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Percobaan Sintesis 4-(4-Metoksibenzilidena) 2-metiloksazol-5-on dari Asetilglisin dan 4-Metoksibenzaldehid Arif Arrahman; . Hayun; Arry Yanuar
PSR (Pharmaceutical Sciences and Research) Vol 8, No 2 (2011)
Publisher : Fakultas Farmasi Universitas Indonesia

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Abstract

Compound 4-(4-methoxybenzylidene)-2-methyloxazole-5-one was one of oxazolone moety derivative. Oxazolones had several different pharmacological activity depend on substituent which was bonded to oxazolone ring. Oxazolones was an important precursor for synthesizing several compounds which had pharmacological activity. For that reason, experiment to synthesize 4-(4-methoxybenzylidene)-2-methyloxazole-5-one from acetyl- glicine and 4-methoxybenzaldehyde as an oxazolone derivative become necessary. Com- pound 4-(4-methoxybenzylidene)-2-methyloxazole-5-one was synthesized over two step of reaction. First step was reacted glycine with acetic anhydride in acidic environment yielded acetylglycine. Second step was reacted acetylglycine with 4-methoxybenzaldehyde yielded 4-(4-methoxybenzylidene)-2-methyloxazole-5-one. The product, which was collected in every step, was purified by washing and recrystalization then the purification to be tested by examining melting range and thin layer chromatography. The compound was eluci- dated by using infrared spectrophotometry and 1H-NMR spectrophotometry. Synthesis of 4-(4-methoxybenzylidene)-2-methyloxazole-5-one yielded rendement over 0,54%. The interpretation of infrared spectrum indicated that the compound which synthesized was different from the former compound but the interpretation of 1H-NMR spectrum indicated that the compound could not be ascertained as 4-(4-methoxybenzylidene)-2-methyloxa- zole-5-one because of there were impurities. 4-(4-methoxybenzylidene)-2-methyloxazol-5-one, oxazolone, 4-methoxyben- zaldehyde, acetylglycine
SKRINING GEN GLUKOSILTRANSFERASE (GTF) DARI BAKTERI ASAM LAKTAT PENGHASIL EKSOPOLISAKARIDA Amarila Malik; Donna M. Ariestanti; Anandayu Nurfachtiyani; Arry Yanuar
Makara Journal of Science Vol 12, No 1 (2008): April
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

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Abstract

Screening for glucosyltransferase gene (gtf) from exopolysaccahride producing lactic acid bacteria. Glucosyltransferase (GTF) is an enzyme involved in exopolysaccharide (EPS) polymer synthesis in microbes. One example of EPS that has been used in pharmaceutical and medical application is dextran. Dextran has been used in conjugated-drug delivery system as matrix. As a group of microbes producing EPS, lactic acid bacteria (LAB) have been well reported carrying sucrase genes glucosyltransferase (gtf), as well as fructosyltransferases (ftf). In an attempt to search for novel gtf genes as the aim of this study, LAB collection isolated from local sources yielded from previous study were screened performing PCR using degenerate primers DegFor and DegRev. An approximately 660 base pairs (bp) amplicons were obtained by using genomic DNAs of those LAB isolates as templates with conserved region of gtf genes catalytic domain as target. Two out of 20 LAB strains were yielded no amplicon as observed on agarose gel, while one strain exhibited non-specific amplicon DNA bands with sizes other than 660 bp. The two negative ones were isolated from soil obtained from dairy product waste field and from waste of soy sauce from previous study, while the latter was isolated from waste of soy sauce. Keywords: glucosyltransferase, gtf, exopolysaccharide, lactic acid bacteria, degenerate primers
Uji Aktivitas Antibakteri 1-[(Kuinazolin-4-on-2-il)metil]piridin-1-ium Bromida dan 2-Bromometilkuinazolin-4-on Hayun Hayun; Arif Arrahman; Herman Suryadi; Arry Yanuar
Pharmaceutical Sciences and Research (PSR) Vol 1, No 1 (2014)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (46.592 KB) | DOI: 10.7454/psr.v1i1.3303

