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INDONESIA
Berkala Ilmiah Mahasiswa Farmasi
Published by Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia
ISSN : 23027851     EISSN : 27741710     DOI : 10.48177
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
BIMFI is a peer-reviewed and open access journal that prioritize the publication manuscript of pharmaceutical and health cluster students. This journal publishes editorial, research article, reviews, evidence-based case report, and also interesting case reports/case study. BIMFI receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Herbal Medicines, Pharmaceutics, Pharmaceutical Microbiology and Biotechnology, Community and Clinical Pharmacy, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 47 Documents
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Si Kenyal Manis, Obat Diabetes Mujarab David Christian Ferdinand
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 6 No 2 (2019): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v6i2.21

Abstract

A serious disease occurs when the pancreas produce insufficient insulin is called diabetes. A various complications that affected to eyes, heart, and nervous system caused by diabetes. The use of synthetic drugs both oral and injection can cause a serious side effects like hypoglycemia. Based on these reasons, many researchers try to develop an anti-diabetic drugs derived from natural resources.One of the plants which potential to decrease glucose level in diabetic patients is Cinnamon (Cinnamomun zeylanicum). Cinnamon extract is very potent to decreases the glucose level in diabetic conditions. Based on this, the cinnamon extract will formulate in softgel forms. The manufacturing process occurs by encapsulate the extract with gelatin film as a shell material. Gelatin is a chewy shell material. The addition of plasticizer in gelatin is very important because its can affected to flexibility of capsule. The encapsulation process with rotary die method occurs using a special machine. The encapsulation process occurs by create a contract manufacture with third person. To ensure theproduct quality, a various test like organoleptic, weight-content uniformity, and rupture test was conducted.
Susu Fermentasi Anti Hipertensi ( SUFERANTIH) Hamnah Al Atsariyah
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 7 No 1 (2020): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v7i1.25

Abstract

Work is a man's duty when he is the head of the household. Long working hours cause physical fatigue both physically and psychologically. It will significantly affect the lifestyle that has an impact on the quality of health. Hypertension is a disease that is triggered due to physical and psychological fatigue. The drug that is often used as a pharmacological therapy for hypertension is captopril, which functions as an angiotensin converting enzyme inhibitor (ACE I). On the other hand captopril has a high toxicological effect including kidney disorders and hypersensitivity reactions appear. So it is necessary to innovate antihypertensive therapy which functions the same as captopril but has no side effects. Fermented milk has a compound that has the potential as an ACE inhibitor which acts to prevent the formation of aldosterone-producing angiotensin II which causes a rise in blood pressure. Fermented milk is a mild preparation that can be consumed without knowing age restrictions. Consumption of fermented milk can be combined with a variety of healthy food menus and other drinks. In the process of lactic acid bacterial fermentation, it will turn beta casein into a compound that has the potential to be ACE I. However, adding to the great potential of fermented milk as an antihypertensive agent, people's misconceptions about milk need to be corrected first. Therefore, "SUFERANTIH" can be an alternative non-pharmacological therapy for hypertension that provides both curative and preventive effects
Bergamot Essential Oil (Citrus bergamia) sebagai Terapi Alternatif Lanjutan untuk Komplikasi Kesehatan yang disebabkan oleh Internet Gaming Disorder (IGD) Intan Lestari
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 7 No 1 (2020): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v7i1.26

Abstract

Activities that are liked by everyone to fill the spare time, especially boys, is playing games online or video-games. The increased duration of playing games can be addictive when playing games and restlessness if he do not play games. If this things continues it can develop into Internet Gaming Disorder (IGD) or gaming disorder. In 2018, International Classification of Diseases (ICD) released an 11th revision and stated that “gaming disorder” was officially declared as a disease. IGD can also potentially cause depression, social difficulties, ADHD and substance abuse. The fruit of the bergamot plant (Citrus bergamia) can be used for bergamot essential oil (BEO) by squeezing and cold pressing the fruit skin. Bergamot essential oil is widely used as aromatherapy to improve mood and symptoms of stress disorders. The aromatic materials will stimulate the autonomic nervous system so the receptors will receive BEO containing linalyl acetate and linalool. The odor will be delivered to the limbic system so that it can improve mood and trigger the release of hormones serotonin and endorphins
Upaya Penyembuhan Alopesia Androgenetik Melalui Obat-Obatan Baru Untuk Meningkatkan Kualitas Hidup Laki-Laki Maryam Hasymia Ishmatullah
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 7 No 1 (2020): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v7i1.28

