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Ni Made Dharma Shantini Suena
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Jurnal Ilmiah Medicamento
Published by Universitas Mahasaraswati
ISSN : -     EISSN : 23564814     DOI : https://doi.org/10.36733/medicamento.v6i1
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmiah Medicamento (JINTO) dengan nomor registrasi e-ISSN 2356-4814 didirikan pada tahun 2014, dan publikasi online dimulai pada tahun 2015. Jurnal diterbitkan dalam bahasa Indonesia. Awalnya JINTO diterbitkan oleh Akademi Farmasi Saraswati Denpasar. Namun sejak awal tahun 2019, penerbit jurnal berubah menjadi Fakultas Farmasi Universitas Mahasaraswati Denpasar karena institusi penerbit sebelumnya yaitu Akademi Farmasi Saraswati Denpasar telah mengalami penyatuan ke dalam institusi Universitas Mahasaraswati Denpasar menjadi Fakultas Farmasi. Jurnal Ilmiah Medicamento diterbitkan setiap enam bulan sekali (Maret dan September) yang berisi penelitian di bidang ilmu farmasi. JINTO menerima artikel yang mencakup berbagai bidang ilmu farmasi seperti: Farmakologi dan Toksikologi; Farmasi Klinik dan Komunitas; Kimia Farmasi; Biologi Farmasi; Teknologi Farmasi; Farmasi Mikrobiologi dan Bioteknologi; Regulatory Affairs and Pharmacy Marketing Research; Pengobatan alternatif.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 267 Documents
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Formulasi Masker Peel Off Ekstrak Buah Naga Merah (Hylocereus lemairei Hook.) dan Pati Jagung dengan Variasi Konsentrasi Polyvinyl Alcohol (PVA) Ni Made Dharma Shantini Suena; I Gusti Agung Ayu Kusuma Wardani; Ni Putu Udayana Antari
Jurnal Ilmiah Medicamento Vol 9 No 2 (2023): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i2.3576

Abstract

Red dragon fruit is rich in nutrients and minerals as well as phytoalbumin and antioxidant compounds such as phenolic compounds and vitamin C. Corn contains vitamins A, B, and E as antioxidants, as well as Thiamin, which can reduce black spots on acne scars and dry out wounds. Peel-off masks are cosmetic preparations for facial care that can form a thin, transparent layer on the surface of the skin and can be peeled off after drying, so they are practical to use. Polyvinyl alcohol (PVA) is a film-forming polymer and can increase viscosity, which in turn plays a role in producing peel-off masks that have good physical quality. This study aims to formulate peel-off masks of red dragon fruit extract (Hylocereus lemairei Hook.) and corn starch with varying concentrations of PVA (F1:2.5%, F2:8.75%, F3:17.5%) in order to have a high-quality good physique. The evaluation of the physical quality of the red dragon fruit and corn starch peel-off masks was organoleptic, homogeneity, pH, spreadability, adhesion, and drying time. The organoleptic preparations (F1-F3) were brownish-orange in color, with a distinctive rose odor, with increased viscosity from F1 to F3, and remained stable for up to 4 weeks of storage. The homogeneity of preparation (F1-F3) was homogeneous and lasted for 4 weeks of storage. The pH value of the preparation on day 1, F1 and F2, had a pH of 4, and F3 had a pH of 4.5. From the 1st to the 4th week, the pH of preparations F1-F3 was 4.5, according to the physiological pH of the skin, 4-8. The spreadability of F1-F3 preparations was in the 5.5-6.5 cm range, according to 5-7 cm provisions. The adhesive power of the F1-F3 preparations was in the range of 5.29-40.1 seconds, which is recommended for more than 1 second. The drying time of F1-F3 preparations was in the range of 20.58-30.45 minutes, according to the provisions of 15-30 minutes. The three red dragon fruit and corn starch peel-off mask formulas (F1, F2, and F3) meet the requirements for good physical quality according to the criteria set and recommended. Increasing the PVA concentration did not affect the pH value and spreadability of the three formulas but increased the adhesiveness value and drying time.
Narrative Review: Efektivitas Biaya Penggunaan Antibiotik untuk Penyakit Pneumonia di Rumah Sakit Indonesia Chandra Arifin; Abd Roriq
Jurnal Ilmiah Medicamento Vol 9 No 2 (2023): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i2.4827

