattus novergicus) Halimatu Sadiyah; Mukti Priastomo; Rolan Rusli
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 9 (2019): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Buah libo (Ficus variegate, Blume) mengandung metabolit sekunder alkaloid, saponin, flavanoid dan polifenol dimana hal tersebut menunjukkan bahwa buah libo memiliki aktivitas antioksidan yang dapat berperan dalam pencegahan dan terapi berbagai penyakit termasuk kerusakan hepar. Penelitian ini bertujuan mengetahui potensi hepatoprotektor dan dosis efektif ekstrak buah libo pada tikus dibandingkan dengan curcumaÒ melalui indikator SGOT dan SGPT serta perubahan berat badan. Jenis penelitian ini eksperimental laboratorik. Subjek penelitian 12 ekor tikus dalam 4 kelompok perlakuan. Data dianalisis menggunakan uji One-Way Anova. Hasil yang diperoleh adalah terdapat perbedaan yang signifikan kadar SGOT dan SGPT.

Pengaruh Pelarut, Suhu, dan pH Terhadap Pigmen Antosianin dari Ekstrak Kulit Buah Naga Merah (Hylocereus Polyrhizus): Effect of Solvent, Temperature, and pH on Anthocyanin Pigments from Red Dragon Fruit Peel Extract (Hylocereus Polyrhizus) Gusti Alamsyah Abdil Almajid; Rolan Rusli; Mukti Priastomo
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Red dragon fruit peel (Hylocereus polyrhizus) is an agricultural waste that contains quite high natural anthocyanin pigments. The purpose of this study was to determine how the effect of solvent, temperature and pH on the total content and stability of anthocyanins from liquid extract of red dragon fruit peel. Extraction of anthocyanins from red dragon fruit peel using maceration method with solvent distilled water, distilled water: acetic acid 10% (1:6), and distilled water: citric acid 10% (1:6) and testing was carried out in the form of anthocyanin stability tests at pH 1, 2, 3, 4, 5 and temperatures 0°C, 10°C, 20°C, 30°C, 40°C, 50°C. The results obtained showed that the use of distilled water:citric acid 10% (1:6) as a solvent resulted in the highest total anthocyanin content with 18.034 mg/200 mg and the results of the anthocyanin stability test showed that it was stable at pH 1, 2, 3 and at temperatures of 10°C, 20°C, 30°C.

Efektivitas Jenis Bahan Masker Kain Berdasarkan Kemampuan Penyaringan Mikroba: Effectiveness of Fabric Mask Material Types Based on Microbial Filtration Capabilities Nilam Sari; Mukti Priastomo; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

A cloth mask is a mask that can be used repeatedly and is made of thicker fabric material. Cloth masks circulating in the community have not guaranteed quality. This study aims to find out the effectiveness of fabric mask materials based on microbial filtration capabilities as well as find out the optimal characteristics of the initial use of cloth mask materials and after washing 50 times. This study was conducted experimentally where the effectiveness of fabric mask material by spraying bacterial suspension, and testing the characteristics of fabric mask materials by conducting fiber observation, light intensity test, steam filtration test, water absorption test and water capillary on the fabric. The results of research on the effectiveness of fabric mask materials showed Asymp.Sig >0.05 so that there are significant differences from all types of fabric mask materials. Based on the results of characteristic testing, the fiber material of the initial cloth mask looks better than after 50 washes. Test the light intensity of the outer layer, inner layer, and filter layers p, f and s after washing there is an increase compared to the initial use. Steam filtration tests of outer layers, inner layers and filter layers p, f and s when the initial user takes time for steam to penetrate the fabric compared to 50 washes. The absorption test of the outer layer during initial use does not occur absorption above 60 seconds and after 50 washes begins absorption. The inner layer and filter layer at the initial use do not absorb above 60 seconds and after 50 washes there is absorption under 60 seconds. The p filter layer does not absorb during initial use and after 50 washes. Filter layer f during initial use and after 50 washes there is absorption under 60 seconds. Capillary test results for 60 seconds the outer layer and the p filter layer during initial use do not absorb while 50 times the washing occurs absorption. The inner layer, filter layer f and s increase after 50 washes. The conclusion of the study was that the effectiveness of the mask material was good enough for the inner and outer layers, the p filter layer was more effective than the f and s filter layers. The characteristic test results at initial use were very good, but after 50 washes there was a decrease.