Abstract

Baldness in men can affect social interactions, thereby reducing quality of life. The type of baldness that most often affects men is Androgenetic Alopecia (AGA) which is caused by hormonal and gene factors. Efforts to find new drugs for AGA therapy are continuing. Various drugs that are currently being developed are Clascoterone with hormonal blocking mechanism; FOL-005 with affecting network repair mechanism; Cysclospoerine with inhibiting hair growth mechanism
Peran Perawatan Kulit (Skincare) Yang Dapat Merawat Atau Merusak Skin Barrier Adira Rahmawaty
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 7 No 1 (2020): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v7i1.32

Abstract

Skincare is something that is highly valued in the present. Not only women but skincare is now beginning to spread to men. Having a bright, white, acne-free skin and free from excess oil is a dream for all people. Before skincare, makeup was the first popular because of the obvious results that were clearly seen in a short time. But the world of makeup that always provides improvement for its users by covering or polishing certain parts of a person's body is now slowly starting to be abandoned and replaced with skincare. This is because so many studies and opinions have emerged that skincare is healthier and the results obtained last longer in the longer term than makeup. The large variety of skincare products that have arisen has caused controversy and consumptive behavior. It also can not be separated from the impact that is felt after the use of skincare for a long time. This article was created to discuss the impact arising from the use of skincare on the skin barrier or the outer layer of skin that protects the skin naturally from a variety of external factors that can damage the skin.
Optimasi Natrium Alginat Dan Kalsium Klorida (Cacl2) Sebagai Agen Sambung Silang Nanopartikel Ekstrak Etanol Daun Katuk (Sauropus Androgynus (L.) Merr) Akhmad Ngafif
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 7 No 2 (2020): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v7i2.33

Abstract

Obesity is defined as a condition with abnormal or excessive fat accumulation in adipose tissue so that it can interfere with health. The increasing prevalence of obesity was a major health problem worldwide. One effort to prevent obesity can be done by utilizing natural materials in Indonesia, including katuk leaves (Sauropus androgynus (L.) Merr). Katuk leaves contain kaempferol compounds which had the effect of reducing body fat or antiobesity. The nanoparticle formulation of katuk leaf ethanol extract made using a polymer of sodium alginate and calcium chloride (CaCl2) as a crosslinking agent. This study aims to determine the effect of the use of sodium alginate and calcium chloride (CaCl2) on physical characteristics in nanoparticle extracts of katuk leaf ethanol, and determine the nanoparticle formula with optimal physical characteristics. Optimized parameters were visual, transmittance, adsorption efficiency, particle size distribution, polydispersity index, zeta potential and particle morphology in the optimal formula of katuk leaf ethanol extract nanoparticles. Based on Design Expert 10.0.1 with the factorial design method, the optimal formula is obtained with a ratio of sodium alginate and calcium chloride (CaCl2) of 0.102%: 0.010%. Visual prediction results obtained 3 (clear); transmitting 90.66% and absorption efficiency 81.1359%. The t-test results showed that these observations differed insignificantly to the results of the predictions indicating that the equation of each optimization parameter was valid. The optimal formula had 66.4% units 54.59 nm of size nanoparticles and 33.6% units 440.1 nm, 0.465 of polydispersity index, -17.6 mV of zeta potential and particle morphology with a non-spherical shape in a loose aggregate.
Identifikasi dan Penetapan Kadar Senyawa Kuinin Fraksi Etil Asetat Kulit Batang Kina (Cinchona succirubra Pav. Ex Klotzsch) Secara KLT-Densitometri Gede Sugiartha Giri
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 7 No 2 (2020): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v7i2.41

Abstract

Alkaloids quinine is found in the quinine plant which is the raw material for the manufacture of quinine pills that are effective in the treatment of malaria. Selection of the method, solvent, identification technique and characterization of the alkaloid quinine compound in the quinine plant (Cinchona succirubra Pav. Ex Klotzsch) need to be done in an effort to produce the compound with the best separation.Extraction by maceration method, identification of groups using phytochemical screening methods. Fractionation using liquid-liquid extraction method and column chromatography. Isolation using preparative chromatography method and TLC-Densitometry method. Maceration extraction obtained the filtrate with a reddish brown color. Phytochemical screening was positive for triterpenoids and alkaloids. Liquid-liquid extraction resulted in the water fraction, ethyl acetate fraction I, and ethyl acetate fraction II. TLC and identification of positive chemical reactions containing quinine in ethyl acetate fraction II. Column chromatography obtained results in the form of 4 fractionations with different colors. Preparative chromatography and compound isolation by TLC-Densitometry showed the average quinine content of ethyl acetate fraction was 15.30%. The ethyl acetate fraction of quinine stem bark (Cinchona succirubra Pav. Ex Klotzsch) produced average quinine alkaloids of 15, 30% according to the cultivated kina plant which contains up to 15% quinine alkaloids.
Studi Penambatan Molekuler dan Prediksi ADMET Senyawa Bioaktif Beberapa Jamu Indonesia terhadap SARS-CoV-2 Main Protease (Mpro) Sheniez Adhitya Yasin; Alya Azzahra; Norman Emil Ramadhan; Vega Mylanda
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 7 No 2 (2020): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v7i2.45