Abstract

Antibacterial activity tests of quinazolin-4-one derivates: 1-[(6-nitroquinazolin-4-one- 2-yl)methyl]piridin-1-ium bromide (1), 1-[(6-aminoquinazolin-4-on-2-yl)methyl]piridin-1-um bromide (2), 2-bromomethylquinazolin-4-one (3) and 2-bromomethyl-6-nitroquinazolin-4-one (4) with trimethoprim (5) as a positive standard were conducted. The antibacterial activity tests were carried out using disc diffusion method againts E. coli, S. aureus and S. thyposa, and determination of minimum inhibitory concentration (MIC). The results showed that compounds 1 and 2 are inactive as antibacterial, whereas compounds 3 and 4 are active. The activities to E. coli were 1⁄4 times the activity of trimethoprim (MIC : 5 x 10 2 μg/ml compared to 1.25 x10 2 μg/ml ). The activity to S. typhosa were 1⁄2-1 times the activity of trimethoprim (MIC: 2.5 and 1.25x10 2 μg/ml compared to 1.25x10 2 μg/ml); but they are not active to S. aureus. Trimethoprim active to S. aureus with MIC : 0.62 x10 2 μg/ ml.
PEMANFAATAN MALTODEKSTRIN PATI TERIGU SEBAGAI EKSIPIEN DALAM FORMULA SEDIAAN TABLET DAN NIOSOM Effionora Anwar; Joshita Djajadisastra; Arry Yanuar; Anton Bahtiar
Pharmaceutical Sciences and Research (PSR) Vol 1, No 1 (2004)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (89 KB) | DOI: 10.7454/psr.v1i1.3368

Abstract

The Use of Maltodextrin from Wheat Starch as an Exipient in Formula Tablet and Niosom dosage form. Wheat starch normally can be used as a tablet filler only, because the flow rate and binding capacity are not good enough. The wheat starch should be treated as follows : protein and amine free Bogasari wheat flour starch were hydrolyzed by α-amylase enzyme (Liquezym EX®) at variable temperature and time incubation to produce maltodextrin with different Dextrose Equivalent (DE) value. The maltodextrin could be used as tablet binder on wet granulation, tablet filler and binder on direct compress, a proniosom carrier to prepare niosom, a tablet filler, binder and disintegrator on direct compress tablet, a sugar coated tablet material. All of the product used active compound as amodel and the quality were evaluated according to the 4thed. of Indonesian Pharmacopeae and other valid references. The result shows that maltodextrin DE 1–5 could be used as a tablet binder which was processed by wet granulation on 2-5% concentration, as a tablet binder and filler which was processed by direct compress on 30-35%; maltodextrin DE 10-15 could be used as a proniosom carrier then continued to niosom preparation with surfactant composition of 2 mmol (1 mmol for span 60 and 1 mmol for cholesterol). The surfactant and drug concentration of 100 mmol/lt and 5 mmol/lt subsequently was proved to loading the drug as much as 81.28%. Maltodextrin DE 15-20 could be used as a tablet filler, binder and disintegrator at 84%, and starch hydrolyzed of DE 35-40 as a sugar coating which was more economical than sugar.
Eksplorasi dan Karakterisasi berbagai Kristal Ibuprofen Arry Yanuar; Nursanti Nursanti; Effionora Anwar
Pharmaceutical Sciences and Research (PSR) Vol 7, No 2 (2010)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (706.615 KB) | DOI: 10.7454/psr.v7i2.3455

Abstract

Ibuprofen is an analgesic anti-inflammatory nonsteroidal (AINS). Generally, ibuprofenhave a bad flowability because a high cohesivity. Another problem in manufacturingis the high tendency for sticking to the punches. Besides these disadvantageous properties,ibuprofen indicates bad dissolution behavior because of its hydrophobic structure.To improve the properties of ibuprofen can be used crystallization method withusing variation of solvents. In this experiment observed crystallization method bycooling, evaporation, and water presence, which used methanol, ethanol, and acetonesolvents. Of all the crystallization results are produced white prism-shaped crystalline.The selected method is cooling method, which is characterized using ScanningElectron Microscopy (SEM), powder X-ray diffraction, and Differential ScanningCalorimetry (DSC). These three characterizations indicate transformation of crystalform which compared with ibuprofen’s standard. The selected method also producesnon cohesive powder which have the size particle is 710-1180µm, compressibilityindex: IBMD 14.2%, IBED 16.6%, IBAD 17.1%; angles of repose: IBMD 28.1º,IBED 29.7º, IBAD 30.1º, and have higher solubility than the common crystal’ssolubility. The result indicates that crystallization method is able to improve flowrate,compressibility index, and dissolution rate properties of ibuprofen’s standard.Keywords : Ibuprofen, Crystal habit, Polymorphism, Crystallization techniques.
Percobaan Sintesis 4-(4-Metoksibenzilidena) 2-metiloksazol-5-on dari Asetilglisin dan 4-Metoksibenzaldehid Arif Arrahman; . Hayun; Arry Yanuar
Pharmaceutical Sciences and Research (PSR) Vol 8, No 2 (2011)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2623.274 KB) | DOI: 10.7454/psr.v8i2.3474