Literature Review: Bahan Alam yang Berpotensi sebagai Antidiabetes: Literature Review: Natural Ingredients that Have Potential as Antidiabetic Novalinda Novalinda; Mukti Priastomo; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Antidiabetes is a treatment that is currently much needed for diabetics, because the cost of treatment is getting higher, so it is recommended to use herbs as an alternative treatment. This study aims to determine natural ingredients that have the potential as antidiabetic. The method used is a systematic review by collecting, analyzing and summarizing 25 journals with the publication year 2016-2021 with keywords namely Antidiabetes, Natural Ingredients, and In Vivo. The results of the journal analysis are Beluntas leaves 0.9 mg/20 gBW, Kecombrang leaves 100 mg/kgBW, Keji Beling leaves 300 mg/kgBW, Kembang Bulan leaves 5.14 ml/200gBW, Kenikir leaves 1400 mg/200gBW, Mango leaves 105 mg /kgBW, Pucuk Merah leaves 100 g/kgBW, Rambutan leaves 50 mg/kgBW, Sambiloto leaves 40 mg/kgBW, Breadfruit leaves 600 mg/kgBW, Avocado seeds 150 mg/kgBW, Kebiul seeds 51mg/20gBW, Green Coffee Beans Arabica 400 mg/kgBW, Dates seeds 10 mL/day, Pumpkin seeds 720 mg/kgBW, Okra seeds 5,46 mg/gBW, Areca seeds 750 mg/kgBW, Buni bark 200 mg/kgBW, Faloak bark 150 mg /kgBW, Surian bark 150 mg/kgBW, Bilimbi fruit 750 mg/kgBW, Purple Sweet Potato fruit 150 mg/kgBW, Papaya flower 200 mg/kgBW, Pineapple peel 250 mg/kgBW and Black Garlic tuber 300 mg/kgBW with this optimal dose can reduce blood glucose levels.

Analisis Efektivitas Biaya Penggunaan Antibiotik pada Pasien Demam Tifoid di RS SMC Periode 2017 Khoirunnisa Wal Hazimah; Mukti Priastomo; Rolan Rusli
Jurnal Sains dan Kesehatan Vol. 2 No. 2 (2019): Jurnal Sains dan Kesehatan
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Penyakit demam tifoid merupakan infeksi akut pada usus halus dengan gejala demam lebih dari satu minggu yang mengakibatkan gangguan pencernaan dan dapat menurunkan tingkat kesadaran. Pengobatan demam tifoid dapat dilakukan dengan cara pemberian terapi antibiotik. Penggunaan antibiotik dengan biaya yang relatif tinggi belum tentu bisa menjamin efektivitas kesembuhan pasien. Tujuan penelitian ini adalah untuk mengetahui efektivitas biaya antibiotik dari pasien demam tifoid di Rumah Sakit Samarinda Medika Citra periode 2017. Metode pengumpulan data dilakukan secara retrospektif berdasarakan catatan rekam medis pasien demam tifoid yang di rawat inap periode Januari hingga Desember 2017. Data efektivitas biaya pengobatan antibiotik dianalisis dengan nilai ACER. Hasil penelitian dari 79 pasien menunjukkan bahwa penderita demam tifoid terbanyak diderita oleh perempuan dengan persentase 53,16 % dan berusia usia 6 hingga 11 tahun dan 26 hingga 35 tahun dengan persentase yang sama sebanyak 17,72 % dengan lama rawat inap 4 hari dan obat antibiotik yang memiliki efektivitas lebih baik adalah ampisilin yang dapat menurunkan suhu demam sebesar 36,70 ºC dengan biaya Rp. 46,695.77 selama 4,3 hari dengan nilai ACER yaitu Rp. 398,543.00.

Antianemic Activity of Coconut (Cocos nucifera) Haustorium Waste Filtrate in Mice Induced by Sodium Nitrite Adzimahtinur Pradawahyuningtyas; Mukti Priastomo; Laode Rijai
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 2 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i2.16477

This study aims to determine the antianemic activity of coconut haustorium (Cocos nucifera) waste against mice induced by sodium nitrite orally for 43 days. The condition of anemia was determined by calculating the hemoglobin level using the Point of Care Test (POCT) method with the easytouch® GCHb and the resulting Hb level was 7.96 ± 0.05 g/dL. After the anemia condition is achieved, the test treatment is given for 21 days by dividing the mice into four groups, each consisting of three mice. The blank group (I) was administered distilled water, the control group (II) was administered Inbion® supplements at a dose of 0.65 mg/20 g BW, groups III and IV were administered coconut haustorium filtrate at a dose of 5 and 15 g/kg, respectively. Then measured the hemoglobin level and the number of erythrocytes. Based on the results of the study, the average hemoglobin levels of the blank, control, I and II groups were 13,9; 15,4; 16,0; and 16.8 g / dL, respectively. The number of erythrocytes during anemia was 1,750,000 / mm3 and after giving coconut kentos was 8,260,000 / mm3. From this study it can be concluded that the highest anti-anemia activity showed by coconut haustorium waste filtrate at dose 15 g/kgBW and had a significant difference in hemoglobin levels (p <0.05) with the blank group.

Co-Authors Adam M. Ramadhan Adzimahtinur Pradawahyuningtyas Ayu Indah Cahyani Delti Delaya Busa Desy Aulia Rahmah Gusti Alamsyah Abdil Almajid Halimatu Sadiyah Ismah Nuri Khoirunnisa Wal Hazimah Laode Rijai Mahdyya Afiana Ramadani Muhammad Faisal Niken Indriyanti Nilam Sari Novalinda Novalinda Rolan Rusli Vita Olivia Siregar

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