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Nursalam Hamzah
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ad-Dawaa : Journal of Pharmaceutical Sciences
Published by Universitas Islam Negeri Alauddin Makassar
ISSN : 26547392     EISSN : 26546973     DOI : 10.24252/djps
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
ad-Dawaa Journal of Pharmaceutical Sciences (DJPS) merupakan jurnal yang terbit dua kali dalam setahun, yaitu setiap Juni dan Desember. Jurnal ini fokus pada seluruh bidang terkait ilmu farmasi, termasuk biologi farmasi, farmakokimia, farmakologi, farmasi klinik dan teknologi farmasi. Jurnal ini juga mempublikasikan artikel terkait integrasi Islam dengan ilmu farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 7 Documents
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Search results for , issue "Vol 5 No 1 (2022)" : 7 Documents clear
AKTIVITAS EKSTRAK HIBISCUS ROSA-SINENSIS L. DAN BACCAUREA RACEMOSA TERHADAP PERTUMBUHAN RAMBUT PADA ALOPECIA YANG DIINDUKSI STRESS Putu Indrayoni; Anak Agung Istri Mas Padmiswari
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 1 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i1.27645

Abstract

Alopecia is the loss of excess hair that causes baldness, either temporarily or permanently. Physical and emotional stress are the most common causes. This study aims to determine the activity of H. rosa-sinensis L. and B. racemosa extracts on stress-induced hair growth in alopecia. Stress induction in male Wistar albino rats was obtained using the tail suspension test (TST) method. The results of the chemical content test were the total phenol content test (4,223.06 mg/100 g), total flavonoid (10,383.12 mg/100 g) and DPPH free radical reduction of B. racemosa (EB) extracts (1,593.17 mg/L GAEAC) were greater than those of the H. rosa-sinensis L. (EH) extract. The longest hair and highest hair density were obtained in the Minoxidil 2% group. While the most hair follicles were found in the group given the combination of EH and EB = 1: 1. The content of phenolic and flavonoid substances affects the hair growth activity. KEYWORDS: alopecia, stress, hibiscus, baccaurea, DPPH
Formulation Of Talas Leaf (Colocasia Esculenta) Emulgel As A Candidate Of Antibacterial Causes Of Bulbs: Formulation Of Talas Leaf (Colocasia Esculenta) Emulgel As A Candidate Of Antibacterial Causes Of Bulbs Maria ulfa; Radhia Reski; Muthiah Ridhayanah
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 1 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i1.28964

Abstract

One of the plants that are used as a boil medicine by the community, especially the people of Papua, is taro leaves (Colocasia esculenta). Taro leaves have antibacterial activity against bacteria that cause boils (S. aureus) with a concentration of 5%. This research aims to obtain a taro leaf emulgel preparation that is physically and determine the effectiveness of taro leaf emulgel against bacteria that cause boils. Taro leaf extract with a concentration of 5% was made into an emulgel preparation using gelling agent carbopol 940. gelling agent carbopol 940 with various concentrations of 1%, 1.5%, and 2%. Then each formula was tested for its antibacterial effectiveness by the good diffusion method against boil-causing bacteria with a positive control of gentamicin cream. Data analysis was carried out by calculating the average of the inhibition zones for each concentration. Taro leaf emulgel formula (Colocasia esculenta) is stable physically and is FII using 1.5% gelling agent. Effectiveness test of taro leaf emulgel formula against boil causing bacteria (S. aureus), namely FI, FII, and FIII, with a resistance of 18.24, 18.99, and 17.58 in the strong category.
Solvent Optimization for Extraction Mesua ferrea L. Leaves As An Antioxidant Using Simplex Lattice Design Method Handa Muliasari; Luh Putu Intan Paramitha Sari; Aliefman Hakim
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 1 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i1.29302

Abstract

Mesua ferrea L. leaves methanol extract has the highest antioxidant activity than the other part of the plant. However methanol is toxic solvent, so the using of methanol for extraction may harmful for health and environment. The purpose of this study was to optimize the solvent combination of ethanol and water for extraction of Mesua ferrea L. leaves by using Simplex Lattice Design (SLD) method. The samples were extracted by Ultrasonic Assisted Extraction (UAE) using variation of solvents ethanol 96%, ethanol 50% and water. The solvent combination was optimized by using SLD method based on the Total Phenolic Content of all crude extract. The result showed that the TPC of ethanol 96%, ethanol 50% and water crude extracts were 574.7±66.97 mgGAE/g, 657.8±37.02 mgGAE/g and 524.23±14.48 mgGAE/g respectively. SLD was calculated and the optimal solvent obtained was ethanol 55% with TPC of 626.235± 23 mgGAE/g. The ethanol 55% extract of Mesua ferrea L. leaves has strong antioxidant activity (IC50 57.77) ppm using DPPH method.
PERBANDINGAN FENOLIK TOTAL PADA EKSTRAK BIJI BUAH WALI (BRUCEA JAVANICA L. MERR) DENGAN METODE EKSTRAKSI MASERASI DAN SONIKASI Baiq Rizkia Dwiyana Meliandari; Wahida Hajrin
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 1 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i1.29317