Abstract

Pneumonia is an acute inflammatory respiratory infection caused by microorganisms. This infection can occur from both toddlers to the elderly and if not properly then the acute respiratory inflammation process will continue to be able to cause various infectious complications. Until now, there are many choices of antibiotic therapy for their treatment, but they have not guaranteed their effectiveness both therapeutically and cost-effectively. The purpose of this study was to analyze the effectiveness and efficiency of pneumonia treatment costs in Indonesian Hospitals. The method used is a literature review approach, namely Systematic Review related to articles with cost-effectiveness analysis or Cost-effectiveness analysis of pneumonia treatment that have been published in the form of research articles. Search articles using three databases, namely Google Scholar, Pubmed, and Garudadekti. Then the selection stage or literature screening was carried out by reading the title, abstract, and continued with the full text of the research article obtained. The results obtained 14 research articles according to the inclusion and exclusion criteria regarding the cost-effectiveness of pneumonia treatment. From the research data, it can be concluded that the antibiotic cefotaxime is widely prescribed and the most cost-effective according to the ACER calculation. However, the ACER value is influenced by different drug administration for each patient, the effectiveness of treatment therapy, the costs incurred by the patient or direct medical costs.
Profil Fitokimia dan Aktivitas Antibakteri dari Massoia aromatic Becc., Acorus calamus L., dan Allium sativum L. terhadap Bakteri Penyebab Rinosinusitis I Made Sugata; I Kadek Darmo Suputra; Putu Emy Suryanti; Made G. Juniartha; I Gusti Agung Ayu Kartika
Jurnal Ilmiah Medicamento Vol 9 No 2 (2023): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i2.5961

Abstract

Triketuka, an herb with multiple therapeutic activities, is featured in Balinese medicinal texts. This herb is composed of Massoia aromatic Becc. (masoyi), Acorus calamus L. (dringo), and Allium sativum L. (garlic). The antibacterial activity of these ingredients against bacteria causing rhinosinusitis has not been fully evaluated. Hence, this study seeks to determine the potential of these three components, especially with regards to their effectiveness against rhinosinusitis. In this research, an in vitro antibacterial test was conducted against Streptococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Pseudomonas aeruginosa. The phytochemical profile of each plant was determined using Liquid Chromatography-Mass Spectrometry. The Minimum Inhibitory Concentration value was determined by carrying out the antibacterial test via the microdilution method. The detected compounds were analyzed for their contributions through the prediction of activity spectra for biologically active substances (PASS) online and Antibac-Pred. As a result of the in vitro antibacterial test, the samples were found to have MIC > 4096 ppm against all bacteria except Massoia aromatic and Acorus calamus against Staphylococcus aureus in MIC 4096 ppm each. This discovery was further verified through PASS online and Antibac-Pred. The studies indicate that certain compounds found in the samples exhibit antibacterial activity, albeit with low efficacy against the tested bacteria. In conclusion, the plants exhibit low antibacterial potential against bacteria that cause rhinosinusitis. Further research on the combination of the three plants is required to enhance their antibacterial efficiency.
Analisis Nilai Sun Protection Factor Krim Tabir Surya Ekstrak Tanaman Gonda (Sphenoclea zeylanica Gaertner) dengan Metode Spektrofotometri UV-Vis Ni Putu Wintariani; I Putu Tangkas Suwantara
Jurnal Ilmiah Medicamento Vol 9 No 2 (2023): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i2.6600

Abstract

Free radicals are unstable atoms that can damage cells, causing disease and aging of the skin. Ultraviolet rays cause skin to darken and wrinkle as free radicals produce excess melanin. One of the anti-radical substances is found in the Gonda plant (Sphenoclea zeylanica Gaertner). The plant extract is made into a sunscreen cream dosage form to protect the skin from the dangers of free radicals from sunlight. The aim of this study was to determine the compounds contained in Gonda plant extract and the SPF value of Gonda plant extract sunscreen cream by in vitro method using UV-Vis spectrophotometry. The results showed that Gonda plant extract contains flavonoids, saponins, tannins, steroids, and alkaloids. The SPF value of the cream with 4 concentrations of Gonda plant extract in the formula, namely cream base (0%), F1 (5%), F2 (10%) and F3 (15%) showed the protection category of "none" (1.510), "maximum" (13.488), "ultra" (20.129) and "ultra" (22.921), respectively. The SPF values of the creams of the four formulas were significantly different (p<0.05), and there was a significant (p<0.001) and strong relationship between extract concentration and SPF value. Gonda plant extract cream had SPF value with maximum protection level at 5% concentration and ultra at 10% and 15% concentration. There was a significant and strong relationship between extract concentration and SPF of the cream.
Jamur dari Mangrove sebagai Sumber Senyawa Metabolit Sekunder Bioaktif yang Berpotensi sebagai Kandidat Antikanker: Review Literatur Ni Kadek Ari Kristiani; I Putu Yogi Astara Putra; Ni Wayan Prasanthi Swarna Putri; Ni Putu Eka Leliqia; Nonye Treasure Ujam; Ni Putu Ariantari
Jurnal Ilmiah Medicamento Vol 9 No 2 (2023): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i2.6910