Abstract

Compound 4-(4-methoxybenzylidene)-2-methyloxazole-5-one was one of oxazolone moety derivative. Oxazolones had several different pharmacological activity depend on substituent which was bonded to oxazolone ring. Oxazolones was an important precursor for synthesizing several compounds which had pharmacological activity. For that reason, experiment to synthesize 4-(4-methoxybenzylidene)-2-methyloxazole-5-one from acetyl- glicine and 4-methoxybenzaldehyde as an oxazolone derivative become necessary. Com- pound 4-(4-methoxybenzylidene)-2-methyloxazole-5-one was synthesized over two step of reaction. First step was reacted glycine with acetic anhydride in acidic environment yielded acetylglycine. Second step was reacted acetylglycine with 4-methoxybenzaldehyde yielded 4-(4-methoxybenzylidene)-2-methyloxazole-5-one. The product, which was collected in every step, was purified by washing and recrystalization then the purification to be tested by examining melting range and thin layer chromatography. The compound was eluci- dated by using infrared spectrophotometry and 1H-NMR spectrophotometry. Synthesis of 4-(4-methoxybenzylidene)-2-methyloxazole-5-one yielded rendement over 0,54%. The interpretation of infrared spectrum indicated that the compound which synthesized was different from the former compound but the interpretation of 1H-NMR spectrum indicated that the compound could not be ascertained as 4-(4-methoxybenzylidene)-2-methyloxa- zole-5-one because of there were impurities. 4-(4-methoxybenzylidene)-2-methyloxazol-5-one, oxazolone, 4-methoxyben- zaldehyde, acetylglycine
Sosialisasi Implementasi Prototype Portal Manajemen Sumber Daya High Performance Computing (HPC): Simulasi Dinamika Molekular Heru Suhartanto; Arry Yanuar; Ari Wibisono; Yohanes Gultom
Charity : Jurnal Pengabdian Masyarakat Vol 3 No 2 (2020): Charity - Jurnal Pengabdian Masyarakat
Publisher : PPM Universitas Telkom

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25124/charity.v3i1.2369

Abstract

Masalah pertama yang dihadapi terkait kegiatan ini adalah Penggunaan sumber daya High Performance Computing (HPC) membutuhkan fasilitas superkomputer yang sangat mahal, baik pengadaan maupun perawatannya. Sehingga fasilitas HPC tersebut hanya dimiliki institusi tertentu yang memiliki sumber pendanaan cukup besar. Terutama di Indonesia, mungkin hanya segelintir lembaga pendidikan dan penelitian yang mampu memilikinya. Hal ini mengakibatkan, pemanfaatan HPC untuk penelitian menjadi terbatas, karena sangat sedikit sekali aktivitas penelitian yang memiliki akses ke fasilitas HPC tertentu. Sehingga hal ini menjadi suatu hambatan tersendiri, terutama untuk kasus penelitian yang menuntut sumber daya komputasi besar. Masalah kedua yakni para peneliti yang umumnya berasal dari berbagai macam disiplin ilmu pengetahuan sering tidak memiliki kemampuan tentang bagaimana menggunakan infrastruktur HPC tersebut. Umumnya, pengguna HPC cloud akan diberikan beberapa server virtual, kemudian server virtual tersebut harus disiapkan secara mandiri sesuai kebutuhan aplikasinya. Setup tersebut berkaitan dengan instalasi Sistem operasi, midleware, aplikasi, serta beberapa konfigurasi yang tidak sederhana. (Rajan et all, 2011) Sehingga, peneliti tersebut harus bertambah pekerjaan dan waktu tambahan untuk mempelajari suatu kemampuan lain yang cukup rumit di luar esensi penelitian itu sendiri agar mampu menggunakan cloud IAAS tersebut Untuk mengatasi masalah masalah pertama tersebut, muncul satu alternatif solusi, yaitu dengan penggunaan layanan cloud Infrastruktur-as-a-Service (IAAS), di mana layanan cloud tersebut menyediakan infrastruktur HPC. Layanan infrastruktur tersebut meliputi prosesor, memory, storage, jaringan internet, listrik serta perawatan. Saat ini banyak bermunculan vendor IAAS, seperti Amazon EC2 (Elastic Computing Cloud for Computing Service), S3 (Simple Storage Service), Microsoft Azure (PAAS), Google AppEngine, dan lainnya. Penulis telah mengembangkan prototype portal Sumber Daya HPC untuk simulasi dinamika molekuler sebagai output dari kegiatan penelitian beberapa tahun belakangan ini. Dalam kegiatan ini, dilakukan ujicoba implementasi prototype tersebut kepada usernya yakni para peneliti baik dosen dan mahasiswa. Sosialisasi pengenalan dan ujicoba prototype tersebut telah dilakukan kepada beberapa rekan dosen, peneliti dan mahasiswa di Universitas Padjajadan dan Institute Teknologi Bandung. Berdasarkan hasil kuesioner kegiatan sosialisasi ini, seluruh peserta merasa puas dengan kegiatan sosialisasi ini dan menganggap prototype tersebut dapat membantu memperbaiki kondisi mereka. Sistem yang diperkenalkan ini juga dianggap sesuai oleh seluruh peserta untuk mengangkat potensi bidang mereka (farmasi/kimia). Sebagian besar peserta juga merasa puas dengan acara yang diselenggarakan ini dan merasa cukup mampu untuk memanfaatkan sistem ini secara mandiri tanpa bantuan/pendampingan dari tim UI.
Analisis Penambatan dan Simulasi Dinamika Molekular Komplex Siklookgesinenase-2 dengan Beberapa Senyawa Turunan Kuinazolinon Yanuar, Arry; Setiajid, Muhammad Aditya; Hayun, .
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 1 (2014)
Publisher : Indonesian Research Gateway