Abstract

Wali Fruit Seed (Brucea javanica L. Merr) is one of the traditional medicines in Indonesia that has acted as an antidiabetic, antioxidant, and anti-inflammatory. Phenolic compounds play a role in acting as a drug. The amount of phenolic can be influenced by the extraction method used. The purpose of this study was to compare the total phenolic content of wali fruit seed extract with maceration and sonication extraction methods. The advantage of maceration was the simplest and most economical method, while sonication had a short extraction time. The method of this research is the extraction process by maceration and sonication. Screening of phenolic compounds with FeCl3 reagent and determination of total phenolics by the Folin-Ciocalteau method. The results obtained were the total phenolic value with the maceration method was 61,1927±0,1560 mg GAE/g extract, while the total phenolic value with the sonication method was 67,9854±0,0968 mg GAE/g extract. This value was significantly different (p<0.05) statistically. Thus, it was found that the total phenolic by the sonication method was greater than the maceration method. KEYWORDS: wali seeds, maceration, sonication, phenolic
Flavonoids: A Review On Extraction, Identification, Quantification, and Antioxidant Activity Haeria Doloking; Nurshalati Tahar; Mukhriani; Surya Ningsi
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 1 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i1.29329

Abstract

Flavonoids are polyphenolic compounds with a fifteen carbon basic skeleton (C6-C3-C6) composed of two benzene rings, A and B, connected by a pyran-C heterocyclic ring. The high interest in flavonoid research appears due to the numerous benefits of this compound based on its antioxidant activity. Various authors reported multiple studies in this regard. The research on methods of extraction, identification, quantification, and testing of antioxidant activity is compiled in this review. The most important part of this study is a review of the antioxidant activity assay method, which is equipped with the reaction mechanism.
Analgesic and Antipyretic Effects of Jamblang (Syzygium cumini (l). Skeel) Leaves Ethanol Extract Suwahyuni Mus; Sitti Rahimah; Fadhilla Maryam
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 1 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i1.31579

Abstract

Analgesic-antipyretic is a compound used to reduce pain and fever. This study aims to determine whether the ethanol extract of Syzygiumium cumini leaves has analgesic and antipyretic activity in mice (Mus musculus) induced by acetic acid and peptone. The method used was the Writhing method with acetic acid induction fanalgesiasic and the rectal temperature measurement method for antipyretic testing. This research was started by extracting Syzygium cumini (L.) Skeels leaves with 70% ethanol solvent by maceration. Syzygium cumini (L.) Skeels leaves extract was then tested in 5 groups the s, positive control growth as up given paracetamol for antipyretic testing and mefenamic acid for analgesic testing, negative control group ( Na.CMC suspension), a dose of 6 mg/Kg, 9 mg/Kg and 12 mg/Kg of body weight. The results indicate that the ethanol extract Syzygiumium cumini leaves has analgesic and antipyretic activity at all treatment doses and the most effectivect is at a dose of 6 kg BW KEYWORD : Syzygium cumini (L) Skeels, Mice, Analgesic, Antipyretic
The Effectiveness of Ethanol Extract Botto’-Botto’ Leaves (Chromolaena Odorata L.) in Transdermal Patch Formulation as Medication in Wound Healing Anshari Masri; Nurfadilah; Zulkifli; Muhammad Taufiq Duppa; Muhammad Subhan A Sibadu
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 1 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i1.31676

Abstract

Botto'-botto' plant (Chromolaena odorata L.) is a native Indonesian plant that belongs to the Asteraceae family and is known to have a high flavonoid content and antioxidant activity that can slow down the oxidation process to prevent infection while accelerating wound healing. botto'-botto' is designed as a patch to make it easier to use and provide the most effective treatment. The purpose of this study was to make a patch preparation and to investigate its effects on wound healing. The patch was formulated and then tested for physical properties (organoleptic, superficial pH, moisture loss, thickness, weight uniformity, and folding endurance test) and their activity against wounds experimentally using rabbits as an animal test with 4 (four) treatment groups, namely the control group, botto'-botto’ patch 10%, 20%, and 30%. Wounds were made with an area of 2 cm and 0.1 cm deep. The wound was plastered with a patch and observed for 18 days. Data were analyzed statistically using ANOVA. The results showed that the patch formulation of leaves extract botto'-botto’ affects for wound healing in rabbits significantly, with p<0.05. Furthermore, the patch formulation of ethanol extract botto’-botto’ with a concentration of 30% had the best and fastest healing effect among all formulas. KEYWORDS: Botto’-botto’, wound healing, transdermal patch

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