Abstract

Cancer was the leading cause of death, which accounting for nearly 10 million deaths globally in 2020. Currently, cancer treatment still relies on chemotherapy, however, most anticancer drugs showed non-specific toxicity to normal cell proliferation resulting in various side effects, and are ineffective against many forms of cancer. In addition, the increasing case of chemoresistance of cancer cells to chemotherapy has boosted the discovery of new anticancer agents. Natural products are known as the origin of several clinically used anticancer agents, e.g. taxol and vincristine. Among natural products, mangrove-derived fungi are of particular scientific interest evidenced by the increasing rate of publications on cytotoxic secondary metabolites reported. Hence, this literature review aims to provide comprehensive information on cytotoxic secondary metabolites isolated from mangrove-derived fungi, which might contribute to the search for anticancer leads from natural resources. Data were collected from original research articles published on scientific-based sources such as Google Scholar, PubMed, Taylor and Francis, Elsevier, and MDPI, in the range of 2011-2022. Fifty-four cytotoxic secondary metabolites with IC50 values below 10 µM were described herein, which were classified in to 8 groups of metabolites. These compounds were reported from 16 genera of mangrove-associated fungi. Among them, Aspergillus and Penicillium were the most frequent producers of cytotoxic metabolites, suggesting their enormous potential as a source of pharmacophores for anticancer candidates.
Pengaruh Penggunaan Peningkat Penetrasi Propilen Glikol terhadap Laju Difusi Polifenol dalam Gel Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus)
Jurnal Ilmiah Medicamento Vol 9 No 2 (2023): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i2.7061

Abstract

Polyphenols contained in the skin of red dragon fruit are efficacious as antioxidants which can be used as topical preparations. Polyphenols are polar, making it difficult to penetrate through the stratum corneum of skin which is rich in lipids. The way that can be done to increase the rate of drug penetration through the skin is the addition of a propylene glycol penetration enhancer. The purpose of this study was to determine the effect of adding propylene glycol as a penetration enhancer on the diffusion rate of polyphenols from red dragon fruit peel extract gel. This type of research was experimental by testing the physical quality of red dragon fruit skin extract gel preparations using the accelerated stability test method and penetration-diffusion testing. Gel preparations were made in 4 formulas with varying concentrations of propylene glycol 5% (F1), 7.5% (F2), 10% (F3) and negative control without propylene glycol. The results showed that all formulas met the physical quality test requirements. Then a penetration test was carried out using a Franz diffusion cell for 4 hours with a phosphate buffer diffusion medium pH 7.4. Polyphenol equivalence treatment was carried out by spectrophotometry. The cumulative amount of polyphenols that diffuses through the membrane after 4 hours is 176.15 µg/cm2 for (F1), 232.76 µg/cm2 for (F2), 239.67 µg/cm2 for (F3) and 126.45 µg/cm2 for (F0). This study concludes that varying the concentration of the penetration enhancer propylene glycol has an effect on the diffusion rate of polyphenols from red dragon fruit skin extract gel preparations, with formula 3 producing the greatest diffusion rate effect.
Kandungan Flavonoid Total dan Aktivitas Antioksidan dari Ekstrak Polaritas yang Berbeda dari Daun Pereskia bleo Ni Made Dwi Mara Widyani Nayaka; Erna Cahyaningsih; Maria Malida Vernandes Sasadara; Putu Era Sandhi Kusuma Yuda; Felia Riska Indriani
Jurnal Ilmiah Medicamento Vol 9 No 2 (2023): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i2.6290

Abstract

Antioxidant agents are essential for the body due to its ability to scavenge free radicals. Medicinal plants contain phytochemicals that act as antioxidants. The current research aimed to determine the total flavonoid content (TFC) and antioxidant activity of Pereskia bleo leaves extracts from various solvents with different polarities. The nonpolar solvent (n-hexane) was used as the first step of extraction and its residues were then macerated using semi-polar (ethyl acetate) and polar (ethanol 96%) solvents consecutively. The TFC was determined using the colorimetric method while antioxidant activity was examined through the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Antioxidant activity was presented as Inhibitory Concentration 50 (IC50) and Antioxidant Activity Index (AAI). It is noticeable that among analyzed extracts, the ethyl acetate extract of P. bleo leaves contained the highest flavonoid content (15.052 ± 0.172 g quercetin equivalent/100 g extract). Furthermore, the greatest antioxidant activity was obtained from n-hexane extract with the value of IC50 and AAI being 217.307 ppm and 0.230, respectively. Pearson coefficient correlation (r) between TFC and AAI was -0.106. The current study concluded that P. bleo leaves extracts using solvents with different polarities showed variation in TFC values and antioxidant activity. Moreover, TFC was not the main contributor to the antioxidant activity of P. bleo leaves extracts.

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