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Abstract

The aims of this research is to observe the inhibition activity of sulfonamides or sulfacetamides substituted of 3-Phenyl-2-styril-4(3H)-quinazolinones with COX-2. The study of COX-2, binding inhibition and dynamics interaction was done with in silico method by molecular docking with Auto Dock 4.0 and molecular dynamics in 2 nanoseconds with Amber 11. Those compound could be divided into 3 groups, based on ΔG scores of docking result: very selective group (-10.92 to -11.33 kcal/mol) compared to SC-558 (-10.90 kcal/mol); selective group compound (-9.22 to -10.68 kcal/mol) compared to celecoxib (-10.63 kcal/mol); non selective group, compound (-6.48 to -6.98 kcal/mol) compared to aspirin (-4.82 kcal/mol). Molecular dynamics simulation of 6COX complex with several quinazolinon derivates showed number and stability of hydrogen bond.Keywords : COX-2, anti-inflammatory, molecular docking, molecular dynamics.
Eksplorasi dan Karakterisasi berbagai Kristal Ibuprofen Arry Yanuar; Nursanti Nursanti; Effionora Anwar
PSR (Pharmaceutical Sciences and Research) Vol 7, No 2 (2010)
Publisher : Fakultas Farmasi Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Ibuprofen is an analgesic anti-inflammatory nonsteroidal (AINS). Generally, ibuprofenhave a bad flowability because a high cohesivity. Another problem in manufacturingis the high tendency for sticking to the punches. Besides these disadvantageous properties,ibuprofen indicates bad dissolution behavior because of its hydrophobic structure.To improve the properties of ibuprofen can be used crystallization method withusing variation of solvents. In this experiment observed crystallization method bycooling, evaporation, and water presence, which used methanol, ethanol, and acetonesolvents. Of all the crystallization results are produced white prism-shaped crystalline.The selected method is cooling method, which is characterized using ScanningElectron Microscopy (SEM), powder X-ray diffraction, and Differential ScanningCalorimetry (DSC). These three characterizations indicate transformation of crystalform which compared with ibuprofen’s standard. The selected method also producesnon cohesive powder which have the size particle is 710-1180µm, compressibilityindex: IBMD 14.2%, IBED 16.6%, IBAD 17.1%; angles of repose: IBMD 28.1º,IBED 29.7º, IBAD 30.1º, and have higher solubility than the common crystal’ssolubility. The result indicates that crystallization method is able to improve flowrate,compressibility index, and dissolution rate properties of ibuprofen’s standard.Keywords : Ibuprofen, Crystal habit, Polymorphism, Crystallization techniques.
Uji Aktivitas Antibakteri 1-[(Kuinazolin-4-on-2-il)metil]piridin-1-ium Bromida dan 2-Bromometilkuinazolin-4-on Hayun .; Arif Arrahman; Herman Suryadi; Arry Yanuar
PSR (Pharmaceutical Sciences and Research) Vol 1, No 1 (2014)
Publisher : Fakultas Farmasi Universitas Indonesia

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Abstract

Antibacterial activity tests of quinazolin-4-one derivates: 1-[(6-nitroquinazolin-4-one- 2-yl)methyl]piridin-1-ium bromide (1), 1-[(6-aminoquinazolin-4-on-2-yl)methyl]piridin-1-um bromide (2), 2-bromomethylquinazolin-4-one (3) and 2-bromomethyl-6-nitroquinazolin-4-one (4) with trimethoprim (5) as a positive standard were conducted. The antibacterial activity tests were carried out using disc diffusion method againts E. coli, S. aureus and S. thyposa, and determination of minimum inhibitory concentration (MIC). The results showed that compounds 1 and 2 are inactive as antibacterial, whereas compounds 3 and 4 are active. The activities to E. coli were ¼ times the activity of trimethoprim (MIC : 5 x 102 μg/ml compared to 1.25 x102 μg/ml ). The activity to S. typhosa were ½-1 times the activity of trimethoprim (MIC: 2.5 and 1.25x102 μg/ml compared to 1.25x102 μg/ml); but they are not active to S. aureus. Trimethoprim active to S. aureus with MIC : 0.62 x102 μg/ ml.