Abstract

The novel coronavirus SARS-CoV-2 continues causing viral respiratory illness, known as Coronavirus Disease-2019 (COVID-19). COVID-19 is considered as the biggest global pandemic disease in 2020 and its antiviral therapies are still lacking worldwide. Current studies are still trying to find potential therapies of the disease, including from natural compounds. Therefore, it is important to acknowledge what the most effective herbs’ compounds can be used against the virus. Jamu is traditional medicine from herbs in Indonesia that possesses some medicinal properties. This research was done to find and explore the potential of Indonesian jamus as novel COVID-19 treatment. 283 bioactive compounds from Indonesian jamus were screened with ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) predictions and Lipinski’s Rule of Five parameters using ProTox-II and SwissADME. The 12 screened compounds then continued to be tested through molecular docking against SARS-CoV-2 Main Protease (Mpro) using AutoDock Vina. The result of our study showed that Curcuminol D has the lowest binding free energy of -6.9 kcal/mol and Ki (inhibition constant) of 2.99 µM compared to the other screened compounds. However, none of the screened compounds has lower binding free energy than the positive controls’, which valued -8.2 kcal/mol (Lopinavir) and -7.8 kcal/mol (Ritonavir). Despite their unfulfilled parameters, the other 271 compounds might have higher potential than the standard drugs. Therefore, the finding in the present study can be used as a starting point in the drug discovery process from natural compounds for treating COVID-19.
Anti-Diabetes Mellitus Potential Compounds Of Flavonoid Citrus Peel: A Review On Mechanism Donny Risnanda Herdien; Cahaya Azzahra Rahmadhani; Septia Nurmala; Arry Yanuar
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 7 No 2 (2020): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v7i2.48

Abstract

Diabetes therapy with commonly used of anti-diabetes drugs (OAD) have unwanted side effects and the high price become problematic, so it is necessary to find or develop other safer, more effective, and inexpensive OAD alternatives. Based on in vitro and in vivo research models, flavonoids are proven to have efficacy in lowering blood glucose levels. In the citrus peel, flavonoid compounds are abundant. However their utilization is not optimal even though the mass production is very high. This study is to review current information regarding the effects of flavonoids on citrus peel in diabetes management and their molecular mechanisms. A literature review was conducted using the electronic databases of Scopus, ScienceDirect, and the American Chemical Society covering the most recent literature published from the years 2010 till present. Several keywords were combined to ensure all in vitro and in vivo studies were obtained. Key words used were “citrus peel”, “flavonoid”, “diabetes mellitus”, “mechanism”, and “blood glucose”.Based on the results of research that has been conducted by previous researchers, it was found that the flavonoids of citrus peel can improve glucose metabolism, hepatic enzyme activity, insulin signalling and lipogenesis regulation, repair damage to pancreatic islet cells and stimulate insulin secretion, and protect against complications of diabetes. Overall, citrus peel flavonoids as an antidiabetic can prevent an increase in blood sugar levels and reduce insulin resistance, the two hallmarks in diabetes melitus. Flavonoids play a role in enzyme inhibition, which is the main mechanism of medicine as well as inhibition at the level of gene expression and its antioxidant properties. Further research on the safety and efficacy of flavonoids is needed for the development of citrus fruit peel flavonoids as an alternative therapy for diabetes melitus.
Berbagai Tumbuhan Obat Tradisional Di Asia Dengan Aktivitas Antiasma Nabila Nayif Nur Akmalia
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 7 No 2 (2020): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v7i2.52

Abstract

Natural ingredients are a good source of active compounds and drugs. The study of plant content is very interesting in the discovery of active compounds, especially for therapy in asthma. Asthma is a chronic disease with symptoms of wheezing, shortness of breath, chest tightness, and coughing. There are several mechanisms of action of anti-asthma compounds related to the types of asthma, namely H1 and H2 receptor inhibitors, reducing immunoglobin E levels, inflammation mediators, preventing secretion of cytokine Th2, and other specific mechanisms. The method used is literature study. The study was conducted by searching keywords such as herbs, anti-asthma, medicinal plants, and anti-asthmatic activity on electronic databases including ClinicalKey, Science Direct, PubMed, and Google Scholar. Therefore, data and explanations about potential medicinal plants found throughout Asia as alternative sources of asthma treatment were obtained.Thirty types of traditional medicinal plants in Asia that have the anti-asthma activity potential to have been obtained by various mechanisms of action. The plants activity data collected in this literature review indicate their use as an alternative source of asthma treatment.

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